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The article discusses a case study of a 40-year-old woman with a history of hidradenitis suppurativa who developed injection-site reactions to secukinumab treatment due to a hypersensitivity reaction to polysorbate 80. The study highlights the importance of testing excipients in biologic drugs to identify the cause of hypersensitivity reactions. Polysorbate 80, a common excipient in biologics, can induce contact urticaria, and its role in immediate hypersensitivity reactions is underexplored. The study suggests that excipients should be carefully considered in cases of unclear reactions to biologics to prevent potential severe reactions. [Extracted from the article]