Search

This work was conducted over three-year monitoring seasons of three almond cultivars (Guara, Marta, and Lauranne) subjected to deficit irrigation in combination with cover crops in a Mediterranean semiarid area (SW, Spain). Four water–soil treatments were evaluated based on the conjunction of two irrigation strategies: fully irrigated (FI), covering 100% of the ETC, and regulated deficit irrigation (RDI), with two soil-management systems: bare soil (BS) and cover crop based on a mixture of vetch (Vicia sativa L.) and oat (Avena sativa L.) (CC). Throughout the study period in trees, the yield, the stem water potential (Ψstem), leaf nutrient content (N, P, K, Ca, Mg, Na, Fe, Zn, Mn, and Cu) in soils, organic carbon, microbial biomass, fluoresceine diacetate, and enzymatic activities (dehydrogenase, protease, β-glucosidase, and alkaline phosphatase) were determined. In addition, the dry matter and carbon fixation by plant covers were evaluated. For Guara and Lauranne, yield reductions (22 and 26%, respectively) were found for water-stressed (RDI-CC) plots with respect to non-stressed combination (FI-CC) plots, contrasting with cv. Marta, without a significant impact on productivity in all combinations. That is, the RDI (~3.000 m3 ha−1) strategy enabled acceptable productivity, offering promising possibilities for cultivation performance under water-scarcity scenarios. Important differences in Ψstem could be observed and ascribed to irrigation strategies, especially for Guara and Lauranne, but without significant effects due to the soil-management systems applied. No differences were observed in the tree nutritional status due to the presence or absence of CC; however, its presence increased the fixation of atmospheric carbon, which was not the case under BS conditions. Additionally, CC significantly fostered the microbial processes and enzymatic activities, particularly in upper soil layers (0–10 cm) and with plenty of water supply in FI-CC plots and to a lesser extent in RDI-CC plots, which could encourage prominent aspects for soil quality and health restoration. Thus, the cover crop is congruent with RDI to facilitate soil functionality and water savings in a changing climate, contributing to resilient farming systems in the Mediterranean environment. [ABSTRACT FROM AUTHOR]

The recent discovery of Psilotum × intermedium in Mexico prompted us to reassess the nomenclature of this genus, which has global implications. From an extensive review of nomenclatural types and herbarium specimens, field collections, and a morpho-anatomical analysis, P. nudum and P. flaccidum are treated as accepted species, while P. × complanatum is treated as an interspecific hybrid between them. With this clarification, we specify their main synonymies and designate seven lectotypes (for Bernhardia schiedeana, Psilotum complanatum var. latissimum, P. complanatum var. mexicanum, P. floridanum, P. neocaledonicum, P. triquetrum, P. triquetrum var. gracile) and we select an epitype to give taxonomic support to the hybrid. We provide descriptions, diagnostic comments, and a key for identification of the accepted taxa, and also update the geographical ranges of these three taxa, mainly in Neotropics. [ABSTRACT FROM AUTHOR]

In Spain, wheelchair basketball competition is well developed and structured; however, reverse integration is not allowed. This study aimed to describe and synthesize the perceptions of Spanish wheelchair stakeholders (players, coaches, referees, and club managers). A mixed-method approach was used, utilizing an ad hoc survey questionnaire (n = 49) and three focus groups (n = 12). Quantitative and qualitative data were interpreted using a triangulation strategy, meaning that both sources of data were combined and analyzed. From the thematic content analysis, two main themes and several subthemes emerged: social context (audience attraction and economic impact, utility and logistics, and promoting inclusion) and sport context (grassroots and elite level). Some reservations at elite level were also reported. From the perspective of the stakeholders explored in this study, reverse integration appears to be well suited for implementation within the Spanish wheelchair basketball framework at all levels. [ABSTRACT FROM AUTHOR]

Demand-responsive transport (DRT) could be an alternative for extending the accessibility of high-speed rail (HSR) servicing cities in rural environments, where fixed public transport does not provide efficient services. This paper proposes a method to analyse the factors that influence the implementation of DRT systems for inter-urban mobility, connecting and integrating towns in rural areas. Methodologically, a vehicle routing problem analysis in a GIS-based environment is applied to a theoretical case study to evaluate the factors that influence DRT efficiency in different scenarios, considering the specific singularities of this kind of inter-urban long-distance mobility. The results suggest the optimal DRT solutions in these rural contexts to be those that, after adjusting the fleet to specific demands, use low-capacity vehicles, which are much better adapted to the geography of sparsely populated areas. Moreover, in adapting DRT systems to HSR travellers' needs, windows catering to these needs should incorporate the option of setting the pickup or arrival times. This paper demonstrates that DRT systems could reach significant levels of service in rural areas compared with fixed lines and even private vehicles, especially when evaluating key aspects of the system's efficiency for its implementation. [ABSTRACT FROM AUTHOR]

Animal vision depends on opsins, a category of G protein-coupled receptor (GPCR) that achieves light sensitivity by covalent attachment to retinal. Typically binding as an inverse agonist, 11-cis retinal photoisomerizes to the all-trans isomer and activates the receptor, initiating downstream signaling cascades. Retinal bound to bistable opsins isomerizes back to the 11-cis state after absorption of a second photon, inactivating the receptor. Bistable opsins are essential for invertebrate vision and nonvisual light perception across the animal kingdom. While crystal structures are available for bistable opsins in the inactive state, it has proven difficult to form homogeneous populations of activated bistable opsins either via illumination or reconstitution with all-trans retinal. Here, we show that a nonnatural retinal analog, all-trans retinal 6.11 (ATR6.11), can be reconstituted with the invertebrate bistable opsin, Jumping Spider Rhodopsin-1 (JSR1). Biochemical activity assays demonstrate that ATR6.11 functions as a JSR1 agonist. ATR6.11 binding also enables complex formation between JSR1 and signaling partners. Our findings demonstrate the utility of retinal analogs for biophysical characterization of bistable opsins, which will deepen our understanding of light perception in animals. [ABSTRACT FROM AUTHOR]

