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The prognosis of angiosarcoma remains very poor, even with combined, multimodal therapy. We report a case with partial response of angiosarcoma of the scalp to sorafenib, which is a new oral, molecular, targeted, multiple-kinase inhibitor. In addition, we confirmed, using immunohistochemistry, that sorafenib suppressed the expression of vascular endothelial growth factors and their receptors on the angiosarcoma tumour cells, and decreased cell numbers by inhibiting cellular proliferation. [ABSTRACT FROM AUTHOR]

Presents a letter to the editor about keratosis follicularis squamosa associated with pseudoacanthosis nigricans in a 32-year-old woman.

Presents a letter to the editor about generalized eruptive histiocytoma with rapid progression and resolution following exanthema subitum.

Objective: Angiosarcoma is a rare malignant neoplasm with a poor prognosis. A retrospective study was performed to accumulate radiotherapy (PT) data. Methods: Data from 17 patients with angiosarcoma of the face and scalp (AFS) who were treated with definitive PT between January 1999 and July 2011 were retrospectively analysed. The total radiation dose was 70Gy, and the fractional doses were 2.0-2.5Gy. Combined with RT, chemotherapy using docetaxel alone, recombinant interleukin-2 immunotherapy alone and both of these was performed in 10, 4 and 2 patients, respectively. Three patients underwent limited surgery before PT. Results: The response rate was 82%, and the median overall survival (OS) rate was 26 months. Locoregional relapse alone, distant metastasis alone and both of these were confirmed in 4, 5 and 4 patients, respectively. Patients treated with docetaxel showed a better prognosis Cp=0.0477), a distant metastasis-free rate (p=0.0063) and a better in-field control rate, although the last was not statistically significant (p=0.1645). Conclusion: Definitive PT combined with docetaxel chemotherapy provided an effective approach for treating AFS. Advances in knowledge: Since patients treated with chemoradiotherpy using docetaxel showed better OS and distant metastasis-free rates than those who did not receive docetaxel, it was warranted to continue use of docetaxel. In chemoradiotherapy at a dose of 70 Gy using docetaxel, 2-year in-field control rate was 67%. [ABSTRACT FROM AUTHOR]

We report on a 10-year-old child who suffered from acute right coronary obstruction due to catheter-induced coronary dissection. Immediate placement of a perfusion catheter into the obstructed right coronary artery and subsequent overnight reperfusion allowed successful recovery of the right coronary artery lumen without implantation of a stent. Follow-up angiography demonstrated spontaneous regression of the dissected coronary artery and normal right and left ventricular wail motion. The indication of stent implantation should be carefully determined in a child ease of iatrogenie coronary dissection because stenting may induce coronary stenosis during growth. [ABSTRACT FROM AUTHOR]