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We investigate barrier-crossing processes corresponding to collective hydrogen-bond rearrangements in liquid water using Markov state modeling techniques. The analysis is based on trajectories from classical molecular dynamics simulations and accounts for the full dynamics of relative angular and separation coordinates of water clusters and requires no predefined hydrogen bond criterium. We account for the complete 12-dimensional conformational subspace of three water molecules and distinguish five well-separated slow dynamic processes with relaxation times in the picosecond range, followed by a quasi-continuum spectrum of faster modes. By analysis of the Markov eigenstates, these processes are shown to correspond to different collective interchanges of hydrogen-bond donors and acceptors. Using a projection onto hydrogen-bond states, we also analyze the switching of one hydrogen bond between two acceptor water molecules and derive the complete transition network. The most probable pathway corresponds to a direct switch without an intermediate, in agreement with previous studies. However, a considerable fraction of paths proceeds along alternative routes that involve different intermediate states with short-lived alternative hydrogen bonds or weakly bound states. [ABSTRACT FROM AUTHOR]

The assessment of skin changes in the context of possible child abuse is an important task in forensic medicine. This requires knowledge of pigmentation variants and pigmentation disorders such as congenital dermal melanocytosis, which includes Mongolian spots. Particularly in the case of atypical localization and dark pigmented skin, the differentiation from hematomas can be challenging. A case of two Nigerian siblings with extensive and atypically localized Mongolian spots is reported. The 1.5-year-old girl showed Mongolian spots on her back and the right side of her trunk. The 8-year-old boy showed Mongolian spots only on the back of his thighs. The authors are not aware of any case in which so called Mongolian spots were present exclusively on the back of the thighs and this case is all the more noteworthy as the back of the thigh is a common localization of blunt force trauma. [ABSTRACT FROM AUTHOR]

Context. Flares in radio-loud active galactic nuclei are thought to be associated with the injection of fresh plasma into the compact jet base. Such flares are usually strongest and appear earlier at shorter radio wavelengths. Hence, very long baseline interferometry (VLBI) at millimeter(mm)-wavelengths is the best-suited technique for studying the earliest structural changes of compact jets associated with emission flares. Aims. We study the morphological changes of the parsec-scale jet in the nearby (z = 0.049) γ-ray bright radio galaxy 3C 111 following a flare that developed into a major radio outburst in 2007. Methods. We analyse three successive observations of 3C 111 at 86 GHz with the Global mm-VLBI Array (GMVA) between 2007 and 2008 which yield a very high angular resolution of ∼45 μas. In addition, we make use of single-dish radio flux density measurements from the F-GAMMA and POLAMI programmes, archival single-dish and VLBI data. Results. We resolve the flare into multiple plasma components with a distinct morphology resembling a bend in an otherwise remarkably straight jet. The flare-associated features move with apparent velocities of ∼4.0c to ∼4.5c and can be traced also at lower frequencies in later epochs. Near the base of the jet, we find two bright features with high brightness temperatures up to ∼1011 K, which we associate with the core and a stationary feature in the jet. Conclusions. The flare led to multiple new jet components indicative of a dynamic modulation during the ejection. We interpret the bend-like feature as a direct result of the outburst which makes it possible to trace the transverse structure of the jet. In this scenario, the components follow different paths in the jet stream consistent with expectations for a spine-sheath structure, which is not seen during intermediate levels of activity. The possibility of coordinated multiwavelength observations during a future bright radio flare in 3C 111 makes this source an excellent target for probing the radio-γ-ray connection. [ABSTRACT FROM AUTHOR]

• Results of first ever FRI total reflux test carried out with a wire gauze packing. • Montz-pak A3-500M tested with p/o-xylene at pressures of 0.1 and 0.02 bara. • Very high packing efficiency achieved, somewhat larger at 0.02 bara. • Delft model used to evaluate and interpret measured efficiency and pressure drop. Results are presented of total reflux experiments carried out at Fractionation Research Inc. with Montz-Pak A3-500M, an advanced corrugated sheet wire gauze packing, using Paraxylene/Orthoxylene system at 0.1 bara and for the first time at 0.02 bara. In both cases an expectedly good performance was achieved, ranging from eight stages at low- to five stages per meter bed height at upper limit of the operating vapour load. Interestingly, within preloading region the packing exhibited a better efficiency at 0.02 bara, however this was at the expense of somewhat increased pressure drop, and, strikingly, no gain on capacity side. Delft model proved capable of capturing observed trends, but exhibits a pronounced discrepancy with respect to measured efficiency and pressure drop at 0.02 bara, and suggests a higher flooding limit than observed. [ABSTRACT FROM AUTHOR]

Context. Few active galactic nuclei (AGN) reveal double-sided jet systems. However, these systems are crucial to understand basic physical properties of extragalactic jets. Aims. We address the questions whether jets in AGN are symmetric in nature, how well they are collimated on small scales, and how they evolve with time. Methods. We monitored the sub-parsec scale morphology of NGC 1052 with the Very Long Baseline Array at 43 GHz from 2005 to 2009. Results. A detailed study of 29 epochs show a remarkable asymmetry between both jets. A kinematic analysis of the outflows reveals higher apparent velocities for the eastern (approaching) jet as compared to the western (receding) jet, i.e., βej = 0.529 ± 0.038 and βwj = 0.343 ± 0.037, respectively. Contradictory to previous studies, we find higher flux densities for the western jet as compared to the eastern. The distribution of brightness temperature and jet width features well-collimated jets up to 1 mas distance to the dynamic center and a nearly conical outflow further outward. By combining flux density ratios and velocities of the jet flows, we were unable to find a combination of intrinsic velocities and inclination angles of the jets that is consistent for all four years of observation; this contradicts findings for symmetrically evolving jets. Spectral index maps between quasi-simultaneous 22 GHz and 43 GHz observations support the existence of an optically thick absorber covering the innermost ≃1.6 mas around the 43 GHz central feature and an optically thin jet emission with a spectral index of ≤−1. Conclusions. Our results fit into a picture in which we expect larger internal energy and/or magnetic flux in the western jet and higher kinetic energy in the eastern jet. Previous observations at lower frequencies have found slower velocities of the moving jet features as compared to this work. Considering the different velocities in different areas, we suggest a spine-sheath structure with a faster inner layer and slower outer layer. [ABSTRACT FROM AUTHOR]

