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Background: Research has suggested that people diagnosed with schizophrenia experience challenges in their abilities to reflect upon themselves, others and their actions in the world. One emerging approach to addressing these forms of subjective disturbance is Metacognitive Reflection and Insight Therapy (MERIT). Aims: In this study, a randomized delayed trial was conducted to assess the effects of MERIT upon metacognition, psychiatric symptoms and quality of life. Materials and Methods: Following recruitment and randomization, data from 54 adults diagnosed with schizophrenia were analysed. Results: Findings included significant interaction effects between group (immediate intervention or waiting condition) and time (pre‐ and post intervention) with regard to the metacognition general score and its domain of mastery, as well as with regard to negative, positive and cognitive symptoms. Discussion: Participating in MERIT seems to improve one's ability to use reflective knowledge to cope with psychological challenges and to improve, or at least maintain, level of symptomatology. Conclusions: These findings are discussed within the framework of agency as an important aspect of recovery. [ABSTRACT FROM AUTHOR]

Home range size is a fundamental trait that can affect the probability of fish being harvested and, at the same time, may be affected by fishing. The relationship between home range size and fishing will impact the effectiveness of fully protected areas (FPAs), as it will influence the number of fish moving into fished areas, affecting both spillover and edge effects. One hypothesis is that individuals within FPAs will present reduced home range size relative to individuals in fished areas. This pattern can be driven by demographic selection (e.g. fishing of individuals with large home ranges leaving the FPAs), improved habitat requiring less foraging movements, or behavioural changes associated with reduced fishing threats. To test the relationship between home range size and protection, we compiled 1143 individual‐level home range sizes based on acoustic tracking, covering 17 species from 11 FPAs in 7 countries, with information on distance from FPA borders. A dichotomic analysis (in/out of FPAs) did not support a significant change in the home range size between FPAs and fished areas. However, continuous analysis across the FPA borders demonstrated reduced home range size within the FPAs. We did not find an effect of FPA age or size on this pattern. While we cannot pinpoint the underlying mechanism for the pattern revealed, we suggest behavioural changes as the main driver for reduced home range within FPAs. This mechanism will lead to more resident populations within FPAs, reducing fishing mortality within FPAs yet limiting spillover benefits to adjacent fisheries. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this study was to assess the trajectory of women's depressive symptoms during the first six months postpartum, identify risk factors (sociodemographic, obstetric and personality) associated with classes, and examine associations between classes and postpartum PTSD at two months and bonding at six months. Methods: The final sample included 212 women who gave birth in the maternity wards of a large tertiary health center that were approached at 1–3 days, two months, and six months postpartum and completed a demographic questionnaire and measures of neuroticism (BFI) and postpartum depression (EPDS), postpartum PTSD (City Birth Trauma Scale) and bonding (PBQ). Obstetric data were taken from the medical files. Results: Cluster analysis revealed three distinctive clusters: "stable-low" (64.2%), "transient-decreasing" (25.9%), and "stable-high" (9.9%). Neuroticism, general-related PTSD symptoms, and bonding were associated with differences between all trajectories. Birth-related PTSD symptoms were associated with differences between both stable-high and transient-decreasing trajectories and the stable-low trajectory. No obstetric or demographic variables were associated with differences between trajectories. Conclusion: We suggest that screening women for vulnerabilities such as high levels of neuroticism and offering treatment can alleviate the possible deleterious effects of high-symptom depression trajectories that may be associated with their vulnerability. [ABSTRACT FROM AUTHOR]

Objectives: To determine the prevalence of proteinuria in patients diagnosed with intrahepatic cholestasis of pregnancy (IHCP), and the association between the presence of proteinuria and adverse pregnancy outcomes. Methods: This was a retrospective cohort study. The study included all pregnant patients between July 2014 and January 2022, at gestational age > 24weeks who had been diagnosed with IHCP and had completed a 24-hour protein collection. High order multifetal gestations were excluded. Patients were divided into 3 groups:1. IHCP without proteinuria (Non-proteinuric group);2. IHCP with proteinuria and normal blood pressure (Isolated proteinuria group), and 3. IHCP with proteinuria and elevated blood pressure (IHCP with preeclampsia (PET)). Primary outcome was defined as a composite maternal-fetal outcome including: preterm labor <34 weeks, arterial cord blood ph<7.1, rate of Cesarean delivery due to non-reassuring fetal monitoring. Parametric and non-parametric statistical methods were used for analysis. Results: A total of 272 met all inclusion criteria and were included, 94 patients (34.5%) had proteinuria; of them, 67 (24.6%) had isolated proteinuria and 27 (9.9%) had PET. Demographic parameters were comparable among the groups. Patients with PET had higher rates of in-vitro fertilization (IVF) treatments, twin gestation and elevated serum creatinine and urea levels. The rate of composite adverse pregnancy outcome was higher in patients with PET compared with patients with and without proteinuria (14/27 (51.9%) vs. 18/67 (26.9%) vs. 49/178 (27.5%), respectively, p = 0.03). Conclusions: Approximately 35% of patients with IHCP have proteinuria. The presence of PET, rather than isolated proteinuria, is associated with adverse pregnancy outcome. [ABSTRACT FROM AUTHOR]

To explore the obstetric, maternal and neonatal outcome in the subsequent pregnancy after a pregnancy with an accidental uterine extension (AUE) during cesarean delivery (CD), as well as the relationship between the different types of AUE (inferior, lateral and superior). A retrospective cohort study of all CD with AUE in a tertiary medical center between 01/2011–01/2022. Women with a prior CD with AUE were compared to a 1:3 ratio matched control group of women with a prior CD without AUE. All AUE were defined in their direction, size and mode of suturing. CD with deliberate uterine extensions were excluded. We evaluated obstetric, maternal and neonatal outcomes in the subsequent pregnancy after a pregnancy with AUE during CD. Comparing women with a prior CD with AUE (n=177) to the matched control group of women with a prior CD without AUE (n=528), we found no significant differences in proportions of uterine rupture or any other major complication or adverse outcome between the groups. There were no significant differences in the outcomes of the subsequent pregnancy in relation to the characteristics of the AUE (direction, size and mode of suturing). Subsequent pregnancies after AUE are not associated with higher maternal or neonatal adverse outcomes including higher proportions of uterine rupture compared to pregnancies without previous AUE. Different characteristics of the AUE do not impact the outcome. [ABSTRACT FROM AUTHOR]

Introduction: In this case report, we demonstrate the application of an aspheric macular lens (Grieshaber, Alcon) for conducting posterior segment procedures after a posterior capsular rupture (PCR) occurrence during cataract surgery. Case Presentation: During a cataract surgery on a 70-year-old female patient, a PCR was identified, accompanied by the descent of the lens into the vitreous, and prompted subsequent interventions. This involved performing posterior-assisted levitation, anterior segment phacoemulsification, and anterior segment vitrectomy. Subsequently, due to the absence of a BIOM posterior viewing system in the operating room, an aspheric macular lens (Grieshaber, Alcon) was positioned on the patient’s eye. Subsequently, pars plana vitrectomy was performed, along with the extraction of residual lens cortical remnants. The procedure concluded with gradually inserting a 3-piece intraocular lens into the sulcus. Conclusion: When managing posterior capsular rupture, using an aspheric macular lens, such as the Grieshaber (Alcon), can be beneficial. [ABSTRACT FROM AUTHOR]

