Search

Background: The historical pathological cut-off values for Wiberg's lateral center-edge (LCE) angle and Lequesne's acetabular index (AI) are below 20° and above 12° for the LCE and AI, respectively. The aim of this study was to reassess these two angles more than 50 years after their introduction using a standardized conventional radiological measurement method, considering changing social habits and their associated physiological changes.Methods: A total of 1,226 anteroposterior radiographs of the pelvis (2,452 hips) were obtained according to a strict standardized radiographic technique allowing reliable measurements of the LCE angle and the AI.Results: Distributions of the LCE and AI were pronouncedly Gaussian, with mean values of 33.6° for the LCE and 4.4° for the AI. The 2.5th and 97.5th empirical percentiles were 18.1 and 48.0° for the LCE and -6.9 and 14.9° for the AI. These intervals contained 95 % of the data in our large sample. Small but statistically significant differences between the sexes and right and left hips have been demonstrated. Correlation between age and coxometric indices was low.Conclusion: The above findings do not conflict with the historical benchmarks. Statistical differences between sexes and between right and left hips were not clinically relevant. No conclusion can be drawn about coxometric indices and clinical manifestations of hip dysplasia. [ABSTRACT FROM AUTHOR]

Abstract: We present fluorescence chip reader for rapid, multiplexed assay measurements on plastic biochips. The system is designed as a low-cost, compact and robust instrument for point of care testing. Fluorescence imaging of biochip arrays is accomplished with a custom designed piezo-motor-driven scanning stage coupled to an optical element based on supercritical angle fluorescence (SAF). The use of SAF not only provides substantial enhancement of the fluorescence collection efficiency but also confines the fluorescence detection volume strictly to the close proximity of the biochip surface, thereby discriminating against fluorescence background from the analyte solution. The high imaging resolution of the SAF scanner is demonstrated by measuring the point spread function of 200nm fluorescence beads. The sensitivity of the system is determined by measuring an array of low fluorophore concentrations and by real-time monitoring of a model bioassay. [Copyright &y& Elsevier]