The energetic feedback that is generated by radio jets in active galactic nuclei (AGNs) has been suggested to be able to produce fast outflows of atomic hydrogen (H I) gas, which can be studied in absorption at high spatial resolution. We have used the Very Large Array (VLA) and a global very long baseline interferometry (VLBI) array to locate and study in detail the H I outflow discovered with the Westerbork Synthesis Radio Telescope (WSRT) in the restarted radio galaxy 3C 236. Based on the VLA data, we confirm a blueshifted wing of the H I with a width of ~1000 km s−1. This H I outflow is partially recovered by the VLBI observation. In particular, we detect four clouds with masses of 0.28 − 1.5 × 104M⊙ with VLBI that do not follow the regular rotation of most of the H I. Three of these clouds are located, in projection, against the nuclear region on scales of ≲40 pc, while the fourth is cospatial to the southeast lobe at a projected distance of ~270 pc. Their velocities are between 150 and 640 km s−1 blueshifted with respect to the velocity of the disk-related H I. These findings suggest that the outflow is at least partly formed by clouds, as predicted by some numerical simulations, and that it originates already in the inner (few tens of pc) region of the radio galaxy. Our results indicate that the entire outflow might consist of many clouds, possibly with comparable properties as those clearly detected, but distributed at larger radii from the nucleus where the lower brightness of the lobe does not allow us to detect them. However, we cannot rule out a diffuse component of the outflow. Because 3C 236 is a low-excitation radio galaxy, it is less likely that the optical AGN is able to produce strong radiative winds. This leaves the radio jet as the main driver for the H I outflow. [ABSTRACT FROM AUTHOR]

Most current cartilage testing devices require the preparation of excised samples and therefore do not allow intra-operative application for diagnostic purposes. The gold standard during open or arthroscopic surgery is still the subjective perception of manual palpation. This work presents a new diagnostic method of ultrasound palpation (USP) to acquire applied stress and strain data during manual palpation of articular cartilage. With the proposed method, we obtain cartilage thickness and stiffness. Moreover, repeated palpations allow the quantification of relaxation effects. USP measurements on elastomer phantoms demonstrated very good repeatability for both, stage-guided (97.2%) and handheld (96.0%) applications. The USP measurements were compared with conventional indentation experiments and revealed very good agreement on elastomer phantoms ( $$r = 0.98$$ ) and good agreement on porcine cartilage samples ( $$r = 0.76$$ ). Artificially degenerated cartilage samples showed reduced stiffness, weak capacity to relax after palpation and an increase of stiffness of approximately 50% with each single palpation. Intact cartilage was measured by USP directly at the patella (in situ) and after excision and removal of the subchondral bone (ex situ), leading to stiffness values of $$12.1\pm 5.5$$ and $$8.5\pm 5.9\,\hbox {MPa}$$ ( $$p<0.05$$ ), respectively. The results demonstrate the potential of the USP system for cartilage testing, its sensitivity to degenerative changes and as a method for quantifying relaxation processes by means of repeated palpations. Furthermore, the differences in the results of in-situ and ex-situ measurements are of general interest, since such comparison has not been reported previously. We point out the limited comparability of ex-situ cartilage with its in-situ biomechanical behavior. [ABSTRACT FROM AUTHOR]

A structural, mechanical and thermal characterization of an Al-Co-Fe-Cr coating alloy was performed. An atomized powder with atomic composition of Al 71 Co 13 Fe 8 Cr 8 was thermally sprayed by high velocity oxygen fuel (HVOF) on a steel substrate. X-ray diffraction, scanning and transmission electron microscopy and differential scanning calorimetry were used to characterize the atomized powder and the sprayed coating. Vickers microhardness and pin-on- plate wear test were carried out for mechanical and tribological characterization and an infrared camera was used to evaluate the insulation capacity of the coating material. The results show that both the atomized powder and the coating material were composed predominantly by a quaternary extension of the hexagonal Al 5 Co 2 phase and by the monoclinic Al 13 Co 4 . Both phases are quasicrystalline approximants of a decagonal Al-Co quasicrystal. The coating samples presented high values of micro-hardness, close to 500 HV and substantially low friction coefficient values, around 0.05. The coatings were good thermal insulators, decreasing by 30% the surface temperature of a sample exposed to a hot plate in comparison with the carbon steel substrate. [ABSTRACT FROM AUTHOR]

In the first part of this article, we extend the formal upscaling of a diffusion–precipitation model through a two-scale asymptotic expansion in a level set framework to three dimensions. We obtain upscaled partial differential equations, more precisely, a non-linear diffusion equation with effective coefficients coupled to a level set equation. As a first step, we consider a parametrization of the underlying pore geometry by a single parameter, e.g. by a generalized “radius” or the porosity. Then, the level set equation transforms to an ordinary differential equation for the parameter. For such an idealized setting, the degeneration of the diffusion tensor with respect to porosity is illustrated with numerical simulations. The second part and main objective of this article is the analytical investigation of the resulting coupled partial differential equation–ordinary differential equation model. In the case of non-degenerating coefficients, local-in-time existence of at least one strong solution is shown by applying Schauder's fixed point theorem. Additionally, non-negativity, uniqueness, and global existence or existence up to possible closure of some pores, i.e. up to the limit of degenerating coefficients, is guaranteed. [ABSTRACT FROM PUBLISHER]

Wear resistant highly amorphous Fe 60 Cr 8 Nb 8 B 24 (at.%) coatings of about 280 μm thickness were prepared through high velocity oxygen fuel (HVOF) thermal spray process onto API 5L X80 steel substrate. Feedstock powders were produced by gas atomization with low purity precursors by modifying AISI 430 stainless steel with additions of niobium (Fe-Nb) and boron (Fe-B). It was found that the coatings were mostly amorphous with some embedded FeNbB and Fe 2 B borides. The formation of a large fraction of amorphous phase was attributed to the high cooling rates of molten droplets combined with a proper powder composition. The average Vickers hardness of the coating (HV 0.3 = 838 ± 23) was about four times higher than that of the API 5L X80 substrate (HV 0.3 = 222 ± 5). The excellent wear resistance of the amorphous coating in the pin-on-disc measurements was attributed to its large fraction of amorphous phase (~ 66%) with reinforcing hard Fe 2 B and FeNbB borides, high Vickers hardness, low oxygen content (< 0.41%), and relatively low porosity (~ 5). The wear rates of the amorphous coatings were about two orders of magnitude lower than that of the API 5L X80 steel substrate (1.0 × 10 − 5 and 8.5 × 10 − 4 mm 3 ·N − 1 ·m − 1 , respectively). API 5L X80 steel exhibited dominant adhesive wear at low sliding speed and oxidative wear at high sliding speed. HVOF coatings presented oxidative wear regardless of the sliding speed. [ABSTRACT FROM AUTHOR]

