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In the context of pavement evaluation, backcalculation is the process of estimation of elastic properties of pavement layers using measured structural responses. A number of backcalculation programs are available for estimating effective pavement layer moduli from surface deflections. Different optimization techniques have been used in the development of these backcalculation models. Genetic algorithm (GA) has been used successfully in the recent past for backcalculation of pavement layer moduli. Selection of appropriate GA parameters is important for the efficient performance of the GA-based algorithm. However, there are no general guidelines available at present for the selection of GA parameters. This paper presents a study conducted for the selection of optimal GA parameters to be adopted for backcalculation of pavement layer moduli. The parameters have been selected on the basis of the level of accuracy desired and the corresponding computational effort (CE). The performance of the GA-based program with the selected parameters was evaluated using some hypothetical and field problems. [ABSTRACT FROM AUTHOR]

The paper presents the details of various investigations conducted for the laboratory evaluation of the performance of crumb–rubber modified asphalt mixes. Crumb rubber (CR) obtained from discarded truck and bus tires was used to modify 80/100 penetration grade asphalt cement. Fatigue and permanent deformation characteristics, temperature and moisture susceptibility, and oxidative aging are some of the performance indicators of mixes evaluated. A static indentation test was adopted for assessing the relative permanent deformation characteristics of different mixes. Three aggregate gradations: (1) superpave; (2) gradation specified by the Ministry of Surface Transport, India for asphalt concrete; and (3) one gap gradation, were considered in the investigation. Compared to normal mixes, CR modified mixes were found to have improved fatigue and permanent deformation characteristics. They also showed lower temperature susceptibility and greater resistance to moisture damage compared to normal mixes. Superpave mixes gave better overall performance compared to the mixes having other aggregate gradations. [ABSTRACT FROM AUTHOR]

Abstract: Background: Laparoscopic live donor nephrectomy is becoming increasingly popular as it has been shown to minimize donor morbidity, length of hospital stay and length of time to return to work. Initial experience suggested that kidneys procured laparoscopically had higher rates of delayed graft function and ureteric complications but with increasing experience, these complications have become less common. Methods: Retrospective chart review of all patients who underwent living donor kidney transplant using kidneys procured laparoscopically at our centre was performed. From the initiation of the laparoscopic donor nephrectomy programme at our institution in November 1998 until February 2002, we performed 71 living donor kidney transplants (69 kidneys procured laparoscopically and two procured by open donor nephrectomy after failed laparoscopic approach). Donor left kidney was used in all except in one patient. Mean duration of warm ischaemia time was 206 ± 79 s. Results: The mean age of the recipients was 42 ± 15 years (range 1–68) including five paediatric recipients (age < 18 years). There were 48 males and 23 females. Nine (13%) were retransplants (seven second transplants and one each of third and fourth transplants). Two patients died with functioning grafts and four patients lost the graft (three thrombosis, one anastomotic rupture). No patient developed ureteric complications. The incidence of delayed graft function (need for dialysis in the first week post-transplant) was 4%. Patient and graft survival rates (actual) were 97% and 91%, respectively. Mean length of hospital stay was 9 ± 7 days (median 7 days). Conclusions: Recipient outcome is not compromised and excellent results can be achieved with living donor kidney transplantation using laparoscopically procured kidneys. [ABSTRACT FROM AUTHOR]

