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Novel, isocratic reversed phase high performance liquid chromatography method was developed and validated for the determination of enzalutamide (EZA) in bulk drug and pharmaceutical formulation. Efficient separation was achieved on PrincetonSPHER C18 100A, 5μ (250×4.6 mm) under the isocratic mode of elution using acetonitrile: water (80:20) % V/V as a mobile phase pumped in to the column at flow rate 1.0 mL/min. The effluent was monitored at 237.0 nm using UV detector. EZA was eluted in the given mobile phase at retention time (tR) of 3.2 minutes. The standard calibration curve was linear over the concentration range 10 - 60 μg/mL with correlation coefficient 0.997. The method was validated for accuracy, precision, sensitivity, robustness, ruggedness and all the resulting data treated statistically. The system suitability parameters like retention time, theoretical plates, tailing factor, capacity factor were found within the limit. [ABSTRACT FROM AUTHOR]

Pharmacoeconomics deals with allocation of health resources considering the cost benefit, safety and efficacy of drugs. The art of finely balancing the availability and cost of essential drugs in resource-scare area is the key to success. Factors like clinical efficacy, safety and cost-effectiveness of the medicines needs to be considered together for granting license for use of new medicines. For effective pharmacoeconomics management we need to close the gap between academics, health care practitioners, pharmaceutical industry and policy makers. This will in turn help us to fulfill the dream of affordable, safe and effective health care for all. [ABSTRACT FROM AUTHOR]

The present study was carried out at the Main Agricultural Research Station, Dharwad during kharif 2012. The experimental material comprised 45 Gossypium barbadense genotypes, which were evaluated for variability for yield and yield components to know the improvement made over commercial check (Suvin) and to identify lines suitable for development of inter specific hybrids. Out of 10 characters studied in 46 potential Barbadense lines, seed cotton yield, number of bolls per plant and number of monopodia per plant recorded high PCV and GCV indicating that substantial variability exists for these characters and also higher heritability was recorded for these characters. The mean performance of Barbadense genotypes indicated that YBD- 10 recorded the highest mean value for seed cotton yield followed by YBIPS 14 andYBD-18. The genotypes YB-IPS 14, DBSI-75-10,1 and RHCB - 010 exhibited high fiber length and strength. The potential lines YB-IPS 14 and YB-IPS 25 are examples for blending of both yield and fiber quality. [ABSTRACT FROM AUTHOR]