Search

We recently presented a quantitative model to explain the particle-size dependence of photoluminescence (PL) quantum yields and revealed that exciton quenching is not diffusion controlled, but limited by surface reactions. However, the exciton decay kinetics has not been analyzed yet using our theoretical model. Here, we study kinetic aspects of the model and show that it should be extended to take into account subdiffusion rather than normal diffusion to maintain consistency with the observed complex decay kinetics; we also show that the PL decay kinetics is nonexponential even when the PL quenching is limited by surface reactions under subdiffusion. Our theoretical analysis of the PL quantum yield and the PL decay kinetics provides a comprehensive picture of mobile charge carriers, immobile polarons, and self-trapped excitons. [ABSTRACT FROM AUTHOR]

The authors implanted P atoms at 50 and 140-keV energies with respective fluences of 1 × 10 14 and 2 × 10 14 /cm 2 into diamond thin films synthesized by chemical vapor deposition on the type-Ib diamond substrate formed by high-pressure and high-temperature conditions. The occupational sites of implanted P atoms were determined in each processing stage of P implantation, ion-beam-induced epitaxial crystallization (IBIEC) annealing by 3-MeV-Ne 2 + ion irradiation at 750 ° C, and thermal annealing at 850 ° C in vacuum, by quantitatively comparing the random and channeling yields in Rutherford backscattering (RBS) measurements. In the analysis of RBS spectra, simulated distributions were fitted to the experimentally obtained spectra and we quantitatively identified the occupational sites and ratio of implanted P atoms. In addition, we investigated the diffusion phenomenon of implanted P atoms during annealing processes from the depth profile of scattered He ions. Consequently, the averaged occupational ratio in the substitutional lattice site was stably recorded around 50%. From the depth profile in the RBS spectra, thermal diffusion of implanted P atoms was clearly observed during the last thermal annealing after MeV-IBIEC annealing. We finally discuss the potentials of the MeV-IBIEC irradiation at relatively low temperatures applying to useful and credible annealing methods for electrical activation as well as recovery of damaged crystallinity. [ABSTRACT FROM AUTHOR]

We studied the photoluminescence decay kinetics of three nanosized anatase TiO2 photocatalysts (particle diameter: 7, 25, or 200 nm) at the pico- and nanosecond timescales for elucidating the origin of the luminescence. Luminescence spectra from these photocatalysts obtained under steady-state excitation conditions comprised green luminescence that decayed on the picosecond timescale and red luminescence that persisted at the nanosecond timescale. Among the photocatalysts with different sizes, there were marked differences in the rate of luminescence decay at the picosecond timescale (<600 ps), although the spectral shapes were comparable. The similarity in the spectral shape indicated that self-trapped excitons (STEs) directly populated in the bulk of the particle by light excitation emit the luminescence in a picosecond timescale, and the difference in the rate of luminescence decay originated from the quenching at the particle surface. Furthermore, we theoretically considered excitation light intensity dependence on the quantum yield of the luminescence and found that the quenching reaction was not limited by the diffusion of the STEs but by the reaction at the particle surface. Both the spectral shape and time-evolution of the red luminescence from the deep trapped excitons in the nanosecond timescale varied among the photocatalysts, suggesting that the trap sites in different photocatalysts have different characteristics with respect to luminescence. Therefore, the relation between trap states and photocatalytic activity will be elucidated from the red luminescence study. [ABSTRACT FROM AUTHOR]

Background: The aim of this study was to investigate the factors affecting patient-reported outcomes after bicruciate-stabilized total knee arthroplasty (BCS TKA) in patients. Methods: We retrospectively examined 122 knees with primary varus knee osteoarthritis that underwent BCS TKA. This study analyzed preoperative, intraoperative, and postoperative predictors of patient satisfaction and persistent postsurgical pain following BCS TKA at 1 year after surgery. We evaluated persistent postsurgical pain using Knee Injury and Osteoarthritis Outcome Score (KOOS) pain subscale and patient satisfaction using a visual analog scale. Results: The univariate analysis showed a significant negative correlation between the KOOS pain subscale and three factors: the preoperative central sensitization inventory (CSI) score, medial joint laxity at 90° flexion, and acute postsurgical pain. Patient satisfaction was significantly positively correlated with lateral joint laxity at 90° flexion and postoperative extension angle. Acute postsurgical pain had a significant negative correlation with patient satisfaction. The multiple regression analysis revealed preoperative CSI score and medial joint laxity at 90° flexion influenced patients' KOOS pain subscale responses. Only lateral joint laxity at 90° flexion had an impact on patient satisfaction. Conclusions: The acquisition of adequate soft tissue balance according to the concept of BCS TKA and preoperative central sensitization syndrome affects the clinical outcomes in BCS TKA. [ABSTRACT FROM AUTHOR]

Unsaturated lipids with C=C groups in their alkyl chains are widely present in the cell membrane and food. The C=C groups alter the lipid packing density, membrane stability, and persistence against lipid oxidation. Yet, molecular-level insights into the structure of the unsaturated lipids remain scarce. Here, we probe the molecular structure and organization of monolayers of unsaturated lipids on the water surface using heterodyne-detected sum-frequency generation (HD-SFG) spectroscopy. We vary the location of the C=C in the alkyl chain and find that at high lipid density, the location of the C=C group affects neither the interfacial water organization nor the tail of the alkyl chain. Based on this observation, we use the C=C stretch HD-SFG response to depth-profile the alkyl chain conformation of the unsaturated lipid. We find that the first 1/3 of carbon atoms from the headgroup are relatively rigid, oriented perpendicular to the surface. In contrast, the remaining carbon atoms can be approximated as free rotators, introducing the disordering of the alkyl chains. [ABSTRACT FROM AUTHOR]

Aim Background Methods Results Discussion/conclusions Implications for nursing policy This study establishes the mediating roles of job satisfaction and organizational identification on the relationship between nurses’ workload and their intention to leave.The shortage of nurses is a prevalent global concern. International studies have shown that many variables are associated with nurses’ intention to leave. There is a shortage of literature on some of these variables, which this study is designed to address.This study employs a descriptive, exploratory, and correlational design. It was conducted with 373 nurses from seven different hospitals in Turkey. The Workload Scale, the Minnesota Work Satisfaction Scale, the Organizational Identification Scale, and the Intention to Leave Scale were applied in the study.The structural equation model shows that the workload of nurses has a negative effect on work satisfaction (β = −0.74; p < 0.001) and organizational identification (β = −0.24; p < 0.001) and a positive impact on intention to leave (β = 0.30; p < 0.001). In addition, work satisfaction (β = −0.32; p < 0.001) and organizational identification (β = −0.24; p < 0.001 were found to affect the intention to leave negatively intention to leave. After the bootstrapping process, the indirect effect was found to be significant.The research findings indicate that work satisfaction and organizational identification mediate the correlation between nurses’ workload and their intention to leave. The findings highlight the need for precautions by revealing the risks of nursing shortages anticipated both today and in the future.In the global nursing crisis, healthcare managers and policymakers must develop strategies to protect the nursing workforce. Policymakers should make sustainable decisions by conducting national self‐assessments on the impact of workload, job satisfaction, and organizational identification on intention to leave to retain nurses. [ABSTRACT FROM AUTHOR]