The increasing age of liver donors and transplant candidates, together with the growing prevalence of metabolic comorbidities, could impact the risk of vascular complications after liver transplantation. We enrolled a consecutive cohort of adult patients undergoing liver transplantation from 2012 to 2021 who had a blinded pathological assessment of atherosclerosis in the donor and recipient hepatic arteries (HA). Patients receiving partial or reduced grafts, retransplantation, or combined organ transplantation were excluded. The relationship between HA atherosclerosis and HA thrombosis after liver transplantation was evaluated using logistic regression in the whole study cohort and in a propensity score‐matched subpopulation. Among 443 eligible patients, 272 had a full pathological evaluation of the donor and recipient HA and were included in the study. HA atheroma was present in 51.5% of donors and in 11.4% of recipients. HA thrombosis occurred in 16 patients (5.9%), being more likely in patients who received a donor with HA atherosclerosis than in those without (10.7% vs. 0.8%; p < 0.001). Donor HA atherosclerosis was an independent risk factor of HA thrombosis (OR = 17.79; p = 0.008), and this finding was consistent in the propensity score‐matched analysis according to age, sex, complex arterial anastomosis, and alcoholic liver disease (OR = 19.29; p = 0.007). Atheromatous disease in the recipient had no influence on the risk of HA thrombosis (OR = 1.70; p = 0.55). In conclusion, patients receiving donors with HA atherosclerosis are at increased risk for HA thrombosis after liver transplantation. The evaluation of the donor graft vasculature could guide antiplatelet therapy in the postoperative period. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to evaluate physical skin changes and patients’ subjective perception of treatment with photothermal bioactivated platelet-rich plasma (MCT Plasma) for hand rejuvenation. Background: Age-related changes in the dorsum of the hand include volume loss, dyschromia, and soft-tissue atrophy, which result in wrinkles and prominent deep structures. Methods: We conducted a prospective, single-center, randomized pilot study on 10 healthy female volunteers from 30 to 65 years with hand aging signs. Patients received two sessions of MCT Plasma on the treated hand and two sessions of standard platelet-rich plasma (PRP) on the control hand. Results were assessed through highfrequency ultrasonography, photographs, a patient satisfaction survey, patient perception of skin aspect, and patient perception of amelioration survey. Results: Ten women with a mean age of 57.5 years (standard deviation 10.5, range 31 - 67) were included, and seven (70%) completed the study. The treated hands’ skin subepidermal low-echogenic band (SLEB) decreased from 20% to 60%, and 57.1% (n = 4) had better results than control. Twenty percent of patients were very satisfied with the results, 40% were satisfied, 40% were neutral, and none were unsatisfied or very unsatisfied. Patients perceived the skin of the treated hand (MCT Plasma) as “much better” (20%), “better” (60%), and “no changes” (20%) compared with the skin of the control hand (standard PRP). No treatment-related adverse events were reported during the study. Conclusions: Hands treated with MCT Plasma tended to have better outcomes in reducing SLEB compared with those treated with standard PRP. Patients were satisfied and the treatment was safe with no technical complications. However, further randomized controlled trials with larger sample sizes are mandatory to validate the extent of improvement provided by this device based on photothermal biomodulation. [ABSTRACT FROM AUTHOR]

Objectives: To investigate the word recognition effects of the use of all-uppercase (e.g., VALENCIA) or titled-case (e.g., Valencia) for city names in traffic signs, controlling for word size, and comparing stationary and dynamic viewing situations. Background: Prior studies provide mixed evidence regarding the effects of word case on the recognition of city names in traffic signs. Moreover, the evidence on the potential impact of visual motion on these effects is scarce. Method: We carried out an experimental study using simulated traffic signs. The task was to indicate, for each sign, whether it contained a given city name or not (word search task, 50% positive trials). Visual motion of signs was manipulated as a between-participants factor: stationary (the sign was still) versus dynamic (the sign expanded as if the participant was approaching to it). Word case was manipulated as a within-participants factor: all-uppercase versus two titled-case conditions varying in font size: width-matched titled-case and point size-matched titled-case. Results: In both the stationary and dynamic conditions, all-uppercase resulted in more incorrect responses and slower latencies than width-matched titled-case. When compared to point size-matched titled-case, all-uppercase produced slower correct responses in the stationary condition, whereas faster in the dynamic condition. Conclusion: Other factors being equal, all-uppercase city names will be recognized worse than their titled-case versions in traffic signs, both in stationary and dynamic situations. Application: Results in the current experimental study would be of interest in the design of traffic signs and other circumstances in which text is presented in motion. [ABSTRACT FROM AUTHOR]

Plasma impedance probes measure the impedance spectrum of an antenna immersed in a plasma. The 1964 work of Balmain remains the standard method to interpret these data, using the peak in the magnitude at the upper-hybrid frequency to infer plasma electron density. The primary limitations of Balmain's model are the assumption of a homogenous plasma and a cylindrical dipole. This work presents a numerical model applicable to inhomogeneous plasma and arbitrary antenna geometry based on the cold, fluid approximation given by Balmain. This model solves Poisson's equation using the finite element method and accounts for the effects of the dipole using the plasma complete electrode model (PCEM). The PCEM is developed in this article and accounts for the voltage shunting effects of the dipole elements, the discrete current to the dipole, and the plasma sheath surrounding the dipole. The sheath is incorporated as a contact impedance between the dipole and the plasma in a manner analogous to the complete electrode model of electrical impedance tomography. The first portion of this paper presents the mathematical framework of the PCEM, starting from Maxwell's equations. The second part of the paper compares the output of this numerical method to Balmain's work and to data collected by an impedance probe in the Space Physics Simulation Chamber at the U.S. Naval Research Laboratory. The PCEM results agree with both the observed data and the prior modeling done by Balmain. An additional consequence of the numerical study is the observation that some second-order resonances not predicted by Balmain's model can be attributed to the presence of the plasma sheath. [ABSTRACT FROM AUTHOR]

Effective mathematics education for Latinx students with learning disabilities (LD) necessitates teachers who uphold high academic expectations, facilitate access to rigorous math curricula, and champion inclusive and meaningful student participation. This study delves into teachers’ perspectives on instructing Latinx students with LD, including those identified as emergent bilinguals. Interviews were conducted with both general and special education math teachers who instruct Latinx students with LD from 3rd to 8th grades. Key findings from the study revealed a nuanced positioning of Latinx students with LD by teachers: (1) they are perceived as having potential for mathematical competence, (2) they are seen as reliant on external support, and (3) they often internalize a self-view of being less competent in math. Despite these mixed perceptions, teachers highlighted strategies to bolster the learning experience for these students, including promoting active class participation, demystifying complex math concepts, and, occasionally, modifying the curriculum. A recurring theme that was also noted was the occasional underestimation of the mathematical abilities of Latinx students with LD by educators, despite their expressed intention to support their learning journey. [ABSTRACT FROM AUTHOR]

To assess personal and work-related factors influencing the stress levels of nurses during prehospital care. Specifically, to identify associations between the level of perceived stress, the degree of professional experience, and the level of knowledge. Secondly, to examine the relationship between stress levels and violence in the work environment. And third, to investigate the main protective factors against work-related stress during prehospital care. Methods: Systematic review in PubMed, WOS, Enfispo, Cochrane, and LILACS databases following the PRISMA methodology (last search 08/Aug/2023). Following the PECO framework, studies on occupational stress factors in ambulance emergency nurses were investigated. Studies in English or Spanish, from 2013 to 2023, and only research articles were admitted, thus excluding reviews, dissertations, and grey literature. Possible bias and level evidence were assessed using critical appraisal tools and GRADE. This protocol was registered in PROSPERO with code CRD42023446080. Results: Fourteen articles were selected, and n=855 prehospital nurses were identified. One study was a clinical trial, and the others were observational and qualitative. The level of evidence was very low (n=7), low (n=6), and moderate (n=1); any study was excluded due to methodological bias. Five categories of stressors were extracted: the management of the health service (ie, workload organisation, and resources), patient care (mainly paediatric care), interpersonal stressors (relationship with peers), environmental factors (exposure to injuries), and personal factors (training, experience, and coping strategies). Violence at work is frequent for prehospital nurses, implying both verbal and physical aggressions. Support from peers was associated with positive results against stress. Conclusion: Managing workload and improving resources in the work environment are essential to reduce fatigue and allow emotional processes to be addressed. Providing workers with coping skills also imposes on them the responsibility to cope with stress. Collective awareness is the main element in reducing the incidence of stress. [ABSTRACT FROM AUTHOR]

