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Background: Breast cancer (BC) is the most common cancer among women worldwide. It has been estimated that approximately 12-20 % of patients will develop liver metastases from breast cancer (BCLM) and that in approximately 5 % of cases the liver is the only metastatic site. Patients with isolated BCLM have the poorest prognosis with a median survival ranging from 19 to 26 months. Methods: A total of 26 women with isolated BCLM and without any sign of disease progression after a cycle of chemotherapy were retrospectively reviewed. Women were treated with hepatic resection (HR) for unilobar disease or surgical 'open' RFA for bilobar disease. Data were collected on either original BC or BCLM and from patients follow-up. Results: Overall survival from BC diagnosis was 47.69 ± 22.25 months (range 33-84, median 45.5 months); it was 52.25 ± 14.57 months (range 33-84, median 48.5 months) for the HR patients and 43.79 ± 27.14 months (range 9-101, median 39 months) for the RFA patients. Overall survival from BCLM treatment was 21.12 ± 12.78 months (range 9-64, median 15.5 months); in detail it was 29.42 ± 14.53 months (range 12-64, median 29.5 months) for the resected patients and 14 ± 4.45 months (range 9-24, median 13.5 months) for patients treated by RFA with a strongly significant survival difference for operated patients ( p = 0.001). Overall disease-free survival from BCLM was 15.96 ± 13.16 months (range 3-64, median 12 months), disease-free survival for resected patients was 23.22 ± 16.2 months (range 8-64, median 18.5 months), and for patients treated by RFA was 9.64 ± 4.22 months (range 3-18, median 9 months; Fig. 1). Overall 1, 2, and 5 years (actuarial) survival was respectively 80.7, 57, and 31 %. Given in details for the two groups, they were respectively 100, 66.6 and 34 % (actuarial) for the resected group patients and 64.2, 21.4, and 11.5 % (actuarial) for the RFA patients.[Figure not available: see fulltext.] Conclusions: Aggressive treatment on isolated BCLM may improve survival for these patients [ABSTRACT FROM AUTHOR]

Desmoid tumors (DTs) are neoplasms of fibroblastic origin characterized by lack of a capsule. They are nonmetastatic and locally aggressive. Intraabdominal DTs are often observed in familial adenomatous polyposis and Gardner syndrome or subsequent to localized traumatic injury. Sporadic forms are defined as nontrauma- or nongenetic-related DTs. Isolated, sporadic pancreatic DTs have been considered anecdotal, with only 9 cases described in the literature. We report the case of a 68-year-old man with a case of sporadic cystic DT localized to the pancreatic tail. The tumor was discovered incidentally during computerized tomography performed for an unrelated condition. The patient was asymptomatic; however, biopsy was performed on the clinical suspicion of cystic cancer of the pancreas. Pathology analysis showed fibroblastic proliferation, and the diagnosis of DT was confirmed by immunohistochemical staining for beta-catenin. The patient underwent resection with no further treatment and remain diseasefree 60 months after surgery. [ABSTRACT FROM AUTHOR]

Inguinal hernia is a worldwide medical problem for its frequency. Elective surgery for inguinal hernia is a common and simple operation, but 5 to 10% of groin hernia requires emergency surgery for incarceration. The aim of our retrospective revision was to evaluate the feasibility of the tissue-based repair technique from Desarda into selected patients with incarcerated groin hernia. Between January 2016 and December 2018, 22 patients were admitted to our institution with a primary groin hernia incarcerated without occlusion signs of or strangulation. Fifteen patients underwent at Desarda's technique performed by the single surgeon experienced in abdominal wall. There were 3 women and 12 men with a mean age of 65.8 years (range 52 to 87 years). Overall morbidity occurred in 6 patients (40%). Length follow-up was set in 6 months. At the end of follow-up any reccurence or chronic pain was detected. The Desarda repair is a simple and straightforward procedure with no complexity involved in the tissue dissection and repair. In our retrospective evaluation feasibility of this treatment, it was possible in selected cases. Desarda's technique has the potential to enlarge the number of tissue-based methods available to groin hernia and also into the acute treatment. [ABSTRACT FROM AUTHOR]

The aim of this study was to provide information about risk of breast cancer (BC) in women with breast complaints undergoing spontaneously clinical examination. The records of 2,879 self-selected symptomatic new patients observed consecutively were reviewed, and the chief breast complaint such as pain, lump and nipple discharge had been recorded. Patients were divided in three groups: Group A, 1,186 (41.2%) patients aged < 41 years; Group B, 809 (28.1%) patients aged 41–55 years; and Group C, 884 (30.7%) patients aged > 55 years. Pain was most common (P < 0.01) in Group A (60.8%), and lump in Groups B (53.3%) and C (89.7%).A total of 318 (11.0%) women had histologically confirmed BC (Group A = 3.5%, Group B = 30.5%, Group C = 66.0%), accounting for 3.2, 16.4 and 12.0% of patients with pain, lump and nipple discharge, respectively. Breast complaints were equally (P = NS) distributed between patients with and without BC. The relative risk (RR) of BC developing ranged between 0.5–1.4, 0.5–1.9, and 0.6–3.0 in Groups A, B, and C, respectively. It ranged between 0.3 and 0.7 in patients with breast pain, and was significantly higher (RR = 1.9–3.0) only in patients with breast lump aged > 40 years. In conclusion, in symptomatic patients BC risk is strictly related to age, and independent of the referred symptoms. Therefore, further investigations have to be warranted only when risk factors different from breast complaints are present. [Copyright &y& Elsevier]