1. 1-(2,5-Dimethoxy-4-nitrophenyl)piperidine.
- Author
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Syeda, Tanjia M., Al-Shaidi, Muadh R., Basri, Ibtihal, Merzouk, Mahboub, and Aldabbagh, Fawaz
- Subjects
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PIPERIDINE , *NITRATION , *PYRROLIDINE , *ISOMERS , *NITROBENZENE - Abstract
Treatment of the non-purified mixture of dinitro isomers obtained from the nitration of 1,4-dimethoxybenzene with piperidine led to the isolation of novel but minor adduct, 1-(2,5-dimethoxy-4-nitrophenyl)piperidine (2b) in 15% yield. Yields of nucleophilic aromatic substitution adducts are high when using purified 1,4-dimethoxy-2,5-dinitrobenzene (1b) with piperidine and pyrrolidine to give (2b) and 1-(2,5-dimethoxy-4-nitrophenyl)pyrrolidine (3b) in 76% and 82% yield, respectively. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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