Aubergine (Solanum melongena L.) (Solanaceae) is a widespread crop in the Mediterranean basin. Verticillium dahliae is one of the main soil-borne pathogens affecting the aubergine crop. Its control has traditionally been achieved by soil fumigation with chemical disinfectants. Restrictions on the use of chemical fumigants have led to the search for solutions in genetic resistance using rootstocks. In southeastern Spain, aubergines are grafted for the control of V. dahliae. Two Solanum torvum rootstocks (Hugo F1 and Torpedo) and a Solanum melongena hybrid (Javah F1) were tested against five isolates of V. dahliae obtained from grafted (A1 and A2) and ungrafted (Vd8, Vd17 and Vd66) aubergines compared with the susceptible cultivar Larne F1 under controlled conditions. Isolates from grafted plants infected all three rootstocks, with differences observed in the percentage of plants with symptoms and in the disease symptom severity. Three strains isolated from the ungrafted aubergines (Vd8, Vd17 and Vd66) infected Javah F1 rootstock. The Hugo F1 and Torpedo rootstocks showed a high level of resistance to V. dahliae, while Javah F1 was susceptible to the pathogen. The Hugo F1 and Torpedo rootstocks are suitable for mitigating the effects of Verticillium wilt in Mediterranean aubergine crops. Understanding the nature of the resistance from S. torvum could enhance the benefits of grafting or facilitate the introduction of resistance into commercial cultivars. [ABSTRACT FROM AUTHOR]

Background: Accurate prenatal diagnosis of cleft lip and palate is essential to discuss severity prediction, perform appropriate parental counseling, and, at last, establish long-term treatment planning. The aim of this systematic review was to analyze the accuracy of various imaging techniques for the prenatal diagnosis of cleft lip and palate, assess the pregnancy phase for orofacial clefts diagnosis, and study the different cleft types in terms of diagnostic methods, timing, and predictability. Methods: A search of the PubMed, EMBASE, Scopus, and Web of Science databases was conducted to identify potentially relevant studies published until January 2024. The quality of the selected articles was assessed using the Newcastle–Ottawa scale for methodological quality assessment of cohort studies and the QUADAS-2 scale for diagnostic test studies. Results: A total of 18 studies met the eligibility criteria and were included in the review. The findings of this review indicate that the majority of studies showed improved diagnostic accuracy when supplementary techniques, such as 3D ultrasound or magnetic resonance imaging, were added to 2D ultrasound. Conclusions: The implementation of magnetic resonance imaging as a standard procedure could significantly improve the precision of diagnosing cleft lip and palate. Therefore, the diagnostic technique used will play a crucial role in the accuracy of the diagnosis. [ABSTRACT FROM AUTHOR]

Summary: Background: Patients with cirrhosis are susceptible to develop bacterial infections that trigger acute decompensation (AD) and acute‐on‐chronic liver failure (ACLF). Infections with multidrug‐resistant organisms (MDRO) are associated with deleterious outcome. MDRO colonisation frequently proceeds MDRO infections and antibiotic therapy has been associated with MDRO colonisation. Aim: The aim of the study was to assess the influence of non‐antibiotic medication contributing to MDRO colonisation. Methods: Three hundred twenty‐four patients with AD and ACLF admitted to the ICU of Frankfurt University Hospital with MDRO screening were included. Regression models were performed to identify drugs associated with MDRO colonisation. Another cohort (n = 129) from Barcelona was included to validate. A third multi‐centre cohort (n = 203) with metagenomic sequencing data of stool was included to detect antibiotic resistance genes. Results: A total of 97 patients (30%) were identified to have MDRO colonisation and 35 of them (11%) developed MDRO infection. Patients with MDRO colonisation had significantly higher risk of MDRO infection than those without (p = 0.0098). Apart from antibiotic therapy (odds ratio (OR) 2.91, 95%‐confidence interval (CI) 1.82–4.93, p < 0.0001), terlipressin therapy in the previous 14 days was the only independent covariate associated with MDRO colonisation in both cohorts, the overall (OR 9.47, 95%‐CI 2.96–30.23, p < 0.0001) and after propensity score matching (OR 5.30, 95%‐CI 1.22–23.03, p = 0.011). In the second cohort, prior terlipressin therapy was a risk factor for MDRO colonisation (OR 2.49, 95% CI 0.911–6.823, p = 0.075) and associated with risk of MDRO infection during follow‐up (p = 0.017). The validation cohort demonstrated that antibiotic inactivation genes were significantly associated with terlipressin administration (p = 0.001). Conclusions: Our study reports an increased risk of MDRO colonisation in patients with AD or ACLF, who recently received terlipressin therapy, while other commonly prescribed non‐antibiotic co‐medications had negligible influence. Future prospective trials are needed to confirm these results. [ABSTRACT FROM AUTHOR]

The variability of solar radiation presents significant challenges for the integration of solar photovoltaic (PV) energy into the electrical system. Incorporating battery storage technologies ensures energy reliability and promotes sustainable growth. In this work, an energy analysis is carried out to determine the installation size and the operating setpoint with optimal constant monthly power through an iterative calculation process, considering various operating setpoints and system parameters. A degradation model is integrated according to the curves offered by battery manufacturers and the charge–discharge cycles are calculated using the rainflow method to guarantee a reliable analysis of the plant. Through massive data analysis in a long-term simulation, indicators are generated that allow for establishing a relationship between the energy unavailability of the system and the BESS dimensions. [ABSTRACT FROM AUTHOR]

• Issues on Dengvaxia resulted in decline in children's vaccination. • Mostly women, those in rural areas, and those with low income held negative perceptions. • Majority of the information on Dengvaxia came from media sources, particularly television. • Information from health professionals protect against negative vaccine perception. • Inadequate functional health literacy is a risk for negative vaccination perception. Issues that arose from the Dengvaxia vaccination program in the Philippines in 2017 were followed by a remarkable decline in immunization coverage in the country. This study intended to describe the Filipinos' perceptions about vaccination after hearing about the Dengvaxia vaccine and the vaccination program and determine its potential relationship with selected demographic factors and other variables such as: health literacy, sources of information on Dengvaxia, information heard about the vaccine, healthcare visits, and perceived health status. The study utilized secondary data derived from a national health literacy survey in the Philippines. A total of 1992 respondents were included in the analysis. Majority were females, had reached college, residing in urban areas, and were unemployed. Most obtained information about Dengvaxia from media, particularly the television and heard that it caused death and prevents dengue. Seventy-one per cent had negative vaccination perception upon obtaining information about Dengvaxia. Sex, residence type, and income were found to be associated with vaccination perception. Females and those living in rural areas were more likely to have a negative vaccination perception while those with the highest income were less likely to have negative vaccination perception. Respondents who heard that Dengvaxia prevents dengue, those who obtained Dengvaxia information from health professionals, and those who visited both public and private health facilities in the last 12 months were less likely to have negative vaccination perception. On the other hand, those with inadequate functional health literacy were more likely to have negative vaccination perception. The study presents the implications of information heard about Dengvaxia on Filipinos' perception on vaccination through selected variables and other factors. The findings are important in designing strategies in communicating health information, building public trust, and in reinforcing policies to improve vaccination uptake. [ABSTRACT FROM AUTHOR]

This study aims to determine if there is a significant difference in attitudes toward elective abortion as a social taboo among young adults when considering their religious affiliation and their extent of religious adherence by drawing from the Social Learning Theory and the Moral Communities Hypothesis. The findings highlight the importance of recognizing the diverse attitudes toward elective abortion among individuals within the predominantly Catholic Philippines. A self-administered online survey questionnaire was utilized in this study. A non-probability convenience sampling method was employed ensuring the major religious groups are represented. To examine whether an attitudinal variation exists when considering religious affiliation and the extent of religious adherence among the sample population of sixty (n = 60), a chi-square (χ²) test of independence was employed. The same was done considering the classificatory variables of sex and marital status. The results showed that attitudes toward elective abortion varied significantly among respondents when considering their religious affiliations (p = < .001), and when dichotomized into Catholic and non-Catholic groups, proportions still varied significantly (p = < .001), with most of the Catholic respondents exhibited a pro-choice attitude. Conversely, most of the non-Catholic respondents exhibited a pro-life attitude. Likewise, attitudes toward elective abortion varied significantly among respondents when considering their extent of religious adherence (p = < .001). Understanding this diversity is crucial for evidence-based policy recommendations and interventions related to bodily autonomy and sexual and reproductive rights, as well as for promoting transparency and well-informed discussion on taboos such as abortion. [ABSTRACT FROM AUTHOR]

