1. P.200 Immunological substrates of depressive symptoms in patients with severe obesity.
- Author
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Stiglbauer, V., Gamradt, S., Scherzer, M., Hofmann, T., Otte, C., Hinkelmann, K., and Gold, S.M.
- Subjects
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MENTAL depression , *OVERWEIGHT persons , *KILLER cells , *SUPPRESSOR cells , *COMORBIDITY - Abstract
B Background: b Major Depressive Disorder (MDD) and obesity are highly prevalent among the general population and pose a major burden on public health. B Results: b Patients with comorbid depression and obesity exhibited lower frequencies of circulating cytotoxic natural killer cells (p < 0.05), dendritic cells (p < 0.05), and CD8+ effector memory T cells (p < 0.05) compared to lean controls, while frequencies of regulatory T cells (p < 0.05) compared to non-depressed obese patients and CD4+ central memory T cells (p < 0.05) compared to lean controls were increased. B Conclusion: b Severe obesity with comorbid depression is associated with lower numbers of circulating cytotoxic natural killer cells and dendritic cells, as well as higher numbers of CD4+ central memory T cells compared to lean controls. [Extracted from the article]
- Published
- 2020
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