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The article discusses the pathology of gestational trophoblastic neoplasia (GTN), a unique and heterogeneous group of conditions which demonstrates differentiation towards various components of gestational trophoblast. It includes variants of hydatidiform mole (HM) which are considered benign, while choriocarcinoma (CC), placental site trophoblastic tumour (PSTT) and the epithelioid trophoblastic tumour (ETT), a variant of PSTT, are malignant gestational trophoblastic tumours (GTT).

The article presents a study which examines the difference of triple negative breast cancer (TNBC), basal-like breast cancer (BLBC) and BRCA1 associated breast cancer (BABC). The study describes the pathology and biology of the three groups of tumor such as the definition of triple negative breast carcinoma by a triple negative phenotype. It discovers the great deal of overlap that exists among the three group of tumors. Therapeutic implications on such tumors are also discussed.

The presence of squamous cell carcinoma (SCC) on endometrial histology raises the possibility of a primary endometrial carcinoma, as well as secondary endometrial involvement by SCC from another site, especially the cervix. This distinction relies on numerous cardinal clinical and pathologic findings and may occasionally be problematic. We document an unusual tumour in a postmenopausal woman who presented with clinical and radiologic features of a primary endometrial cancer, confirmed on endometrial histology as a keratinising SCC. Subsequent pathologic evaluation of the hysterectomy specimen, however, demonstrated an exclusively in situ cervical SCC, with extensive endometrial intramucosal spread and widespread infiltration of the myometrium, macroscopically mimicking a primary endometrial neoplasm. We review the pathologic distinction between primary endometrial SCC and secondary corpus involvement of cervical SCC, as well as the broader differential diagnosis when SCC is identified on endometrial histology. [ABSTRACT FROM AUTHOR]