Methylmalonic acid (MMA) is a byproduct of propionate metabolism linked to vitamin B12 deficiency. MMA alters cellular metabolism through direct regulation of metabolic enzymes. MMA activates succinate receptor 1 and drives inflammation. MMA acts as a signaling molecule through methylmalonylation of proteins. MMA is linked to the development of several age-related chronic disorders. Metabolic byproducts have conventionally been disregarded as waste products without functions. In this opinion article, we bring to light the multifaceted role of methylmalonic acid (MMA), a byproduct of the propionate metabolism pathway mostly commonly known as a clinical biomarker of vitamin B12 deficiency. MMA is normally present at low levels in the body, but increased levels can come from different sources, such as vitamin B12 deficiency, genetic mutations in enzymes related to the propionate pathway, the gut microbiota, and aggressive cancers. Here, we describe the diverse metabolic and signaling functions of MMA and discuss the consequences of increased MMA levels, such as during the aging process, for several age-related human pathologies. [ABSTRACT FROM AUTHOR]

The unique dynamic configuration of an enantioselective chiral‐at‐metal catalyst based on Rh(III) and a non‐chiral tetradentate ligand is described and resolved. At room temperature, the catalyst undergoes a dynamic configuration process leading to the formation of two interconvertible metal‐stereoisomers, remarkably without racemization. Density functional theory (DFT) calculations indicate that this metal‐isomerization proceeds via a concerted transition state, which features a trigonal bipyramidal geometry stabilized by the tetradentate ligand. Furthermore, the resolved enantiopure complex shows high catalytic enantioinduction in the Friedel‐Crafts reaction, achieving enantiomeric ratios as high as 99 : 1. [ABSTRACT FROM AUTHOR]

Fruit logistics during harvesting involves a large-scale deployment of material and human resources. In olive groves and, for small producers, the operation can be carried out in different ways, however, none of these allow a production monitoring or traceability of the harvested fruit. This study presents a compatible methodology with the usual harvesting logistics employed for harvest monitoring. The procedure uses a mechanical system for loading and unloading big bags of fruit weighing approximately 200 kg with a loading arm that can be adapted to a conventional trailer. An electronic system connected to a cloud application is installed on the trailer for geo-referenced recording of the yield. Tests to determine the accuracy of the Global Navigation Satellite System (GNSS) reported values of around 19 mm and 590 mm for the system with and without corrections, respectively, using the Networked Transport of RTCM via Internet Protocol (NTRIP). The error determination tests of the loading bolt weighing system showed high accuracy and linearity with a mean absolute error of 1.1 ± 0.99 kg. The complete system was tested in a traditional olive grove and an intensive olive grove. The harvest maps generated allowed the yield visualisation and to keep a traceability record of the harvested fruit batches. Application of the proposed methodology and systems presents a reduced operation time between loading and unloading of consecutive fruit batches (~ 2.5 min). The proposed system would be useful for small producers with limited resources who need to control production and fruit traceability on their farm. [ABSTRACT FROM AUTHOR]

"Fantasy: How It Works" by Brian Attebery challenges traditional notions of fantasy literature by exploring its meaning and purpose rather than providing a strict definition. The book delves into various aspects of fantastic storytelling and worldbuilding, emphasizing their interconnectedness. Attebery also examines the intertextual nature of fantasy literature and highlights the influence of science fiction. The review suggests that the book will be valuable for scholars studying utopian and dystopian literature. Overall, "Fantasy: How It Works" offers multiple interpretations of fantasy literature and encourages readers to reconsider its significance in the field of literary scholarship. [Extracted from the article]

Background: Ball possessions and game rhythm are promising variables to better understand teams' collective behaviour during a basketball game. However, the role of these variables is not well documented in teams with intellectual impairments (II). This study aimed to explore ball possession and game rhythm differences between II and non‐II basketball games. Methods: Data were obtained through video observations (53 II games) and the International Basketball Federation records (53 non‐II games). Results: Independent t‐tests (P ≤ 0.05) revealed that the number of ball possessions was higher and game rhythm was faster in II games. Two‐way repeated‐measures analysis of variance (P ≤ 0.05) showed that ball possessions and game rhythm developed differently throughout the II games compared with the non‐II games. Conclusions: The differences may be due to the decision‐making, tactical and self‐regulatory limitations of players with II. These limitations adequately explain why players with II respond differently to the environmental cues and monitor insufficiently their actions compared with players without II. Additionally, the higher number of ball possessions and the faster game rhythm in II games could be an indicator of more intuitive, and thus faster, game‐related decision‐making. In conclusion, the study provides further understanding of the role of cognition in basketball and contributes to better explain the differences between II and non‐II games. [ABSTRACT FROM AUTHOR]

A unique component of early childhood involves understanding how caregivers and educators promote children's developmental outcomes, with play opportunities being a key avenue for enhancing these skills. Targeted coaching is one type of support that can tap into active family engagement during playful learning. This collective case study examined how remote-based eCoaching could support family-centered practices related to the facilitation of pretend play in caregivers of preschool children in the home setting. Four mother–child dyads of preschool children, with and without a disability, participated in eCoaching focusing on pretend play behaviors. During the implementation of eCoaching, three primary findings emerged related to knowledge acquisition, mothers' facilitation of play with their children, and changes in children's pretend play behaviors. In general, both mothers and children benefited from the eCoaching experience. In addition, mothers' perceptions of eCoaching as a means of family-based support were positive, and all deemed eCoaching easy to engage in and beneficial. [ABSTRACT FROM AUTHOR]

In Spain there is a high incidence of in-work poverty, which has not changed much after the so-called Great Recession, despite its strong impact on the economy and the labour market. The first objective of this article is to analyse the evolution of poverty during the economic cycle between the previous crisis and the period immediately prior to the COVID-19 pandemic, using indicators with a poverty line anchored at the beginning of that period. This addresses the relative nature of the official indicator, which is calculated for each year, preventing it from capturing changes in the incidence of poverty over time. A second objective is to determine which dimensions are most relevant for in-work poverty and its evolution. Thus, in-work poverty is conceptualised as a phenomenon composed of an individual and a household reality, distinguishing between individual poverty (low-pay situations), household poverty (coming from in-work poverty statistics), and severe poverty (the conjunction of family poverty and low pay). In addition, the last purpose is to analyse the influence of economic cycles, both on the weight of each of the types of in-work poverty and on the factors that explain them, exploring which groups suffered most from the Great Recession and whether this was a temporary situation. Our findings were mainly threefold. First, in 2019, just before the COVID crisis, in-work poverty rates had not recovered from the previous crisis, especially in the case of severe poverty. Second, individual in-work poverty declines during the crisis, associated with an increase in the overall unemployment rate and a parallel increase in severe poverty, but partially recovers in 2019. Third, the most severe type of in-work poverty, where the individual and household dimension converge, has similar characteristics to household in-work poverty, mainly influence by the presence of children and single-parent families. [ABSTRACT FROM AUTHOR]

