1. Focused Ultrasound-Induced Suppression of Auditory Evoked Potentials in Vivo.
- Author
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Daniels, Dianne, Sharabi, Shirley, Last, David, Guez, David, Salomon, Sharona, Zivli, Zion, Castel, David, Volovick, Alex, Grinfeld, Javier, Rachmilevich, Itay, Amar, Talia, Liraz-Zaltsman, Sigal, Sargsyan, Narek, Mardor, Yael, and Harnof, Sagi
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AUDITORY evoked response , *ULTRASONIC therapy , *MAGNETIC resonance imaging , *ULTRASONIC imaging , *BRAIN damage , *MEDICAL imaging systems , *ANIMAL experimentation , *BIOLOGICAL models , *RATS , *SWINE , *PILOT projects , *NEURAL pathways , *ACOUSTIC stimulation - Abstract
The goal of this study was to determine the feasibility of focused ultrasound-based neuromodulation affecting auditory evoked potentials (AEPs) in animals. Focused ultrasound-induced suppression of AEPs was performed in 22 rats and 5 pigs: Repetitive sounds were produced, and the induced AEPs were recorded before and repeatedly after FUS treatment of the auditory pathway. All treated animals exhibited a decrease in AEP amplitude post-treatment in contrast to animals undergoing the sham treatment. Suppression was weaker for rats treated at 2.3 W/cm2 (amplitudes decreased to 59.8 ± 3.3% of baseline) than rats treated at 4.6 W/cm2 (36.9 ± 7.5%, p <0.001). Amplitudes of the treated pigs decreased to 27.7 ± 5.9% of baseline. This effect lasted between 30 min and 1 mo in most treated animals. No evidence of heating during treatment or later brain damage/edema was observed. These results demonstrate the feasibility of inducing significant neuromodulation with non-thermal, non-invasive, reversible focused ultrasound. The long recovery times may have clinical implications. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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