What is the role, if there is any, of our free will in the deterministic experience of being an addict? The acknowledgment of free will has theoretical, practical, and social consequences as well as an impact on those struggling with addiction. This article examines the freewill dynamic of people in active addiction and recovery phases through a Kantian lens, mainly in terms of autonomy and heteronomy, using the 12-step program as a case study. We show that free will and deterministic experience of compulsive use both manifest in addiction and recovery in a dynamic and episodic manner. We also show how heteronomy may be functional in recovery and in cultivating autonomous conduct. In addition to an interpretive grounding, we provide guidelines for the restoration of the individual's agency by assessing the factors enabling its cultivation in the 12-step program. This process converges into several procedural categories: diffused heteronomy, taking responsibility for the entrustment of will, the liminal stage with its nurture of autonomy and moral identity, and spiritual freedom. [ABSTRACT FROM AUTHOR]

Homework assignments, or specific tasks patients are asked to engage in or complete between sessions, are a controversial topic among psychoanalysts. While many argue these interventions contradict psychoanalytic principles, others believe they can help address problems and promote coping skills. We propose that homework can be a legitimate aspect of relational psychoanalysis when used in a way that is attuned to the patient's experience and that homework may be an important component of treating personality disorders (PD). We present the case of a man diagnosed with narcissistic PD. He often felt superior to and reported that he despised others, though the core self‐image was of fragile. He embraced the role of the omnipotent caregiver, which came with boredom and anger and lack of satisfaction in his social life. The patient tried to control therapy, asserting that he could psychoanalyze himself. As a result, therapy was stalled and progress was limited. At this point, the therapist asked him to complete homework assignments that encouraged him to refrain from his compulsive caregiving to better understand what motivated this behavior. Through this process, the patient came to realize he acted out of avoidance, as he did not want to disclose his own vulnerabilities and flaws. At that point he was able to experience relationships while adopting different stances and finding new meanings. We argue that homework can be fully integrated into the relational psychoanalytic repertoire to improve self‐reflection and foster change in patients with PD. [ABSTRACT FROM AUTHOR]

On October 7, 2023 (10/7), Hamas militants brutally attacked Israeli towns and villages surrounding the Gaza Strip, resulting in the killing of more than 1100 people, most of whom were civilians slaughtered in their own homes. The killings occurred under highly traumatic circumstances, including shooting, the burning of homes, hunting down people who attempted to escape, and severe sexual assault. Thus, many Israelis today experience a unique mix of both posttraumatic and severe grief reactions. Traumatic grief (TG) is often defined as a condition that results from the death of a significant other and includes symptoms similar to posttraumatic stress disorder (PTSD) that are specifically related to the deceased, such as intrusive thoughts and memories about the deceased and hypervigilance expressed by constantly looking for them or cues associated with them. However, whereas definitions, phenomenological descriptions, and clinical illustrations of PTSD are abundant and widely validated, TG has yet to receive formal diagnostic status. In this paper, we aim to reexamine TG in the context of post‐10/7 Israel. We argue that TG is a critical concept for clinicians working in Israel and other conflict‐exposed areas of the world today, as it accurately captures the painful mix of grief‐ and trauma‐related symptoms. We also suggest potential explanations for the lack of acknowledgment of TG as a formal diagnosis and discuss the possible role of historical events in the formation of new, relevant psychiatric diagnoses. [ABSTRACT FROM AUTHOR]

The ability to amplify, translate, and process small ionic potential fluctuations of neural processes directly at the recording site is essential to improve the performance of neural implants. Organic front-end analog electronics are ideal for this application, allowing for minimally invasive amplifiers owing to their tissue-like mechanical properties. Here, we demonstrate fully organic complementary circuits by pairing depletion-and enhancement-mode p-and n-type organic electrochemical transistors (OECTs). With precise geometry tuning and a vertical device architecture, we achieve overlapping output characteristics and integrate them into amplifiers with single neuronal dimensions (20 micrometers). Amplifiers with combined p-and n-OECTs result in voltage-to-voltage amplification with a gain of >30 decibels. We also leverage depletion and enhancement-mode p-OECTs with matching characteristics to demonstrate a differential recording capability with high common mode rejection rate (>60 decibels). Integrating OECT-based front-end amplifiers into a flexible shank form factor enables single-neuron recording in the mouse cortex with on-site filtering and amplification. [ABSTRACT FROM AUTHOR]

We, the QUARTET Collaboration, propose an experiment to measure the nuclear charge radii of light elements with up to 20 times higher accuracy. These are essential both for understanding nuclear physics at low energies, and for experimental and theoretical applications in simple atomic systems. Such comparisons advance the understanding of bound-state quantum electrodynamics and are useful for searching for new physics beyond the Standard Model. The energy levels of muonic atoms are highly susceptible to nuclear structure, especially to the mean square charge radius. The radii of the lightest nuclei (with the atomic number, Z = 1 , 2 ) have been determined with high accuracy using laser spectroscopy in muonic atoms, while those of medium mass and above were determined using X-ray spectroscopy with semiconductor detectors. In this communication, we present a new experiment, aiming to obtain precision measurements of the radii of light nuclei 3 ≤ Z ≤ 10 using single-photon energy measurements with cryogenic microcalorimeters; a quantum-sensing technology capable of high efficiency with outstanding resolution for low-energy X-rays. [ABSTRACT FROM AUTHOR]

Dans cet article, l'auteure retrace les premiers moments de l'introduction de la psychanalyse en pédopsychiatrie et le contexte de leur émergence dans les années 1920 et 1930 en France. Ils sont contemporains de la difficile introduction de la psychanalyse dans l'univers médical. La psychanalyse de l'enfant apparaît alors comme une prophylaxie des troubles névrotiques et suscite l'intérêt des psychopédagogues et des éducateurs. L'auteure retrace les travaux pionniers de la psychanalyste Sophie Morgenstern au sein de la consultation de psychiatrie infantile de Georges Heuyer, et ceux de Pierre Mâle dans sa consultation de psychiatrie infantile à Henri Rousselle. Celui-ci deviendra, à la Libération, le spécialiste de la psychothérapie de l'adolescent. Cependant, l'héritage de Morgenstern va être oublié ou renié par ceux qui vont lui succéder, et elle s'interroge sur les raisons de ce phénomène. Ces travaux pionniers, qui dessinent un nouveau visage de l'enfance normale et anormale, vont connaître une forte expansion après la Seconde Guerre mondiale. In this paper, the author describes the first moments of the introduction of psychoanalysis in child psychiatry and the context of their emergence in the 1920s and 1930s in France. They are contemporaneous with the difficult introduction of psychoanalysis into the medical world. Child psychoanalysis then appeared as a prophylaxis of neurotic disorders, and aroused the interest of educational psychologists and educators. It traces the pioneering work of psychoanalyst Sophie Morgenstern in Georges Heuyer's child psychiatry consultation, and that of Pierre Mâle in Henri Rousselle's child psychiatry consultation. After the Liberation, he became the recognized specialist in adolescent psychotherapy. On the other hand, Morgenstern's legacy will be forgotten or disowned by those who will succeed her, and the author wonders about the reasons for this phenomenon. This pioneering work, which drew a new face of normal and abnormal childhood, was to be greatly expanded after the Second World War. [ABSTRACT FROM AUTHOR]