The pulmonary vein wall contains a myocardial layer whose ectopic automaticity is the major cause of atrial fibrillation. This review summarizes the results obtained in isolated pulmonary vein myocardium from small experimental animals, focusing on the studies with the guinea pig. The diversity in the action potential waveform reflects the difference in the repolarizing potassium channel currents involved. The diastolic depolarization, the trigger of automatic action potentials, is caused by multiple membrane currents, including the Na+-Ca2+ exchanger current and late INa. The action potential waveform and automaticity are affected differentially by α- and β-adrenoceptor stimulation. Class I antiarrhythmic drugs block the propagation of ectopic electrical activity of the pulmonary vein myocardium through blockade of the peak INa. Some of the class I antiarrhythmic drugs block the late INa and inhibit pulmonary vein automaticity. The negative inotropic and chronotropic effects of class I antiarrhythmic drugs could be largely attributed to their blocking effect on the Ca2+ channel rather than the Na+ channel. Such a comprehensive understanding of pulmonary vein automaticity and class I antiarrhythmic drugs would lead to an improvement in pharmacotherapy and the development of novel therapeutic agents for atrial fibrillation. [ABSTRACT FROM AUTHOR]

Assessing the risk of postoperative cardiovascular events before performing non-cardiac surgery is clinically important. The current risk score systems for preoperative evaluation may not adequately represent a small subset of high-risk populations. Accordingly, this study aimed at applying iterative random forest to analyze combinations of factors that could potentially be clinically valuable in identifying these high-risk populations. To this end, we used the Japan Medical Data Center database, which includes claims data from Japan between January 2005 and April 2021, and employed iterative random forests to extract factor combinations that influence outcomes. The analysis demonstrated that a combination of a prior history of stroke and extremely low LDL-C levels was associated with a high non-cardiac postoperative risk. The incidence of major adverse cardiovascular events in the population characterized by the incidence of previous stroke and extremely low LDL-C levels was 15.43 events per 100 person-30 days [95% confidence interval, 6.66–30.41] in the test data. At this stage, the results only show correlation rather than causation; however, these findings may offer valuable insights for preoperative risk assessment in non-cardiac surgery. [ABSTRACT FROM AUTHOR]

This study investigated the dependence of irradiation fluence and pulse duration on the non–thermal alloying of Cu and Sn through laser irradiation. Femtosecond and picosecond laser irradiation were applied to the GaN part of a bilayer of Cu and Sn deposited on GaN. The laser beam operated at a wavelength and repetition rate of 1030 nm and 1 MHz, respectively, with pulse durations of 0.65 and 38 ps. Subsequently, the irradiated samples were thinned using a focused ion beam, and the cross-sections were examined with transmission electron microscopy. The lattice constants of the resultant phases were identified from selected area diffraction patterns. In data analysis, we identified the phases as β-Sn and ε-phases first, if discernible within a 5% error margin, employing high-temperature phases when identification was not possible. In the irradiated area, only Cu and Sn were detected under a lower fluence and shorter pulse duration. However, δ-phases, which are alloys of Cu and Sn, formed at relatively higher fluences and longer pulse durations. This high-temperature phase, unique to picosecond laser irradiation, cannot be obtained through conventional thermodynamic processes, highlighting the unique capabilities of laser-induced processing in creating novel alloy phases. These findings advance our understanding of laser-material interactions and provides a foundation for developing advanced materials with tailored properties for various applications. [ABSTRACT FROM AUTHOR]

Technologies for rapid and high-throughput separation of rare cells from large populations of other types of cells have recently attracted much attention in the field of bioengineering. Among the various cell separation technologies proposed in the past, dielectrophoresis has shown particular promise because of its preciseness of manipulation and noninvasiveness to cells. However, one drawback of dielectrophoresis devices is that their application of high voltage generates Joule heat that exposes the cells within the device to high temperatures. To further explore this problem, this study investigated the temperature field in a previously developed cell separation device in detail. The temperature rise at the bottom of the microfluidic channel in the device was measured using a micro-LIF method. Moreover, the thermofluidic behavior of the cell separation device was numerically investigated by adopting a heat generation model that takes the electric-field-dependent heat generation term into account in the energy equation. Under the operating conditions of the previously developed cell separation device, the experimentally obtained temperature rise in the device was approximately 20 °C, and the numerical simulation results generally agreed well. Next, parametric calculations were performed with changes in the flow rate of the cell sample solution and the solution conductivity, and a temperature increase of more than 40 °C was predicted. The results demonstrated that an increase in temperature within the cell separation device may have a significant impact on the physiological functions of the cells, depending on the operating conditions of the device. [ABSTRACT FROM AUTHOR]

The integration of visual letters and speech sounds is a crucial part of learning to read. Previous studies investigating this integration have revealed a modulation by audiovisual (AV) congruency, commonly known as the congruency effect. To investigate the cortical oscillations of the congruency effects across different oscillatory frequency bands, we conducted a Japanese priming task in which a visual letter was followed by a speech sound. We analyzed the power and phase properties of oscillatory activities in the theta and beta bands between congruent and incongruent letter‐speech sound (L‐SS) pairs. Our results revealed stronger theta‐band (5–7 Hz) power in the congruent condition and cross‐modal phase resetting within the auditory cortex, accompanied by enhanced inter‐trial phase coherence (ITPC) in the auditory‐related areas in response to the congruent condition. The observed congruency effect of theta‐band power may reflect increased neural activities in the left auditory region during L‐SS integration. Additionally, theta ITPC findings suggest that visual letters amplify neuronal responses to the following corresponding auditory stimulus, which may reflect the differential cross‐modal influences in the primary auditory cortex. In contrast, decreased beta‐band (20–35 Hz) oscillatory power was observed in the right centroparietal regions for the congruent condition. The reduced beta power seems to be unrelated to the processing of AV integration, but may be interpreted as the brain response to predicting auditory sounds during language processing. Our data provide valuable insights by indicating that oscillations in different frequency bands contribute to the disparate aspects of L‐SS integration. [ABSTRACT FROM AUTHOR]

Supramolecular chirality is the major branch of supramolecular chemistry, which not only plays important roles in biological processes but also in synthetically designed aggregated systems. To understand the complex processing of biological systems, the only way is to design supramolecular chiral ensembles that mimic natural biomolecules such as Deoxyribonucleic acid (DNA), Ribonucleic acid (RNA), amino acids, etc. In addition, chiral systems and self‐assemblies as molecular motifs with breaking spatial inversion symmetry have been regarded as key substances in electronics and spintronics as well as in fundamental chemistry and physics. Here, in this review, our major concern is understanding modulation in spatial arrangements and packing modes under the impact of any external stimuli, which results in tailoring the handedness of resulted supramolecular chiral superstructures. We, in this review, highlighted the role of external stimuli such as solvent, chemical additives, photo exposure, etc. in altering the supramolecular chirality for their future utility as “active switches” in optoelectronic and spintronic devices and applications. [ABSTRACT FROM AUTHOR]

