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Herein, we report a case of a collision tumor involving a multinodular and vacuolating neuronal tumor (MVNT) and a diffuse astrocytoma. A collision tumor between these two entities has not previously been reported. The patient is a 35‐year‐old woman who presented with new‐onset hearing loss and ringing in her right ear. Magnetic resonance imaging identified a non‐enhancing mass involving the gray matter and subcortical white matter of the left middle frontal gyrus. Additionally, tiny clustered nodules were noted along the underlying subcortical ribbon and superficial subcortical white matter of the left superior frontal gyrus. The patient underwent a left frontal craniotomy and complete resection of the mass. Histologic examination of the resected specimen demonstrated a collision tumor consisting of a diffuse astrocytoma (isocitrate dehydrogenase [IDH] mutant, central nervous system [CNS] World Health Organization [WHO] grade 2) and an MVNT, with the latter demonstrating characteristic morphologic and immunohistochemical features. [ABSTRACT FROM AUTHOR]

The black hole information puzzle can be resolved if two conditions are met. The first is that the information about what falls inside a black hole remains encoded in degrees of freedom that persist after the black hole completely evaporates. These degrees of freedom should be capable of purifying the information. The second is if these purifying degrees of freedom do not significantly contribute to the system's energy, as the macroscopic mass of the initial black hole has been radiated away as Hawking radiation to infinity. The presence of microscopic degrees of freedom at the Planck scale provides a natural mechanism for achieving these two conditions without running into the problem of the large pair-creation probabilities of standard remnant scenarios. In the context of Hawking radiation, the first condition implies that correlations between the in and out Hawking partner particles need to be transferred to correlations between the microscopic degrees of freedom and the out partners in the radiation. This transfer occurs dynamically when the in partners reach the singularity inside the black hole, entering the UV regime of quantum gravity where the interaction with the microscopic degrees of freedom becomes strong. The second condition suggests that the conventional notion of the vacuum's uniqueness in quantum field theory should fail when considering the full quantum gravity degrees of freedom. In this paper, we demonstrate both key aspects of this mechanism using a solvable toy model of a quantum black hole inspired by loop quantum gravity. [ABSTRACT FROM AUTHOR]

Traditionally, freight wagon technology has lacked digitalization and advanced monitoring capabilities. This article presents recent advancements in freight wagon digitalization, covering the system's definition, development, and field tests on a commercial line in Sweden. A number of components and systems were installed on board on the freight wagon, leading to the intelligent freight wagon. The digitalization includes the integration of sensors for different functions such as train composition, train integrity, asset monitoring and continuous wagon positioning. Communication capabilities enable data exchange between components, securely stored and transferred to a remote server for access and visualization. Three digitalized freight wagons operated on the Nässjo–Falköping line, equipped with strategically placed monitoring sensors to collect valuable data on wagon performance and railway infrastructure. The field tests showcase the system's potential for detecting faults and anomalies, signifying a significant advancement in freight wagon technology, and contributing to an improvement in freight wagon digitalization and monitoring. The gathered insights demonstrate the system's effectiveness, setting the stage for a comprehensive monitoring solution for railway infrastructures. These advancements promise real-time analysis, anomaly detection, and proactive maintenance, fostering improved efficiency and safety in the domain of freight transportation, while contributing to the enhancement of freight wagon digitalization and supervision. [ABSTRACT FROM AUTHOR]

In this paper, we construct a solvable toy model of the quantum dynamics of the interior of a spherical black hole with falling spherical scalar field excitations. We first argue about how some aspects of the quantum gravity dynamics of realistic black holes emitting Hawking radiation can be modeled using Kantowski–Sachs solutions with a massless scalar field when one focuses on the deep interior region r ≪ M (including the singularity). Further, we show that in the r ≪ M regime, and in suitable variables, the KS model becomes exactly solvable at both the classical and quantum levels. The quantum dynamics inspired by loop quantum gravity is revisited. We propose a natural polymer quantization where the area a of the orbits of the rotation group is quantized. The polymer (or loop) dynamics is closely related to the Schroedinger dynamics away from the singularity with a form of continuum limit naturally emerging from the polymer treatment. The Dirac observable associated with the mass is quantized and shown to have an infinite degeneracy associated with the so-called ϵ -sectors. Suitable continuum superpositions of these are well-defined distributions in the fundamental Hilbert space and satisfy the continuum Schroedinger dynamics. [ABSTRACT FROM AUTHOR]

The celebrated mass-energy equivalence relation, E = m c 2 , was derived by Einstein using thought experiments involving the kinematics of the emission of light and the relativity principle. Textbook derivations often follow paths similar to Einstein's or analyze the kinematics of particle collisions in different inertial frames. In such derivations, the direct dynamical link with fundamental fields describing matter (e.g., Maxwell theory or other) is overshadowed. Here, we show that the formula can be derived directly from the dynamical equations of electromagnetic energy confined in a box (which can be thought of as a toy model of a composite particle). The mass-energy equivalence relation follows from the inertia or (taking the equivalence principle for granted) weight of confined radiation. The present derivation offers an interesting pedagogical perspective on the formula, provides a simple toy model for the origin of mass, and can serve as a bridge to general relativity. [ABSTRACT FROM AUTHOR]