The recent emerging technologies (e.g., hybrid vehicles and wearable electronic devices) laid down critical and stringent considerations for their power sources. In this regard, supercapacitors (SCs) have become an attractive energy storage solution, thanks to their superior power density and stability over batteries. The continuous development of SCs is an active field of research toward practical application and commercialization. Yet, finding electrode materials with high capacitance, excellent cycle-life, and mechanical stability is of major interest to exceed the current state-of-the-art SCs. The unique set of features of conducting polymers (CPs), including remarkable electrochemical properties, tunable synthesis, solution-processable capabilities, and mechanical flexibility, promotes them at the forefront of materials for SCs electrodes. This review provides a comprehensive summary of CP-based SCs technology. We first start with a brief overview of CPs' unique properties and the principal synthetic methods that enable innovative fabrication. Then, a compact summary of the electrochemical and physicochemical characterization techniques is presented to assess the quality and mechanism of CP-based SCs. We limit our discussion to the published works in the last ten years. Finally, we highlight several research trends, key challenges, and opportunities of CP-based SCs for future research and development. [ABSTRACT FROM AUTHOR]

Background: Prolonged grief disorder (PGD) was recently approved as a formal diagnosis in the DSM‐5‐TR. The implementation of bereavement interventions is frequently requested, but their effectiveness has been controversial. Narrative reconstruction (NR) is a time‐limited integrative therapy, originally developed for the treatment of post‐traumatic stress disorder (PTSD) and adapted for the treatment of PGD. NR consists of exposure to the loss memory, a detailed written reconstruction of the loss memory narrative, and an elaboration of the personal significance of that memory for the bereaved. Objectives: In this study we evaluated the efficacy of NR for PGD. Method: In this study, 33 participants with PGD were quasi‐randomized—that is, assigned to an immediate (n = 20) or delayed (n = 13) 16‐session NR intervention. PGD, intrusion, avoidance and depression symptoms, as well as levels of the loss memory integration, were assessed at pretreatment, post‐treatment, and at a 3‐month follow‐up. Results: Mixed linear models showed significant intervention effects for PGD and intrusive symptomatology. Results also showed an increase in integration of the loss memory, and improvements remained stable for all outcomes at follow‐up. Conclusion: In this study we established NR as an effective intervention for PGD and call for further validation in future studies. Integrating this intervention into the routine care of people with PGD seems important and beneficial. [ABSTRACT FROM AUTHOR]

Purpose. Postintravitreal injection (IVI) endophthalmitis is a rare but devastating complication. Herein, we report the incidence ,and clinical and microbiological characteristics, as well as the visual outcome, in IVIs endophthalmitis in two medical centers. Methods. All patients undergoing intravitreal injections between 1/2018 and 12/2019 in two large medical centers were analyzed for post-IVI endophthalmitis. Results. Of the total of 51,356 IVIs performed, 23 cases of post-IVI endophthalmitis were diagnosed, yielding an overall incidence of 0.045%. The median interval from IVI to symptoms onset was 2 days (IQR: 1–5). Cultures were positive in 56% of the cases (100% Gram-positive bacteria and 76% coagulase-negative staphylococcus). Parameters associated with higher culture-positive rates included samples taken during vitrectomy, WBC on vitreous smear, the number of IVIs in the 12 months prior to presentation, and the time interval from last IVI to diagnostic sampling. At 6- and 12-month follow-up, the median change in VA (logMAR) was −1.10 (IQR: (−1.32)–(−0.40)) and −1.02 (IQR: (−1.10)–(−0.30)), respectively. Younger age and better BCVA at presentation were associated with better VA outcome, while positive culture result and systemic steroids treatment were each associated with the worse visual outcome. We found no difference in visual outcomes between PPV and TAI as a primary procedure. Conclusion. Post-IVI endophthalmitis is a rare complication, and most patients do not regain their initial VA. Certain parameters (clinical, microbiological, and therapeutic) may help anticipate the outcome and guide decision making regarding diagnosis and treatment. [ABSTRACT FROM AUTHOR]

2D materials are of interest in various applications such as energy conversion, storage, and sensing. These materials are prepared by bottom‐up or top‐down methods that are difficult to control and suffer from low yield. Synthesis in molten salt is suggested as an alternative in which the balance between exfoliation and solubility is explored. It is demonstrated that when a pellet of 2D material is insoluble in molten salt (graphite in any salt), it is exfoliated. For low solubility (MoS2 in NaCl/KCl), the 2D material nucleates and grows into a small flowerlike structure composed of thin MoS2 sheets through Ostwald ripening. For high solubility in the molten salt (MoS2 in CsCl), it forms larger flowers. Herein, the molten salt treatment of high and low surface area MoS2 (micron‐size particles and a single large pellet, respectively) is compared. The particles yielded facet MoS2 crystals through dissolution–nucleation–recrystallization process and the pellet yielded flowers. Herein, methods for synthesizing 2D materials with controllable size and shape are promoted by simple molten salt treatment that opens an avenue to the development of soluble (MoS2) and non‐soluble (graphite) materials with different morphologies in a simple and affordable way. [ABSTRACT FROM AUTHOR]

Narrative reconstruction is a time-limited integrative therapy, originally developed in the context of post-traumatic stress disorder and adjusted for the treatment of prolonged grief disorder (PGD). It consists of exposure to the loss memory and narrating a detailed written reconstruction of it. In this paper, we describe narrative reconstruction interventions and modifications for the treatment of PGD as well as the underlying mechanisms of change including integration of the loss episode into the life narrative. A case demonstration of narrative reconstruction with a patient with PGD presented for illustration and the integrative nature of narrative reconstruction for PGD is discussed. [ABSTRACT FROM AUTHOR]

Previous investigations have demonstrated the therapeutic advantages of extremely low-frequency electromagnetic fields (ELF-EMFs) in mitigating inflammation and influencing biological processes. We aimed to shed light on the effects of ELF-EMF on recovery rate following high-intensity exercise. Nine male athletes (26.7 ± 6.0 years; 69.6 ± 7.7 kg, VO2peak 57.3 ± 6.8 mL/kg/min) completed five visits in a double-blinded crossover design, performing two consecutive testing days, following a ventilatory thresholds assessment. Following 62 min of high-intensity cycling, participants lay on an ELF-EMF mattress under active (A) and non-active (NA) conditions, immediately post protocol and during the night. Physical performance and blood markers were assessed at baseline and at 60 min (60 P) and 24 h (24 H) post-protocol. The A-condition demonstrated a notable reduction in interleukin-10 (IL-10) concentrations (mean difference = −88%, p = 0.032) and maximal isometric strength of the quadriceps muscles (mean difference = ~8%, p = 0.045) compared to the NA-condition between 60 P and 24 H. In a sensitivity analysis, the A-condition revealed that younger athletes who possessed lower fat mass experienced attenuated inflammation and biochemical responses and improved physical performance. In conclusion, ELF-EMF showed no significant overall effects on performance and inflammation after intense cycling among athletes. Post-hoc analysis revealed modest benefits of ELF-MLF, suggesting a context-dependent impact. Further research with a larger sample size and multiple sessions is needed to confirm the recovery potential of ELF-EMF. [ABSTRACT FROM AUTHOR]

