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Linear IgA/IgG bullous dermatosis (LAGBD) is an autoimmune blistering disease characterized by the local accumulation of IgA- and IgG-class anti-basement membrane autoantibodies. It typically presents as a generalized pruritic vesiculobullous eruption. No cases of localized LAGBD have yet been reported. We report a case of a 78-year-old man with LAGBD localized to the perianal area. The patient complained of suffering from persistent ulcers around the anus for more than 3 years. Physical examination revealed several blisters and ulcers up to 2-cm in diameter around the anus. No lesions were found elsewhere on the body. Histological analysis of a skin biopsy revealed subepidermal blistering, while direct immunofluorescence showed the linear deposition of IgA and IgG antibodies at the dermoepidermal junction. Indirect immunofluorescence of normal human skin whose layers had been separated using 1M NaCl showed the binding of both IgA and IgG to the epidermal side. Immunoblotting demonstrated the presence of circulating IgA and IgG autoantibodies that bound to a 120-kDa protein. This is the first case of localized LAGBD whose skin lesions were restricted to the perianal region. [ABSTRACT FROM AUTHOR]

The article describes cases of older patients with methotrexate-associated lymphoproliferative disorders (MTX-LPD). Topics cited include the cutaneous manifestations of MTX-LPD, association of MTX with Epstein-Barr virus (EBV) positive diffuse large B-cell lymphoma, spontaneous regression of lymphoma after MTX discontinuation, and expression of EBV in tumor cells.

The article describes a case study concerning a 31-year-old male patient with Kindler syndrome (KS) accompanied by severe intestinal involvement. Topics discussed include multiple blisters and erosions presented by the patient at birth, mutations in the FERMT1 gene that cause KS, and cutaneous features. Also mentioned are intestinal involvement such as colitis and diarrhea in childhood, occurrence of severe late-onset ileal strictures, and genotype correlation.

The article focuses on a case report detailing the rare occurrence of cutaneous intestinal metaplasia in the urostomy area of a patient who underwent a cystectomy with ileal conduit urinary diversion, highlighting the histopathological findings, and differentiation from other skin lesions. It discusses the unique manifestation of cutaneous intestinal metaplasia triggered by continuous urine contact, emphasizing the importance of histological examination for refractory peristomal lesions.

The article present a case study of an 80‑year‑old Japanese man with hard nodules on the second to fourth fingers of the right hand. Topics include physical examination revealed hard skin coloured to reddish nodules on the right hand and the left side of the forehead; mentions a skin biopsy specimen from the digit showed dermal nodular proliferation of atypical chondrocyte‑like cells; and also mentions the lung tumor specimen showed a biphasic pattern consisting of atypical squamoid cells.

The article presents a case study of a 32-year-old Japanese man with a 5-month history of painful nodules on the fingers. His physical examination and diagnostic imaging revealed no tumors in other sites. His histopathology revealed that the tumor was covered by a fibrous capsule and was composed of myxoid areas with ossification at the periphery.

Granuloma faciale (GF) is an uncommon inflammatory dermatosis that is characterized by one or several asymptomatic brown red nodules or plaques usually occurring on the face. GF is known to be extremely resistant to treatment. Various treatments have been attempted, including topical or intralesional or systemic corticosteroids, dapsone, antimalarials, colchicine, topical tacrolimus, and topical psoralen; however, none of these have been found to be reliably efficacious. We tried numerous combinations and rotations of therapeutic modalities for GF over a long time. We described a case of GF in which the eruptions were carefully observed over the course of 14 years before finally resolving. Our experience suggests that continuous and careful follow-up, and trials of combinations and rotations of therapeutic modalities are essential for treating GF. [ABSTRACT FROM AUTHOR]

The article discusses a science study on cyanobacterium species 6803 and 7942 conducted to examine whether alternative electron flow (AEF) can replace the photosynthetic electron flux in cyanobacteria. Topics include techniques used, use of open oxygen-electrode system to monitor oxygen-exchange, and quenching of chlorophyll fluorescence. The results show that AEF functioned in 6803 and replaced the photosynthetic electron flux.

The article presents a case study of a 54-year-old Japanese woman presented with multiple nodules arising within a hairless birthmark on her head. It mentions that past medical history of the patient as unremarkable, with no neurological, skeletal or congenital anomalies. It mentions that scanning view of the surgical specimen revealed multiple dermal nodules within a melanocytic naevus.

A case study describing the exacerbation of pemphigus foliaceus after electron-beam radiation for extramammary Paget's disease is presented. Topics discussed include the clinical history of the patient, how the diagnosis of pemphigus foliaceus was made, and the necessity of precautions against the exacerbation of pemphigus after irradiation. The need to be aware of the occurrence of pemphigus after irradiation even in cases with no history of blistering diseases is noted.

The article describes a case study concerning a 63-year-old man diagnosed with myelodysplastic syndrome (MDS) and acquired trisomy 8. Topics discussed include the development of oral aphthae, intestinal and genital ulceration and high fever, the symptoms' similarity to those of Behçet's disease (BD), and gene expression patterns. Also mentioned are screening for underlying hematological disorders and better training of dermatologists to examine patients with BD-like mucocutaneous lesions.