Search

This review summarizes the applications of organophosphates in organic synthesis. After a brief introduction, it discusses cross-coupling reactions, including both transition-metal-catalyzed and transition-metal-free substitution reactions. Subsequently, oxidation and reduction reactions are described. In addition, this review highlights the applications of organophosphates in the synthesis of natural compounds, demonstrating their versatility and importance in modern synthetic chemistry. [ABSTRACT FROM AUTHOR]

A new method for the preparation of halocyclobutenes is described. The developed process involves the dehydration of halocyclobutanols by using tetrafluoroboric acid–diethyl ether complex in dichloromethane at room temperature. The process allows for high yields of halocyclobutenes to be achieved by using alcohols that do not trigger the formation of isomeric allylic halides. [ABSTRACT FROM AUTHOR]

A new method for the preparation of halocyclobutenes is described. The developed process involves the dehydration of halocyclobutanols by using tetrafluoroboric acid–diethyl ether complex in dichloromethane at room temperature. The process allows for high yields of halocyclobutenes to be achieved by using alcohols that do not trigger the formation of isomeric allylic halides. [ABSTRACT FROM AUTHOR]

The present work describes the preparation of halohydrins from 2‐halocyclobutanones by means of reactions with Grignard reagents at −78 °C. We discovered that the prepared cyclobutanols underwent a thermal ring‐opening reaction. Depending on the structure of the starting cyclobutanol, different products were formed. More specifically, 1‐substituted 2‐bromocyclobutan‐1‐ol was found to open to γ‐substituted butyrophenones. A novel 1,3‐dihydro‐2H‐inden‐2‐ylidene derivative was obtained for indene‐derived cyclobutanols. Based on the outcomes of the performed experiments, a mechanism for the ring‐opening of cyclobutanols can be proposed. [ABSTRACT FROM AUTHOR]

This review summarizes the current state-of-the-art procedures in terms of the preparation of N-arylindoles. After a short introduction, the transition-metal-free procedures available for the N-arylation of indoles are briefly discussed. Then, the nickel-catalyzed and palladium-catalyzed N-arylation of indoles are both discussed. In the next section, copper-catalyzed procedures for the N-arylation of indoles are described. The final section focuses on recent findings in the field of biologically active N-arylindoles. [ABSTRACT FROM AUTHOR]