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Objective: To investigate the clinical curative effect of spinal balancing manipulation combined with acupuncture in the treatment of third lumbar transverse process syndrome. Methods: A total of 100 patients with third lumbar trans-verse process syndrome were divided into two groups, as the study group and the control group, with 50 patients in each group. Patients in the control group were given drug treatment of Celecoxib. On the basis of drug treatment in the control group, patients in the study group were given spinal balancing manipulation combined with acupuncture treatment. The clinical efficacy (total effective rate) after treatment was compared between the two groups. The efficacy rating scale for lower back pain disorders, Japanese orthopaedic association (JOA), was applied to evaluate the lumbar function of the patient. Serum interleukin 6 (IL-6), prostaglandin E2 (PGE2), and interleukin 10 (IL-10) levels of the two groups were measured before and after treatment. The visual analogue scoring (VAS) was applied to evaluate the subjective pain degree of patient's lower back. Results: After treatment, total effective rate of the study group was 94.00%, and the control group was 80.00%. The total effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P < 0.05). After treatment, the subjective symptoms, clinical signs, ability of daily living and JOA score were significantly decreased in patients of the two groups. Moreover, the decreased degree was more obvious in the study group than that in the control group, and the differences were statistically significant (P < 0.05). After treatment, the IL-6, PGE2 and IL-10 levels of the two groups obviously decreased comparing with those before treatment, and the differences were statistically significant (P < 0.05). After treatment, the IL-6, PGE2 and IL-10 levels of the study group were lower than those of the control group, and the differences were statistically significant (P < 0.05). After treatment, the subjective pain degree (VAS score) significantly decreased in the two groups, and the decreased degree in the study group was more obvious than the control group. Moreover, the differences were statistically significant (P < 0.05). Conclusions: The spinal balancing manipulation combined with acupuncture treatment can effectively improve the curative effect of third lumbar transverse process syndrome. The therapeutic method can improve lumbar function, relieve pain and reduce inflammatory response. [ABSTRACT FROM AUTHOR]

Background/Aims: Renal ischemia-reperfusion injury (IRI) is a common consequence of acute kidney injury. Nicotinamide adenine dinucleotide phosphate (NADPH), which is derived from the pentose phosphate pathway, is essential for the proper functioning of essential redox and antioxidant defense systems. Previous studies have indicated that NADPH is responsible for protecting the brain from ischemic injury. The goal of this study was to analyze the protective function of NADPH in renal IRI. Methods: The IRI animal model was generated through a midline laparotomy surgery that clamped both sides of the renal pedicles for 40 min to induce renal ischemia. The in vitro model was generated by removing oxygen and glucose from human kidney epithelial cells (HK-2 cells), followed by reoxygenation to imitate IRI. Renal function and histopathological changes were observed and evaluated. Additionally, malondialdehyde and glutathione levels were determined in renal tissue homogenate as indicators of oxidative stress. ROS production in cells was determined by DHE staining. Protein biomarker expression was evaluated by western blot, apoptosis was analyzed by TUNEL staining, and p65 nuclear translocation was visualized by immunofluorescence. Results: Our data indicated that NADPH safeguarded the kidneys from histological and functional damage, and significantly reduce cell injury along with preventing potential increases in blood urea nitrogen and creatinine levels. Furthermore, we observed that NADPH increased glutathione levels, while reducing levels of malondialdehyde and reactive oxygen species. Additionally, our results suggested that NADPH treatment may alleviate IRI-induced apoptosis and inflammation. Conclusion: NADPH treatment may protect against renal IRI and should be further developed as a new treatment for acute kidney injury. [ABSTRACT FROM AUTHOR]

The influence of labyrinth seal on the stability of unbalanced rotor system was presented. Under the periodic excitation of rotor unbalance, the whirling vibration of rotor is synchronous if the rotation speed is below stability threshold, whereas the vibration becomes severe and asynchronous which is defined as unstable if the rotation speed exceeds threshold. The Muszynska model of seal force and shooting method were used to investigate synchronous solution of the dynamic equation of rotor system. Then, based on Floquet theory the stability of synchronous solution and unstable dynamic characteristic of system were analyzed. [ABSTRACT FROM AUTHOR]