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The Ocean Surface Topography Mission/Jason-2 (OSTM/Jason-2) satellite altimetry mission was successfully launched on June 20, 2008, as a cooperative mission between CNES, EUMETSAT, NASA, and NOAA. OSTM/Jason-2 will continue to precisely measure the surface topography of the oceans and continental surface waters, following on the same orbit as its predecessors, TOPEX/Poseidon and Jason-1. To maintain the high-accuracy measurements, the mission carries a dual-frequency altimeter, a three-frequency microwave radiometer, and three precise positioning systems. The objectives of the mission are both operational and scientific. The mission will provide near-real time high-precision altimetric measurements for integration into ocean forecasting models and other products. The mission will also extend the precise surface topography time series started by TOPEX/Poseidon in 1992 over two decades in order to study long-term ocean variations such as mean sea level variations and interannual and decadal oscillations. The measurement system has been adapted to provide quality data nearer to the coasts, and over lakes and rivers. This paper provides an overview of the OSTM/Jason-2 mission in terms of the system design and a brief introduction to the science objectives. [ABSTRACT FROM AUTHOR]

The burden of antibiotic resistance is currently estimated by mathematical modeling, without real count of resistance to key antibiotics. Here we report the real rate of resistance to key antibiotics in bacteria isolated from humans during a 5 years period in a large area in southeast in France. We conducted a retrospective study on antibiotic susceptibility of 539,107 clinical strains isolated from hospital and private laboratories in south of France area from January 2014 to January 2019. The resistance rate to key antibiotics as well as the proportion of bacteria classified as Difficult-to-Treat (DTR) were determined and compared with the Mann–Whitney U test, the χ2 test or the Fisher's exact test. Among 539,037 isolates, we did not observe any significant increase or decrease in resistance to key antibiotics for 5 years, (oxacillin resistance in Staphylococcus aureus, carbapenem resistance in enterobacteria and Pseudomonas aeruginosa and 3rd generation cephalosporin resistance in Escherichia coli and Klebsiella pneumoniae). However, we observed a significant decrease in imipenem resistance for Acinetobacter baumannii from 2014 to 2018 (24.19–12.27%; p = 0.005) and a significant increase of ceftriaxone resistance in Klebsiella pneumoniae (9.9–24.03%; p = 0.001) and Enterobacter cloacae (24.05–42.05%; p = 0.004). Of these 539,037 isolates, 1604 (0.3%) had a DTR phenotype. Over a 5-year period, we did not observe a burden of AR in our region despite a high rate of antibiotic consumption in our country. These results highlight the need for implementation of real-time AR surveillance systems which use factual data. [ABSTRACT FROM AUTHOR]