Amyotrophic lateral sclerosis (ALS) progressively impairs motor neurons, leading to muscle weakness and loss of voluntary muscle control. This study compared the effects of SOD1 mutation on masticatory and limb muscles from disease onset to death in ALS model mice. Notably, limb muscles begin to atrophy soon after ALS-like phenotype appear, whereas masticatory muscles maintain their volume and function in later stages. Our analysis showed that, unlike limb muscles, masticatory muscles retain their normal structure and cell makeup throughout most of the disease course. We found an increase in the number of muscle satellite cells (SCs), which are essential for muscle repair, in masticatory muscles. In addition, we observed no reduction in the number of muscle nuclei and no muscle fibre-type switching in masticatory muscles. This indicates that masticatory muscles have a higher resistance to ALS-related damage than limb muscles, likely because of differences in cell composition and repair mechanisms. Understanding why masticatory muscles are less affected by ALS could lead to the development of new treatments. This study highlights the importance of studying different muscle groups in ALS to clarify disease aetiology and mechanisms. [ABSTRACT FROM AUTHOR]

Amyotrophic lateral sclerosis (ALS) progressively impairs motor neurons, leading to muscle weakness and loss of voluntary muscle control. This study compared the effects of SOD1 mutation on masticatory and limb muscles from disease onset to death in ALS model mice. Notably, limb muscles begin to atrophy soon after ALS-like phenotype appear, whereas masticatory muscles maintain their volume and function in later stages. Our analysis showed that, unlike limb muscles, masticatory muscles retain their normal structure and cell makeup throughout most of the disease course. We found an increase in the number of muscle satellite cells (SCs), which are essential for muscle repair, in masticatory muscles. In addition, we observed no reduction in the number of muscle nuclei and no muscle fibre-type switching in masticatory muscles. This indicates that masticatory muscles have a higher resistance to ALS-related damage than limb muscles, likely because of differences in cell composition and repair mechanisms. Understanding why masticatory muscles are less affected by ALS could lead to the development of new treatments. This study highlights the importance of studying different muscle groups in ALS to clarify disease aetiology and mechanisms. [ABSTRACT FROM AUTHOR]

Benzodifuranone derivatives, structural analogues of widely studied diketopyrrolopyrrole, have been reported to show photoluminescence exclusively in solution states. Here, upon introducing bulky aromatic groups into benzodifuranone dyes, crystals with unprecedented solid‐state emission were obtained. A crystallographic analysis revealed that the emissive properties should most likely be attributed to the absence of stacking between the dye scaffolds. In addition to the solid‐state emission, the compound showed responsivity to external stimuli, i. e. luminescent mechanochromism and thermosalient effect. [ABSTRACT FROM AUTHOR]

We present a novel synthesis method for producing stable titanium dioxide nanoparticles (<10 nm) dispersed in hydrophobic solvents using organophosphates. Our approach enables the control of nanoparticles' electric field responsiveness by altering the dispersing medium's composition, expanding their potential applications in electronics, photovoltaics, and photocatalysis. [ABSTRACT FROM AUTHOR]

Orbit-following simulations of fast-ion transport and losses with time-dependent electromagnetic perturbations are performed to clarify the roles of Alfvén eigenmodes (AEs) and the low-frequency magnetohydrodynamic (MHD) mode observed in the kinetic-MHD hybrid simulation of AE bursts in the Large Helical Device. Fast-ion pressure profile flattening in the kinetic-MHD hybrid simulation can be reproduced by an orbit-following simulation with only the primary single AE of the time-dependent amplitude following the kinetic-MHD hybrid simulation result, while orbit-following simulations with constant AE amplitude of average level during AE burst cannot reproduce the fast-ion pressure profile flattening observed. The effects of other modes are negligible on the fast-ion pressure profile flattening. The fast-ion losses in kinetic-MHD hybrid simulation can be reproduced by an orbit-following simulation with time-dependent amplitude when the low-frequency MHD mode is considered in addition to multiple AEs. This indicates the synergetic effect of multiple AEs and the low-frequency MHD mode on fast-ion losses. [ABSTRACT FROM AUTHOR]

In recent years, Japan has experienced numerous natural disasters, such as typhoons and earthquakes. Teleoperated ground robots (including construction equipment) are effective tools for restoration work at disaster sites and other locations that are dangerous and inaccessible to humans. Using visual information obtained from various viewpoints by a drone can allow for more effective remote control of a teleoperated ground robot, making it easier for the robot to perform a task. We previously proposed and developed a remote-controlled drone system using only human eyes. However, the effectiveness of using this drone system during the remote control of a robot has never been verified. In this paper, as the first step in verifying the effectiveness of the remote-controlled drone system using only the eyes when remote-controlling a robot, we consider its effectiveness in a simple task based on the task times, subjects' eye fatigue, and subjective evaluations of subjects. First, the previously proposed drone system is briefly described. Next, we describe an experiment in which a drone was controlled by the eyes using the drone system while a robot was controlled by hand, and an experiment in which both the drone and robot were controlled by hand without using the drone system. Based on the experimental results, we evaluate the effectiveness of the remote-controlled drone system using only the eyes when remote-controlling a robot. [ABSTRACT FROM AUTHOR]

In this study, we investigated inspection robots that can safely, accurately, and quickly perform hammer sound inspections on tile exterior walls and present new wall hammering inspection systems using two-wheeled multi-copters. Our results yielded the following five advantages. First, the proposed multi-copter can use its wheels not only to move freely on the walls of buildings but also to overcome obstacles on the walls. Therefore, almost any tile wall surface can be inspected for hammering sound. Second, the multi-copter was equipped with both hammer-shaped rods to hit the tile exterior wall and microphones to collect the hammer sound of the tile, while moving quickly on the wall surface. Third, the wall hammering inspection systems can be used safely with a work assistance mechanism using a wire even in densely populated areas, such as urban areas, because the multi-copter has high wind resistance against crosswinds by both pushing against the wall and operating by the wire. Fourth, we presented some automatic control systems that make the multi-copter operation easy during hammering inspections and demonstrated its usefulness through experiments. Fifth, we proposed useful methods for detecting floating tiles based on the hammering results, conducted some outdoor flight experiments on building exterior walls, and demonstrated that floating tiles can be determined with high accuracy. [ABSTRACT FROM AUTHOR]