Intellectual property (IP) management has posed continuous problems in the digital world, so understanding its associated concepts and the particularities they present is crucial. Within artificial intelligence (AI), machine learning (ML) and natural language processing (NLP) have enabled the intelligent processing and analysis of large volumes of data, making them widely used tools. In order to help fill the research gap that exists due to the novelty of the concepts, a bibliometric analysis is proposed of 404 scientific documents linked to AI, ML, NLP and IP, extracted from the Web of Science (WoS) core collection repository. The results demonstrate a current trend in research on the management of IP, related to digital tools and highlight the issues that arise from the management of IP stemming from their use. This research also identifies how these tools have been used to facilitate the management and identification of IP. In this sense, this study brings originality to the field of intellectual property management by examining previous studies and proposing new avenues for future research, thus broadening the current understanding of the subject. Entrepreneurs and business leaders can benefit from this study as it uncovers the complexities of IP management and thus enhances understanding of the opportunities and challenges in the AI era. [ABSTRACT FROM AUTHOR]

Recent developments in deep learning have shown success in accurately predicting the location of biological markers in Optical Coherence Tomography (OCT) volumes of patients with Age-Related Macular Degeneration (AMD) and Diabetic Retinopathy (DR). We propose a method that automatically locates biological markers to the Early Treatment Diabetic Retinopathy Study (ETDRS) rings, only requiring B-scan-level presence annotations. We trained a neural network using 22,723 OCT B-Scans of 460 eyes (433 patients) with AMD and DR, annotated with slice-level labels for Intraretinal Fluid (IRF) and Subretinal Fluid (SRF). The neural network outputs were mapped into the corresponding ETDRS rings. We incorporated the class annotations and domain knowledge into a loss function to constrain the output with biologically plausible solutions. The method was tested on a set of OCT volumes with 322 eyes (189 patients) with Diabetic Macular Edema, with slice-level SRF and IRF presence annotations for the ETDRS rings. Our method accurately predicted the presence of IRF and SRF in each ETDRS ring, outperforming previous baselines even in the most challenging scenarios. Our model was also successfully applied to en-face marker segmentation and showed consistency within C-scans, despite not incorporating volume information in the training process. We achieved a correlation coefficient of 0.946 for the prediction of the IRF area. [ABSTRACT FROM AUTHOR]

Carlos V will play an important role in the educational panorama of the 16th century. He will be a key piece for the emergence of new institutions, he will intervene in others with an already consolidated trajectory and he will found three universities of which he will be patron: Granada, in 1526, and Mexico and Lima, both in 1551. In order to determine How the founding memory of the Carolina universities survives today, the study of the different shields used by them during their history has been undertaken. [ABSTRACT FROM AUTHOR]

Determining the treatment of subtalar joint (STJ) instability requires a better understanding of the biomechanical principles underlying the condition and, a proper diagnosis. This study aimed to analyze "in vivo" the range of motion of the subtalar joint (STJ) measured on two (2D) and three dimensions (3D) image-based on CT Scan using an original device that maintains a simulated weightbearing. The secondary goal was to correlate the 2D and 3D measurement. An observational study was conducted, using an original Dynamic Simulated Weightbearing Device. Asymptomatic ankles were included. Each subject underwent a CT scan under mechanical stress and simulated weightbearing conditions, maintaining maximum eversion and inversion hindfoot positions. The images were obtained, combining both inversion and eversion positions in a single model, which allows for to calculation of the motion vector as well as the helical axis. The helical axis (rotation angle and translation distance), subtalar tilt, anterior drawer, and, subtalar and calcaneocuboid uncoverage were the determinations. Forty asymptomatic ankles were included. The average range of motion of the STJ amounts to 31.5° ± 9.1° of rotation and 1.56 ± 0.8 mm of translation distance. The anterior drawer and subtalar uncoverage variables were statistically significantly related to each other (r = 0.57; P = 0.00001). However, these 2-D measured variables were not related to kinematic measures of rotation through the helical axis (3D) (p = 0.14; p = 0.19) The average range of motion of the STJ amounts to 31.5° ± 9.1° of rotation and 1.56 ± 0.8 mm of translation distance. We found no significant correlation between 2D and 3D measurements. In our opinion, the rotation angle and translation distance should be considered the most accurate measurements and should be calculated on every STJ instability for comparison with the asymptomatic population Observational study. Level of evidence III [ABSTRACT FROM AUTHOR]

The production of clinical-grade recombinant adeno-associated viral (AAV) vectors for gene therapy trials remains a major hurdle in the further advancement of the gene therapy field. During the past decades, AAV research has been predominantly focused on the development of new capsid modifications, vector-associated immunogenicity, and the scale-up vector production. However, limited studies have examined the possibility to manipulate non-structural components of AAV such as the Rep genes. Historically, naturally isolated, or recombinant library-derived AAV capsids have been produced using the AAV serotype 2 Rep gene to package ITR2-flanked vector genomes. In the current study, we mutated four variable amino acids in the conservative part of the binding domain in AAV serotype 6 Rep to generate a Rep2/6 hybrid gene. This newly generated Rep2/6 hybrid had improved packaging ability over wild-type Rep6. AAV vectors produced with Rep2/6 exhibited similar in vivo activity as standard AAV6 vectors. Furthermore, we show that this Rep2/6 hybrid also improves full/empty capsid ratios, suggesting that Rep bioengineering can be used to improve the ratio of fully encapsulated AAV vectors during upstream manufacturing processes. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic and health services impacts related to physical distancing posed many challenges for older adults with cancer. The goal of this study was to examine the impact of the pandemic on cancer treatment plans and cancer treatment experiences of older adults (ie, aged 65 years and older) and their caregiver' experiences of caring for older adults during the pandemic to highlight gaps in care experienced. In this multi-centre qualitative study guided by an interpretive descriptive research approach we interviewed older adults diagnosed with cancer and caregivers caring for them. Participants were recruited via cancer treatment centres in the provinces of British Columbia and Ontario (Vancouver and Toronto), Canada, and through an online ad sent out through patient advocacy organization newsletters. Interviews were recorded and transcribed verbatim and data were analyzed using an interpretive thematic analysis approach. A total of 27 individuals (17 older adults, 52.9% female; 10 caregivers, 90% female) participated in interviews lasting on average 45 minutes. Older adults with cancer described many impacts and pressures created by the pandemic on their cancer experiences, though they generally felt that the pandemic did not impact treatment decisions made and access to care. We grouped our findings into two main themes with their accompanying sub-themes, related to: (1) alterations in the individual and dyadic cancer experience; and (2) navigating health and cancer systems during the pandemic. The additional stressors the pandemic placed on older adults during their treatment and decision-making process and their caregivers expose the need to create or avail additional supports for future disruptions in care. [ABSTRACT FROM AUTHOR]

The type III secretion system (T3SS) is a specialized nanomachine that enables bacteria to secrete proteins in a specific order and directly deliver a specific set of them, collectively known as effectors, into eukaryotic organisms. The core structure of the T3SS is a syringe‐like apparatus composed of multiple building blocks, including both membrane‐associated and soluble proteins. The cytosolic components organize together in a chamber‐like structure known as the sorting platform (SP), responsible for recruiting, sorting, and initiating the substrates destined to engage this secretion pathway. In this article, we provide an overview of recent findings on the SP's structure and function, with a particular focus on its assembly pathway. Furthermore, we discuss the molecular mechanisms behind the recruitment and hierarchical sorting of substrates by this cytosolic complex. Overall, the T3SS is a highly specialized and complex system that requires precise coordination to function properly. A deeper understanding of how the SP orchestrates T3S could enhance our comprehension of this complex nanomachine, which is central to the host‐pathogen interface, and could aid in the development of novel strategies to fight bacterial infections. [ABSTRACT FROM AUTHOR]