This manuscript contributes to the existing body of literature on learner training in computer-enhanced learning environments by examining how students conceptualize and experience their roles as learners in flipped Spanish courses and how these interpretations shape their behaviors and beliefs about learning under this new instructional approach. The goal of this study is to better understand learners' attitudes toward flipped instruction (FI) and use that knowledge to identify areas in the training that could be developed to more effectively prepare lower-level Spanish students for FI. Participants (n = 431) completed an online survey. Confirmatory factor analysis (CFA) was conducted to determine the reliability of the instrument and a logistic regression was used to explore the variables associated with having a positive attitude toward FI. Our findings indicate that the main predictors of liking FIs are (i) being enrolled in an elementary course, (ii) having taken flipped courses in other subject areas, (iii) having a clear understanding of how the online platform works, and (iv) understanding the philosophy behind flipped courses. These results allow us to outline specific initiatives in the design of a learner training program for FI. [ABSTRACT FROM AUTHOR]

In a recent work we have argued that noisy energy momentum diffusion due to space-time discreteness at the Planck scale (naturally expected to arise from quantum gravity) can be responsible for the generation of a cosmological constant at the electro-weak phase transition era of the cosmic evolution. Simple dimensional analysis and an effectively Brownian description of the propagation of fundamental particles on a granular background yields a cosmological constant of the order of magnitude of the observed value, without fine tuning. While the energy diffusion is negligible for matter in standard astrophysical configurations (from ordinary stars to neutron stars), here we argue that a similar diffusion mechanism could, nonetheless, be important for black holes. If such effects are taken into account, two observational puzzles might be solved by a single mechanism: the ' H 0 tension' and the relatively low rotational spin of the black holes detected via gravitational wave astronomy. [ABSTRACT FROM AUTHOR]

Skin pigmentation is dependent on cellular processes including melanosome biogenesis, transport, maturation and transfer to keratinocytes. However, how the cells finely control these processes in space and time to ensure proper pigmentation remains unclear. Here, we show that a component of the cytoplasmic dynein complex, Dynlt3, is required for efficient melanosome transport, acidity and transfer. In Mus musculus melanocytes with decreased levels of Dynlt3, pigmented melanosomes undergo a more directional motion, leading to their peripheral location in the cell. Stage IV melanosomes are more acidic, but still heavily pigmented, resulting in a less efficient melanosome transfer. Finally, the level of Dynlt3 is dependent on β-catenin activity, revealing a function of the Wnt/β-catenin signalling pathway during melanocyte and skin pigmentation, by coupling the transport, positioning and acidity of melanosomes required for their transfer. Aktary et al. identify novel roles for the dynein light chain Dynlt3 in melanosome transport, maturation, and transfer to keratinocytes. They also find that the Wnt/βcatenin signalling pathway controls Dynlt3 levels and thus also contributes to the regulation of melanocyte transport and skin pigmentation. [ABSTRACT FROM AUTHOR]

The tension between the value of the Hubble constant H 0 determined from local supernovae data and the one inferred from the cosmic microwave background based on the Λ CDM cosmological model may indicate the need for new physics. Here, we show that this ‘Hubble tension’ can be resolved in models involving an effective energy flux from the matter sector into dark energy resulting naturally from a combination of unimodular gravity and an energy diffusion process. The scheme is one where dark energy has the standard equation of state w = - 1 . This proposal provides an alternative phenomenological paradigm accounting for the observations, while offering a general framework to study diffusion effects coming from novel fundamental physical processes. [ABSTRACT FROM AUTHOR]

Progressive connective tissue disease (CTD)-related lung disease is a challenging condition that requires lung transplantation in some patients. Treatment with rituximab may improve lung function. To evaluate the effect of rituximab in patients with progressive CTD-related lung disease who met criteria for inclusion in waiting list for a lung transplant. Retrospective study of patients with progressive CTD-related lung disease with criteria for lung transplant (FVC < 60% and/or DLCO < 40%) that started treatment with rituximab because of disease progression. Clinical variables, pulmonary function tests and chest computed tomography were used to monitor the effect of rituximab. The cohort included 18 patients; systemic sclerosis (7), rheumatoid arthritis (5), systemic lupus erythematosus (4), Sjögren syndrome (1) and antisynthetase syndrome (1). The radiologic patterns observed were: usual interstitial pneumonia (1), non-specific interstitial pneumonia (9), lymphoid interstitial pneumonia (1), emphysema-usual interstitial pneumonia (1), shrinking lung syndrome (3) and undetermined pattern (3). Over the previous year to rituximab initiation a decline in FVC (− 3.8%, p = 0.095) and DLCO (− 8.4%, p = 0.004) was observed. After 2 years of treatment, DLCO significantly improved (+ 12.4%, p < 0.001 at 1 year and + 15.3%, p = 0.001 at 2 years). Six patients (33.3%) presented adverse events related to rituximab. No patient required lung transplant or died during the study period. Rituximab is an effective treatment for patients with severe and progressive CTD-related lung disease, which allows to delay lung transplantation in some cases. [ABSTRACT FROM AUTHOR]