Sea ice monitoring is key to analyzing the Earth's climate system. Long-term sea ice extent (SIE) has been continuously monitored using various spaceborne passive microwave radiometers (PMRs) since November 1978. As the lifetime of a satellite is usually approximately 5 years, bias caused by differences in PMRs should be eliminated to obtain objective SIE trends. Most sea ice products have been analyzed for long-term trends with a bias adjustment based on the coarse resolution special sensor microwave imager (SSM/I) in operation for the longest period. However, since 2002, Japanese microwave radiometers of the Advanced Microwave Scanning Radiometer (AMSR) series, which have the highest spatial resolution in PMR, have been available. In this study, we developed standardization techniques for processing SIE including calibration of the brightness temperature (TB), tuning the sea ice concentration (SIC) algorithm, and adjusting the SIC threshold to retrieve a consistent SIE trend based on the AMSR for the Earth Observing System (AMSR-E, one of the AMSR that operated from May 2002 to October 2011). Analysis results showed that the root-mean-square error between AMSR-E SICs and those of moderate resolution imaging spectroradiometer (MODIS) was 15%. In this study, SIE was defined as the sum of the areas where the AMSR-E SIC was >15%. When retrieving SIE, we adjusted the SIC threshold for each PMR to be consistent with the SIE calculated based on the 15% SIC threshold for AMSR-E. We then calculated a time-series of the SIE trends over approximately 45 years using the adjusted SIE data. Therefore, we revealed the dramatic decrease in global sea ice extent since 1978. This technique enables retrieval of more accurate long-term sea ice trends for more than half a century in the future. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic has significantly impacted Japanese society, including its relationship with cultural heritage. This paper shares findings of a large-scale web-based survey conducted from January to February 2022, reaching over 10,000 respondents using a smartphone questionnaire system, aimed at answering the following questions: 'What impact has the pandemic had on societies and local communities in Japan?' and 'What policies should be implemented to protect cultural heritage in response to this new situation in Japan?'. A cross-cutting analysis of the collected responses and respondent attributes was performed. The paper offers four recommendations for long- and short-term cultural heritage policies to enhance future protection. Firstly, it emphasizes increasing cultural heritage awareness, targeting youth and the economically disadvantaged. Secondly, it recommends a reassessment of the prevailing policy structures related to temples and shrines. This recognises the traditional role these institutions have played as community gathering places. Thirdly, it emphasizes supporting smaller, rural festivals with financial aid for repairs, promotions, and bridging migrant gaps. Finally, it suggests integrating the younger generation into the cultural heritage discourse through educational initiatives and digital resources, ensuring continued relevance and intergenerational connection to cultural heritage in Japan. These policy suggestions stand as the linchpin for perpetuating cultural heritage and fostering intergenerational engagement therein. [ABSTRACT FROM AUTHOR]

Aim: Many rheumatoid arthritis (RA) patients prioritize pain improvement in treatment. As pain can result from various causes, including noninflammatory factors such as central sensitivity syndrome (CSS), we hypothesized that CSS might impact treatment satisfaction. In this cross‐sectional study, we assessed the CSS effects on clinical disease activity and treatment satisfaction in RA patients. Methods: In total, 220 consecutive RA patients receiving long‐term follow‐up were evaluated for clinical disease activity and treatment satisfaction. CSS was evaluated using the Central Sensitization Inventory (CSI). An overall score of ≥40 indicates the presence of CSS. We queried "How satisfied are you with your treatment?"; answers included (a) very satisfied, (b) satisfied, (c) not satisfied, or (d) very dissatisfied. For univariate analysis, we condensed these answers into "dissatisfied" or "satisfied." We also evaluated treatment satisfaction using the visual analog scale (VAS), with scores ranging from 0 mm (very dissatisfied) to 100 mm (very satisfied). Results: Of the 220 patients, 17 (7.7%) were classified as having CSS. CSI score was significantly correlated with the clinical disease activity index (CDAI; r =.322, p <.01) and treatment satisfaction (r = −.336, p <.01). Regarding treatment satisfaction, univariate analysis revealed that patient global assessment (PtGA), pain VAS, Health Assessment Questionnaire‐Disability Index (HAQ‐DI), Disease Activity Score in 28 joints with C‐reactive protein, CDAI, and CSI scores of patients who were satisfied with treatment differed significantly from those of dissatisfied patients. Multivariate analysis revealed that CSI, PtGA, and HAQ‐DI scores were associated with treatment satisfaction. Conclusion: In RA patients, CSS may affect the disease activity index and reduce treatment satisfaction. [ABSTRACT FROM AUTHOR]

Olfactory dysfunction is associated with aging and the earliest stages of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases; it is thought to be an early biomarker of cognitive decline. In marmosets, a small non-human primate model used in brain research, olfactory pathway activity during olfactory stimulation has not been well studied because of the difficulty in clearly switching olfactory stimuli inside a narrow MRI. Here, we developed an olfactory-stimulated fMRI system using a small-aperture MRI machine. The olfactory presentation system consisted of two tubes, one for supply and one for suction of olfactory stimulants and a balloon valve. A balloon valve installed in the air supply tube controlled the presentation of the olfactory stimulant, which enabled sharp olfactory stimulation within MRI, such as 30 s of stimulation repeated five times at five-minute intervals. The olfactory stimulation system was validated in vivo and in a simulated system. fMRI analysis showed a rapid increase in signal values within 30 s of olfactory stimulation in eight regions related to the sense of smell. As these regions include those associated with Alzheimer's and Parkinson's diseases, olfactory stimulation fMRI may be useful in clarifying the relationship between olfactory dysfunction and dementia in non-human primates. [ABSTRACT FROM AUTHOR]

The low‐concentration boron doping is performed from 1016 to 1018 cm−3 by ion implantation into heteroepitaxially synthesized large‐area diamond and electrical properties are investigated. Photoluminescence analysis is first carried out to clarify the optical properties of the heteroepitaxial diamond substrate. As a result, defect complexes of nitrogen‐vacancy and silicon‐vacancy are hardly detected in this substrate, suggesting that optically high‐purity diamond can be accomplished by heteroepitaxial growth. Then, the electrical properties of resistivity, mobility, carrier concentration, and conductive type by Hall effect measurements are investigated. For the samples with doping concentrations higher than 1016 cm−3, the electrical activation of implanted B acting as acceptors is confirmed. The compensation ratio for the sample with 3.5 × 1017 cm−3 concentration reaches 76%, indicating the presence of compensating donor‐like centers. With increasing the doping concentration to 3.5 × 1018 cm−3, the compensation ratio is significantly reduced to 35%. The observed mobility of the higher doped sample takes almost the ideal value observed for the sample doped by chemical vapor deposition process. It is suggested that the heteroepitaxial synthesis of large‐area and high‐purity substrates should contribute to the further development of the application to electronic, optical, and sensing devices in the future. [ABSTRACT FROM AUTHOR]

Accumulating evidence suggests that the passenger strands microRNAs (miRNAs) derived from pre-miRNAs are closely involved in cancer pathogenesis. Analysis of our miRNA expression signature of lung adenocarcinoma (LUAD) and The Cancer Genome Atlas (TCGA) data revealed that miR-144-5p (the passenger strand derived from pre-miR-144) was significantly downregulated in LUAD tissues. The aim of this study was to identify therapeutic target molecules controlled by miR-144-5p in LUAD cells. Ectopic expression assays demonstrated that miR-144-5p attenuated LUAD cell aggressiveness, e.g., inhibited cell proliferation, migration and invasion abilities, and induced cell cycle arrest and apoptotic cells. A total of 18 genes were identified as putative cancer-promoting genes controlled by miR-144-5p in LUAD cells based on our in silico analysis. We focused on a family with sequence similarity 111 member B (FAM111B) and investigated its cancer-promoting functions in LUAD cells. Luciferase reporter assay showed that expression of FAM111B was directly regulated by miR-144-5p in LUAD cells. FAM111B knockdown assays showed that LUAD cells significantly suppressed malignant phenotypes, e.g., inhibited cell proliferation, migration and invasion abilities, and induced cell cycle arrest and apoptotic cells. Furthermore, we investigated the FAM111B-mediated molecular networks in LUAD cells. Identifying target genes regulated by passenger strands of miRNAs may aid in the discovery of diagnostic markers and therapeutic targets for LUAD. [ABSTRACT FROM AUTHOR]

