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The throughput of mass spectrometers and the amount of publicly available metabolomics data are growing rapidly, but analysis tools such as molecular networking and Mass Spectrometry Search Tool do not scale to searching and clustering billions of mass spectral data in metabolomics repositories. To address this limitation, we designed MASST+ and Networking+, which can process datasets that are up to three orders of magnitude larger than those processed by state-of-the-art tools. MASST+ speeds up querying of metabolomics mass spectrometry data by two orders of magnitude. [ABSTRACT FROM AUTHOR]

Predictions of species occurrence allow land managers to focus conservation efforts on locations where species are most likely to occur. Such analyses are rare for herpetofauna compared to other taxa, despite increasing evidence that herptile populations are declining because of landcover change and habitat fragmentation. Our objective was to create predictions of occupancy and colonization probabilities for 15 herptiles of greatest conservation need in Iowa. From 2006–2014, we surveyed 295 properties throughout Iowa for herptile presence using timed visual-encounter surveys, coverboards, and aquatic traps. Data were analyzed using robust design occupancy modeling with landscape-level covariates. Occupancy ranged from 0.01 (95% CI = -0.01, 0.03) for prairie ringneck snake (Diadophis punctatus arnyi) to 0.90 (95% CI = 0.898, 0.904) for northern leopard frog (Lithobates pipiens). Occupancy for most species correlated to landscape features at the 1-km scale. General patterns of species' occupancy included negative effects of agricultural features and positive effects of water features on turtles and frogs. Colonization probabilities ranged from 0.007 (95% CI = 0.006, 0.008) for spiny softshell turtle (Apalone spinifera) to 0.82 (95% CI = 0.62, 1.0) for western fox snake (Pantherophis ramspotti). Colonization probabilities for most species were best explained by effects of water and grassland landscape features. Predictive models had strong support (AUC > 0.70) for six out of 15 species (40%), including all three turtles studied. Our results provide estimates of occupancy and colonization probabilities and spatial predictions of occurrence for herptiles of greatest conservation need across the state of Iowa. [ABSTRACT FROM AUTHOR]

Readily accessible (PSi)Ni(II)‐benzyl complexes supported by bidentate phosphino(silyl) ligation were found to be effective pre‐catalysts for the direct hydrogenation of a variety of highly sterically hindered, unfunctionalized alkenes under relatively mild conditions (2.5‐5 mol% Ni, 10 atm H2, 50 °C) and without the need for additional additives or activator species. A range of substrates, including di‐, tri‐, and tetra‐substituted alkenes were evaluated in this regard and afforded good to moderate yields. Substrates featuring α,β‐unsaturated carbonyl functionality were also readily hydrogenated with no evidence for reduction of carbonyl or ester C−O functionalities. Deuteration experiments highlight the occurrence of chain walking which occurs in the background of the reported catalytic chemistry. [ABSTRACT FROM AUTHOR]

Colour polymorphic species often exhibit variation in morphology, physiology, and behaviour among morphs. In particular, dominance status may be signalled by the interaction between behaviour and colour morph. Behavioural traits associated with dominance include boldness, exploration, and aggression, which influence access to preferred habitat, territorial defence, and mate acquisition. In ectotherms, the social structure associated with morphs may result in the exploitation of structural niches differing in thermal quality. Hence, social interactions among morphs may generate concordant variation in thermal preference and environmental temperature. However, few studies have assessed thermal preference variation in colour polymorphic species and its covariation with behaviour. Doing so can provide insight into niche specialization and the maintenance of colour polymorphism in populations. Here, we investigated the patterns of covariation in boldness behaviour, exploratory behaviour, and thermal preference in the tree lizard, Urosaurus ornatus. We assessed trait variation between territorial and non‐territorial male morphs and between orange and yellow female morphs. Boldness and exploratory behaviour were repeatable in male U. ornatus and bolder individuals were significantly more likely to incur tail loss, a potential consequence of bold behaviour. Territorial male morphs were significantly bolder and more exploratory and preferred higher body temperatures with a narrower Tset than non‐territorial morphs. Female morphs did not vary in behavioural or thermal traits. This study highlights behavioural mechanisms that underly ecological niche segregation and variable habitat use between morphs in a colour polymorphic species. [ABSTRACT FROM AUTHOR]

Naphthenic acids, NAs, are a major contaminant of concern and a focus of much research around remediation of oil sand process affected waters, OSPW. Using activated carbon adsorbents are an attractive option given their low cost of fabrication and implementation. A deeper evaluation of the effect NA structural differences have on uptake affinity is warranted. Here we provide an in-depth exploration of NA adsorption including many more model NA species than have been assessed previously with evaluation of adsorption kinetics and isotherms at the relevant alkaline pH of OSPW using several different carbon adsorbents with pH buffering to simulate the behaviour of real OSPW. Uptake for the NA varied considerably regardless of the activated carbon used, ranging from 350 mg/g to near zero highlighting recalcitrant NAs. The equilibrium data was explored to identify structural features of these species and key physiochemical properties that influence adsorption. We found that certain NA will be resistant to adsorption when hydrophobic adsorbents are used. Adsorption isotherm modelling helped explore interactions occurring at the interface between NA and adsorbent surfaces. We identified the importance of NA hydrophobicity for activated carbon uptake. Evidence is also presented that indicates favorable hydrogen bonding between certain NA and surface site hydroxyl groups, demonstrating the importance of adsorbent surface functionality for NA uptake. This research highlights the challenges associated with removing NAs from OSPW through adsorption and also identifies how adsorbent surface chemistry modification can be used to increase the removal efficiency of recalcitrant NA species. [ABSTRACT FROM AUTHOR]

