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We studied the effect of norepinephrine and selective β-adrenoceptor blockers on the growth of retinal tissue explants from 10-12-day-old chicken embryos in organotypic culture. The test drugs produced a dose-dependent effect on cell proliferation. Norepinephrine (10 M) and atenolol (10 M) are shown to signifi cantly stimulate explant growth. Combined treatment with norepinephrine (10 M) and atenolol (10 M) results in cumulation of their stimulatory effects. The results suggest that the retina-stimulating effect of norepinephrine is based on its interactions with other types of adrenoceptors. [ABSTRACT FROM AUTHOR]