Background: We report on community-based participatory research (CBPR) initiated by women firefighters in order to share successful elements that can be instructive for other community-engaged research. This CBPR initiative, known as the Women Worker Biomonitoring Collaborative (WWBC) is the first we are aware of to investigate links between occupational exposures and health outcomes, including breast cancer, for a cohort of exclusively women firefighters. Methods: In order to be reflective of the experiences and knowledge of those most intimately involved, this article is co-authored by leaders of the research initiative. We collected leaders' input via recorded meeting sessions, emails, and a shared online document. We also conducted interviews (N = 10) with key research participants and community leaders to include additional perspectives. Results: Factors contributing to the initiative's success in enacting broadscale social change and advancing scientific knowledge include (1) forming a diverse coalition of impacted community leaders, labor unions, scientists, and advocacy organizations, (2) focusing on impacts at multiple scales of action and nurturing different, yet mutually supportive, goals among partners, (3) adopting innovative communication strategies for study participants, research partners, and the broader community, (4) cultivating a prevention-based ethos in the scientific research, including taking early action to reduce community exposures based on existing evidence of harm, and (5) emphasizing co-learning through all the study stages. Furthermore, we discuss external factors that contribute to success, including funding programs that elevate scientist-community-advocacy partnerships and allow flexibility to respond to emerging science-policy opportunities, as well as institutional structures responsive to worker concerns. Conclusions: While WWBC shares characteristics with other successful CBPR partnerships, it also advances approaches that increase the ability for CBPR to translate into change at multiple levels. This includes incorporating partners with particular skills and resources beyond the traditional researcher-community partnerships that are the focus of much CBPR practice and scholarly attention, and designing studies so they support community action in the initial stages of research. Moreover, we emphasize external structural factors that can be critical for CBPR success. This demonstrates the importance of critically examining and advocating for institutional factors that better support this research. [ABSTRACT FROM AUTHOR]

Because marine protected areas (MPAs) are not equally effective across their areas, monitoring should progress from dichotomic (within vs. outside) to a finer spatial resolution. Here, we examine the effect of an Eastern Mediterranean no-take MPA on fishes across the MPA and into fished areas, using three methods: underwater visual censuses, acoustic surveys, and towed-diver surveys. The Eastern Mediterranean includes non-indigenous species, so the effect of the MPA was also evaluated for its resistance to invasion. The fine-scale analysis revealed ecological phenomena that could not be captured by dichotomic sampling, such as the edge effect, a reduction of fish biomass along the MPA periphery. Despite their differences, all three methods revealed similar spatial patterns. The fine-scale analysis did not support a biotic resistance of the MPA to non-indigenous species. Our study supports the prevalence of edge effects even in well-enforced no-take MPAs and highlights the need for continuous monitoring to reveal these patterns. [ABSTRACT FROM AUTHOR]

We present an updated value of the Muonium 1S–2S transition frequency, highlighting contributions from different QED corrections as well as the large uncertainty in the Dirac contribution, stemming from the uncertainty of the electron to muon mass ratio. Improving the measurement of this spectral line would allow to extract a more accurate determination of fundamental constants, such as the electron to muon mass ratio or, combined with the Muonium hyperfine splitting, an independent value of the Rydberg constant. Furthermore, we report on the current status of the Mu-MASS experiment, which aims at measuring the Muonium 1S–2S transition frequency at a 10 kHz uncertainty level. [ABSTRACT FROM AUTHOR]

Objective: To study obstetric outcomes of a second pregnancy among women with a first ectopic pregnancy (EP) treated with methotrexate compared with laparoscopic salpingectomy. Methods: A retrospective cohort study including all women with a first EP and a following pregnancy that concluded by delivery at ≥24 weeks of gestation between March 2011 and April 2021. Second pregnancy outcomes were compared between women treated with methotrexate and those treated with salpingectomy in their first pregnancy. Results: Overall, 125 women were included, of which 64 (51.2%) were treated with methotrexate and 61 (48.8%) were treated with salpingectomy. In women treated with salpingectomy, the proportion of women conceiving by in vitro fertilization and those with measured gestational sac diameter or β‐subunit human chorionic gonadotropin was higher. The proportion of women conceiving by in vitro fertilization in their second pregnancy was higher in the salpingectomy group (55.2% versus 18.0%, P < 0.001). All maternal and neonatal outcomes were similar in both groups. The rate of low birth weight < 2500 g was 7.8% in the methotrexate group versus 18% in the salpingectomy group (P = 0.111). Conclusion: Maternal and neonatal outcomes of a second pregnancy among women treated for EP in their first pregnancy are similar in women treated by methotrexate and those treated by salpingectomy. Synopsis: The method of treatment for a first ectopic pregnancy is not associated with maternal and neonatal outcome in the following delivery. [ABSTRACT FROM AUTHOR]

Engagement with science is a prominent feature for many social movements, yet the dimensions of that scientific engagement and bidirectional relationships between science and advocacy are incompletely theorized in social movement scholarship. While social movement scholarship has previously demonstrated the importance of external political and economic factors for social movement processes and efficacy, we show that the emergence and success of environmental health activism is also dependent on dynamic relationships between scientific evidence and lay demands for particular types of knowledge production and application. Despite decades of industrial production and widespread contamination, per- and polyfluoroalkyl substances (PFAS) were a politically obscure class of chemicals until a recent spike in attention from activist, regulatory, and scientific circles. Drawing from in-depth interviews with activists of PFAS-impacted communities, we develop the scientific opportunity concept to examine how activists create and mobilize scientific factors to support their goals, and how scientific factors, in turn, support the emergence of further activism. Dimensions of scientific opportunity include availability of funding streams, openness and receptivity of institutionalized scientific spaces, presence of collaborative or community-led research, methodological and technological advancements aligned with activist demands, availability of relevant scientific findings and datasets, and presence of prominent scientific allies. We conclude by discussing the relevance of our concept to a wide range of social movements addressing science and technology. [ABSTRACT FROM AUTHOR]

The organic electrochemical transistor (OECT) is one of the most versatile devices within the bioelectronics toolbox, with its compatibility with aqueous media and the ability to transduce and amplify ionic and biological signals into an electronic output. The OECT operation relies on the mixed (ionic and electronic charge) conduction properties of the material in its channel. With the increased popularity of OECTs in bioelectronics applications and to benchmark mixed conduction properties of channel materials, the characterization methods have broadened somewhat heterogeneously. We intend this review to be a guide for the characterization methods of the OECT and the channel materials used. Our review is composed of two main sections. First, we review techniques to fabricate the OECT, introduce different form factors and configurations, and describe the device operation principle. We then discuss the OECT performance figures of merit and detail the experimental procedures to obtain these characteristics. In the second section, we shed light on the characterization of mixed transport properties of channel materials and describe how to assess films' interactions with aqueous electrolytes. In particular, we introduce experimental methods to monitor ion motion and diffusion, charge carrier mobility, and water uptake in the films. We also discuss a few theoretical models describing ion–polymer interactions. We hope that the guidelines we bring together in this review will help researchers perform a more comprehensive and consistent comparison of new materials and device designs, and they will be used to identify advances and opportunities to improve the device performance, progressing the field of organic bioelectronics. [ABSTRACT FROM AUTHOR]

Background: Major depressive disorder (MDD) is largely managed in primary care, but physicians vary widely in their understanding of symptoms and treatments. This study aims to better understand the evolution of depression from initial diagnosis over a 3-year period.Methods: This was a noninterventional, retrospective, longitudinal study, with 2 waves of participant interviews approximately 3 years apart. Phone interviews were conducted using the hybrid artificial intelligence (AI) Sleep-EVAL system, an AI-driven diagnostic deep learning tool. Participants were noninstitutionalized adults representative of the general population in 8 US states. Diagnosis was confirmed according to the DSM-5 using the Sleep-EVAL System.Results: 10,931 participants completed Wave 1 and 2 (W1, W2) interviews. The prevalence of MDD, including partial and complete remission, was 13.4 % and 19.6 % in W1 and W2, respectively. About 42 % of MDD participants at W1 continued to report depressive symptoms at W2. Approximately half of antidepressant (AD) users in W1 were moderately to completely dissatisfied with their treatment; 29.6 % changed their AD for a different one, with 16.4 % switching from one SSRI to another between W1 and W2. Primary care physicians were the top AD prescribers, both in W1 (45.7 %) and W2 (59%), respectively.Limitations: Data collected relied on self-reporting by participants. As such, the interpretation of the data may be limited.Conclusions: Depression affects a sizeable portion of the US population. Dissatisfaction with treatment, frequent switching of ADs, and changing care providers are associated with low rates of remission. Residual symptoms remain a challenge that future research must address. [ABSTRACT FROM AUTHOR]