Shortening analgesic onset has been researched and it has been documented that prewarming epidural medications to body temperature (37°C) prior to administration increases medication efficacy. Our double-blind randomized controlled trial was designed to investigate if a lower degree of prewarming in providers' pockets could achieve similar results without the need of a bedside incubator. A total of 136 parturients were randomized into either the pocket-warmed group or the room temperature group to receive 10 mL of 0.125% bupivacaine with 2 μg/mL fentanyl epidural bolus at either the 27.8 ±1.7°C or 22.1 ±1.0°C temperatures, respectively. Primary outcome, time to analgesic onset (verbal rating scale pain score ≤ 3) was recorded in 0-, 5-, 10-, 15-, 20-, 30-, and 60-minutes intervals. It was observed that the pocket-warming group (n = 64) and room temperature group (n = 72) had no significant difference of analgesic onset time (median 8 vs. 6.2 minutes; p = 0.322). The incidence of adverse events such as hypotension, fever (≥ 38°C), nausea, vomiting, and number of top-off epidural boluses, as well as patient satisfaction rates and mode of delivery, were not significantly different between the groups as well. Further research is warranted to confirm these findings and explore the impact of different temperatures on analgesic onset time as well as the logistical issues associated with their clinical implementations. [ABSTRACT FROM AUTHOR]

The youth self-report version of the Child and Adolescent Dispositions Scale (CADS) measures three orthogonal temperament dimensions that are hypothesized to dispose children and adolescents to develop psychological problems through transactions with the environment. The CADS was developed using exploratory and confirmatory factor analyses (CFA) of ratings of a pool of items from which synonyms and antonyms of DSM symptoms were excluded in two population-based samples. The criterion validity of the resulting three CADS dimensions of negative emotionality, prosociality, and daring has been well established in multiple samples. We examined the factor structure and criterion validity correlations of the CADS using data on 14.0–18.0 year olds in the English community based Neuroscience in Psychiatry 2400 Study. Using CFA, the three hypothesized CADS factors were identified, which were validated by their predicted cross-cutting correlations with measures of anxiety, depression, and conduct problems. Nonetheless, the fit of the CFA was not acceptable, likely because the expectation of simple structure in CFA was not met. The same data were re-analyzed using exploratory structural equation modeling (ESEM) to identify sources of poor fit. Two of the three fit indices suggested acceptable fit for the three-factor ESEM solution (Standardized Root Mean-Square Residual = 0.047; Root Mean-Square Error of Approximation = 0.067; Comparative Fit Index = 0.878). If replicated in other samples, these results suggest that some prosociality items with cross-loadings on more than one factor should be considered for elimination or replacement to improve the measurement of these dispositional dimensions. [ABSTRACT FROM AUTHOR]

Porphyromonas gingivalis produces five classes of serine/glycine lipids that are recovered in lipid extracts from periodontitis‐afflicted teeth and diseased gingival tissues, particularly at sites of periodontitis. Because these lipids are recovered in diseased gingival tissues, the purpose of the present study was to evaluate the capacity of cultured human gingival fibroblasts (HGF), keratinocytes, and macrophages to hydrolyze these lipids. We hypothesize that one or more of these cell types will hydrolyze the serine/glycine lipids. The primary aim was to treat these cell types for increasing time in culture with individual highly enriched serine/glycine lipid preparations. At specified times, cells and culture media samples were harvested and extracted for hydrolysis products. The serine/glycine lipids and hydrolysis products were quantified using liquid chromatography–mass spectrometry (LC–MS) and free fatty acids were quantified using gas chromatograph–mass spectrometer. LC–MS analysis used two different mass spectrometric methods. This study revealed that treatment of HGF or macrophage (THP1) cells with lipid (L) 654 resulted in breakdown to L342 and subsequent release into culture medium. However, L654 was converted only to L567 in gingival keratinocytes. By contrast, L1256 was converted to L654 by fibroblasts and macrophages but no further hydrolysis or release into medium was observed. Gingival keratinocytes showed no hydrolysis of L1256 to smaller lipid products but because L1256 was not recovered in these cells, it is not clear what hydrolysis products are produced from L1256. Although primary cultures of gingival fibroblasts and macrophages are capable of hydrolyzing specific serine/glycine lipids, prior analysis of lipid extracts from diseased gingival tissues revealed significantly elevated levels of L1256 in diseased tissues. These results suggest that the hydrolysis of bacterial lipids in gingival tissues may reduce the levels of specific lipids, but the hydrolysis of L1256 is not sufficiently rapid to prevent significant accumulation at periodontal disease sites. [ABSTRACT FROM AUTHOR]