Cardiac hypertrophy is a mechanism to compensate for increased cardiac work load, that is, after myocardial infarction or upon pressure overload. However, in the long run cardiac hypertrophy is a prevailing risk factor for the development of heart failure. During pathological remodelling processes leading to heart failure, decompensated hypertrophy, death of cardiomyocytes by apoptosis or necroptosis and fibrosis as well as a progressive dysfunction of cardiomyocytes are apparent. Interestingly, the induction of hypertrophy, cell death or fibrosis is mediated by similar signalling pathways. Therefore, tiny changes in the signalling cascade are able to switch physiological cardiac remodelling to the development of heart failure. In the present review, we will describe examples of these molecular switches that change compensated hypertrophy to the development of heart failure and will focus on the importance of the signalling cascades of the TGFβ superfamily in this process. In this context, potential therapeutic targets for pharmacological interventions that could attenuate the progression of heart failure will be discussed. [ABSTRACT FROM AUTHOR]

This paper is concerned with the internal exact controllability of a generalized Bresse system with variable coefficients, which the controls functions acts in an arbitrarily small subinterval (l1, l2) of (0, L). Our computation suggests a minimal time control and a regionwhere the controls are more effective. The variable coefficients can be viewed as a generalization of Laplacian operator. The main result is obtained by applying Hilbert Uniqueness Method proposed by Lions, without using the Holmgren's uniqueness theoremor the hypothesis of equal-speedwaves of propagation. [ABSTRACT FROM AUTHOR]

Context: Most deaths in the United States occur among older persons who have 1 or more disabling conditions. As a result, many deaths are preceded by an extended period during which family members provide care to their disabled relative.Objective: To better understand the effect of bereavement on family caregivers by examining predeath vs postdeath changes in self-reported and objective health outcomes among elderly persons providing varying levels of care prior to their spouse's death.Design and Setting: Prospective, population-based cohort study conducted in 4 US communities between 1993 and 1998.Participants: One hundred twenty-nine individuals aged 66 to 96 years whose spouse died during an average 4-year follow-up. Individuals were classified as noncaregivers (n = 40), caregivers who reported no strain (n = 37), or strained caregivers (n = 52).Main Outcome Measures: Changes in depression symptoms (assessed by the 10-item Center for Epidemiological Studies-Depression [CES-D] scale), antidepressant medication use, 6 health risk behaviors, and weight among the 3 groups of participants.Results: Controlling for age, sex, race, education, prevalent cardiovascular disease at baseline, and interval between predeath and postdeath assessments, CES-D scores remained high but did not change among strained caregivers (9.44 vs 9.19; P =.76), while these scores increased for both noncaregivers (4.74 vs 8.25; F(1,116) = 14.33; P<.001) and nonstrained caregivers (4.94 vs 7.13; F(1,116) = 4.35; P =.04). Noncaregivers were significantly more likely to be using nontricyclic antidepressant medications following the death than the nonstrained caregiver group (odds ratio [OR], 12.85; 95% confidence interval [CI], 1.02-162.13; P =.05). The strained caregiver group experienced significant improvement in health risk behaviors following the death of their spouse (1.47 vs 0.66 behaviors; F(1,118) = 20.23; P<.001), while the noncaregiver and nonstrained caregiver groups showed little change (0.27 vs 0.27 [P =.99] and 0.46 vs 0.27 [P =.39] behaviors, respectively). Noncaregivers experienced significant weight loss following the death (149.1 vs 145.3 lb [67.1 vs 65.4 kg]; F(1,101) = 8.12; P =.005), while the strained and nonstrained caregiving groups did not show significant weight change (156.2 vs 155.2 lb [70.3 vs 69.8 kg] [P =.41] and 156.2 vs 154.0 lb [70.3 vs 69.3 kg] [P =.12], respectively).Conclusions: These data indicate that the impact of losing one's spouse among older persons varies as a function of the caregiving experiences that precede the death. Among individuals who are already strained prior to the death of their spouse, the death itself does not increase their level of distress. Instead, they show reductions in health risk behaviors. Among noncaregivers, losing one's spouse results in increased depression and weight loss. [ABSTRACT FROM AUTHOR]

Context: There is strong consensus that caring for an elderly individual with disability is burdensome and stressful to many family members and contributes to psychiatric morbidity. Researchers have also suggested that the combination of loss, prolonged distress, the physical demands of caregiving, and biological vulnerabilities of older caregivers may compromise their physiological functioning and increase their risk for physical health problems, leading to increased mortality.Objective: To examine the relationship between caregiving demands among older spousal caregivers and 4-year all-cause mortality, controlling for sociodemographic factors, prevalent clinical disease, and subclinical disease at baseline.Design: Prospective population-based cohort study, from 1993 through 1998 with an average of 4.5 years of follow-up.Setting: Four US communities.Participants: A total of 392 caregivers and 427 noncaregivers aged 66 to 96 years who were living with their spouses.Main Outcome Measure: Four-year mortality, based on level of caregiving: (1) spouse not disabled; (2) spouse disabled and not helping; (3) spouse disabled and helping with no strain reported; or(4) spouse disabled and helping with mental or emotional strain reported.Results: After 4 years of follow-up, 103 participants (12.6%) died. After adjusting for sociodemographic factors, prevalent disease, and subclinical cardiovascular disease, participants who were providing care and experiencing caregiver strain had mortality risks that were 63% higher than noncaregiving controls (relative risk [RR], 1.63; 95% confidence interval [CI], 1.00-2.65). Participants who were providing care but not experiencing strain (RR, 1.08; 95 % CI, 0.61-1.90) and those with a disabled spouse who were not providing care (RR, 1.37; 95% CI, 0.73-2.58) did not have elevated adjusted mortality rates relative to the noncaregiving controls.Conclusions: Our study suggests that being a caregiver who is experiencing mental or emotional strain is an independent risk factor for mortality among elderly spousal caregivers. Caregivers who report strain associated with caregiving are more likely to die than noncaregiving controls. [ABSTRACT FROM AUTHOR]