Objectives This study aims to establish an inventory of the teaching of Therapeutic Patient Education (TPE) in the initial training of French midwives. Method: A descriptive quantitative study was conducted in France. An online questionnaire comprising 27 questions was distributed to 35 French midwifery schools. Results: Out of 19 schools that responded to the survey, 11 taught TPE, 8 did not address it in training. This teaching is mainly transversal. The obstacles to the teaching of TPE are the current density of the program, the absence of a text regulating this teaching and the difficulties in circumscribing the field of TPE in relation to that of prevention, promotion and health education. The simulation is used in only one school. Discussion: This survey shows a willingness of educational teams to invest in the teaching of health education, including TPE. For this, it is a question of strengthening the training of teachers in order to clarify the areas of intervention of the midwife calling for health promotion, prevention and health education; to offer specific internships to students and to use simulation. Extending the duration of initial training is an opportunity to plan specific teaching and to discuss the place of the health service. [ABSTRACT FROM AUTHOR]

[Display omitted] Phase change materials have the potential for use in high-density thermal energy storage. However, their low thermal conductivity and the need for shape stabilization restrict their performances and implementation in various fields. The inclusion of thermally conductive nanomaterial as a single or hybrid filling is expected to form 3D network that enhances the thermal performances of phase change materials. The encapsulation of the colloidal composites in a polymer matrix stabilizes the phase change material. A paraffin matrix was loaded with carbon-based fillers of various dimensionalities, namely, 1D-carbon nanotubes, 2D-graphene nanoplatelets, and 3D-graphite flakes. The thermal conductivity of the colloidal composite was measured by transient plane source and the latent heat capacity by differential scanning calorimetry techniques. Modeling the thermal conductivity by the effective medium approach predicts the experimental results. The thermal conductivity of the phase change material loaded with fillers is enhanced from 0.2 to 11 W (m K)-1 (×55) compared with a filler-free paraffin matrix. We attribute this enhancement to the synergetic effect of the hybrid fillers (8 vol% graphite flakes and 12 vol% graphene nanoplatelets) and consequent compression (25 bar) of the colloidal composite. Moreover, the obtained phase change material is completely stable during charging and discharging cycles. [ABSTRACT FROM AUTHOR]

Proteasome 26S, the eukaryotic proteasome, serves as the machinery for cellular protein degradation. It is composed of the 20S core particle and one or two 19S regulatory particles, composed of a base and a lid. To date, several human diseases have been associated with mutations within the 26S proteasome subunits; only one of them affects a base subunit. We now delineate an autosomal recessive syndrome of failure to thrive, severe developmental delay and intellectual disability, spastic tetraplegia with central hypotonia, chorea, hearing loss, micropenis and undescended testes, as well as mild elevation of liver enzymes. None of the affected individuals achieved verbal communication or ambulation. Ventriculomegaly was evident on MRI. Homozygosity mapping combined with exome sequencing revealed a disease‐associated p.I328T PSMC1 variant. Protein modeling demonstrated that the PSMC1 variant is located at the highly conserved putative ATP binding and hydrolysis domain, and is suggested to interrupt a hydrophobic core within the protein. Fruit flies in which we silenced the Drosophila ortholog Rpt2 specifically in the eye exhibited an apparent phenotype that was highly rescued by the human wild‐type PSMC1, yet only partly by the mutant PSMC1, proving the functional effect of the p.I328T disease‐causing variant. [ABSTRACT FROM AUTHOR]

Background and Objective: Sleep paralysis is a common phenomenon which causes and consequences are seldomly studied. The aim of this study was to investigate the incidence and prevalence of sleep paralysis (SP) in the American adult population and its evolution on a 3-year period.Methods: This longitudinal study was conducted between 2002 and 2015 and included a representative sample of the US general population. A total of 12,218 subjects were initially interviewed (W1) and 10,931 were re-interviewed three years later (W2). The subjects participated in telephone interviews using the Sleep-EVAL expert system. Each interview lasted for about 1 h. SP episodes were assessed according to their frequency and duration.Results: At W1, 9.7% (95%CI: 9.1%-10.3%) reported having ≥1 episode of SP in the previous year. At W2, 15.1% (95%CI: 14.4%-15.8%) reported SP. A total of 29.9% of subjects with SP at W1 still reported episodes at W2. The 1-year incidence was 2.7% (95%CI: 2.4-3.0%). After adjusting for age and sex, prevalent SP (i.e., present at W2) was predicted by age and race and the following factors present at W1: major depressive disorder, pain, hypersomnolence, cataplexy, hypnagogic and hypnopompic hallucinations, posttraumatic stress disorder, a reduction in sleep duration of ≥60 min, and the use of analgesic/antipyretic medication. Incident SP (i.e. new cases at W2) had similar predictive factors.Discussion: Episodes of SP are frequent in the general population. Its persistence is predicted by several factors associated with narcolepsy like hypersomnolence and cataplexy but also by other factors like posttraumatic stress disorder or pain. [ABSTRACT FROM AUTHOR]

Previous work using the numerical comparison task has shown that an empty set, the nonsymbolic manifestation of zero, can be represented as the smallest quantity of the numerical magnitude system. In this study, we examined whether an empty set can be represented as such under conditions of automatic processing in which deliberate processing of stimuli magnitudes is not required by the task. In Experiment 1, participants performed physical and numerical comparisons of empty sets (i.e., empty frames) and of other numerosities presented as framed arrays of 1 to 9 dots. The physical sizes of the frames varied within pairs. Both tasks revealed a size congruity effect (SCE) for comparisons of non-empty sets. In contrast, comparisons to empty sets produced an inverted SCE in the physical comparison task, whereas no SCE was found for comparisons to empty sets in the numerical comparison task. In Experiment 2, participants performed an area comparison task using the same stimuli as Experiment 1 to examine the effect of visual cues on the automatic processing of empty sets. The results replicated the findings of the physical comparison task in Experiment 1. Taken together, our findings indicate that empty sets are not perceived as "zero," but rather as "nothing," when processed automatically. Hence, the perceptual dominance of empty sets seems to play a more important role under conditions of automatic processing, making it harder to abstract the numerical meaning of zero from empty sets. [ABSTRACT FROM AUTHOR]

Child loss may undermine one's faith. Whereas much is known about religion's role following loss, less is known about the experience of divine struggle—namely, struggling with complex God-related emotions/beliefs—particularly among diverse sociocultural samples. Employing a narrative approach, we interviewed 20 bereaved Modern-Orthodox parents. Analysis revealed three types of divine struggle (explicit, implicit/silenced, none) differentiated by four categories: core emotional experience, response type, significance of faith in the coping process, and the impact of grief-induced divine struggle on parent-God relationship. Findings emphasize the need for culturally-sensitive inquiry of divine struggle, that divine struggle may be silenced, and therapists' awareness is critical. [ABSTRACT FROM AUTHOR]