The identification of CD30 expression by immunohistochemistry is essential for the treatment of lymphomas using an antibody‐drug conjugate targeting CD30. However, no standardized protocol for CD30 staining has been available. In this study, we compared three common automated immunostaining platforms {Bond III (B III), Dako Omnis (DO) and Ventana BenchMark ULTRA (VBMU)}. A primary antibody for CD30, the Ber‐H2 clone, was diluted 50‐ to 400‐fold for B III and DO, and ready‐to‐use antibody was used for VBMU. An enhancement step using a linker was introduced in all protocols. First, several candidate dilutions were selected for each platform by staining six cases. These candidate conditions were then confirmed with 60 cases of various types of peripheral T‐cell lymphomas (PTCLs). The concordance rates of CD30 expression among platforms differed depending on cutoff values and antibody dilutions, except for anaplastic large cell lymphoma. The concordance rates among three platforms in the evaluation of "positive" or "negative" were 100% and 97% when the cutoff values were 1% and 10% respectively, if using 400‐diluted antibody in B III and 100‐diluted antibody in DO. This study demonstrated the feasibility of equalizing CD30 staining of PTCLs among different platforms by adjusting protocols. [ABSTRACT FROM AUTHOR]

To compensate for mineral deficiencies in food sources, numerous ungulate species use various methods, such as salt licking, soil ingestion, and gnawing on antlers or bones. While osteophagia, the act of gnawing on antlers or bones, is well-documented in cervid species, it has only been observed in sika deer (Cervus nippon) on Mageshima Island in southern Japan despite their widespread distribution. This study aimed to provide an initial account of the observations of osteophagia in sika deer from central Japan. One of the 15 camera traps deployed in the Hakone Nature Forest of Tamagawa University for wildlife monitoring serendipitously captured multiple instances of adult female sika deer gnawing on a four-tined antler on July 9th and 16th in 2018. These occurrences coincided with the fawning season of the species during which mineral deficiencies in the diet are prevalent, suggesting that osteophagia serves as a response to nutrient deficiencies in the diet of sika deer in central Japan. Thus, systematic surveys may yield additional evidence of this behavior in sika deer across diverse geographical areas given the absence of studies on osteophagia in sika deer conducted in other regions. Digital video images related to the article are available at http://www.momo-p.com/showdetail-e.php?movieid=momo240508cn01a. [ABSTRACT FROM AUTHOR]

In this study, we propose self‐retrieval learning, a self‐supervised learning method that does not require an annotated dataset. In self‐retrieval learning, keywords extracted from documents are used as queries to construct training data that imitate the relationship between query and corpus, such that the documents themselves are retrieved. In the usual supervised learning for information retrieval, a pair of query and corpus document is required as training data, but self‐retrieval learning does not require such data. In addition, it does not use information such as reference lists or other documents connected to the query, but only the text of the documents in the target domain. In our experiments, self‐retrieval learning was performed on the EU and UK legal document retrieval task using a retrieval model called DRMM. We found that self‐retrieval learning not only does not require supervised datasets, but also outperforms supervised learning with the same model in terms of retrieval accuracy. © 2024 Institute of Electrical Engineers of Japan and Wiley Periodicals LLC. [ABSTRACT FROM AUTHOR]

Antigen-presenting cells (APCs) play an important role in virus infection control by bridging innate and adaptive immune responses. Macrophages and dendritic cells (DCs) possess various surface receptors to recognize/internalize antigens, and antibody binding can enhance pathogen-opsonizing uptake by these APCs via interaction of antibody fragment crystallizable (Fc) domains with Fc receptors, evoking profound pathogen control in certain settings. Here, we examined phagocytosis-enhancing potential of Fc domains directly oriented on a retroviral virion/virus-like particle (VLP) surface. We generated an expression vector coding a murine Fc fragment fused to the transmembrane region (TM) of a retroviral envelope protein, deriving expression of the Fc-TM fusion protein on the transfected cell surface and production of virions incorporating the chimeric Fc upon co-transfection. Incubation of Fc-displaying simian immunodeficiency virus (SIV) with murine J774 macrophages and bone marrow-derived DCs derived Fc receptor-dependent enhanced uptake, being visualized by imaging cytometry. Alternative preparation of a murine leukemia virus (MLV) backbone-based Fc-displaying VLP loading an influenza virus hemagglutinin (HA) antigen resulted in enhanced HA internalization by macrophages, stating antigen compatibility of the design. Results show that the Fc-TM fusion molecule can be displayed on certain viruses/VLPs and may be utilized as a molecular adjuvant to facilitate APC antigen uptake. • Antibody Fc can be surface-displayed on virions and virus-like particles (VLPs). • Fc-displaying viruses/VLPs undergo enhanced uptake by antigen-presenting cells. • Imaging cytometry depicts enhanced Fc-displayed virus internalization. • Loading antigen-compatible design can harness immunization regimens. [ABSTRACT FROM AUTHOR]

Background: Primary bladder lymphoma is generally regarded as having a favorable prognosis due to the predominance of low-grade lymphomas confined to the bladder. However, our investigation reveals that cases with extravesical extension, predominantly involving diffuse large B-cell lymphoma (DLBCL), exhibit a distinct clinical course with varied prognostic outcomes. Methods: In this report, we present and analyzed the clinical features and outcomes of 47 patients with primary bladder lymphoma with extravesical extension, including the case that we experienced. Results: An 77-year-old man who experienced fever, anorexia, and general malaise was referred to our hospital. Initial laboratory tests indicated severe renal failure, pyuria, and Escherichia coli bacteremia, accompanied by diffuse thickening of the bladder walls and increased attenuation in the surrounding adipose tissues. Initially misdiagnosed with a severe urinary tract infection leading to sepsis, the patient was treated with antibiotics and hemodialysis. Upon readmission due to abdominal pressure, imaging identified an intra-abdominal mass connected to the bladder wall. A bladder biopsy was performed, resulting in the diagnosis of primary bladder DLBCL with perivesical extension, classified as germinal center B-cell type. Taking inspiration from this case, the review of 46 patients was implemented. As a result, we resolved that primary bladder lymphoma often includes indolent types like Mucosa-associated lymphoid tissue lymphoma, but cases with extravesical expansion are predominantly DLBCL. Conclusions: This case emphasizes the diagnostic complexities of distinguishing primary bladder lymphoma from urinary tract infections and underscores the prognostic implications of extravesical extension. Our comprehensive review of the literature on primary bladder lymphomas with extravesical involvement highlights the clinical characteristics, therapeutic challenges, and need for heightened diagnostic vigilance and tailored treatment strategies for this subset of patients. [ABSTRACT FROM AUTHOR]