The value of the cosmological constant is explained in terms of a noisy diffusion of energy from the low energy particle physics degrees of freedom to the fundamental Planckian granularity which is expected from general arguments in quantum gravity. The quantitative success of our phenomenological model is encouraging and provides possibly useful insights about physics at the scale of quantum gravity. [ABSTRACT FROM AUTHOR]

Background: Persons with HIV infection are at increased risk for hepatitis B virus infection. In 2016, the World Health Organization resolved to eliminate hepatitis B as a public health threat by 2030.Objective: To estimate the prevalence of hepatitis B vaccination among U.S. patients receiving medical care for HIV infection ("HIV patients").Design: Nationally representative cross-sectional survey.Setting: United States.Participants: 18 089 adults receiving HIV medical care who participated in the Medical Monitoring Project during 2009 to 2012.Measurements: Primary outcomes were prevalence of 1) no documentation of hepatitis B vaccination or laboratory evidence of immunity or infection (candidates to initiate vaccination), and 2) initiation of vaccination among candidates, defined as documentation of at least 1 vaccine dose in a 1-year surveillance period during which patients received ongoing HIV medical care.Results: At the beginning of the surveillance period, 44.2% (95% CI, 42.2% to 46.2%) of U.S. HIV patients were candidates to initiate vaccination. By the end of the surveillance period, 9.6% (CI, 8.4% to 10.8%) of candidates were vaccinated, 7.5% (CI, 6.4% to 8.6%) had no documented vaccination but had documented infection or immunity, and 82.9% (CI, 81.1% to 84.7%) remained candidates. Among patients at facilities funded by the Ryan White HIV/AIDS Program (RWHAP), 12.5% (CI, 11.1% to 13.9%) were vaccinated during the surveillance period versus 3.7% (CI, 2.6% to 4.7%) at facilities not funded by RWHAP. At the end of surveillance, 36.7% (CI, 34.4% to 38.9%) of HIV patients were candidates to initiate vaccination.Limitation: The study was not designed to describe vaccine series completion or actual prevalence of immunity.Conclusion: More than one third of U.S. HIV patients had missed opportunities to initiate hepatitis B vaccination. Meeting goals for hepatitis B elimination will require increased vaccination of HIV patients in all practice settings, particularly at facilities not funded by RWHAP.Primary Funding Source: Centers for Disease Control and Prevention. [ABSTRACT FROM AUTHOR]

Lung involvement in rheumatologic diseases has a broad spectrum of clinical and radiological presentations, from acute and inflammatory predominance to chronic and fibrotic lung disorders. Therapy has to be guided by the type of rheumatologic disease, the kind of lung involvement and the risk associated with the clinical state of the patient and prognostic factors. Although several therapeutic approaches have been used, the best treatment is still not certain; clinical trials are mandatory, which would require a better knowledge of the pulmonary pathogenesis of immunologic diseases. The following review is focused on the therapeutic options for those rheumatologic disorders that could present as a predominant interstitial lung disease which may confer a bad or life-threatening prognosis. © 2015 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

The combination of computational models and biophysical simulations can help to interpret an array of experimental data and contribute to the understanding, diagnosis and treatment of complex diseases such as cardiac arrhythmias. For this reason, three-dimensional (3D) cardiac computational modelling is currently a rising field of research. The advance of medical imaging technology over the last decades has allowed the evolution from generic to patient-specific 3D cardiac models that faithfully represent the anatomy and different cardiac features of a given alive subject. Here we analyse sixty representative 3D cardiac computational models developed and published during the last fifty years, describing their information sources, features, development methods and online availability. This paper also reviews the necessary components to build a 3D computational model of the heart aimed at biophysical simulation, paying especial attention to cardiac electrophysiology (EP), and the existing approaches to incorporate those components. We assess the challenges associated to the different steps of the building process, from the processing of raw clinical or biological data to the final application, including image segmentation, inclusion of substructures and meshing among others. We briefly outline the personalisation approaches that are currently available in 3D cardiac computational modelling. Finally, we present examples of several specific applications, mainly related to cardiac EP simulation and model-based image analysis, showing the potential usefulness of 3D cardiac computational modelling into clinical environments as a tool to aid in the prevention, diagnosis and treatment of cardiac diseases. [ABSTRACT FROM AUTHOR]