Context. Comets are believed to hold a relatively pristine record of the physical and chemical processes that occurred during the formation and evolution of the solar system. Thorough investigations of these small bodies, such as the one that will be performed by the ESA/Rosetta cornerstone mission, are thus supposed to bring strong and unique constraints on the origins of the solar system. Aims. Because comet 67P/Churyumov-Gerasimenko was only recently selected as the target for the ESA/Rosetta mission, there has been little opportunity to study its pre-perihelion activity. This phase is, however, very important for the mission, since the global mapping of the nucleus and the choice of landing site for Philae will be performed during this pre-perihelion phase. Here, we report previously unpublished data of the last pre-perihelion passage of this comet, observed between May and September 2008. Methods. The gas and dust activity of comet 67P/Churyumov-Gerasimenko are studied through visible spectroscopy and broadband imaging, respectively, covering a range of pre-perihelion heliocentric distances between 2.99 and 2.22 AU. Results. The data we have gathered on the dust activity are consistent with trends observed by other authors and show a strong asymmetry between the pre- and post-perihelion phases of the orbit. The spectra do not show any lines due to the emission of volatiles, and upper limits on their production rates are typically one order of magnitude lower than at the equivalent post-perihelion heliocentric distances. The asymmetry in the pre- and post-perihelion phases of the activity may be due to a dusty crust quenching the activity at the surface of 67P. We estimate that this crust could be about 12 cm thick, although not uniform across the surface. Even if no gas is individually detected, the coma surface brightness profiles might indicate a possible contamination from gaseous species emitted before the comet actually reaches perihelion. [ABSTRACT FROM AUTHOR]

In Germany, many hydro-geothermal plants have been constructed in recent years, primarily in the region of Munich. As the host formation here mainly consists of carbonates, nearly all recently drilled wells have been acidized in order to improve the well yield. In this study, the effectiveness of these acid treatments is analyzed with respect to the amount of acid used and the number of acid treatments carried out per well. The results show that the first acid treatment has the largest effect, while subsequent acidizing improves the well only marginally. Data also indicate that continued acidizing can lead to degradation of the well. These findings may not only be important for geothermal installations in Germany but also for projects, for example, in Austria, France or China where geothermal energy is produced from carbonate formations as well. [ABSTRACT FROM AUTHOR]

Abstract: On the journey to its target comet 67P/Churyumov-Gerasimenko the ESA Rosetta spacecraft had a close fly-by at the main-belt asteroid (21) Lutetia at a heliocentric distance of r=2.72AU, and a geocentric distance of Δ=3.05AU. Closest approach occurred on 10 July 2010, 15:45UT at a distance of ∼3170km. Rosetta passed the asteroid with a relative fly-by velocity of 15km/s. The fly-by strategy allowed continuous observations of (21) Lutetia before, during and for 30min after closest approach, and the spacecraft to go through zero phase angle 18min before closest approach at a distance of 16400km from the asteroid. Most of the scientific instruments on board Rosetta were switched on obtaining imaging and spectral observations covering wavelengths from the UV to sub-mm, as well as in-situ measurements of the asteroid and its direct environment. A brief summary of the fly-by is provided concentrating mainly on an overview of the instrument operations, the visual appearance of the asteroid during the encounter, and a synopsis of the fly-by results published in this special issue. [Copyright &y& Elsevier]

The unique properties of oligonucleotide (and small interfering RNA)-modified gold nanoparticle conjugates make them promising intracellular gene regulation agents. We found that gold nanoparticles stably functionalized with covalently attached oligonucleotides activate immune-related genes and pathways in human peripheral blood mononuclear cells, but not an immortalized, lineage-restricted cell line. These findings have strong implications for the application of oligonucleotide-modified gold nanoparticle conjugates in translational research and in the development of therapeutics and gene delivery systems. [ABSTRACT FROM AUTHOR]

Potential advantages are given for high-temperature cleaning by filtration. Prospective filter constructions and types of filter materials are determined. In addition, problems restricting the use of high-temperature filtration are noted. [ABSTRACT FROM AUTHOR]

STUDY DESIGN.: Anatomic study. OBJECTIVE.: To measure C1 and C2 critical areas related to the screws trajectory, according to Harms technique, in Latin specimens. To investigate vertebral's artery course in cadavers. SUMMARY OF BACKGROUND DATA.: To our knowledge there are no studies addressing vertebral surface measurements for screw placement, according to Harms C1-C2 instrumentation technique, nor cadaveric measurements of the trajectory of the vertebral artery in Latin specimens. METHODS.: C1 and C2 specimens were measured. C1 measurements: height, width, anteroposterior diameter (intraosseus screw length) and convergence in the axial plane of the lateral mass; length from the posterior border of the posterior C1 arch to the anterior cortex of the articular mass (total screw length). C2 measurements: width, height, convergence and sagittal inclination of the pars interarticularis. Direction of the trajectory of the vertebral artery in the suboccipital region in fresh cadavers. RESULTS.: C1: left mass width 14.20 mm, right: 14.32 mm; left intraosseus screw length: 17.17 mm, right 16.9 mm; left total length of the screw: 27.14 mm, right: 26.72 mm; left mass height: 10.22 mm, right: 10.29 mm. Right mass convergence: 24.68°, left: 22.44°. C2: width: left 8.75 mm, right: 8.53 mm; height: left 10 mm, right 9.81 mm; convergence: left 42.15°, right: 38.98°; sagittal inclination: left 35.50°, right 33.07°. Vertebral artery's medial border is between 13 and 22 mm from the middle line of C1 posterior arch. CONCLUSION.: Convergence and inclination of the pars are slightly greater than the suggested by Harms. Individual and/or racial variations must be considered. There is enough space for safe placement of a 3.5 mm screw in the lateral masses of C1 and through the pars of C2. Dissecting the superior face of the posterior arch of C1 laterally more than 10 mm from the posterior tubercule could injure the vertebral artery. [ABSTRACT FROM AUTHOR]

Starting in the late 1980-s and continuing on through the mid- 1990's a series of research projects were carried out on a variety of waste remediation applications through collaborative efforts between Westinghouse Savannah River (now SRNL) and the University of Florida. All of these remediation methods made use of microwave hybrid heating in one form or another. The areas investigated included vitrification of simulated nuclear waste, destruction of electronic circuitry, transuranic wastes (TRU), tire waste, medical waste, fly ash, and gaseous aromatic hydrocarbons such as benzene, toluene and styrene. A brief overview of these projects is provided. Hybrid or microwave-assisted heating continues to be an important processing method and its application in the commercial sector and new research areas are briefly summarized as well. [ABSTRACT FROM AUTHOR]