Steatotic liver escalates the risk of diverse cancers ranging from primary liver cancer to extrahepatic cancers and liver metastasis. Dysregulated hepatic lipid metabolism triggers hepatocyte damage and oxidative stress, resulting in steatotic liver-associated hepatocellular carcinoma. Extracellular vesicles, operating both locally and remotely, play a pivotal role in extrahepatic cancer development and liver metastasis in the context of steatotic liver. Steatotic liver remodels the tumor microenvironment, promoting tumor expansion through the involvement of M2 macrophages, and concurrently suppressing antitumor immunity. Recognizing steatotic liver as a cancer risk underscores the need for early detection, tailored management, and strategic interventions to improve patient outcomes. Steatotic liver, characterized by the accumulation of fat in the liver, poses significant health risks including metabolic dysfunction-associated steatotic liver disease (MASLD) and an elevated risk of primary liver cancer. Emerging evidence indicates a robust association between steatotic liver and increased susceptibility to extrahepatic primary cancers and their metastases. The deposition of fat induces dynamic changes in hepatic microenvironments, thereby fostering inflammation and immune responses that enhance liver metastasis from extrahepatic primary cancers. This review explores the impact of steatotic liver on hepatic carcinogenesis and metastasis from extrahepatic cancers, with a specific focus on hepatocyte-derived factors and the immune microenvironment. By emphasizing novel conclusions, this article underscores the timely relevance of understanding these intricate connections. [ABSTRACT FROM AUTHOR]

Background: Elderly gastric cancer patients (EGCPs) require treatment according to not just the stage of their cancer, but also to their general condition and organ function, and rather than full treatment, the appropriate amount of treatment is necessary. Methods: A total of 425 patients who underwent gastrectomy for primary gastric cancer in our institution between April 2013 and March 2020 were classified by age into two groups: elderly patients (EP, age ≥ 80 years, n = 89); and younger patients (YP, age < 80 years, n = 336). The preoperative, intraoperative, and postoperative conditions of the two groups were then compared. Propensity score matching (PSM) was performed, and factors affecting complications and survival outcomes were examined in detail. In addition, the necessary treatment strategy for EGCPs in the preoperative, intraoperative, and postoperative periods was investigated. Results: Of the preoperative factors, American Society of Anesthesiologists physical status (ASA-PS) was significantly higher, and respiratory function was significantly lower in the EP group than in the YP group, and the prognostic nutritional index (PNI) also tended to be lower. Of the intraoperative factors, there was no difference in the level of lymph node dissection. However, the EP group had significantly higher rates of postoperative pneumonia and anastomotic leakage. Of the postoperative factors, on simple comparison, postoperative long-term outcomes of the EP group were significantly worse (63.8% vs. 85.4%, p < 0.001), but there was no significant difference in disease-specific survival (DSS), and the DSS survival curves after PSM were almost identical, indicating that the survival rate in the EP group was decreased by death from other disease. Though the survival rate of laparoscopic surgery was significantly better than that of open surgery in the YP group, there was a significantly lower rate of postoperative complications in the EP group after PSM. Conclusions: In EGCPs, one needs to be aware of short-term complications such as pneumonia and anastomotic leakage due to respiratory dysfunction and malnutrition that are present before surgery. Furthermore, to suppress deaths from other diseases that reduce postoperative survival rates, prevention of postoperative complications (particularly pneumonia) through minimally invasive surgery can be effective. [ABSTRACT FROM AUTHOR]

Pyrene derivatives bearing substituents at positions 1, 3, 6, and 8 find numerous applications, as exemplified by their use in lasers, sensors, and bioimaging probes. However, these derivatives typically have point‐symmetric or short‐axially symmetric structures, whereas long‐axially symmetric derivatives remain underexplored because of the difficulty in obtaining their precursor, 1,3‐dibromopyrene. To address this problem, we herein synthesized 1,3‐dibromopyrene from 1‐methoxypyrene in an overall yield (71 % over four steps) considerably exceeding those of existing methods. 1,3‐Dibromopyrene was converted into 13OPA, a long‐axially symmetric pyrene dye with electron‐donor (alkoxy) groups at positions 1 and 3 and electron‐acceptor (formyl) groups at positions 6 and 8. 13OPA exhibited photophysical properties distinct from those of its point‐symmetric and short‐axially symmetric isomers, featuring a broad and strongly redshifted absorption, strong fluorescence with reduced sensitivity to protic solvents, and small dipole moment change upon photoexcitation. The derivatization of 13OPA into a Schiff base and its functionalization via Lewis acid‐base pairing were also demonstrated. Thus, our work expands the design scope of pyrene‐based molecules, particularly those used as emitters. [ABSTRACT FROM AUTHOR]

We investigated the impact of annealing on the structural characteristics and superconducting critical temperature ( T c ) of the eutectic high-entropy alloy (HEA) superconductor NbScTiZr. The HEA manifests an eutectic microstructure composed of body-centered cubic (bcc) and hexagonal close-packed phases. Both the lattice parameters of the bcc phase and grain size of the eutectic structure exhibited pronounced sensitivity to variations in annealing temperature. The observed dependence of the lattice parameter on annealing temperature supports the possibility that lattice strain occurs at lower annealing temperatures. The as-cast sample demonstrated superconductivity at T c of 7.9 K, which increased to 9 K after annealing at 800 ∘ C. However, when subjected to annealing at 1000 ∘ C, T c diminishes to 8.7 K. The annealing temperature dependence of T c cannot be comprehensively elucidated based solely on the electronic density of states at the Fermi level. It is plausible that the lattice strain may influence the annealing temperature dependence of T c . Our results for the critical current density J c reveal that the self-field J c of the as-cast NbScTiZr at 2 K exceeds 10 6 A/cm 2 . [ABSTRACT FROM AUTHOR]

Objectives: This study aimed to evaluate the efficacy and safety of Vibegron for the treatment of residual overactive bladder (OAB) symptoms after laser vaporization of the prostate (photo‐selective vaporization of the prostate, contact laser vaporization of the prostate, and thulium laser vaporization). Methods: This randomized, open‐label, parallel‐group, single‐center superiority trial with a 12‐week observation (jRCTs071190040) enrolled male patients with OAB aged 40 years or older who had undergone laser vaporization of the prostate for not less than 12 weeks and not more than 1 year earlier. Patients were allocated to receive Vibegron 50 mg once daily or follow‐up without treatment for 12 weeks. Results: Forty‐seven patients were enrolled between January 2020 and March 2023. The median age (interquartile range) was 75.5 (72.5–78.5) years for the Vibegron group and 76.5 (71.0–81.0) years for the control group. The intergroup difference in the mean change (95% confidence interval) in the 24‐hour urinary frequency at 12 weeks after randomization was −3.66 (−4.99, −2.33), with a significant decrease for the Vibegron group. The Overactive Bladder Symptom Score, International Prostate Symptom Score, IPSS storage score, and Overactive Bladder Questionnaire score significantly improved for the Vibegron group. Voided volume per micturition also increased for the Vibegron group. Conclusions: The administration of 50 mg of Vibegron once daily for 12 weeks showed significant improvement compared with follow‐up without treatment in bladder storage (OAB) symptoms after laser vaporization of the prostate for symptomatic benign prostatic hyperplasia. [ABSTRACT FROM AUTHOR]

