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T cells have a well-described role in renal injury, which leads to the secondary development of renal fibrosis. It has generally been assumed that this fibrotic response is an indirect consequence of T cell-mediated renal injury, rather than T cells' being directly involved in fibrosis. Tapmeier et al. now provide evidence that CD4(+) T cells promote interstitial fibrosis in the obstructed mouse kidney in a mechanism that appears to dissociate myofibroblast accumulation and matrix deposition. [ABSTRACT FROM AUTHOR]

Presents the abstract 'Blockade of CD40-CD50 Ligand Reduced Renal Injury in Chronic Proteinuric Renal Disease,' by Yiping Wang, Lukas Kairaitis, Yuet-Ching Tay, Yang Wang, Ling Zheng and David C.H. Harris.