OBJECTIVES: To identify key features of interventions that need to be considered in the design, execution, and reporting of interventions. METHODS: Based on prior work on decomposing psychosocial and clinical interventions, current guidelines for describing interventions, and a review of a broad range of intervention studies, we developed a comprehensive intervention taxonomy. RESULTS: Specific recommendations, rationales, and definitions of intervention delivery and content characteristics including mode, materials, location, schedule, scripting, and sensitivity to participant characteristics, interventionist characteristics, adaptability, implementation, content strategies, and mechanisms of action are provided. CONCLUSIONS: Applying this taxonomy will advance intervention science by (a) improving intervention designs, (b) enhancing replication and follow-up of intervention studies, (c) facilitating systematic exploration of the efficacy and effectiveness of intervention components through cross-study analysis, and (d) informing decisions about the feasibility of implementation in broader community settings. [ABSTRACT FROM AUTHOR]

A laboratory study of older adults with osteoarthritis and their spouses was conducted to examine the unique influence of exposure to suffering on caregivers' risk for impaired psychological and physical health. Spouses' blood pressure (BP) and heart rate (HR) were monitored during 2 tasks designed to capture their partners' suffering. First, spouses watched their partners (and a stranger) carry heavy logs across an 8-ft space for 3 min, a task that elicited pain expression. Second, spouses spoke about their partners' suffering (and also about a typical meal with their partners). Results showed that spouses' BP and HR increased when watching and talking about their partners' suffering, and exposure to a partner's suffering was more physiologically stressful than to a stranger's suffering. These findings suggest that heightened physiological stress caused by exposure to a loved one's suffering may be one pathway to caregivers' increased risk for cardiovascular disease. [ABSTRACT FROM AUTHOR]

Background: The outcomes of informal caregivers of survivors of critical illness likely depend on patient characteristics, which may change over time. To date, few studies have examined patient-specific predictors of post-ICU informal caregiver burden, and none has tested whether predictors vary after hospital discharge.Methods: We designed a prospective, longitudinal observational study, enrolling 48 patient-caregiver dyads from four ICUs in a university hospital. Informal caregiver depression symptoms were measured with the Center for Epidemiologic Studies Depression scale. Lifestyle disruption was measured with the Activity Restriction Scale. Linear regression models were built to test for patient- and caregiver-specific predictors of depression symptoms and lifestyle disruption 2, 6, and 12 months after ICU admission.Results: Patients had a mean (SD) age of 52.5 (19.7) years, 67% were men, median (interquartile range) Acute Physiology and Chronic Health Evaluation score was 52 (38.5, 65). The caregivers had a mean (SD) age of 52.8 (12.8) years, 91.2% were women, and 48% were spouses. Predictors of caregiver depression symptoms were patient gender (men) at 2 and 12 months and tracheostomy at 12 months. Predictors of lifestyle disruption were patient education (more common among high school graduates) and patient gender (men) at 2 months, and tracheostomy, functional dependency, and patient gender (men) at 12 months.Conclusions: The determinants of post-ICU informal caregiver burden likely depend on characteristics of the patient as well as the caregiver and may vary over time. Further research is necessary to better understand the longitudinal determinants of burden in order to develop more effective caregiver interventions. [ABSTRACT FROM AUTHOR]

Abstract: Hand radiographs from 554 male and 288 female subjects aged 10–30 years, which had been taken due to traumatological indications, were evaluated. A classification into five ossification stages was applied to assess the epiphyseal development of distal radius and distal ulna (1: epiphysis not ossified; 2: epiphysis ossified, nonunion of the epiphysis and metaphysis; 3: partial union of the epiphysis and metaphysis; 4: complete union of the epiphysis and metaphysis, epiphyseal scar visible; 5: complete union of the epiphysis and metaphysis, epiphyseal scar nondiscernable). It was established that male subjects with an ossification stage 4 of the radius or ulna and female subjects with an ossification stage 5 of the radius were at least 14 years old. The occurrence of ossification stage 5 of the radius proves that a male individual has reached the age of 18 years. [Copyright &y& Elsevier]

Abstract: This paper reports the discovery of a new family of electrocatalytic materials which can be used as efficient cathode for the production of sodium chlorate. The material consists of an iron aluminide (Fe3Al) alloy doped with a catalytic element such as ruthenium. High energy ball milling is used to prepare these new metastable nanocrystalline alloys and their cathodic overvoltages for the hydrogen evolution reaction in a chlorate electrolyte are about 400mV lower than that of iron cathodes. Contrary to the previously reported Ti2RuFe catalytic material, these new electrocatalysts do not absorb hydrogen and therefore, are more stable during the hydrogen evolution reaction. [Copyright &y& Elsevier]

One of the two planetary cornerstone missions of the European Space Agency is the Rosetta mission to comet 67P/Churyumov-Gerasimenko. Rosetta is a rendezvous mission with a comet nucleus, which combines an Orbiter with a Lander. It will monitor the evolution of the comet nucleus and the coma as a function of increasing and decreasing solar flux input along the comet’s pre- and post-perihelion orbit. Different instrumentations will be used in parallel, from multi-wavelength spectrometry to in-situ measurements of coma and nucleus composition and physical properties. Rosetta will go in orbit around the nucleus of its target comet 67P/Churyumov-Gerasimenko, when it is still far from the Sun and accompany the comet along its way to perihelion and beyond. In addition the Rosetta Lander Philae will land on the nucleus surface, before the comet is too active to permit such a landing (i.e. at around r = 3 AU) and examine the surface and subsurface composition of the comet nucleus as well as its physical properties. [ABSTRACT FROM AUTHOR]

In patients with Crohn's disease and ulcerative colitis parenteral nutrition (PN) is indicated when enteral nutrition is not poßible or should be avoided for medical reasons. In Crohn's patients PN is indicated when there are signs/symptoms of ileus or subileus in the small intestine, scars or intestinal fistulae. PN requires no specific compounding for chronic inflammatory bowel diseases. In both diseases it should be composed of 55-60% carbohydrates, 25-30% lipids and 10-15% amino acids. PN helps in the correction of malnutrition, particularly the intake of energy, minerals, trace elements, deficiency of calcium, vitamin D, folic acid, vitamin B12, and zinc. Enteral nutrition is clearly superior to PN in severe, acute pancreatitis. An intolerance to enteral nutrition results in an indication for total PN in complications such as pseudocysts, intestinal and pancreatic fistulae, and pancreatic absceßes or pancreatic ascites. If enteral nutrition is not poßible, PN is recommended, at the earliest, 5 days after admißion to the hospital. TPN should not be routinely administered in mild acute pancreatitis or nil by moth status <7 days, due to high costs and an increased risk of infection. The energy requirements are between 25 and 35 kcal/kg body weight/day. A standard solution including lipids (monitoring triglyceride levels!) can be administered in acute pancreatitis. Glucose (max. 4-5 g/kg body weight/day) and amino acids (about 1.2-1.5 g/kg body weight/day) should be administered and the additional enrichment of TPN with glutamine should be considered in severe, progreßive forms of pancreatitis. [ABSTRACT FROM AUTHOR]