Background. The piggyback technique (PT), with preservation of the cava, is being used more frequently in adult orthotopic liver transplantation (OLT). The advantages of PT include hemodynamic stability during the anhepatic phase without a large-volume fluid infusion and obviating the need for veno-venous bypass (VVB). At our center, we changed our practice in July 1997 from the standard technique (ST) of OLT with routine use of VVB to PT and selective use of VVB. The purpose of the present study was to analyze the results with the two different practices, ST-routine VVB versus PT-selective VVB. Methods. Forty OLTs were performed during the period July 1995–July 1997 using ST-routine VVB (group I) and 36 during August 1997–December 1998 using PT-selective VVB (group II). The etiology of liver disease was similar in the two groups, with hepatitis C and alcoholic liver disease accounting for half of the patients in each group. The UNOS status, age, sex, and percentage of patients with previous upper abdominal surgery were also similar between the two groups. Results. In the PT-selective VVB era (group II), 34/36 patients (94%) underwent OLT with PT and VVB was used for 8 (22%) patients. The decision to use VVB was elective for 3 patients (fulminant hepatic failure, 2; severe portal hypertension, 1) and urgent for 5 patients (hemodynamic instability during hepatectomy). The intraoperative use of packed red blood cells (PRBC) (mean±SD) was 15±12 units for group I and 9±8 units for group II (p=0.023). Anastomosis time and total operating time (mean±SD) were 91±30 min and 9.5±3.2 h, respectively, for group I patients compared with 52±28 min and 7.6±1.6 h, respectively, for group II patients (p<0.0001 and 0.002, respectively). Median post-operative stays in the intensive care unit (ICU) and in the hospital were 5 and 17 d, respectively, for group I and 4 and 11 d, respectively, for group II (p=NS). Mean serum ... [ABSTRACT FROM AUTHOR]

Background. Enteric drainage (ED) is associated with reduced morbidity compared with bladder drainage (BD) after simultaneous kidney–pancreas transplantation (SKPT) and is becoming increasingly common (more than 50% of SKPTs done in the US in 1998 were performed with enteric drainage). Although several studies have reported the morbidity and graft survival of ED compared with BD previously, there are limited data available comparing the length of stay and hospital charges between these two drainage procedures. Methods. Fourteen SKPTs were performed during the period January 1995–May 1998 using BD and 20 during June 1998–August 1999 using ED. Hospital charges analyzed included the following categories: pharmacy, inpatient room, laboratory, operating room, medical–surgical supply, radiology/nuclear medicine, and miscellaneous. Organ acquisition charges and professional fees were not included in this analysis. Results. The mean hospital stay for patients with ED was 7.8±2.2 d (range 5–12 d; median 7.5 d) compared with 15.9±7 d (range 8–38 d; median 15 d) for patients with BD (p=0.002). The mean hospital charges during initial hospitalization for the ED group were $36 582±11 424 compared with $64 555±29 054 for the BD group (p=0.005). There was a significant decrease in the charges relating to pharmacy, inpatient room, laboratory, radiology/nuclear medicine, and miscellaneous category in the ED group compared with the BD group, while the charges relating to operating room and medical–surgical supply were no different between the two groups. One-year actuarial kidney and pancreas graft survival rates were 83% and 93%, respectively, for the BD group and 90% and 80%, respectively, for the ED group (p=NS). Conclusions. SKPT patients with ED had a 43% reduction in hospital charges and equivalent pancreas and kidney graft survival rates compared with SKPT patients with BD. A shorter hospital stay a... [ABSTRACT FROM AUTHOR]

Discusses the differences between enteric drainage, which is associated with reduced morbidity, and bladder drainage after simultaneous kidney and pancreas transplantations (SKPT). Comparison of the lengths of hospital stays following each procedure; Number of SKPT patients who had enteric drainage who had reduced hospital stays.

Discusses how the piggyback technique is being used more frequently in adult orthotopic liver transplantation. Advantages of the piggyback technique, including hemodynamic stability during the anhepatic phase without a large-volume fluid infusion; How the technique is safe and can be performed in the majority of adult patients.

