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This study focused on local strain behaviour near the slit edge of spot-welded joints, where the fatigue crack initiated, and investigated methods of evaluating cumulative fatigue damage. A method of evaluating local strain amplitude by following modified Goodman's law gave almost the same result as an evaluation approach based on the external force and provided reasonable result on general strength design. An approach based on Smith-Watson-Topper's equation was easy to evaluate cumulative fatigue damage compared with the method based on modified Goodman's law and gave a good agreement with a criterion of the modified Miner's rule. [ABSTRACT FROM AUTHOR]

Presents a letter to the editor commenting on endoscopically resected colorectal leiomyomas containing eosinophilic globules.

AIM: Pyridoxamine inhibits the development of diabetic complications. CD36 is a receptor/transporter which binds fatty acids of lipoproteins. The objective of the present study was to examine the pleiotropic effects of pyridoxamine, especially CD36 expression in KK-A(y)/Ta mice with type 2 diabetic nephropathy. METHODS: KK-A(y)/Ta mice were divided into 2 groups as follows: pyridoxamine treatment group and a tap water group as controls. The urinary ACR, fasting serum insulin, TG and lipoprotein subclasses were measured as biochemical parameters. The renal expressions of malondialdehyde (MDA) were evaluated by immunohistochemistry. CD36 mRNA expressions in kidney and adipose tissue were also evaluated using real-time PCR. RESULTS: Pyridoxamine decreased levels of urinary ACR, serum TG, especially VLDL and fasting serum insulin. MDA accumulation in the pyridoxamine treated group was significantly lower than those in the non-treatment group. The CD36 accumulation and mRNA expressions in kidney and adipose tissue in the treatment group were significantly higher than those in the non-treatment group. CONCLUSIONS: It appears that pyridoxamine ameliorated lipid peroxidation and insulin resistance in KK-A(y)/Ta mice. This pleiotropic effect of pyridoxamine was related to CD36 expression in the kidney and adipose tissue. [ABSTRACT FROM AUTHOR]