The time-of-flight method is a fundamental approach for characterizing the transport properties of semiconductors. Recently, the transient photocurrent and optical absorption kinetics have been simultaneously measured for thin films; pulsed-light excitation of thin films should give rise to non-negligible in-depth carrier injection. Yet, the effects of in-depth carrier injection on the transient currents and optical absorption have not yet been elucidated theoretically. Here, by considering the in-depth carrier injection in simulations, we found a 1/t1−α/2 initial time (t) dependence rather than the conventional 1/t1−α dependence under a weak external electric field, where α < 1 is the index of dispersive diffusion. The asymptotic transient currents are not influenced by the initial in-depth carrier injection and follow the conventional 1/t1+α time dependence. We also present the relation between the field-dependent mobility coefficient and the diffusion coefficient when the transport is dispersive. The field dependence of the transport coefficients influences the transit time in the photocurrent kinetics dividing two power-law decay regimes. The classical Scher–Montroll theory predicts that a1 + a2 = 2 when the initial photocurrent decay is given by 1 / t a 1 and the asymptotic photocurrent decay is given by 1 / t a 2 . The results shed light on the interpretation of the power-law exponent of 1 / t a 1 when a1 + a2 ≠ 2. [ABSTRACT FROM AUTHOR]

Effective impurity doping into diamond by an ion implantation technique has been one of the crucial issues for realizing diamond-based high-power electronic devices. Especially for n-type impurity doping, the electrical activation has not been accomplished yet in a practically available level. In this study, local structures and depth profiles of implanted phosphorus atoms were studied by x-ray absorption spectroscopy, secondary ion mass spectroscopy, and first-principles calculations. P ion implantations were performed at two extreme substrate temperatures of room temperature and 900 ° C at multiple incident energies from 10 to 150 keV for flat doping and a single energy of 200 keV for δ -doping followed by activation annealing at 1300 ° C. The x-ray absorption spectra and the theoretical calculation showed that most of the implanted phosphorus atoms implanted with a flat doping concentration are existent in the substitutional site; however, they seem to bond with hydroxyl or vacancy complexes, probably resulting in electrical inactivation. Indeed, secondary ion mass analysis showed that a large number of O and H atoms are distributed in the P-doped layer, probably diffused from the surface through a damaged network. On the other hand, impurity diffusion was not observed in the P δ -doped sample followed by high-temperature annealing with a cap layer. It is clearly suggested that a damaged layer by ion irradiation near the surface acts as diffusion channels and trap sites of various impurities. High-temperature annealing with a cap layer is also quite effective in suppressing the formation of the defective layer that becomes a diffusion path of O and H. [ABSTRACT FROM AUTHOR]

Boundaries between space plasmas occur in numerous contexts and scales, from astrophysical jets to planetary magnetospheres. Mass and momentum transport across boundaries poses a fundamental problem in magnetospheric physics. Kelvin-Helmholtz instability (KHI) is a promising mechanism to facilitate transport. Although previous studies have suggested KHI occurrence in various space plasmas, theory predicts that compressibility prevents KHI excitation at boundaries with large density gradients because of previously considered boundary structures where density varies with velocity. Based on the observations of a large density gradient boundary by MAVEN at Mars, where we can observe an extreme case, in this study, we show that it is the entropy, instead of the previously considered density, that varies with the velocity in the real velocity-sheared boundary. The entropy-based boundary structure places the velocity shear in a lower-density region than the traditional density-based structure and weakens the compressibility effect. This new boundary structure thus enables KHI excitation even at large density gradient boundaries, such as at the ionopause of unmagnetized planets and the plasmapause of magnetized planets. The result suggests the ubiquitous occurrence of KHI in the plasma universe and emphasizes its important role in planetary cold plasma escape from unmagnetized planets. [ABSTRACT FROM AUTHOR]

In the case of a new nuclear reactor, existing evaluation experience is limited; thus, accidents and troubles may occur as a result of such lack of experience. To deal with such situations, it is desirable to use a virtual nuclear plant to reproduce behaviors under various conditions and identify unknown anomalies from the behaviors. Then, when an abnormal situation occurs, one can quickly determine the cause of the abnormality to operate plant equipment and return the plant to a stable condition as quickly as possible. Two types of deep neural network (DNN) systems have been constructed to support the identification of unknown anomalies and the determination of their causes. One is a surrogate system that can estimate physical quantities of a nuclear power plant in a computational time of several orders less than a physical simulation model. The other is an abnormal situation identification system that can estimate the state of the disturbance causing an anomaly from physical quantities of a nuclear power plant. Both systems are trained and tested using data obtained from the analytical code for incore and plant dynamics (ACCORD), which reproduces the steady and dynamic behavior of the actual High Temperature Engineering Test Reactor (HTTR) under various scenarios. The DNN models are built by adjusting the main hyperparameters. Through these procedures, these systems are shown to be able to perform with a high degree of accuracy. [ABSTRACT FROM AUTHOR]

We investigated the degradation of neutral beam (NB) fast-ion confinement depending on the NB power without magnetohydrodynamics instabilities in the Large Helical Device (LHD). In the LHD deuterium experiment, the neutron emission rate per NB power decreased by up to 20% with increasing injected NBs during a single discharge. Because there were no significant variations in the electron temperature and density, the NB shine-through rate, or the magnetic fluctuation due to the change in NB power, the reduction in the neutron emission rate indicates the degradation of the fast-ion confinement. In this paper, we formulated this degradation depending on the NB power and quantitatively estimated the degraded effective confinement time. In addition, we performed neutron emission rate simulations using the obtained effective confinement time. The simulation and experimental results were in good agreement, suggesting that the degraded effective confinement time is valid. [ABSTRACT FROM AUTHOR]

The automatic activation of letter–speech sound (L-SS) associations is a vital step in typical reading acquisition. However, the contribution of L-SS integration during nonalphabetic native and alphabetic second language (L2) reading remains unclear. This study explored whether L-SS integration plays a similar role in a nonalphabetic language as in alphabetic languages and its contribution to L2 reading among native Japanese-speaking adults with varying English proficiency. A priming paradigm in Japanese and English was performed by presenting visual letters or symbols, followed by auditory sounds. We compared behavioral and event-related responses elicited by congruent letter–sound pairs, incongruent pairs, and baseline condition (symbol–sound pairs). The behavioral experiment revealed shorter RTs in the congruent condition for Japanese and English tasks, suggesting a facilitation effect of congruency. The ERP experiment results showed an increased early N1 response to Japanese congruent pairs compared to corresponding incongruent stimuli at the left frontotemporal electrodes. Interestingly, advanced English learners exhibited greater activities in bilateral but predominantly right-lateralized frontotemporal regions for the congruent condition within the N1 time window. Moreover, the enhancement of P2 response to congruent pairs was observed in intermediate English learners. These findings indicate that, despite deviations from native language processing, advanced speakers may successfully integrate letters and sounds during English reading, whereas intermediate learners may encounter difficulty in achieving L-SS integration when reading L2. Furthermore, our results suggest that L2 proficiency may affect the level of automaticity in L-SS integration, with the right P2 congruency effect playing a compensatory role for intermediate learners. [ABSTRACT FROM AUTHOR]