Faced with an extreme shortage of organs transplant professionals continue to explore various strategies to expand the donor pool. Transplantation of kidneys from older and very young donors are two such options. Although kidneys from young donors (less than 5 years of age) have been associated with a high rate of technical complications and suboptimal results, use of these kidneys en bloc has been advocated to improve the outcomes. We reviewed our experience with en bloc kidney transplantation at the University of Kentucky over the past 10 years. Between 1991 and 2000 ten patients underwent kidney transplantation using kidneys en bloc from donors <5 years age. The mean age of the donors was 2.8 years with a mean weight of 16 kg (range 13-21). Mean age of the recipients was 42 years. One patient lost the graft on day one from venous thrombosis. One patient lost the graft 7 years post-transplant from chronic rejection. All of the remaining patients are doing well with functioning grafts (mean follow-up 4.5 years; range 6 months to 10 years). Both one-year and five-year graft survival rates are 89 per cent. The present study confirms that excellent results can be achieved with kidney transplantation using kidney transplantation using kidneys en bloc from donors younger than 5 years of age. [ABSTRACT FROM AUTHOR]

Bituminous mixes are generally designed with gradation and air void content ranges adopted by different agencies. The selected gradation and binder content are permitted to vary within specified tolerance limits. This leads to the possibility of a wide range of mixes with varying mix performance. Thus, it is essential to understand the influence of variation in these parameters on the performance of mixes. The present study aims to examine the sensitivity of the mix performance to variation within the specified gradation and air void ranges. Five aggregate gradations were considered for designing mixes for the volumetric design criterion of 4% air voids. For three of the five gradations, mixes were also designed for two additional design air void contents, 3% and 5%. Rutting resistance of the mixes was measured using a rut tester and moisture resistance was evaluated in terms of Tensile Strength Ratio (TSR). The densification characteristics represented by voids in mineral aggregate (VMA) values of the mixes prepared using the five aggregate gradations are similar to those of the corresponding aggregate packing characteristics (dry aggregate air voids, DAAV). A good relationship was observed between mix rutting and minimum voids in mineral aggregate and DAAV. Sensitivity analysis carried out with different aggregate gradations, design air void contents and tolerances, indicated that rut depth as well as TSR vary over a wide range for the combinations of mixes considered (all within the gradation, air void content and tolerance limits).Compared to the design air void content, aggregate gradation is found to have significantly larger effect on rut depth whereas both gradation and design air void content have similar effect on the TSR value. Using the results obtained from the present investigation, the Indian Marshall mix design criteria (MoRTH 2013) for stability and flow were revisited and new criteria are proposed. [ABSTRACT FROM AUTHOR]

Highlights • Two methods of lime modification, wet and dry were considered for evaluating the rutting performance of bituminous mixes. • Wet mixes (with 30% lime in binder) showed better resistance to rutting compared to dry mixes (with 1.5% lime as filler). • Lime modification has been found to be more effective in improving the rut resistance at higher temperatures. Abstract Hydrated lime has conventionally been used in bituminous mixes primarily for improving the moisture damage resistance of bituminous mixes. Most of the available literature is about studies conducted on mixes in which lime was added as filler. The present study explores the effect of different proportions of hydrated lime added by two different methods (wet and dry) on the rutting performance of bituminous mixes. The rutting characteristics of unmodified and lime modified binders were evaluated in terms of superpave binder rutting parameter (G∗/sinδ) and non-recoverable creep compliance (J nr ). Mix rutting performance was measured in terms of E∗, E∗/sinφ, flow number and accumulated strain measured in dynamic creep test. Rutting performance of mixes improved significantly by lime modification. Wet method of addition of lime has significantly higher beneficial effect than the dry method. Flow number determined at 60 °C demonstrated the beneficial effect of lime more distinctly compared with the dynamic creep test conducted at 40 °C. It was also observed in this study that the beneficial effect of lime addition in reducing rutting (which is a high temperature phenomenon) was realized more at higher mix temperatures. [ABSTRACT FROM AUTHOR]

