Search

High entropy ceramics are considered as promising materials for thermal barrier coatings due to phonon scattering caused by lattice distortion. In this study, perovskite high-entropy ceramics (Ba 0.5 Sr 0.5)(Ti 0.25 Zr 0.25 Hf 0.25 Sn 0.25)O 3 (BSTZHS) were successfully prepared by dramatically increasing the conformational entropy of ceramics with complex crystal structures. The results showed that the sample exhibits a single-phase perovskite crystal structure with a dense surface, each element of the sample was uniformly distributed. Moreover, the thermal conductivity of (Ba 0.5 Sr 0.5)(Ti 0.25 Zr 0.25 Hf 0.25 Sn 0.25)O 3 decreased significantly compared to SrZrO 3 and BaZrO 3 (the minimum thermal conductivity is 1.37 W/(m·K) at 273–1273 K). This study also identified descriptors for predicting the decrease in thermal conductivity of perovskite high-entropy ceramics. As well, the samples not only exhibit outstanding mechanical properties (Young's modulus E = 255.7 ± 8.6 GPa、flexural strength F b = 142.1 ± 4.8 MPa), but also good resistance to CMAS corrosion. Various results support that (Ba 0.5 Sr 0.5)(Ti 0.25 Zr 0.25 Hf 0.25 Sn 0.25)O 3 is potential to be used for thermal barrier coatings. [ABSTRACT FROM AUTHOR]

Macrophages within tissues display a strong plastic ability in respond to environmental cues in both physiologic influences and disease. However, the macrophage phenotype and its distribution in the bone marrow biopsies (BMB) samples of human acute leukemia (AL) remain poorly understood. In this study, 97 BMB samples of patients with acute leukemia and 30 iron-deficiency anemias (IDA) as control group were evaluated with immunohistochemistry. In comparison with controls, the counts of CD68+, CD163+, and CD206+macrophages were remarkably increased in BMB samples of acute leukemia (P < 0.01), as well as their infiltration density was roaring up-regulation (P < 0.01). The expression levels of CD68+, CD163+, and CD206+macrophages were decreased in patients with complete remission, but there still existed statistically significant contrast to the control group (P < 0.01). The ratios of the CD163-positive cells or CD206-positive cells to CD68-positive cells were most prevalent in the BMB samples of human acute leukemia compared with the control group (P < 0.01), which support that macrophages were polarized to M2 macrophages. [ABSTRACT FROM AUTHOR]

Four ardeemin analogues (I)-(III) are isolated and their reversal effects on multidrug-resistant tumor cell lines are evaluated. [ABSTRACT FROM AUTHOR]

Kawasaki disease (KD) is a complex disease, leading to the damage of multisystems. The pathogen that triggers this sophisticated disease is still unknown since it was first reported in 1967. To increase our knowledge on the effects of genes in KD, we extracted statistically significant genes so far associated with thismysterious illness fromcandidate gene studies and genome-wide association studies. These genes contributed to susceptibility to KD, coronary artery lesions, resistance to initial IVIG treatment, incomplete KD, and so on. Gene ontology category and pathways were analyzed for relationships among these statistically significant genes. These genes were represented in a variety of functional categories, including immune response, inflammatory response, and cellular calcium ion homeostasis. They were mainly enriched in the pathway of immune response. We further highlighted the compelling immune pathway ofNF-ATsignal and leukocyte interactions combinedwith another transcription factorNF-kB in the pathogenesis of KD. STRING analysis, a network analysis focusing on protein interactions, validated close contact between these genes and implied the importance of this pathway. This data will contribute to understanding pathogenesis of KD. [ABSTRACT FROM AUTHOR]