Papetti, Daniele M, Van Abeelen, Kirsten, Davies, Rhodri, Menè, Roberto, Heilbron, Francesca, Perelli, Francesco P, Artico, Jessica, Seraphim, Andreas, Moon, James C, Parati, Gianfranco, Xue, Hui, Kellman, Peter, Badano, Luigi P, Besozzi, Daniela, Nobile, Marco S, and Torlasco, Camilla
• Cardiac ischemic scar can be accurately assessed on dark blood late enhancement imaging. • The developed model accurately segments ischemic scar (IoU: 0.85 on test dataset). • The developed model reduces computational time 5-fold compared to manual segmentation. • The developed system automatically generates a quantitative clinical report. Myocardial infarction scar (MIS) assessment by cardiac magnetic resonance provides prognostic information and guides patients' clinical management. However, MIS segmentation is time-consuming and not performed routinely. This study presents a deep-learning-based computational workflow for the segmentation of left ventricular (LV) MIS, for the first time performed on state-of-the-art dark-blood late gadolinium enhancement (DB-LGE) images, and the computation of MIS transmurality and extent. DB-LGE short-axis images of consecutive patients with myocardial infarction were acquired at 1.5T in two centres between Jan 1, 2019, and June 1, 2021. Two convolutional neural network (CNN) models based on the U-Net architecture were trained to sequentially segment the LV and MIS, by processing an incoming series of DB-LGE images. A 5-fold cross-validation was performed to assess the performance of the models. Model outputs were compared respectively with manual (LV endo- and epicardial border) and semi-automated (MIS, 4-Standard Deviation technique) ground truth to assess the accuracy of the segmentation. An automated post-processing and reporting tool was developed, computing MIS extent (expressed as relative infarcted mass) and transmurality. The dataset included 1355 DB-LGE short-axis images from 144 patients (MIS in 942 images). High performance (> 0.85) as measured by the Intersection over Union metric was obtained for both the LV and MIS segmentations on the training sets. The performance for both LV and MIS segmentations was 0.83 on the test sets. Compared to the 4-Standard Deviation segmentation technique, our system was five times quicker (<1 min versus 7 ± 3 min), and required minimal user interaction. Our solution successfully addresses different issues related to automatic MIS segmentation, including accuracy, time-effectiveness, and the automatic generation of a clinical report. [ABSTRACT FROM AUTHOR]