Abstract: This study was conducted with an objective to improve the tenderness of tough buffalo meat using ammonium hydroxide. Buffalo meat chunks from Biceps femoris muscle were marinated with distilled water (control), 0.1%, 0.5% and 1.0% solution of ammonium hydroxide for 48h at 4±1°C and subjected to various physico-chemical analysis and ultrastructural studies. Ammonium hydroxide increased (P <0.05) the pH, water holding capacity (WHC), collagen solubility, total and salt soluble protein extractability and cooking yield. Reduction (P <0.05) in Warner–Bratzler shear force values were observed in all ammonium hydroxide treated samples compared to non-treated control. Electrophoretic pattern of muscle proteins exhibited reduction in the intensity and number of certain protein bands for 0.1% and 0.5% ammonium hydroxide treated samples compared to control. Scanning and transmission electron microscopy also revealed breakdown of endothelium layers surrounding muscle fibers and weakening of Z-discs respectively, in treated samples compared to controls. These results suggest that ammonium hydroxide might be used to tenderize tough buffalo meat. [Copyright &y& Elsevier]

Simultaneous pancreas-kidney transplantation (SPKT) is the treatment of choice for patients with end-stage renal failure due to type 1 diabetes mellitus. With advances in surgical techniques and immunosuppression management, outcomes have improved, with current 1- and 10-year pancreas graft survival rates of 86% and 53%, respectively. Induction therapy with either alemtuzumab or rabbit antithymocyte globulin (rATG) in combination with a calcineurin inhibitor (CNI) and mycophenolate mofetil (MMF) or sirolimus appears to be safe and effective in the setting of rapid steroid withdrawal (RSW), with excellent graft survival and low rejection rates. There are no large randomized trials between alemtuzumab and rATG to determine whether one is better than the other. Anti-interleukin (IL)-2 receptor antibody induction and no induction in combination with a CNI, MMF or sirolimus, and prednisone have demonstrated excellent graft survival rates but are associated with a higher incidence of acute rejection. The efficacy of anti-IL-2 receptor antibodies or no induction in the setting of RSW is unproven. Both of the CNIs, ciclosporin and tacrolimus, are effective in preventing acute rejection in SPKT recipients; however, pancreas allograft survival may be better with tacrolimus. MMF is more effective than azathioprine in preventing acute rejection. Sirolimus appears to be effective in preventing acute rejection, but the combination of sirolimus with a CNI may accentuate the nephrotoxicity of the CNI. RSW with induction therapy is safe and effective in SPKT recipients, but longer follow-up data on outcomes are needed. Recent analysis of registry data shows that most transplant centres are using an induction agent followed by a combination of tacrolimus, MMF and corticosteroids in SPKT recipients. [ABSTRACT FROM AUTHOR]

Presents a study on a two-stage heuristic approach for the allocation of buses to regional bus transit routes. Determination of routes and allocation of bus frequencies to different routes; Surplus allocation; Features of some of the existing frequency-setting models; Application of the model to a regional transit network in India.

The biliary anastomosis has been called ‘the Achilles heel’ of liver transplantation (Rabkin JM, Orloff SL, Reed MH. Transplantation 1998: 65 [2]: 193; Davidson BR, Rai R, Kurzawinski TR. Br J Surg 1999: 86 [4]: 447). Biliary complications after liver transplantation reportedly occur at an incidence of 20–30%, 10–15% as bile leaks. The management of bile leaks, especially early bile leaks, is controversial. In the present study, we report our experience with the management of bile leaks after liver transplantation. In this retrospective study, we reviewed 85 liver transplants over a 3-yr period. In 79, the biliary anastomosis was choledochocholedochostomy (CDCD) over a small-caliber T-tube, while choledochojejunostomy (CDJ) was used in 7. Over a mean follow up period of 13.5 months (median 10 months), 10 patients (12%) experienced a clinically significant bile leak within the first 3 months after liver transplantation. The early leaks, occurring within 1 month of transplant, were successfully managed by observation (Davidson BR, Rai R, Kurzawinski TR. Br J Surg 1999: 86 [4]: 447) or endoscopic retrograde cholangiopancreatography (ERCP) and the placement of a biliary stent for a duration of 6–12 wk (Randall HB, Wachs ME, Somberg KA. Transplantation 1996: 61 [2]: 258). One of these resulted from accidental dislodgement of the T-tube on postoperative day 1; one resulted from necrosis at the CDCD anastomosis and required CDJ; the remaining four resulted from leaks along the T-tube track. One of the late leaks occurred following the planned removal of the T-tube at 3 months after liver transplantation; the other two were leaks along the T-tube track. All were successfully treated by ERCP and stent placement, though in one case, ERCP was initially unsuccessful because of the inability to advance a guidewire, necessitating a fluoroscopically aided guide wire placement during a mini laparotomy. ERCP was then successfully performe... [ABSTRACT FROM AUTHOR]

