1. Normal meninges harbor oncogenic somatic mutations in meningioma-driver genes.
- Author
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Boetto, Julien, Plu, Isabelle, Ducos, Yohan, Blouin, Antoine, Teranishi, Yu, Letournel, Franck, Martin-Négrier, Marie-Laure, Faisant, Maxime, Godfraind, Catherine, Maurage, Claude-Alain, Deramecourt, Vincent, Duchesne, Mathilde, Meyronnet, David, Delteil, Clémence, Rigau, Valérie, Vandenbos-Burel, Fanny, Seilhean, Danielle, Boluda, Susana, Chiforeanu, Dan Christian, and Marguet, Florent
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SOMATIC mutation , *MENINGES , *DURA mater , *GENETIC variation - Abstract
The occurrence of I TRAF7 i mutations in the normal meninges also questions its intrinsic pathogenic value, since meningiomas frequently harbor a second co-mutation ( I KLF4 i SP I K409Q i sp or one of the main oncogenes of the PI3K pathway, I AKT1 i and I PIK3CA i ) [[1], [5]]. Meningioma oncogenesis is dominated by the occurrence of well-known driver gene mutations that form co-exclusive mutational groups, but 20% of meningiomas do not harbor any somatic mutation [[4]-[6]]. Variants are reported ordered by gene mutation frequency, and colored depending on the consequence of the mutation. d Summary of the four mutations present in the normal meninges in main driver genes for meningioma (NF2 and TRAF7). [Extracted from the article]
- Published
- 2023
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