Abstract: Over the past 10 years the isotopic ratios of carbon (12C/13C) and nitrogen (14N/15N) have been determined for a dozen comets, bright enough to allow obtaining the required measurements from the ground. The ratios were derived from high-resolution spectra of the CN coma measured in the B2∑+−X2∑+ (0, 0) emission band around 387nm. The observed comets belong to different dynamical classes, including dynamically new as well as long- and short-period comets from the Halley- and Jupiter-family. In some cases the comets could be observed at various heliocentric distances. All values determined for the carbon and nitrogen isotopic ratios were consistent within the error margin irrespective of the type of comet or the heliocentric distance at which it was observed. Our investigations resulted in average ratios of 12C/13C=91±21 and nitrogen 14N/15N=141±29. Whilst the value for the carbon isotopic ratio is in good agreement with the solar and terrestrial value of 89, the nitrogen isotopic ratio is very different from the telluric value of 272. [Copyright &y& Elsevier]

Adverse--and even positive--outcomes in a chronic stress experience. [ABSTRACT FROM AUTHOR]

This article presents some recent imaging and spectroscopic observations that led to results which are significant for understanding the properties of comet nuclei. The coma morphology and/or composition were investigated for 12 comets belonging to different dynamical classes. The data analysis showed that the coma morphology of three non-periodic comets is not consistent with the general assumption that dynamically new comets still have a relatively uniform nucleus surface and therefore do not exhibit gas and/or dust jets in their coma. The determination of carbon and nitrogen isotopic ratios revealed the same values for all comets investigated at various heliocentric distances. However, the relative abundance of the rare nitrogen isotope 15N is about twice as high as in the Earth’s atmosphere. Observations of comets at splitting events and during outbursts led to indications for differences between material from the nucleus surface and the interior. The monitoring of the induced outburst of 9P/Temple revealed that under non-steady state conditions the fast disintegration of species is detectable. [ABSTRACT FROM AUTHOR]

Connexin (Cx) 43 is the predominant protein forming gap junctions and non-junctional hemichannels in ventricular myocardium. The Cx43 proteins are central to the cardioprotection afforded by ischaemic preconditioning (IP). The specific role of mitochondrial Cx43 in protection by IP is reviewed. [ABSTRACT FROM AUTHOR]

The design and performance of a four-axis low-profile eucentric UHV goniometer for in situ reflection high-energy electron diffraction (RHEED) studies during film deposition is reported. The design provides one translational and three rotational degrees of freedom that are fully independent. Although developed to facilitate high-pressure RHEED during the growth of oxide thin films by pulsed laser deposition, this goniometer design is applicable to other UHV techniques including molecular beam epitaxy. The goniometer requires only a single DN 100 CF flange (6 in. o.d., 100 mm i.d.), making it suitable for small deposition systems, too. Samples, attached to a resistively heated holder, can be easily transferred on and off of the goniometer without breaking vacuum. The holder accommodates samples up to 10 mm×10 mm in size and allows them to be heated to 900 °C in pure oxygen while being attached to the goniometer. Full eucentric motion of the hot sample is possible with a typical axis precision of <0.1°. Most of the mechanism is located in air, allowing the use of standard materials and lubricants, substantially reducing the in-vacuum mechanics, and increasing the precision, reliability, and robustness of the system. [ABSTRACT FROM AUTHOR]

Abstract: Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) generation. To date, 3 distinct NOS isoforms have been identified: neuronal NOS (NOS1), inducible NOS (NOS2), and endothelial NOS (NOS3). Biochemically, NOS consists of a flavin-containing reductase domain, a heme-containing oxygenase domain, and regulatory sites. NOS catalyse an overall 5-electron oxidation of one Nω-atom of the guanidino group of l-arginine to form NO and l-citrulline. NO exerts a plethora of biological effects in the cardiovascular system. The basal formation of NO in mitochondria by a mitochondrial NOS seems to be one of the main regulators of cellular respiration, mitochondrial transmembrane potential, and transmembrane proton gradient. This review focuses on recent advances in the understanding of the role of enzyme and enzyme-independent NO formation, regulation of NO bioactivity, new aspects of NO on cardiac function and morphology, and the clinical impact and perspectives of these recent advances in our knowledge on NO-related pathways. [Copyright &y& Elsevier]

In the failing heart, the local angiotensin II concentration is increased, and the extent of cardiac angiotensin II release is related to the clinical signs of heart failure. The enzymes involved in myocardial generation of angiotensin II are the angiotensin-converting enzyme (ACE) and chymases. While myocardial angiotensin II is mainly generated by chymases in the human heart, ACE inhibitors nevertheless improve left ventricular (LV) function, attenuate LV remodelling and reduce mortality in heart failure patients. These beneficial actions of ACE inhibitors, however, relate to their beneficial effect on kinin metabolism. Angiotensin II type 1 receptor (AT1) antagonists also mediate part of their beneficial effects through increased bradykinin formation. However, in contrast to ACE inhibitors, AT1 receptor antagonists attenuate downstream signalling of angiotensin II-induced AT1 receptor activation, which increases the activity of existing proteins (e.g. NADPH oxidase) and the de novo synthesis of proteins (e.g. inducible nitric oxide synthase, tumor necrosis factor-α ) in cardiomyocytes. Given the multiple actions of AT1 receptor activation on cardiomyocyte and non-cardiomyocyte function in the presence of an increased myocardial AngII concentration, the reduction of cardiovascular mortality and rate of hospitalization following AT1 receptor blockade in heart failure patients not receiving ACE inhibitors is not surprising. Most importantly, the beneficial effects of AT1 receptor blockade are not only achieved when used as an alternative to ACE inhibition, but also when used on top of ACE inhibitors. Copyright © 2005 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

A field experiment was carried out to determine the effect of different land use systems such as continuous grass and agricultural crops rotation on the bioavailability of heavy metals in soils contaminated by former excessive sewage sludge application. The results show that Cd and Zn concentrations increased to 2 and 3.5 folds within 3 cuts of grass, respectively. Even 10 years after the end of excessive sewage sludge application the concentration of Cd in winter and summer wheat is 3.4 and 2.5 folds higher than the control, respectively. Zn concentration increased by two folds for both crops. In conclusion, the uptake depends on plant species and the degree of soil contamination. The availability of heavy metals was not changed with time. [ABSTRACT FROM AUTHOR]