Fibromyalgia is a widespread chronic condition characterized by pain and fatigue. Among the long list of physiological disturbances linked to this syndrome, mitochondrial imbalance and oxidative stress stand out. Recently, the crosstalk between mitochondria and intestinal microbiota has caught the attention of biomedical researchers, who have found connections between this axis and several inflammatory and pain-related conditions. Hence, this pilot descriptive study focused on characterizing the mitochondrial mass/mitophagy ratio and total antioxidant capacity in PBMCs, as well as some microbiota components in feces, from a Peruvian cohort of 19 females and 7 males with FM. Through Western blotting, electrochemical oxidation, ELISA, and real-time qPCR, we determined VDAC1 and MAP1LC3B protein levels; total antioxidant capacity; secretory immunoglobulin A (sIgA) levels; and Firmicutes/Bacteroidetes, Bacteroides/Prevotella, and Roseburia/Eubacterium ratios; as well as Ruminococcus spp., Pseudomonas spp., and Akkermansia muciniphila levels, respectively. We found statistically significant differences in Ruminococcus spp. and Pseudomonas spp. levels between females and males, as well as a marked polarization in mitochondrial mass in both groups. Taken together, our results point to a mitochondrial imbalance in FM patients, as well as a sex-dependent difference in intestinal microbiota composition. [ABSTRACT FROM AUTHOR]

Plasma impedance probes (PIPs) are a type of RF probe that primarily measures electron density. This work introduces two advancements: a streamlined analytical model for interpreting PIP-monopole measurements and techniques for achieving ≥ 1 MHz time-resolved PIP measurements. The model's improvements include introducing sheath thickness as a measurement and providing a more accurate method for measuring electron density and damping. The model is validated by a quasi-static numerical simulation, which compares the simulation with measurements, identifies sources of error, and provides probe design criteria for minimizing uncertainty. The improved time resolution is achieved by introducing higher-frequency hardware, updated analysis algorithms, and a more rigorous approach to RF calibration. Finally, the new model and high-speed techniques are applied to two datasets: a 4 kHz plasma density oscillation resolved at 100 kHz with densities ranging between 2 × 1014 and 3 × 1015 m−3, and a 150 kHz oscillation resolved at 4 MHz with densities ranging between 4 × 1014 and 6 × 1014 m−3. [ABSTRACT FROM AUTHOR]

Photovoltaic generation is one of the key technologies in the production of electricity from renewable sources. However, the intermittent nature of solar radiation poses a challenge to effectively integrate this renewable resource into the electrical power system. The price reduction of battery storage systems in the coming years presents an opportunity for their practical combination with utility-scale photovoltaic plants. The integration of properly sized photovoltaic and battery energy storage systems (PV-BESS) for the delivery of constant power not only guarantees high energy availability, but also enables a possible increase in the number of PV installations and the PV penetration. A massive data analysis with long-term simulations is carried out and indicators of energy unavailability of the combined system are identified to assess the reliability of power production. The proposed indicators allow to determine the appropriate sizing of the battery energy storage system for a utility-scale photovoltaic plant in a planning stage, as well as suggest the recommended operating points made for each month through a set of graphs and indicators. The presence of an inflection zone has been observed, beyond which any increase in storage does not generate significant reductions in the unavailability of energy. This critical zone is considered the sweet spot for the size of the storage, beyond which it is not sensible to increase its size. Identifying the critical point is crucial to determining the optimal storage size. The system is capable of providing reliable supply of constant power in monthly periods while ensuring capacity credit levels above 95%, which increases the penetration of this renewable resource. Despite the fact that the study focuses exclusively on the analysis from an energy perspective, it is important to consider the constraints associated to real storage systems and limit their oversizing. [ABSTRACT FROM AUTHOR]

The Santander Foundation has published the book "Twelve Lyrics for a New World", edited by Francisco Javier Expósito Lorenzo. The book brings together twelve recognized poets, such as Antonio Colinas, Aurora Luque, and Carlos Pardo, who respond to the question "Where is the human being heading?". Each poet contributes with a collection of poems that address topics such as the pandemic and human consciousness. The book seeks to reflect on the role of poetry and its ability to illuminate our path in a threatened world. The text explores the difference between the historian's perspective and that of the poet. While the historian seeks to understand events through the experiences and testimonies of others, the poet looks back and within themselves. The poet does not need the vision of the ordinary man, but rather contemplates with the eyes of the spirit. The poet does not create, but rather finds and discovers the poem. The text also highlights that the reader is the true author of the poem, as each reader interprets the poem in their own way. The poet summons the reader and claims their space for poetry. [Extracted from the article]

Auxetic materials are known for their unique ability to expand/contract in multiple directions when stretched/compressed. In other words, they exhibit a negative Poisson's ratio, which is usually positive for most of materials. This behavior appears in some biological tissues such as human skin, where it promotes wound healing by providing an enhanced mechanical support and facilitating cell migration. Skin tissue engineering has been a growing research topic in recent years, largely thanks to the rapid development of 3D printing techniques and technologies. The combination of computational studies with rapid manufacturing and tailored designs presents a huge potential for the future of personalized medicine. Overall, this review article provides a comprehensive overview of the current state of research on auxetic constructs for skin healing applications, highlighting the potential of auxetics as a promising treatment option for skin wounds. The article also identifies gaps in the current knowledge and suggests areas for future research. In particular, we discuss the designs, materials, manufacturing techniques, and also the computational and experimental studies on this topic. [ABSTRACT FROM AUTHOR]

Direct evidence for Palaeolithic sound-making instruments is relatively rare, with only a few examples recorded from Upper Palaeolithic contexts, particularly in European cultures. However, theoretical considerations suggest that such artefacts have existed elsewhere in the world. Nevertheless, evidence for sound production is tenuous in the prehistoric archaeological record of the Levant, the study of music and its evolution being sparsely explored. Here we report new evidence for Palaeolithic sound-making instruments from the Levant with the discovery of seven aerophones made of perforated bird bones in the Final Natufian site of Eynan-Mallaha, Northern Israel. Through technological, use-wear, taphonomic, experimental and acoustical analyses, we demonstrate that these objects were intentionally manufactured more than 12,000 years ago to produce a range of sounds similar to raptor calls and whose purposes could be at the crossroads of communication, attracting hunting prey and music-making. Although similar aerophones are documented in later archaeological cultures, such artificial bird sounds were yet to be reported from Palaeolithic context. Therefore, the discovery from Eynan-Mallaha contributes new evidence for a distinctive sound-making instrument in the Palaeolithic. Through a combined multidisciplinary approach, our study provides important new data regarding the antiquity and development of the variety of sound-making instruments in the Palaeolithic at large and particularly at the dawn of the Neolithic in the Levant. [ABSTRACT FROM AUTHOR]

This study investigated the changes that occur in mothers' language and interactions with their preschool-aged children who have language difficulties when a Spanish language-based intervention was provided within their homes. The intervention was provided using toys and routines that existed within their homes. Three Spanish speaking mothers of Mexican descent participated alongside their preschool children in a language-based intervention. The mothers were interviewed before and after the intervention to understand their experiences and perceptions. They were video recorded interacting with their children during play-based events to document language events between the mothers and their child. Study findings demonstrated that mothers changed in their use of language strategies and had positive opinions about the intervention. To build on culturally responsive interventions, specific factors were identified to promote a positive experience when working with Mexican immigrant mothers. [ABSTRACT FROM AUTHOR]