Background Studies examining face processing among individuals with congenital deafness show inconsistent results that are often accounted for by sign language skill. However, working memory for faces as an aspect of face processing has not yet been examined in congenital deafness. Purpose To explore working memory for faces among individuals with congenital deafness who are skilled in sign language. Research Design A quasi-experimental study of individuals with congenital deafness and a control group. Study Sample Sixteen individuals with congenital deafness who are skilled in sign language and 18 participants with intact hearing, matched for age, and education. Intervention The participants performed two conditions of the N-back test in ascending difficulty (i.e., 1-back and 2-back). Data Collection and Analysis Levene's and Shapiro–Wilk tests were used to assess group homoscedasticity and normality, respectively. A two-way repeated measures analysis of variance was applied to compare the groups in response time and accuracy of the N-back test, as well as Pearson correlation between response time and accuracy, and sign language skill duration. Results The congenital deafness group performed better than controls, as was found in the response time but not in the accuracy variables. However, an interaction effect showed that this pattern was significant for the 1-back but not for the 2-back condition in the response time but not the accuracy. Further, there was a marginal effect in response time but a significant one in accuracy showing the 2-back was performed worse than the 1-back. No significant correlation was found between response time and accuracy, and sign language skill duration. Conclusion Face processing advantage associated with congenital deafness is dependent on cognitive load, but sign language duration does not affect this trend. In addition, response time and accuracy are not equally sensitive to performance differences in the N-back test. [ABSTRACT FROM AUTHOR]

Background: While past research detected a direct link between symptoms of fibromyalgia (FM) and psychological distress, body appreciation was suggested as a viable mediator of this link. The aim of the present study was to further develop an explanatory model for the effect of FM on women’s psychological distress and identify possible protective and risk factors. Specifically, it was hypothesized that self-compassion would moderate the indirect effect of body appreciation and self-criticism on psychological distress in women with FM.This study comprised a total of 293 women, aged 20–68 (M = 34.8, SD = 12.3), of whom 146 were women with FM and 147 were heathy controls. All the women completed questionnaires regarding demographic characteristics, depression (PHQ-9), anxiety (GAD-7), self-criticism (DEQ-SC), body appreciation (BAS2), and the self-compassion scale (SCS).A moderated serial mediation model demonstrated lower body appreciation in participants with FM compared to controls. These lower levels of body appreciation, together with lower levels of self-compassion, were associated with greater self-criticism and, consequently, higher levels of psychological distress.The results emphasize the role of self-compassion as a protective mechanism against psychological distress among women with FM. Future studies should further investigate the effect of self-compassion-focused interventions on patients with FM.Method: While past research detected a direct link between symptoms of fibromyalgia (FM) and psychological distress, body appreciation was suggested as a viable mediator of this link. The aim of the present study was to further develop an explanatory model for the effect of FM on women’s psychological distress and identify possible protective and risk factors. Specifically, it was hypothesized that self-compassion would moderate the indirect effect of body appreciation and self-criticism on psychological distress in women with FM.This study comprised a total of 293 women, aged 20–68 (M = 34.8, SD = 12.3), of whom 146 were women with FM and 147 were heathy controls. All the women completed questionnaires regarding demographic characteristics, depression (PHQ-9), anxiety (GAD-7), self-criticism (DEQ-SC), body appreciation (BAS2), and the self-compassion scale (SCS).A moderated serial mediation model demonstrated lower body appreciation in participants with FM compared to controls. These lower levels of body appreciation, together with lower levels of self-compassion, were associated with greater self-criticism and, consequently, higher levels of psychological distress.The results emphasize the role of self-compassion as a protective mechanism against psychological distress among women with FM. Future studies should further investigate the effect of self-compassion-focused interventions on patients with FM.Results: While past research detected a direct link between symptoms of fibromyalgia (FM) and psychological distress, body appreciation was suggested as a viable mediator of this link. The aim of the present study was to further develop an explanatory model for the effect of FM on women’s psychological distress and identify possible protective and risk factors. Specifically, it was hypothesized that self-compassion would moderate the indirect effect of body appreciation and self-criticism on psychological distress in women with FM.This study comprised a total of 293 women, aged 20–68 (M = 34.8, SD = 12.3), of whom 146 were women with FM and 147 were heathy controls. All the women completed questionnaires regarding demographic characteristics, depression (PHQ-9), anxiety (GAD-7), self-criticism (DEQ-SC), body appreciation (BAS2), and the self-compassion scale (SCS).A moderated serial mediation model demonstrated lower body appreciation in participants with FM compared to controls. These lower levels of body appreciation, together with lower levels of self-compassion, were associated with greater self-criticism and, consequently, higher levels of psychological distress.The results emphasize the role of self-compassion as a protective mechanism against psychological distress among women with FM. Future studies should further investigate the effect of self-compassion-focused interventions on patients with FM.Conclusions: While past research detected a direct link between symptoms of fibromyalgia (FM) and psychological distress, body appreciation was suggested as a viable mediator of this link. The aim of the present study was to further develop an explanatory model for the effect of FM on women’s psychological distress and identify possible protective and risk factors. Specifically, it was hypothesized that self-compassion would moderate the indirect effect of body appreciation and self-criticism on psychological distress in women with FM.This study comprised a total of 293 women, aged 20–68 (M = 34.8, SD = 12.3), of whom 146 were women with FM and 147 were heathy controls. All the women completed questionnaires regarding demographic characteristics, depression (PHQ-9), anxiety (GAD-7), self-criticism (DEQ-SC), body appreciation (BAS2), and the self-compassion scale (SCS).A moderated serial mediation model demonstrated lower body appreciation in participants with FM compared to controls. These lower levels of body appreciation, together with lower levels of self-compassion, were associated with greater self-criticism and, consequently, higher levels of psychological distress.The results emphasize the role of self-compassion as a protective mechanism against psychological distress among women with FM. Future studies should further investigate the effect of self-compassion-focused interventions on patients with FM. [ABSTRACT FROM AUTHOR]

The study presented in this article aims to highlight the relationship between the regulation of innovative activities as a way of increasing competitiveness and the consequent economic performance of the G-20 member countries. Because of the above objective, we sought to answer the research hypothesis: Does the influence of the regulation of the innovative environment contribute to increasing the competitiveness of countries? The study was conducted through quantitative research using indicators from countries belonging to the G20, published in the World Competitiveness Report of the World Economic Forum (FEM). The data were submitted to statistical analysis, through multiple linear regression. The results obtained allowed to identify the positive contribution to the regulation of the economy influenced by the degree of competitiveness and, consequently, the innovative capacity of the countries studied. [ABSTRACT FROM AUTHOR]

Previous research has shown that null numerosity can be processed as a numerical entity that is represented together with non-null numerosities on the same magnitude system. The present study examined which conditions enable perceiving nonsymbolic (i.e., an empty set) and symbolic (i.e., 0) representations of null numerosity as a numerical entity, using distance and end effects. In Experiment 1, participants performed magnitude comparisons of notation homogeneous pairs (both numerosities appeared in nonsymbolic or symbolic format), as well as heterogeneous pairs (a nonsymbolic numerosity versus a symbolic one). Comparisons to 0 resulted in faster responses and an attenuated distance effect in all conditions, whereas comparisons to an empty set produced such effects only in the nonsymbolic and symbolic homogeneous conditions. In Experiments 2 and 3, participants performed same/different numerosity judgments with heterogeneous pairs. A distance effect emerged for "different" judgments of 0 and sets of 1 to 9 dots, but not for those with an empty set versus digits 1–9. These findings indicate that perceiving an empty set, but not 0, as a numerical entity is determined by notation homogeneity and task requirements. [ABSTRACT FROM AUTHOR]