Okujava M, Schulz R, Hoppe M, Ebner A, Jokeit H, Woermann FG. Bilateral mesial temporal lobe epilepsy: comparison of scalp EEG and hippocampal MRI-T2 relaxometry. Acta Neurol Scand 2004 DOI: 10.1111/j.1600-0404.2004.00305.x © Blackwell Munksgaard 2004. Bilateral hippocampal abnormality is frequent in mesial temporal lobe sclerosis and might affect outcome in epilepsy surgery. The objective of this study was to compare the lateralization of interictal and ictal scalp EEG with MRI T2 relaxometry. Forty-nine consecutive patients with intractable mesial temporal lobe epilepsy (MTLE) were studied with scalp EEG/video monitoring and MRI T2 relaxometry. Bilateral prolongation of hippocampal T2 time was significantly associated with following bitemporal scalp EEG changes: (i) in ictal EEG left and right temporal EEG seizure onsets in different seizures, or, after regionalized EEG onset, evolution of an independent ictal EEG over the contralateral temporal lobe (left and right temporal asynchronous frequencies or lateralization switch; P = 0.002); (ii) in interictal EEG both left and right temporal interictal slowing ( P = 0.007). Bitemporal T2 changes were not, however, associated with bitemporal interictal epileptiform discharges (IED). Lateralization of bilateral asymmetric or unilateral abnormal T2 findings were associated with initial regionalization of the ictal EEG in all but one patient ( P < 0.005), with lateralization of IED in all patients ( P < 0.005), and with scalp EEG slowing in 28 (82,4%) of 34 patients ( P = 0.007). Our data suggest that EEG seizure propagation is more closely related to hippocampal T2 abnormalities than IED. Interictal and ictal scalp EEG, including the recognition of ictal propagation patterns, and MRI T2 relaxometry can help to identify patients with bitemporal damage in MTLE. Further studies are needed to estimate the impact of bilateral EEG and MRI abnormal findings on the surgical outcome. [ABSTRACT FROM AUTHOR]

In this paper, we present the hydrogen storage properties of Mg-Cd alloys prepared by ball milling. Mechanical alloying of a mixture of Mg and Cd elemental powders containing up to 20 at.%Cd leads to a magnesium solid solution. The lattice spacings of the hcp Mg phase shrink with dissolution of cadmium atoms in Mg. The mechanically alloyed pure Mg-Cd alloys are very difficult to activate for hydrogen absorption. However, if vanadium and graphite additives are added, a Mg(Cd)-V-C nanocomposite forms after ball milling and the activation then becomes very easy. The hydrogen absorption/desorption kinetics are very fast. The plateau pressure and slope of hydrogen absorption/desorption increase, while the hydrogen storage capacity decreases with increasing cadmium content. [ABSTRACT FROM AUTHOR]

Bull spermatozoa were examined for the presence and localization of constitutive Nitric Oxide Synthase (NOS), as nitric oxide (NO) is involved in calcium-dependent capacitation. In bull spermatozoa, NO generation is enhanced by l-arginine (3 μ m) and abolished by the NOS-inhibitor N-nitro- l-arginine methyl ester ( l-NAME). In addition, presence of NOS in bull spermatozoa was verified by immunohistochemistry, revealing the existence of both neuronal NOS (nNOS) and endothelial NOS (eNOS) immunoreaction. These findings were confirmed by Western blot technique, showing immunoreactive bands at 161 kDa (nNOS) and 133 kDa (eNOS). Confocal laser microscopy localized nNOS related immunofluorescence at the acrosome cap of sperms and their flagellum-mainpart. This technique also identified eNOS staining spread over the spermatozoan head. In conclusion, immunohistochemistry, Western blot technique, and NO generation suggest the presence of n- and eNOS in bull spermatozoa. [ABSTRACT FROM AUTHOR]

Purpose: To investigate the factors which influence the persistence of interictal epileptiform discharges (IED) after epilepsy surgery. Methods: In this retrospective study we included patients with intractable medial temporal lobe epilepsy (MTLE) who underwent presurgical evaluation including high-resolution MRI and video-EEG monitoring with seizure registration prior to an anterior temporal lobe resection. The postsurgical outcome was assessed by our team 6 months and 2 years after the surgery. Results: One hundred and forty-seven patients fulfilled the inclusion criteria. The mean age of the patients was 31.8 (range 16–59 years). In 22 patients (15%) interictal epileptiform discharges were present on the postoperative routine EEG. We found that both the preoperative spike frequency (P<0.001) and postoperative seizures (P=0.04) were independently associated with the presence of IED on the postoperative routine EEG. The preoperative spike frequency was not associated with the postoperative outcome. The extent of resection showed no influence on the presence of postoperative IED. Conclusion: We hypothesize that two factors independently influence the presence of postoperative spikes: chronic interictal disturbance (represented as preoperative spike frequency) and the acute (postoperative) seizures. Our study confirmed that persistent postoperative IED had a prognostic value regarding the outcome of the epilepsy surgery. [Copyright &y& Elsevier]