Multiple sclerosis (MS), the leading cause of disability in young adults, is an inflammatory disease of the central nervous system characterized by localized areas of demyelination. Apoptosis signal‐regulating kinase 1 (ASK1) is a mitogen‐activated protein kinase kinase kinase that has been shown to be implicated in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. Interestingly, ASK1 signaling regulates glial cell interactions and drives neuroinflammation in EAE mice. To further investigate its clinical significance, in the present study, we examined the activation of ASK1 in the post‐mortem brain of MS patients. ASK1 activation was found in active lesions of the corpus callosum in both microglia/macrophages and astrocytes. Moreover, ASK1 activation in astrocytes was higher than that in microglia/macrophages, which was in line with our findings in EAE mice. Our results suggest an important role of ASK1 in glial cells, indicating that ASK1 might be a good therapeutic target for MS. [ABSTRACT FROM AUTHOR]

OBJECTIVE: Self-directed and lifelong learning (SDLL) skills are essential skillsets in both undergraduate and graduate medical education (UME and GME). Hence, medical schools' accreditation bodies emphasize the requirements to acquire these skills in their accreditation standards. For example, in the United States, the Liaison Committee on Medical Education (LCME) clearly defines the components of the SDLL process in Element 6.3 of Accreditation Standard Six. Among the active learning pedagogies, problem-based learning (PBL) provides ample learning opportunities where SDLL skills are effectively applied. The aim of this article is to streamline the process of developing, delivering, and evaluating PBL sessions in line with the SDLL accreditation requirements through a 10-step design and implementation process. METHODS: Our 10-step process, detailed in the article, starts with developing learning objectives that inform the content of the PBL case and the required embedded learning triggers. The process carefully addresses the components of the SDLL process and other aspects of the accreditation needs within the framework of PBL. The approach to implementation, feedback, assessment, and evaluation is explicitly described to meet the regulatory expectations. DISCUSSION: In addition to the essential role in UME and GME, SDLL skills are vital requisites for continuing medical education of all physicians. Instilling this skillset early in medical students helps to cultivate their ability to apply these skills in their future professional roles. Using accreditation standards as a foundation for creating learning experiences, for example, PBL, requires careful content development and sequencing. Such a process needs explicit standardized steps that should not only be feasible, but also transferable for usage by different medical schools. CONCLUSION: Our streamlined 10-step process of designing and delivering an SDLL-oriented PBL experience can easily be adopted by other medical schools to address the SDLL skills acquisition as well as meeting the accreditation requirements. [ABSTRACT FROM AUTHOR]

Osteoporosis is often detected late and becomes severe because of a lack of subjective symptoms. Digital panoramic radiography (DPR) has been reported to be useful for osteoporosis screening based on the morphological classification of the mandibular inferior cortex. The purpose of this study was to evaluate the sensitivity and specificity of the mandibular cortical index (MCI) in the diagnosis of osteoporosis in a group of patients who were and were not using antiosteoporosis medication (AOM). Three hundred and fifty female patients aged 40 years or older who had DPR imaging performed during a 6-year period from December 2015 to February 2022 met the selection criteria. Two examiners recorded mandibular cortical width and MCI from the images. These results were statistically examined together with the patients' demographic data. Forty-nine patients were using AOM (13 nonbisphosphonate/denosumab and 36 bisphosphonate/denosumab). MCI type 3 was the most common in the AOM group. In the MCI classification, DPR imaging among the AOM group was more sensitive (0.95) than that of the control group. This method of estimating osteoporosis based on MCI classification using DPR images has high sensitivity, especially in patients using AOM, suggesting that this method is useful as a screening test. [ABSTRACT FROM AUTHOR]

The aim of this study was to examine the childhood trauma experiences and current happiness levels of nursing students. The quantitative part of the study was carried out with 349 student nurses and the qualitative part with 25 student nurses. An explanatory-sequential mixed methods design was used. Data were collected using Demographic Information Form, Childhood Trauma Questionnaire-Short Form, Oxford Happiness Questionnaire-Short Form and semi-structured Interview Form between November 2020 and September 2021. Quantitative data were analysed using descriptive statistics with the SAS 9.4 package program. Transcribed qualitative data were analysed using Braun and Clarke's six stage thematic analysis approach, and this was performed with the MAXQDA 2020 package program. In the quantitative section, it was determined that as the participants' childhood traumatic experiences increased, their happiness levels decreased. In the qualitative section six themes were formed (Childhood Trauma, Effects of Childhood Trauma, Coping with Childhood Trauma, Growing Up After Trauma, Perceptions of Future Parenting, Empowerment Through Nursing Education). It was determined that participants had various childhood traumatic experiences and mostly been exposed to emotional neglect. Some of the participants' childhood traumas continued to affect them in adulthood, and nursing education contributed to coping with trauma and raising awareness about it. [ABSTRACT FROM AUTHOR]

Military sexual trauma (MST) is a prevalent issue within the U.S. military. Victims are more likely to develop comorbid diseases such as posttraumatic stress disorder (PTSD) and major depressive disorder (MDD). Nonetheless, not everyone who suffers from MST develops PTSD and/or MDD. DNA methylation, which can regulate gene expression, might give us insight into the molecular mechanisms behind this discrepancy. Therefore, we sought to identify genomic loci and enriched biological pathways that differ between patients with and without MST, PTSD, and MDD. Saliva samples were collected from 113 female veterans. Following DNA extraction and processing, DNA methylation levels were measured through the Infinium HumanMethylationEPIC BeadChip array. We used limma and bump hunting methods to generate the differentially methylated positions and differentially methylated regions (DMRs), respectively. Concurrently, we used Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genome to find enriched pathways. A DMR close to the transcription start site of ZFP57 was differentially methylated between subjects with and without PTSD, replicating previous findings and emphasizing the potential role of ZFP57 in PTSD susceptibility. In the pathway analyses, none survived multiple correction, although top GO terms included some potentially relevant to MST, PTSD, and MDD etiology. We conducted one of the first DNA methylation analyses investigating MST along with PTSD and MDD. In addition, we found one DMR near ZFP57 to be associated with PTSD. The replication of this finding indicates further investigation of ZFP57 in PTSD may be warranted. • We investigated the differences in DNA methylation levels between subjects with and without MST, PTSD, and MDD. • This is the first study investigating the epigenetics status associated with MST. • A DMR close to the TSS of the ZFP57 gene was differentially methylated between subjects with and without PTSD. • This finding replicates previous findings and emphasizes the potential role of ZFP57 in PTSD susceptibility. [ABSTRACT FROM AUTHOR]

Controlling nanoscale heat generation, dissipation, and transport is crucial for miniaturizing electronic devices and for designing highly efficient thermoelectric materials. However, it has been challenging to directly measure thermal properties at individual atom level. Herein, direct atomic‐resolution column‐by‐column imaging of the rattling motion of Ba atoms in a clathrate compound Ba8Ga16Ge30 using atomic‐resolution scanning transmission electron microscopy with a segmented detector is shown. The directional anisotropy of the rattling motion is clearly visualized in real space and its amplitude and anisotropy are quantitatively evaluated by Bayesian analysis of the thermal diffuse scattering distribution. These results open a new possibility for directly characterizing nanoscale thermal properties in materials and devices, even those containing heavy elements such as thermoelectric materials. [ABSTRACT FROM AUTHOR]