1. Interleukin-3 receptor in acute leukemia.
- Author
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Testa, U., Riccioni, R., Diverio, D., Rossini, A., Lo Coco, F., and Peschle, C.
- Subjects
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INTERLEUKIN-3 , *MYELOID leukemia , *LEPROSTATIC agents , *INTERLEUKINS , *COLONY-stimulating factors (Physiology) , *BONE marrow diseases - Abstract
Recent studies indicate that abnormalities of the interleukin-3 receptor (IL-3R) are frequently observed in acute myeloid leukemias (AMLs) and may contribute to the proliferative advantage of leukemic blasts. This review analyzes the evidences indicating that the IL-3R represents one of the target molecules involved in the stimulation of proliferation of AMLs, and the overexpression of the IL-3Ra chain may represent one of the mechanisms contributing to the development of a highly malignant leukemic phenotype. Furthermore, there is evidence that the IL-3Ra is a marker of leukemic stem cells, at variance with normal stem cells that are IL-3Ra-. Finally, the IL-3R may represent an important target for the development of new antileukemic drugs.Leukemia (2004) 18, 219-226. doi:10.1038/sj.leu.2403224 Published online 4 December 2003 [ABSTRACT FROM AUTHOR]
- Published
- 2004
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