Background: Although family caregiving has been intensively studied in the past decade, little attention has been paid to the impact of end-of-life care on caregivers who are family members of persons with dementia or to the caregivers' responses to the death of the patient.Methods: Using standardized assessment instruments and structured questions, we assessed the type and intensity of care provided by 217 family caregivers to persons with dementia during the year before the patient's death and assessed the caregivers' responses to the death.Results: Half the caregivers reported spending at least 46 hours per week assisting patients with activities of daily living and instrumental activities of daily living. More than half the caregivers reported that they felt they were "on duty" 24 hours a day, that the patient had frequent pain, and that they had had to end or reduce employment owing to the demands of caregiving. Caregivers exhibited high levels of depressive symptoms while providing care to the relative with dementia, but they showed remarkable resilience after the death. Within three months of the death, caregivers had clinically significant declines in the level of depressive symptoms, and within one year the levels of symptoms were substantially lower than levels reported while they were acting as caregivers. Seventy-two percent of caregivers reported that the death was a relief to them, and more than 90 percent reported belief that it was a relief to the patient.Conclusions: End-of-life care for patients with dementia was extremely demanding of family caregivers. Intervention and support services were needed most before the patient's death. When death was preceded by a protracted and stressful period of caregiving, caregivers reported considerable relief at the death itself. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the morbidity from chronic pelvic pain after pelvic inflammatory disease (PID).Methods: A total of 547 women were studied as part of the PID Evaluation and Clinical Health (PEACH) Study. Chronic pelvic pain was defined as pelvic pain reported at two or more consecutive interviews conducted every 3 to 4 months through 32 months and was graded as mild to moderate (low pain intensity) or moderate to severe (high pain intensity). Mean Medical Outcomes Study Short Form (SF-36) scores at 32 months were compared by chronic pelvic pain categories.Results: The mean (+/- standard deviation) physical health composite scores and mental health composite scores from the SF-36 were progressively lower among women with increasing grade of chronic pelvic pain (physical health composite scores: no chronic pelvic pain = 87.3 +/- 10.7, mild to moderate chronic pelvic pain = 79.1 +/- 14.6, moderate to severe chronic pelvic pain = 73.6 +/- 16.0, P < .01; mental health composite scores: no chronic pelvic pain = 78.7 +/- 13.6, mild to moderate chronic pelvic pain = 69.1 +/- 15.8, moderate to severe chronic pelvic pain = 67.5 +/- 17.1, P < or = .01). Individual physical function, bodily pain, general health, vitality, social function, and mental health scores were also significantly lower among women with chronic pelvic pain and by increasing grade of pain intensity.Conclusion: Chronic pelvic pain after PID is associated with reduced physical and mental health. [ABSTRACT FROM AUTHOR]

Binary Ca–Ni and ternary Ca–Mg–Ni alloys have been synthesized by mechanical alloying. The phase structures and hydrogen storage properties of the as-milled nanocrystalline and the thermally annealed alloys have been investigated. The phase structure changes with the (Ca+Mg)/Ni and the Mg/Ca ratios in the Ca–Mg–Ni ternary system. A too high Mg/Ca ratio leads to the formation of a MgNi2 phase. The plateau pressure increases with Mg content in the CaxMg1−xNi2 and CaxMg1−xNi3 pseudo-binary alloys, however, the hydrogen storage capacity decreases. Mg does not substitute Ca in the CaNi5 and Ca2Ni7 compounds. Adding or substituting a small amount of Mg in these compounds destroys the A2B7 as well as the AB5 structures and results in an AB3 phase and an accompanying nickel phase. [Copyright &y& Elsevier]

Purpose: Temporal lobe epilepsy (TLE) is frequently associated with hippocampal sclerosis (HS) and complex febrile convulsions (CFC). The causal relationship between TLE, HS, and CFC is unclear. There is also contradictory data whether CFC-associated TLE is a distinct epilepsy syndrome and has different surgical outcome than other medial TLEs.Methods: We investigated 133 patients (aged 16–59 years) with HS-associated TLE. Thirty-six patients with CFC (CFC group) versus 97 patients without febrile convulsions (NFC group) were compared for clinical history, video-EEG recorded seizure semiology, and surgical outcome.Results: In the CFC group the right-sided HS (67% versus 32%) occurred more frequently than in the NFC group (P<0.001). The two groups did not differ according to the clinical features, both groups share the typical symptoms and findings of the medial TLE. In the CFC group, seizure-freedom 2 years after surgery was 91%, while in the NFC group it was only 64% (P=0.023). This difference was significant even after considering the other known predictive factors for medial TLE.Conclusions: Medial TLE with CFC is not a distinct epilepsy syndrome. The surgical outcome, however, is much more favorable in these patients in comparison with medial TLE patients who had no history of febrile convulsions. [Copyright &y& Elsevier]

Constructed wetlands have been proposed as a potential best management practice (BMP) to mitigate effects of pesticide-associated agricultural runoff. Wetland mesocosms (14 m×59–73 m) were amended with chlorpyrifos to simulate a storm runoff event at concentrations of 73, 147 and 733 μg/l. Water, sediment and plant samples collected weekly for 12 weeks indicated that chlorpyrifos rapidly sorbed to sediment and plant material, with approximately 47–65% of measured chlorpyrifos mass retained within the first 30–36 m of wetland mesocosms. Of the measured mass, approximately 55% and 25% were retained by sediments and plants, respectively. A field-scale evaluation of a constructed wetland''s mitigation capability was performed in the Lourens River watershed of Cape Town, South Africa. Results indicate that the wetland was able to retain and considerably decrease the concentration (and hence toxicity) of chlorpyrifos and suspended sediment entering the receiving waterbody (Lourens River). This research provides fundamental answers concerning constructed wetland capabilities that are necessary for constructing field-scale systems within agricultural watersheds. [Copyright &y& Elsevier]

Objective: To determine the applicability of a fast spin-echo (FSE) pulse sequence for T2 relaxation time measurements in diagnostic imaging of temporal lobe epilepsy (TLE) and in epilepsy research. To compare FSE T2-relaxometry to the measurements with multi-echo sequence and visual assessment of MR scans. Methods: MR imaging and T2 relaxometry was performed with widely used 1.5 T scanner only. Fast dual-echo sequence (TE-14/85 ms) and multi-echo pulse sequence were used for T2 measurements. Normal ranges of T2 values in regions of interest in temporal lobe were estimated in 20 healthy controls. Sixty-five patients with intractable focal epilepsy were studied. Fifty-five patients had TLE, three multilobar focal epilepsy and seven extratemporal focal epilepsy. Results: T2 measurements with the FSE showed good reproducibility in the test objects and control subjects. In one TLE case unilateral focal T2 changes were not identified visually. T2-relaxometry was more sensitive than visual inspection of MR scans in assessing bilateral hippocampal changes: there were 15 cases with abnormal bilateral T2 values. Visually bilateral changes were detected in six out of these 15 cases (40%). In six cases (40%) only unilateral changes were diagnosed visually, and in three cases (20%) bilateral changes were classified as probable with qualitative evaluation. T2 relaxation time measurement supplied additional objective data in cases with ambiguous hippocampal changes on visual assessment: T2-relaxometry confirmed hippocampal abnormalities in seven cases judged visually as probable. In four cases with the suspicion of hippocampal changes T2 values appeared to be normal. Conclusion: In TLE patients, images constructed from FSE sequences can be used to estimate T2 relaxation times easily and reliably. T2 measurements are an objective method to diagnose structural changes in the temporal lobe. T2-relaxometry is most helpful to assess bilateral hippocampal abnormalities, and thus might have an impact on estimating postsurgical outcome. [Copyright &y& Elsevier]