The combination of computational models and biophysical simulations can help to interpret an array of experimental data and contribute to the understanding, diagnosis and treatment of complex diseases such as cardiac arrhythmias. For this reason, three-dimensional (3D) cardiac computational modelling is currently a rising field of research. The advance of medical imaging technology over the last decades has allowed the evolution from generic to patient-specific 3D cardiac models that faithfully represent the anatomy and different cardiac features of a given alive subject. Here we analyse sixty representative 3D cardiac computational models developed and published during the last fifty years, describing their information sources, features, development methods and online availability. This paper also reviews the necessary components to build a 3D computational model of the heart aimed at biophysical simulation, paying especial attention to cardiac electrophysiology (EP), and the existing approaches to incorporate those components. We assess the challenges associated to the different steps of the building process, from the processing of raw clinical or biological data to the final application, including image segmentation, inclusion of substructures and meshing among others. We briefly outline the personalisation approaches that are currently available in 3D cardiac computational modelling. Finally, we present examples of several specific applications, mainly related to cardiac EP simulation and model-based image analysis, showing the potential usefulness of 3D cardiac computational modelling into clinical environments as a tool to aid in the prevention, diagnosis and treatment of cardiac diseases. [ABSTRACT FROM AUTHOR]

Stressful conditions can affect resource allocation among different life-history traits. The effect of dietary restriction (DR) on longevity and reproduction has been studied in many species, but we know little about its effects on energetics, especially in flying animals that have high energy demand. We assessed the effects of DR on metabolic rate throughout the entire adult life span in two butterfly species, Colias eurytheme and Speyeria mormonia. We cut the food intake of adult females in half and measured resting metabolic rate (RMR) and flight metabolic rate (FMR) together with body mass repeatedly throughout life. In both species, DR reduced body mass, but mass-corrected FMR was not affected, indicating that flight capacity was retained. DR lowered RMR and reduced fecundity but had no effect on life span. FMR declined with age, but the rate of senescence was not affected by DR. In contrast, aging had a strong negative effect on RMR only in control females, whereas food-restricted females had more stable RMR throughout their lives. The results suggest that flight capacity is conserved during nutritional stress but that investment in flight and survival may negatively affect other important physiological processes when resources are limited. [ABSTRACT FROM AUTHOR]

Abstract: Although arrestins bind dozens of non-receptor partners, the interaction sites for most signaling proteins remain unknown. Here we report the identification of arrestin-3 elements involved in binding MAP kinase JNK3α2. Using purified JNK3α2 and MBP fusions containing separated arrestin-3 domains and peptides exposed on the non-receptor-binding surface of arrestin-3 we showed that both domains bind JNK3α2 and identified one element on the N-domain and two on the C-domain that directly interact with JNK3α2. Using in vitro competition we confirmed that JNK3α2 engages identified N-domain element and one of the C-domain peptides in the full-length arrestin-3. The 25-amino acid N-domain element has the highest affinity for JNK3α2, suggesting that it is the key site for JNK3α2 docking. The identification of elements involved in protein–protein interactions paves the way to targeted redesign of signaling proteins to modulate cell signaling in desired ways. The tools and methods developed here to elucidate the molecular mechanism of arrestin-3 interactions with JNK3α2 are suitable for mapping of arrestin-3 sites involved in interactions with other partners. [Copyright &y& Elsevier]

Abstract: Melanoma is a major problem for many individuals worldwide. Although no effective treatment is available, promising new strategies are being developed. A better understanding of the inner workings of the disease would undoubtedly lead to improved treatments. Mouse melanoma models have been used to elucidate many key regulatory pathways involved in melanoma initiation and progression, and models with mutations in the oncogenes RAF and RAS have been particularly informative. Here, we summarize and evaluate the human relevance of various RAF and RAS mouse melanoma models and their contribution to our understanding of melanoma. [Copyright &y& Elsevier]

This article reviews the present status of the spin-foam approach to the quantization of gravity. Special attention is payed to the pedagogical presentation of the recently-introduced new models for four-dimensional quantum gravity. The models are motivated by a suitable implementation of the path integral quantization of the Plebanski formulation of gravity on a simplicial regularization. The article also includes a self-contained treatment of 2+1 gravity. The simple nature of the latter provides the basis and a perspective for the analysis of both conceptual and technical issues that remain open in four dimensions. [ABSTRACT FROM AUTHOR]

We present a statistical mechanical calculation of the thermodynamical properties of (nonrotating) isolated horizons. The introduction of the Planck scale allows for the definition of a universal horizon temperature (independent of the mass of the black hole) and a well-defined notion of energy (as measured by suitable local observers) proportional to the horizon area in Planck units. The microcanonical and canonical ensembles associated with the system are introduced. Black hole entropy and other thermodynamical quantities can be consistently computed in both ensembles and results are in agreement with Hawking's semiclassical analysis for all values of the Immirzi parameter. [ABSTRACT FROM AUTHOR]