Objective: Oncologists are exposed to suffering, loss, and death, which can potentially lead to grief reactions. Although grief over patients may be a natural consequence of the close and longstanding oncologist-patient relationship, the empathy that oncologists feel toward their patients may put them at risk for compassion fatigue (CF). This study examined the mediating role of the two components of CF-secondary traumatic stress (STS) and burnout-in the relation between empathy and grief among oncologists.Method: Participants included 71 Israeli oncologists. Measures consisted of a demographic questionnaire, the Texas Revised Inventory of Grief-Present, the Interpersonal Reactivity Index, and the Professional Quality of Life questionnaire.Results: Oncologists reported moderate levels of grief and relatively high levels of both STS and burnout. In addition, they reported high levels of the three components of empathy: perspective taking, empathic concern, and personal distress. The PROCESS SPSS macro revealed support for the mediation model. The mediators (STS and burnout) fully accounted for the relationship between the following two components of empathy-perspective taking and personal distress-and grief.Conclusions: Oncologists commonly experience grief over patients. We found that oncologists' grief was related to their empathy, and that this association was explained by their levels of CF. The current research may mark a step toward recognizing oncologists' grief as well as understanding the processes associated with it. [ABSTRACT FROM AUTHOR]

Oxygen reduction reaction (ORR) is a critical process for several electrocatalytic and photocatalytic devices. Poly(3,4‐ethylenedioxythiophene), PEDOT, is an efficient ORR catalyst, with hydrogen peroxide (H2O2) being the primary reaction product. Although H2O2 is a green fuel for batteries and fuel cells and used as an industrial oxidant, it is toxic for living systems. As such, its production should be limited when PEDOT films are used in bioelectronic devices. In this work, the ORR behavior of a series of electropolymerized PEDOT films is investigated. By varying the counterion (monomeric vs polymeric), including a hydroxyl‐terminated EDOT monomer in the polymer architecture, or adding a conductivity enhancer in the reaction mixture, the authors aim to understand the parameters governing the ORR properties. It is that the polymer's pristine doping level—influenced by counterion type and the presence of the conductivity enhancer—controls the ORR pathway in PEDOT films. High levels of intrinsic doping led to films with H2O2 as the major ORR product. This work suggests strategies for the design of conducting polymers with optimized performance for electrocatalytic applications and minimized production of harmful chemicals for bioelectronic devices. [ABSTRACT FROM AUTHOR]

The study presented in this article aims to highlight the relationship between the regulation of innovative activities as a way of increasing competitiveness and the consequent economic performance of the G-20 member countries. Because of the above objective, we sought to answer the research hypothesis: Does the influence of the regulation of the innovative environment contribute to increasing the competitiveness of countries? The study was conducted through quantitative research using indicators from countries belonging to the G20, published in the World Competitiveness Report of the World Economic Forum (FEM). The data were submitted to statistical analysis, through multiple linear regression. The results obtained allowed to identify the positive contribution to the regulation of the economy influenced by the degree of competitiveness and, consequently, the innovative capacity of the countries studied. [ABSTRACT FROM AUTHOR]

Objectives: To promote functional recovery in persons diagnosed with a psychotic disorder, vocational interventions have emerged over the last few decades which range from sheltered employment to supported employment in the community. Design: Using data from a 6‐month vocational rehabilitation programme, we examined whether assessments of the therapeutic alliance were related to the quality of work performed in this work placement. Our first hypothesis was that stronger alliances would be related to better work performance. Second, we expected that client assessments of the TA would better predict outcomes than therapist assessments. Third, we expected that the discrepancy between assessment scores from the client and therapist (client rating minus therapist rating) would be a better predictor for outcome than individual assessments by the therapists or clients. Results: Clients systematically rated the alliance higher than therapists. Modelling the data longitudinally, we found both therapist and client ratings predictive of outcome, though client assessments over time were inversely related to work performance. Conclusions: Discrepancy in scores was also shown to be predictive of work performance during the program. Clinicians are advised to routinely assess the therapeutic alliance from both client and therapist perspectives and calculate the discrepancy between them as they may indicate ruptures are occurring and thus hamper the intervention. Practitioner points: Clinicians are advised to regularly assess the therapeutic alliance from both their own and the client's perspective.Growing discrepancy in scores may impede intervention effectiveness.Therapeutic alliance may help buffer against work stresses experienced by participants in a vocational programme.Be aware that therapists tend to rate the alliance lower than their clients. [ABSTRACT FROM AUTHOR]

Coronavirus outbreak created diverse challenges for mental health services in general and to psychotherapy in particular. One of the most prominent of these is the move from delivering psychotherapy in face to face sessions to telephone or internet-based platforms. While this is a challenge to all psychotherapies, this paper examines specific considerations that should be taken into account when doing recovery-oriented integrative psychotherapy with persons with schizophrenia. Based on our clinical experiences conducting trials of psychotherapy with people with schizophrenia in Israel and in the United States, we describe several changes that took place as we were providing psychotherapy at the outbreak of the pandemic. These include general changes in the platform of psychotherapy and in the focus of sessions at both process and content levels. These changes represent both barriers and opportunities for the recovery process. Following a description of these changes we discuss and outline adaptations that are needed for sustaining patient's sense of their own agency and of the intersubjective nature of the session. [ABSTRACT FROM AUTHOR]

The soil's undrained shear strength is affected by the rate of shearing. This dependency can be inferred from mechanical laboratory testing at different operation rates or from using different in situ testing methods (associated with dissimilar shear-rate fields). However, all test results of a given soil can be correlated with a constant rate-independent shear strength by accounting the soil viscous behavior. This work investigates the viscosity model's role in evaluating the reference strength of soft clays. Three viscosity models are examined by their influence on the reference undrained shear strength values. The clay is tested by vane shearing at different rotation rates, in which the viscosity parameters are calculated based on strength ratios between tests at different rotation rates. The experimental results are compared with two types of analytical solutions, rigorous and simple, to examine the effect of the solution order on the obtained reference strength values. Among the examined viscosity models, this work finds the power-law model as more appropriate and applicable for rate-effect analysis in soft clays. [ABSTRACT FROM AUTHOR]

Objective: While previous studies have indicated that therapists' self-disclosure (TSD) can have curative effects, the contextual variables that may moderate the link between TSD and treatment outcome have not been sufficiently explored. Using session-by-session psychotherapy data, we examined the extent to which within-client distress and between-clients emotion regulation difficulties moderated the associations between TSD and session outcomes. Method: The sample comprised 68 clients treated according to the principles of psychodynamic psychotherapy by 47 therapists in a university clinic. Emotion regulation difficulties were assessed at the beginning of treatment, and functioning and distress levels as well as symptoms were assessed at the beginning of each session. After each session, therapists completed a measure of frequency and centrality of their immediate and non- immediate self-disclosure interventions during the session. Results: At the within-client level, in sessions marked by high pre-session client distress, immediate TSD was associated with a better next session outcome. At the between-clients level, for clients who had low emotion regulation difficulties, immediate TSD was marginally associated with better outcomes. Conclusion: These findings highlight the importance of considering within-client level as well as between-clients level variables when deciding upon self-disclosure. [ABSTRACT FROM AUTHOR]