Background: Different causes may be responsible for delayed inflammatory reactions after hyaluronic acid injections, among them several mechanisms of SARS‐CoV‐2. Aims: The study's objective was to assess the percentage of adverse reactions after hyaluronic acid injections in a cohort of adult patients with a test for SARS‐CoV‐2 or vaccinated during the COVID‐19 pandemic. Patients/Methods: An observational, retrospective, comparative, multi‐center, non‐interventional in a real‐life setting study was carried out with patients treated with facial injections of hyaluronic acid from May to September 2021, with a test to discard SARS‐COV 2 or that had been vaccinated. Results: Sixty‐three patients were included. Seven (11.1%) were vaccinated patients without a test for SaRS‐CoV‐2 and 56 (88.9%) with antigenic or PCR screening tests (18 [32.1%] negative and 39 [69.6%] positives for COVID‐19). The mean age was 51.3 (SD 12.71; range 23–70), and 57 (90.5%) were female. Twenty‐three patients (36.5%) had a history of adverse events with hyaluronic acid injections. During the study, 15 adverse events were reported; 11 patients (73.3%) had a history (p = 0.0018); two patients (13.3%) had been vaccinated; 13 (86.7%) had performed a SARS‐CoV2 test (six [46.2%] negatives, and seven [53.8%] with a positive result; p = 0.5969). All adverse study events were resolved, and none had sequelae. Conclusion: Adverse events after hyaluronic acid facial injections were higher among patients with a history but not among those diagnosed with COVID‐19. The new scenario related to COVID‐19 infections or vaccinations would require readapting criteria for applying hyaluronic acid injections. [ABSTRACT FROM AUTHOR]

Background: With a number of vaccines against COVID-19 now widely available globally, it is opportune to determine what tips the decision to get vaccinated. In most countries like the Philippines where the government provides these vaccines for free to all its citizens, their COVID-19 vaccine awareness and COVID-19 information sources as well as their socio-demographic profile were considered as primary factors that could possibly affect vaccination decisions. Participants' income level was considered as a possible financial consideration that can affect vaccination decision as transport to vaccination sites might entail costs to them. Methods: This study used a cross sectional survey design wherein participants came from all regions of the Philippines. An online questionnaire was voluntarily answered by Filipinos aged 18–80 years of age. Results: A total of 2,268 participated in the survey with 1,462 having complete responses which were included in the analysis. Those who are younger, with higher educational attainment, with public health insurance, with employers requiring vaccination, high awareness about COVID-19 vaccination, and high vaccine confidence are more likely to get vaccinated. On the other hand, those with long-standing illness and those residing outside the national capital region are less likely to get vaccinated. Conclusion: Vaccination decisions among Filipinos are determined by their age, educational attainment, health insurance, employer requirement, high awareness of the disease, and a high level of vaccine confidence. [ABSTRACT FROM AUTHOR]

Through the design of a survey and measure validation using exploratory factor analysis (EFA), we aimed to identify and define constructs required for special education teacher leadership that may inform the focus of professional development opportunities. Results of the analysis indicate a four-factor model is best suited for measuring special education teacher leadership capacity at the individual level. The teacher leadership domains that were defined through the EFA were as follows: (a) pedagogical confidence, (b) ethical considerations, (c) collaboration, and (d) assessment practices. Additionally, we identify differences between general and special education teacher identification of leadership skills, which can assist in targeting professional development to the specific needs of special education teachers that differ from general educators. Implications for research and professional development are presented to improve our understanding of and preparation of special teacher leadership. Through this work, we present a teacher leadership framework for the professional development of special education teacher leadership. [ABSTRACT FROM AUTHOR]

In spinal muscular atrophy (SMA), mutations in or loss of the Survival Motor Neuron 1 (SMN1) gene reduce full-length SMN protein levels, which leads to the degeneration of a percentage of motor neurons. In mouse models of SMA, the development and maintenance of spinal motor neurons and the neuromuscular junction (NMJ) function are altered. Since nifedipine is known to be neuroprotective and increases neurotransmission in nerve terminals, we investigated its effects on cultured spinal cord motor neurons and motor nerve terminals of control and SMA mice. We found that application of nifedipine increased the frequency of spontaneous Ca2+ transients, growth cone size, cluster-like formations of Cav2.2 channels, and it normalized axon extension in SMA neurons in culture. At the NMJ, nifedipine significantly increased evoked and spontaneous release at low-frequency stimulation in both genotypes. High-strength stimulation revealed that nifedipine increased the size of the readily releasable pool (RRP) of vesicles in control but not SMA mice. These findings provide experimental evidence about the ability of nifedipine to prevent the appearance of developmental defects in SMA embryonic motor neurons in culture and reveal to which extent nifedipine could still increase neurotransmission at the NMJ in SMA mice under different functional demands. [ABSTRACT FROM AUTHOR]

Introduction: Hallux valgus (HV) deformity affects the orientation of the metatarsophalangeal (MTP) joint in three planes. Displacement in the coronal plane results in axial rotation of the first metatarsal, with progressive subluxation of the first MTP joint. Multiple techniques have been described to correct the malrotation itself. However, none of them have checked intraoperatively the final position of the first metatarsal head and sesamoids previous to the fixation of the Lapidus procedure or first metatarsal bone osteotomies. The aim of this article is to describe a novel technique to check the first ray rotation and sesamoids position through sonographic assistance. Materials and methods: Before fixation of the Lapidus procedure, with the ankle in maximal dorsiflexion, the surgeon takes the linear ultrasound probe and places it on the sole to visualize the sesamoids, which should be viewed at the same level, with the flexor hallucis longus (FHL) centered between both. Once the ideal position of the head of the first ray has been achieved, temporary fixation with K-wires is performed over the first TMT joint and M1–M2 joint for further sonographic verification of the sesamoids beneath the first metatarsal head. The height of the sesamoids relative to the second metatarsal head should be checked by sonographic control too. Results: Four patients were included. Three females and one male. Their mean age was 76.4 years (R 61–72). Their mean BMI was 29 (R 27.5–32.24). The mean IMA (intermetatarsal angle) was 18.2 (R 17.2–19) degrees and the mean MPA (metatarsophalangeal angle) was 50 (R 36–63) degrees. Conclusions: Sonographic assistance, is a widely available, inexpensive, and comparative imaging technique that can guide the first ray rotation and sesamoids position in HV surgery, theoretically improving radiological outcomes. [ABSTRACT FROM AUTHOR]

This study assessed an innovative temporary edge protection system (TEPS) designed and developed to improve the ergonomics, health and safety at trench works in the construction industry, which ranks as one of the most hazardous worldwide. A wooden prototype of this innovative TEPS was built, and its mechanical resistance was compared to a conventional one. Thereafter, field tests were carried out to evaluate the efficacy of this pioneering TEPS. Both in analytical studies and field tests, the mechanical resistance to static loads of the TEPS complied with EU standards, and outperformed the conventional TEPS. The novel TEPS is effective as fall protection for different trench shoring systems and in buildings without edge protection systems. Moreover, this novel lightweight TEPS is easy to transport, with simple and safe on-site installation. [ABSTRACT FROM AUTHOR]