Abstract: Mixed oxides of the Cu/Mn/Mg/Al and Co/Mn/Mg/Al type were obtained by means of the thermal decomposition of hydrotalcites, with manganese as the main active phase and with variations in their content by means of the addition of Cu or Co (molar ratio Cu/Mn or Co/Mn between 0.05 and 0.5). The effect of a second active phase on the material was evaluated in the total oxidation of three volatile organic compounds, VOCs (toluene, ethanol and butanol). The catalysts were characterized by means of X-ray fluorescence (XRF), X-ray diffraction (XRD), temperature-programmed reduction with hydrogen (TPR-H2) and physisorption of nitrogen at 77K. All the solids were active in the oxidation reaction of the VOCs, where the scale of difficulty to oxidize the different organic compounds evaluated was: butanol

We review the usual account of the phenomena of spontaneous symmetry breaking, pointing out the common misunderstandings surrounding the issue, in particular within the context of quantum field theory. In fact, the common explanations one finds in this context, indicate that under certain conditions corresponding to the situation called spontaneous symmetry breaking, the vacuum of the theory does not share the symmetries of the Lagrangian. We explain in detail why this statement is incorrect in general, and in what limited set of circumstances such a situation could arise. We concentrate on the case of global symmetries, for which we found no satisfactory exposition in the existing literature, and briefly comment on the case of gauge symmetries where, although insufficiently publicized, accurate and complete descriptions exist. We briefly discuss the implications for the phenomenological manifestations usually attributed to the phenomena of spontaneous symmetry breaking, analyzing which might be affected by our analysis and which are not. In particular we describe the mass generation mechanism in a fully symmetric scheme (i.e. with a totally symmetric vacuum), and briefly discuss the implications of this analysis to the problem of formation of topological defects in the early universe. [ABSTRACT FROM AUTHOR]

We study the classical field theoretical formulation of static generic isolated horizons in a manifestly SU(2) invariant formulation. We show that the usual classical description requires revision in the non-static case due to the breaking of diffeomorphism invariance at the horizon leading to the non-conservation of the usual pre-symplectic structure. We argue how this difficulty could be avoided by a simple enlargement of the field content at the horizon that restores diffeomorphism invariance. Restricting our attention to static isolated horizons we study the effective theories describing the boundary degrees of freedom. A quantization of the horizon degrees of freedom is proposed. By defining a statistical mechanical ensemble where only the area αH of the horizon is fixed macroscopically-states with fluctuations away from spherical symmetry are allowed-we show that it is possible to obtain agreement with the Hawkings area law (S = αH/(4α2 p)) without fixing the Immirzi parameter to any particular value: consistency with the area law only imposes a relationship between the Immirzi parameter and the level of the Chern-Simons theory involved in the effective description of the horizon degrees of freedom. [ABSTRACT FROM AUTHOR]

Encephalitis due to leucine-rich glioma inactivated 1 (Lgi1) antibodies, a subtype of VGKC-complex encephalitis, results in characteristic faciobrachial dystonic seizures (FBDS) [1]. Provided the circumscribed set of reactive and inflammatory pathologies in the limbic region and amygdala, the main entities in the differential diagnosis are more common forms of limbic encephalitis and viral encephalitis in particular. In cases of possible limbic encephalitis without a premortem diagnosis (i.e. the question is raised by neuropathologic findings), sera and/or cerebrospinal fluid collected at autopsy can be submitted for an autoimmune encephalopathy panel to clarify the final diagnosis. [Extracted from the article]

Focused on a study that analyzed the buccal striation pattern in teeth samples from Homo heidelbergensis hominid fossils recovered from Sima de los Huesos, Spain. Inferences about dietary behavior from analysis; Results and discussion; Conclusions.

Presents an extension of the method for solving the eikonal equation, in either flat or curved space times, with arbitrary Cauchy data, to the case of data given on characteristic surface. Relationship between the Cauchy and characteristic data for the same solution; Wave-front singularities.

Studies buccal microwear in a sample of 153 molar teeth from different modern hunter-gatherer, pastoralist and agriculturalist groups with different diets, preserved at museum collections. Striations in carnivorous groups versus in vegetarians; Biomechanics and phytolith content of plants.

Studies intrapopulational tooth striation variability in individuals from the medieval agriculturalist population of La Olmeda, Spain. Buccal striation pattern as a dietary indicator; Factors affecting striation patterns; Choice of surface to analyze.