Focuses on biliary anastomosis and how it tends to complicate liver transplantation. Occurrence of biliary complications in the form of bile leaks; Details of a three-year study on liver transplants; Methods; Results; Conclusions.

Abstract: The antioxidant and antimicrobial efficacy of grape seed extract (GSE) was studied in restructured mutton slices (RMS) under aerobic and vacuum packaging conditions during refrigerated storage. The RMS treated with grape seed extract (GSE) had significantly (P<0.05) lower thiobarbituric acid reactive substance (TBARS) values and free fatty acids (FFA) % compared to control (C) and butylated hydroxy anisole (BHA) treated RMS during storage at 4±1°C. Addition of GSE significantly (P<0.05) reduced the total psychrophilic and coliform counts in RMS during refrigerated storage. The GSE treated mutton slices recorded significantly (P<0.05) superior scores of color, flavor, juiciness and overall palatability than C and BHA treated RMS. The TBARS values, FFA % and microbial counts increased significantly (P<0.05) during storage. It can be concluded that GSE has excellent antioxidant and antimicrobial properties compared to control and BHA treated RMS during refrigerated storage under aerobic and vacuum conditions. [Copyright &y& Elsevier]

Potential donors with congenital renal anomalies but normal renal function are often overlooked because of a possible increase in technical difficulty and complications associated with the surgery. However, as the waiting list for a deceased donor kidney transplant continues to grow, it is important to consider these kidneys for potential transplant. This paper describes the procurement of a crossed fused ectopic kidney, and subsequent parenchymal transection prior to transplantation as part of a combined simultaneous kidney pancreas transplant. The transplant was uncomplicated, and the graft had immediate function. The patient is now two years from transplant with excellent function. [ABSTRACT FROM AUTHOR]

Data on body weight at 4 weeks age, age at first egg and cumulative egg production up to 12, 16 and 20 weeks of age of a total 617 Black and Brown strains of Japanese quails were analyzed. Strains, generations and hatches had significant influence on all the traits studied. Black quails were significantly heavier and laid more eggs. The quails of fifth generation recorded lowest least-squares mean for age at first egg with higher egg production. Heritabilities varied from moderate to high in Black and were high in Brown strains. Genetic and phenotypic correlations among the traits varied from low to high. [ABSTRACT FROM AUTHOR]

Backcalculation of pavement layer moduli refers to the process of evaluating the pavement layers using pavement surface deflections. The genetic algorithm (GA) technique was successfully used in the past for backcalculation. The BACKGA model developed by the Indian Institute of Technology, Kharagpur is one such program used for backcalculation using the GA technique. Though GA-based backcalculation models are considered to be robust due to the search algorithm adopted in the process, they require more computational time due to the large number of times the surface deflections are computed using different sets of layer moduli. In the present work, artificial neural network (ANN) models have been developed for computing surface deflections using elastic moduli and thicknesses of pavement layers as inputs. The ANN models have been used in BACKGA for forward calculation of surface deflections to combine the computational efficiency of ANNs with the robustness of the GAs. The performance of the resulting model, BACKGA–ANN, has been evaluated and found to be satisfactory. [ABSTRACT FROM AUTHOR]