Sequencing of B-cell and T-cell immune receptor repertoires helps us to understand the adaptive immune response, although it only provides information about the clonotypes (lineages) and their frequencies and not about, for example, their affinity or antigen (Ag) specificity. To further characterize the identified clones, usually with special attention to the particularly abundant ones (dominant), additional time-consuming or expensive experiments are generally required. Here, we present an extension of a multiscale model of the germinal center (GC) that we previously developed to gain more insight in B-cell repertoires. We compare the extent that these simulated repertoires deviate from experimental repertoires established from single GCs, blood, or tissue. Our simulations show that there is a limited correlation between clonal abundance and affinity and that there is large affinity variability among same-ancestor (same-clone) subclones. Our simulations suggest that low-abundance clones and subclones, might also be of interest since they may have high affinity for the Ag. We show that the fraction of plasma cells (PCs) with high B-cell receptor (BcR) mRNA content in the GC does not significantly affect the number of dominant clones derived from single GCs by sequencing BcR mRNAs. Results from these simulations guide data interpretation and the design of follow-up experiments. [ABSTRACT FROM AUTHOR]

This study compiles and updates the checklist of ferns and lycophytes from the Sierra Madre Occidental (SMOc). For this, we revised information on these taxa from regional floristic studies, databases, and herbaria. Our updated list includes 312 species, of which 276 are ferns and 36 are lycophytes integrated into 27 families and 75 genera. The richest families are Pteridaceae (118), Polypodiaceae (31), Selaginellaceae (30), Aspleniaceae (25), and Dryopteridaceae (25). The three most diverse genera were Selaginella (30), Asplenium (25), and Myriopteris (22). The species-rich Mexican states that include the SMOc are Durango (166 species), Chihuahua (149), and Jalisco (146). As in other tropical mountains, species richness in the SMOc is concentrated at the elevation interval of 1500 to 2000 m (236 species). The mid-mountain vegetation forests (Quercus and Pinus-Quercus forests) harbor the most pteridoflora richness (52% of the species). Four species of ferns are listed as threatened in the Mexican Official Norm NOM-059-SEMARNAT-2010, 17 species are listed in the IUCN, and only one tree ferns are in CITES. The SMOc has a Nearctic affinity, and its fern and lycophyte diversity are lower than in other Mexican Transition Zone mountain chains, such as the Sierra Madre del Sur, the Trans-Mexican Volcanic Belt, and the Sierra Madre Oriental. Notwithstanding, its biological composition is unique and distinctive. The species number reported in the SMOc represents 31% of the pteridoflora diversity recorded in Mexico. [ABSTRACT FROM AUTHOR]

Recession of environmental barrier coatings (EBC) in environments containing steam is a pressing concern that requires further research before their implementation in gas turbine engines can be realized. In this work, free-standing plasma-sprayed Yb2Si2O7 coatings were exposed to flowing steam at 1350 and 1400 °C for 96 h. Three samples were investigated, one coating with a low porosity level (< 3%) and 1 wt.% Al2O3 representing traditional EBCs porosity levels; and two coatings with higher porosity levels (~ 20%) representing abradable EBCs. Phase composition and microstructural evolution were studied in order to reveal the underlying mechanism for the interaction between high temperature steam and ytterbium disilicate. The results show depletion of Yb2SiO5 near the surface and formation of ytterbium garnet (Yb3Al5O12) on top of all three coatings due to the reaction with gaseous Al-containing impurities coming from the alumina furnace tubes. The 1 wt.% Al2O3 added to the EBC sample exacerbated the formation of garnet at 1400 °C compared to the abradable samples, which presented lower quantities of garnet. Additionally, inter-splat boundaries were visible after exposure, indicating preferential ingress of gaseous Al-containing impurities through the splat boundaries. [ABSTRACT FROM AUTHOR]

Active motion examination of patients with cervical spine-related pathologies is necessary to establish baseline function, set physical therapy goals, and choose interventions. This study investigated the sagittal plane active range of motion (ROM) of the global (GCS) and upper cervical spine (UCS) in relation to age and sex in healthy volunteers. One hundred twenty-two volunteers aged 18 to 75 years participated. Volunteers were excluded if they displayed any characteristic that could affect cervical spine ROM. GCS and UCS flexion and extension were each measured three times using a CROM device. Linear regression models (LRMs) were developed to explore the relationships between age and sex and GCS and UCS ROM. The LRM for age showed a decrease in GCS flexion (−2.01°), GCS extension (−3.33°), and UCS extension (−1.87°) for every decade of increasing age. The LRM for sex showed that men displayed less ROM than women in GCS extension (−6.52°) and UCS extension (−2.43°). These results suggest an age-related loss of sagittal plane GCS ROM and UCS extension ROM, and sex-related differences in GCS and UCS extension with women having greater motion than men. [ABSTRACT FROM AUTHOR]

There is a controversy regarding when it is appropriate to apply the irrigation restriction in almond trees (Prunus dulcis Mill.) to save water without penalizing yield. We hypothesized that knowing when plants demand fewer photoassimilates would be a good indicator of less sensitivity of the crop to water deficit. One parameter that defines the photosynthetic capacity is the triose phosphate utilization (TPU). Due to its connection to the export of sugars from the leaves to other sink organs, it is a good candidate for being such an indicator. The objective was to analyze the seasonal evolution of the photosynthetic capacity of three almond cultivars (cvs Guara, Marta and Lauranne) subjected to water stress during vegetative, kernel-filling and postharvest stages. Two sustained deficit irrigation (SDI) treatments (SDI75 and SDI65 with water reductions of 25 and 35%, respectively) and a control treatment (FI) consisting of fully irrigated trees were applied. The response of curves AN-Ci was analyzed to assess the maximum carboxylation rate (Vcmax), maximum rate of electron transport (Jmax), TPU and mesophyll conductance to CO2. In addition, leaf water potential and yield were measured. Our experimental findings showed any significant differences in the variables analyzed among cultivars and irrigation treatments. However, consistent differences arose when the results were compared among the phenological stages. During the kernel-filling and the postharvest stages, a progressive limitation by TPU was measured, suggesting that the demand for photoassimilates by the plant was reduced. This result was supported by the correlation found between TPU and fruit growth rate. As a consequence, a downregulation in Jmax and Vcmax was also measured. This study confirms that the kernel-filling stage might be a good time to apply a reduction in the irrigation and suggests a method to detect the best moments to apply a regulated deficit irrigation in almond trees. [ABSTRACT FROM AUTHOR]

Alcohol-related liver disease (ALD) represents one of the leading causes of chronic liver disease and is a major cause of liver-related deaths worldwide. ALD encompasses a range of disorders including simple steatosis, alcoholic steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Patients with underlying ALD and continued heavy alcohol consumption can also develop an episode of acute-on-chronic liver injury called alcohol-associated hepatitis, the most severe form of the disease, which portends a poor prognosis. The most important risk factor for the development of ALD is the amount of alcohol consumed. Individual susceptibility to progression to advanced fibrosis among heavy drinkers is likely determined by a combination of behavioral, environmental, genetic, and epigenetic factors, but the mechanisms are largely unknown. The only effective therapy for ALD is prolonged alcohol abstinence. Diagnosis of ALD involves assessing patients for alcohol use disorder and signs of advanced liver disease. In clinical practice, the histological assessment for ALD diagnosis is uncommon, and it is usually based on the medical history, clinical manifestations, and laboratory and imaging tests. Several promising biomarkers that can have both diagnostic and prognostic value in patients with ALD have been identified in recent years. This review provides an overview of the clinical spectrum of ALD, the diagnostic approach of the disease from different perspectives as well as current diagnostic and prognostic biomarkers. [ABSTRACT FROM AUTHOR]