The present study investigates the quality of four three-dimensional (3D) printing technologies to accurately reproduce the complex pore structure of a real undisturbed soil sample for laboratory experiments of transport in porous media at a 1:1 scale. Four state-of-the-art 3D printing technologies were evaluated (digital light synthesis, PolyJet with gel support material, low-force stereolithography, and PolyJet with water-soluble support material) using a combination of 3D image analysis from microtomopraphy and flow simulations of the pore structure produced with each 3D printing technique. Accuracy, as determined by matching solid and void volumes, permeability, connected porosity, specific surface area, and pore size distribution of the print against the original digital soil structure, was found to be substantially better for digital light synthesis, as compared to the other tested technologies. Repeatability, as determined by the same metrics but compared between identical prints, was found to be comparable across all printing technologies and did not significantly improve for prints at greater magnification (1.5 ×). Wettability of the samples was improved by plasma treatment of the prints. The thorough analysis herein presented demonstrates that advanced, yet relatively inexpensive 3D printing approaches can be used to generate real-scale high quality analogs of soils/rocks that are much needed for experimental laboratory work. Such a method can open countless opportunities for studying the coupling of pore-structure and hydrodynamics on reactive mass transport in environmental science and engineering, soil science, and other subsurface related fields. • Four 3D printed soil analogues were produced from an undisturbed soil image. • The digital light synthesis technology recreated the most accurate pore structure. • All four printing technologies were highly and similarly reproducible. • The wettability of the printed analogue can be tuned by plasma treatment. • We present an approach that produces accurate and identical soil/rock analogues. [ABSTRACT FROM AUTHOR]

Quantum networking protocols relying on interference and precise time-of-flight measurements require high-precision clock synchronization. This study describes the design, implementation, and characterization of two optical time transfer methods in a metropolitan-scale quantum networking research testbed. With active electronic stabilization, sub-picosecond time deviation (TDEV) was achieved at integration times between 1 and 10 5 s over 53 km of deployed fiber. Over the same integration periods, 10-ps level TDEV was observed using the White Rabbit–Precision Time Protocol over 128 km. Measurement methods are described to understand the sources of environmental fluctuations on clock synchronization toward the development of in situ compensation methods. Path delay gradients, chromatic dispersion, polarization drift, and optical power variations all contributed to clock synchronization errors. The results from this study will inform future work in the development of compensation methods essential for enabling experimental research in developing practical quantum networking protocols. [ABSTRACT FROM AUTHOR]

X-linked megalocornea (XMC) is a rare anterior segment malformation characterized by a nonprogressive enlargement of the cornea to 13 mm or greater in the setting of normal intraocular pressure. XMC is caused by mutations in the CHRDL1 gene and it is inherited as an X-linked recessive trait affecting only males. Here, we describe the results of phenotypic and genetic assessment in a novel XMC pedigree. Three subjects (a father and his two daughters) underwent a complete clinical and imaging ocular examination including biomicroscopy, fundoscopy, tonometry, visual acuity, Pentacam Scheimpflug imaging, anterior segment Swept Source OCT, and ultrabiomicroscopy. Genetic analysis was performed through whole exome sequencing in 3 family members. Candidate variants were validated by sanger sequencing The affected father exhibited megalocornea, very deep anterior chambers, retrocorneal pigmentation, iris atrophy, queer iris configuration, extremely open iridocorneal angles, and cataracts. Notably, both daughters showed queer iris configuration and abnormally widely open iridocorneal angles in both eyes. Genetic analysis identified a novel hemizygous c.207+1G>A splicing variant in CHRDL1 in the affected father. Both mildly affected daughters were heterozygous for the pathogenic variant. Here, we report an additional XMC family due to a novel mutation in the CHRDL1 gene. Mild anterior segment anomalies were observed in two heterozygous carriers demonstrating for the first time a CHRDL1-linked phenotype in females. A detailed comparison of the clinical and genetic features of this pedigree with those observed in previously published XMC cases is also presented. [ABSTRACT FROM AUTHOR]

We argue that discreteness at the Planck scale (naturally expected to arise from quantum gravity) might manifest in the form of minute violations of energy-momentum conservation of the matter degrees of freedom when described in terms of (idealized) smooth fields on a smooth spacetime. In the context of applications to cosmology, such "energy diffusion" from the low energy matter degrees of freedom to the discrete structures underlying spacetime would lead to the emergence of an effective dark energy term in Einstein's equations. We estimate this effect using a (relational) hypothesis about the materialization of discreteness in quantum gravity which is motivated by the strict observational constraints supporting the validity of Lorentz invariance at low energies. Arguments based on a simple dimensional analysis lead to an estimate of an effective cosmological constant agreeing in order of magnitude with its observed value. If correct, this would constitute remarkable empirical evidence for a Planckian granular aspect of spacetime. [ABSTRACT FROM AUTHOR]

