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This paper proposes a speech coding algorithm, MP-CELP (multipulse-based CELP). In MP-CELP, a multipulse excitation signal quantization method is proposed, where all of the pulse amplitudes are simultaneously vector-quantized (VQ). In order to improve quantization performance, a combination search between multiple pulse location candidates and the amplitude VQ codevectors is developed. When the number of pulse location candidates is 16, segmental SNR (SNRseg) is improved by 0.77 dB. Fast search for the pulse locations greatly reduces the search complexity while maintaining high speech quality. The speech quality for 11 kb/s MP-CELP with 10-ms frame is equivalent to that for ITU-T G.728 (16 kb/s LD-CELP). 22.8 kb/s MP-CELP, where 11.8 kb/s soft-decision FEC (forward error correction) is attached to 11 kb/s MP-CELP, provides significantly higher speech quality than 22.8 kb/s GSM full-rate speech coding standard, and MOS values are improved by 1.0 to 1.5 at 7 and 13% transmission error rates. © 1997 Scripta Technica, Inc. Electron Comm Jpn Pt 3, 80(11): 55–63, 1997 [ABSTRACT FROM AUTHOR]

Mobile network operators are experiencing a tremendous increase in data traffic due to the growing popularity of bandwidth-intensive video services. This challenge can be faced either by boosting the capacity of the network infrastructure, or by means of offloading traffic from the backhaul and core network and serving contents from distributed cache servers close to the users. Network operators can extend the coverage of traditional CDNs by making usage of caching locations much closer to the users than traditional CDNs. Additionally, network operators can optimize the caching and delivery of contents by exploiting the complete knowledge of their network for designing a cost-effective infrastructure able to achieve both improved user satisfaction and cost savings. This article provides thoroughly justified design principles for a highly distributed operator-owned CDN while focusing on four key aspects: the optimal location of cache servers, mechanisms for request routing, content replica placement, and content outsourcing and retrieval. [ABSTRACT FROM PUBLISHER]

Abstract: Basic properties and battery performances of the novel high temperature stable lithium salt (Li2B12F12, Dilithium Dodecafluorododecaborate; Li2DFB) were studied using a Mn-based cathode and anode composed of a hard carbon and graphite mixture. The effect of co-solvents (mainly linear carbonate in electrolyte formulation of PC/EC/co-solvent (5/30/65vol% mixture)) on conductivity, viscosity, charge–discharge capacities, rate performance, temperature performance, cycle life and storage life at 60°C was investigated. Conductivity of Li2DFB electrolyte increased with reducing its viscosity by changing co-solvent and increasing the volume of the higher dielectric solvent. Li2DFB electrolytes showed comparable discharge capacity and columbic efficiency against LiPF6 electrolyte. Li2DFB electrolytes improved the storage life and cycle life of a Mn-based cell at 60°C. [Copyright &y& Elsevier]

Abstract: During our effort to develop dual VEGFR2 and Tie-2 inhibitors as anti-angiogenic agents for cancer therapy, we discovered 4-amino-5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)- aminocarbonylamino)phenyl)furo[2,3-d]pyrimidine (8a) possessing strong inhibitory activity at both the enzyme and cellular level against VEGFR2 and Tie-2. Compound 8a demonstrated high pharmacokinetic exposure through oral administration, and showed marked tumor growth inhibition and anti-angiogenic activity in mouse HT-29 xenograft model via once-daily oral administration. [Copyright &y& Elsevier]