Although the clinical significance of therapeutic alliance with people with psychosis is well established, the agreement between client and therapist assessments of therapeutic alliance and the longitudinal changes of both assessments have been rarely addressed. The current study examined client and therapist assessments of therapeutic alliance longitudinally and sought to determine whether insight and severity of symptoms moderated the degree to which therapist and client assessments were in agreement with one another. Forty‐five participants diagnosed with a schizophrenia spectrum disorder and their therapists were administered a therapeutic alliance questionnaire (Working Alliance Inventory‐Short Form) monthly for 6 months. Baseline symptoms were assessed using the PANSS. Results did not produce evidence that insight into illness moderated the relationship between agreement on the therapeutic alliance. However, symptoms of emotional discomfort at baseline predicted differences in agreement between clients and therapists on the relationship aspect of therapeutic alliance over the course of therapy. These results suggest that the ability to express symptoms of emotional discomfort may affect whether clients and therapists form similar appraisals of the strength of the therapeutic alliance. [ABSTRACT FROM AUTHOR]

Growing awareness that many who are diagnosed with schizophrenia recover has spurred the development of new psychosocial approaches to treatment. These new approaches include forms of individual and group psychotherapy whose focus extends beyond reducing symptoms and improving skills to subjective outcomes related to sense of self. This paper introduces an issue of In Session which presents six case reports which illustrating these approaches in differing international contexts. First, we explore the larger issues of subjective outcomes from schizophrenia. We then discuss each of the papers separately along with implications of these papers as a group for how treatment might promote the recapturing of a sense of self or place in the world. [ABSTRACT FROM AUTHOR]

Background: The aim of this study was to evaluate the impact of different therapy regimens, including sodium oxybate (SXB)-containing regimens, on patient-reported outcomes (PROs) in people with narcolepsy.Methods: Online surveys were used to collect information from persons with narcolepsy in the Nexus Narcolepsy Registry. Surveys contained questionnaires assessing self-reported sleep quality (SQ; via single question), daytime sleepiness and function (Epworth Sleepiness Scale and Functional Outcomes of Sleep Questionnaire), health-related quality of life (HRQoL; 36-Item Short Form Health Survey [SF-36]), work productivity and impairment (Work Productivity and Activity Impairment: Specific Health Problem), and history of injuries or motor vehicle accidents. Treatment with SXB (including monotherapy or combination therapy; SXB group) was compared with non-SXB therapy (No SXB group). The P values presented are nominal, as there are no adjustments for multiplicity.Results: From June 2015 through December 2017, 983 participants completed 1760 surveys. SQ and daytime functioning scores were better in the SXB group compared with the No SXB group (all P < 0.001). HRQoL scores were better for the SXB group compared with the No SXB group for the SF-36 Physical Component (P = 0.016), Mental Component (P < 0.001), and all 8 subscales. Additionally, PROs were better for the SXB group for presenteeism, overall work and activity impairment, and risk of motor vehicle accidents (all P ≤ 0.001).Conclusion: Based on participants' self-assessments, treatment regimens with SXB were associated with better outcomes than regimens not containing SXB across many PROs, including SQ, HRQoL, work and activities, and risk of traffic accidents. CLINICALTRIALS.Gov Identifier: NCT02769780. [ABSTRACT FROM AUTHOR]

Objective/background: The real-world experience of people with narcolepsy is not well understood.Patients/methods: The Nexus Narcolepsy Registry (NCT02769780) is a longitudinal, web-based patient registry of self-reported data from adults with physician-diagnosed narcolepsy. Surveys were electronically distributed every 6 months; the current analysis reports registry population demographics, narcolepsy diagnosis journey, and predictors of diagnostic delays.Results: The registry population included in this analysis (N = 1024) was predominantly female (85%) and White (92%), with a mean age of 37.7 years. Most participants had education/training beyond high school (93%). Mean (median) reported ages at narcolepsy symptom onset, first consultation for symptoms, and narcolepsy diagnosis were 18.1 (16), 26.4 (24), and 30.1 (28) years, respectively. A majority (59%) of participants reported ≥1 misdiagnosis, and 29% reported consulting ≥5 physicians before narcolepsy diagnosis. More than half (56%) of participants' first consultations for narcolepsy symptoms were with a general practitioner, whereas the diagnosing clinician was usually a sleep specialist (64%) or neurologist (27%). Pediatric symptom onset was associated with a longer mean interval to first consultation than adult symptom onset (10.7 and 4.6 years, respectively; P < 0.001) and a longer mean interval between first consultation and diagnosis (4.5 and 2.2 years, respectively; P < 0.001). Overall, mean (95% CI) time from symptom onset to diagnosis was 11.8 (11.1-12.5) years.Conclusions: The Nexus Narcolepsy Registry data indicate that onset of narcolepsy symptoms frequently occurs in childhood or adolescence. In many individuals, the diagnostic process is long and involves multiple physicians and frequent misdiagnosis. [ABSTRACT FROM AUTHOR]

Phase Change Materials (PCM) possess high heat storage density, but commonly have low thermal conductivity that results in poor heat transfer. Another common problem is the shape stabilization of the storage medium. These problems could be solved by loading the medium with thermally conductive fillers, such as graphite, and encapsulating it in a thermally conductive polymer matrix shell, hence enhancing the thermal properties of both. We suggest a ternary system in which a graphite-epoxy composite provides an encapsulating scaffold to the paraffin, which is also loaded with graphite-based filler. Various graphite-based fillers differing in sizes and geometry were explored, aiming at optimizing their intrinsic properties, such as defect density, and consequently enhancing the thermal properties of the PCM as a whole. It was demonstrated that by judicious choice of the filler, enhancement is achieved for the thermal conductivity of: (1) the shell (epoxy-graphite flakes composite) by 4000% compared to the neat epoxy; (2) the medium (paraffin-graphite flakes composite) by > 2000% compared to the neat paraffin; and (3) the integrated PCM system (paraffin-epoxy-graphite flakes composite) by 1000% compared to that of neat paraffin. The PCM composite is completely preserved during phase change cycling. • Various graphite-based fillers differing in size and geometry were explored for PCM. • Graphite flakes (GF) were found to be the best filler for the overall properties. • Ternary paraffin-GF-epoxy thermally conductive shape-stabilized system was achieved. • Properties of the ternary system were completely preserved during thermal cycling. [ABSTRACT FROM AUTHOR]

Background: Prolonged grief disorder (PGD) is a chronic and disabling condition that affects approximately 10% of non-traumatically bereaved people. Narrative reconstruction (NR), originally designed for the treatment of posttraumatic stress disorder (PTSD), is a time-limited integrative therapy consisting of exposure to the loss memory, detailed written reconstruction of the loss memory narrative, and an elaboration of the personal significance of that memory for the bereaved. Objective: This pilot study examined the efficacy of NR therapy in reducing symptoms in bereaved people diagnosed with PGD. Method: Ten PGD patients participated in the study and were treated with 16 weekly sessions of NR. PGD, PTSD, and depression symptoms, as well as levels of loss integration, were assessed at pre-treatment, post-treatment, and at a 3-month follow-up. Results: Following NR, participants showed significant reductions in PGD, depression, and PTSD symptoms, and elevated levels of trauma integration. Symptoms showed further improvement at the three-month follow-up. Conclusions: These findings provide preliminary evidence for the feasibility and efficacy of NR in treating PGD. Narrative reconstruction therapy requires further evaluation in randomized controlled trials. NR consists of exposure through written reconstruction of the loss and elaboration of its significance. NR reduced PGD and depression and increased loss integration improving further at the follow-up. Findings provide preliminary evidence for the efficacy of NR in treating PGD. [ABSTRACT FROM AUTHOR]