This paper presents the results of a study on data preprocessing and modeling for predicting corrosion in water pipelines of a steel industrial plant. The use case is a cooling circuit consisting of both direct and indirect cooling. In the direct cooling circuit, water comes into direct contact with the product, whereas in the indirect one, it does not. In this study, advanced machine learning techniques, such as extreme gradient boosting and deep neural networks, have been employed for two distinct applications. Firstly, a virtual sensor was created to estimate the corrosion rate based on influencing process variables, such as pH and temperature. Secondly, a predictive tool was designed to foresee the future evolution of the corrosion rate, considering past values of both influencing variables and the corrosion rate. The results show that the most suitable algorithm for the virtual sensor approach is the dense neural network, with MAPE values of (25 ± 4)% and (11 ± 4)% for the direct and indirect circuits, respectively. In contrast, different results are obtained for the two circuits when following the predictive tool approach. For the primary circuit, the convolutional neural network yields the best results, with MAPE = 4% on the testing set, whereas for the secondary circuit, the LSTM recurrent network shows the highest prediction accuracy, with MAPE = 9%. In general, models employing temporal windows have emerged as more suitable for corrosion prediction, with model performance significantly improving with a larger dataset. [ABSTRACT FROM AUTHOR]

We demonstrate ultrafast laser driven nonlinear scanning tunneling microscopy (STM), under ambient conditions. The design is an adaptation of the recently introduced cross-polarized double beat method, whereby z-polarized phase modulated fields are tightly focused at a tunneling junction consisting of a sharp tungsten tip and an optically transparent gold film as substrate. We demonstrate the prerequisites for ultrafast time-resolved STM through an operative mechanism of nonlinear laser field-driven tunneling. The spatial resolution of the nonlinear laser driven STM is determined by the local field intensity. Resolution of 0.3 nm-10 nm is demonstrated for the intensity dependent, exponential tunneling range. The demonstration is carried out on a junction consisting of tungsten tip and gold substrate. Nano-structured gold is used for imaging purposes, to highlight junction plasmon controlled tunneling in the conductivity limit. [ABSTRACT FROM AUTHOR]

Even though satellite-based positioning increases rescue workers' safety and efficiency, signal availability, reliability, and accuracy are often poor during fire operations, due to terrain formation, natural and structural obstacles or even the conditions of the operation. In central Europe, the stakeholders report a strong necessity to complement the location for mixed indoor-outdoor and GNSS blocked scenarios. As such, location information often needs to be augmented. For that, European Global Navigation Satellite System Galileo could help by improving the availability of the satellites with different features. Moreover, a multi-sensored collaborative system could also take advantage of the rescue personnel who are already involved in firefighting and complement the input data for positioning. The Autonomous Indoor & Outdoor Safety Tracking System (AIOSAT) is a multinational project founded through the Horizon 2020 program, with seven partners from Spain, Netherlands and Belgium. It is reaching the first year of progress (out of 3) and the overarching objective of AIOSAT system is to advance beyond the state of the art in tracking rescue workers by creating a high availability and high integrity team positioning and tracking system. On the system level approach, this goal is achieved by fusing the GNSS, EDAS/EGNOS, pedestrian dead reckoning and ultra-wide band ranging information, possibly augmented with map data. The system should be able to work both inside buildings and rural areas, which are the test cases defined by the final users involved in the consortium and the advisory board panel of the project [ABSTRACT FROM AUTHOR]

In this Letter, we consider the possibility of reconciling metric theories of gravitation with a violation of the conservation of energy-momentum. Under some circumstances, this can be achieved in the context of unimodular gravity, and it leads to the emergence of an effective cosmological constant in Einstein's equation. We specifically investigate two potential sources of energy nonconservation--nonunitary modifications of quantum mechanics and phenomenological models motivated by quantum gravity theories with spacetime discreteness at the Planck scale--and show that such locally negligible phenomena can nevertheless become relevant at the cosmological scale. [ABSTRACT FROM AUTHOR]

Amorphous, glassy or disordered materials play important roles in developing structural materials from metals or ceramics, devices from semiconductors or medicines from organic compounds. Their local structure is frequently similar to crystalline ones. A computer program is presented here that runs under the Windows operating system on a PC to extract pair distribution function (PDF) from electron diffraction in a transmission electron microscope (TEM). A polynomial correction reduces small systematic deviations from the expected average Q-dependence of scattering. Neighbor distance and coordination number measurements are supplemented by either measurement or enforcement of number density. Quantification of similarity is supported by calculation of Pearson's correlation coefficient and fingerprinting. A rough estimate of fractions in a mixture is computed by multiple least-square fitting using the PDFs from components of the mixture. PDF is also simulated from crystalline structural models (in addition to measured ones) to be used in libraries for fingerprinting or fraction estimation. Crystalline structure models for simulations are obtained from CIF files or str files of ProcessDiffraction. Data from inorganic samples exemplify usage. In contrast to previous free ePDF programs, our stand-alone program does not need a special software environment, which is a novelty. The program is available from the author upon request. [ABSTRACT FROM AUTHOR]

The purpose of this review is to discuss the structural and physiological changes that underlie age-related neuromuscular dysfunction and to summarize current evidence on the potential role of nutritional interventions on neuromuscular dysfunction-associated pathways. Age-related neuromuscular deficits are known to coincide with distinct changes in the central and peripheral nervous system, in the neuromuscular system, and systemically. Although many features contribute to the age-related decline in neuromuscular function, a comprehensive understanding of their integration and temporal relationship is needed. Nonetheless, many nutrients and ingredients show promise in modulating neuromuscular output by counteracting the age-related changes that coincide with neuromuscular dysfunction. In particular, dietary supplements, such as vitamin D, omega-3 fatty acids, β-hydroxy-β-methylbutyrate, creatine, and dietary phospholipids, demonstrate potential in ameliorating age-related neuromuscular dysfunction. However, current evidence seldom directly assesses neuromuscular outcomes and is not always in the context of aging. Additional clinical research studies are needed to confirm the benefits of dietary supplements on neuromuscular function, as well as to define the appropriate population, dosage, and duration for intervention. [ABSTRACT FROM AUTHOR]

Abstract: Brain–computer interfaces and neural prostheses based on the detection of electrocorticography (ECoG) signals are rapidly growing fields of research. Several technologies are currently competing to be the first to reach the market; however, none of them fulfill yet all the requirements of the ideal interface with neurons. Thanks to its biocompatibility, low dimensionality, mechanical flexibility, and electronic properties, graphene is one of the most promising material candidates for neural interfacing. After discussing the operation of graphene solution‐gated field‐effect transistors (SGFET) and characterizing their performance in saline solution, it is reported here that this technology is suitable for μ‐ECoG recordings through studies of spontaneous slow‐wave activity, sensory‐evoked responses on the visual and auditory cortices, and synchronous activity in a rat model of epilepsy. An in‐depth comparison of the signal‐to‐noise ratio of graphene SGFETs with that of platinum black electrodes confirms that graphene SGFET technology is approaching the performance of state‐of‐the art neural technologies. [ABSTRACT FROM AUTHOR]

The combination of computational models and biophysical simulations can help to interpret an array of experimental data and contribute to the understanding, diagnosis and treatment of complex diseases such as cardiac arrhythmias. For this reason, three-dimensional (3D) cardiac computational modelling is currently a rising field of research. The advance of medical imaging technology over the last decades has allowed the evolution from generic to patient-specific 3D cardiac models that faithfully represent the anatomy and different cardiac features of a given alive subject. Here we analyse sixty representative 3D cardiac computational models developed and published during the last fifty years, describing their information sources, features, development methods and online availability. This paper also reviews the necessary components to build a 3D computational model of the heart aimed at biophysical simulation, paying especial attention to cardiac electrophysiology (EP), and the existing approaches to incorporate those components. We assess the challenges associated to the different steps of the building process, from the processing of raw clinical or biological data to the final application, including image segmentation, inclusion of substructures and meshing among others. We briefly outline the personalisation approaches that are currently available in 3D cardiac computational modelling. Finally, we present examples of several specific applications, mainly related to cardiac EP simulation and model-based image analysis, showing the potential usefulness of 3D cardiac computational modelling into clinical environments as a tool to aid in the prevention, diagnosis and treatment of cardiac diseases. [ABSTRACT FROM AUTHOR]

Background: Aujeszky's disease is mainly a swine disease, still endemic worldwide. It can infect other mammalians, including human beings, and it is usually fatal with nervous symptoms. Ever since the disease was detected in 1988 in Argentina, many outbreaks have been reported involving both feral swine and dogs. Aim: At present, in Argentina, Pseudorabies virus (PRV) cases are sporadically reported; however, clinical cases are informed. This study aims to obtain information about the seroprevalence of PRV in wild boars and to isolate and characterize PRV from clinical samples. Methods: From 2018 to 2019, 78 wild boars' serum samples from Bahía de Samborombón natural reserve were analyzed for antibodies to PRV using a virus neutralization test. Clinical samples from 17 pigs, 2 wild boars, 1 dog, and 1 cat were collected from 2013 to 2019 for viral isolation and detection of the presence of the gD gene by PCR. For sequence analysis, the gC partial gene was amplified. Results: Five strains were isolated from the dog, cat, and swine samples. The new PRV strains identified were confirmed by BLAST analysis, which revealed between 99.74% and 100% of similarity to the NIA-3 strain and phylogenetic analysis of the partial gene encoding the gC protein revealed that the PRV strains have divided into two main clades, clade 1 and clade 2. Conclusion: This report informed that most new cases of PRV were detected in the central regions of Argentina, where pig production is concentrated. The study in Bahía de Samborombón revealed a high percentage of detection but, the sampling is not representative of that of the rest of the country. Therefore, a systematic sampling effort of wild boar throughout the country should be included in the national program control. Although in Argentina only the inactivated Bartha vaccine is allowed, recombination risk should not be ignored if attenuated vaccines are incorporated into the National control plan. The two strains, one from the cat and one from the dog sample, are directly related to infected swine. The information about clinical cases and molecular characterization of new strains is important for a better understanding of the dynamics of PRV and to promote preventive measures. [ABSTRACT FROM AUTHOR]