Hoarding behavior is prevalent in children and adolescents, yet clinicians do not routinely inquire about it and youth may not spontaneously report it due to stigma. It is unknown whether hoarding behavior, over and above obsessive-compulsive symptoms (OCS), is associated with major clinical factors in a general youth population. This observational study included N = 7054 youth who were not seeking help for mental health problems (ages 11–21, 54% female) and completed a structured interview that included evaluation of hoarding behavior and OCS, as a part of the Philadelphia Neurodevelopmental Cohort between November 2009 and December 2011. We employed regression models with hoarding behavior and OCS (any/none) as independent variables, and continuous (linear regression) or binary (logistic regression) mental health measures as dependent variables. All models covaried for age, sex, race, and socioeconomic status. A total of 374 participants endorsed HB (5.3%), most of which reported additional OCS (n = 317). When accounting for OCS presence, hoarding behavior was associated with greater dimensional psychopathology burden (i.e., higher P-factor) (β = 0.19, p <.001), and with poorer functioning (i.e., lower score on the child global assessment scale) (β = − 0.07, p <.001). The results were consistent when modeling psychopathology using binary variables. The results remained significant in sensitivity analyses accounting for count of endorsed OCS and excluding participants who met criteria for obsessive-compulsive disorder (n = 210). These results suggest that hoarding behavior among youth is associated with poorer mental health and functioning, independent of OCS. Brief hoarding-behavior assessments in clinical settings may prove useful given hoarding behavior's stigma and detrimental health associations. [ABSTRACT FROM AUTHOR]

Instruments such as Doppler lidars, radar wind profilers, and uncrewed aircraft systems could be used in observation networks to fill in the temporal and spatial gap that exists for low-level wind observations. These instruments, however, do not directly observe the wind and require a retrieval to be used to obtain wind estimates from their observations. Also, the depth and uncertainty of observations collected by these instruments vary depending on the environment that they are sampling. Optimal estimation is a variational retrieval method that combines information from a prior dataset and observations to retrieve an atmospheric state. This technique can be beneficial to use when observations have large uncertainties or provide insufficient information to obtain the atmospheric state by themselves. A new optimal estimation retrieval for obtaining wind profiles from typical lower atmospheric wind profiling instrumentation has been developed. This retrieval allows for more observations from wind profiling instrumentation to be used when retrieving wind profiles, increases the depth of retrieved profiles, and eliminates vertical data gaps. This retrieval can also be used to easily combine observations from different instruments or even with model data to create combined data wind retrievals that leverage the strengths of the different data sources to retrieve a wind profile that is superior to those obtained by the individual observations or data sources. It is envisioned that this retrieval will be continued to be developed and maintained as community software as lower atmospheric wind observing capabilities further develop and expand. [ABSTRACT FROM AUTHOR]

Lavandula angustifolia Mill., lavender, is an aromatic plant in the Lamiaceae family. Lavender is an important economic plant that is cultivated throughout the world. Previous studies have shown that the primary pollinators of lavender in Europe and North Africa are bee species, specifically Bombus spp. However, similar studies have not been previously performed in North America. The current study, on cultivated population lavender (grown from seed) in Utah (USA), found a diverse community of bees visiting lavender over a 4-week sequential and successive blooming period. The observed and identified bees were distinguished across 8 genera and 12 species, of which 3 were species not native to North America. The most observed bees were Apis mellifera (88.3%), Bombus fervidus (4.2%), and B. huntii (3.7%). To investigate seed production and viability, lavender plants were either caged off and their access withheld from pollinators, or selectively granted access to various pollinators, to determine (1) if lavender is capable of self-pollination, (2) if pollination increases both the seed production rates and seed viability of lavender, and (3) which bee species are the most efficient pollinators of lavender. The findings from this study demonstrate the ecological interactions between pollinators both native and non-native to North America on lavender, a plant native to the Mediterranean region. [ABSTRACT FROM AUTHOR]

The synthesis and structural characterization of the first sulfur-containing derivatives of the C,C-biscarborane {ortho-C2B10}2 cluster – thiol, thioether, and disulfide – are reported. The biscarboranyl dithiol (1-HS-C2B10H10)2 exhibits an exceedingly long intracluster carbon–carbon bond length of 1.858(3) Å, which is attributed to the extensive interaction between the lone pairs of the thiol groups and the unoccupied molecular orbital of the carborane cluster. The structures of the doubly deprotonated biscarboranyl dithiolate anion (1-S-C2B10H10)22− with various counter cations feature an even longer carbon–carbon bond length of 2.062(10) Å within the cluster along with a short carbon–sulfur bond of 1.660(7) Å, both indicative of significant delocalization of electron density from the sulfur atoms into the cluster. [ABSTRACT FROM AUTHOR]

Objective: In a cohort of high-school football athletes with sport-related concussion (SRC), we sought to investigate the role of seasonality, defined as time of injury during a season, on recovery. Design: Retrospective cohort study. Setting: Regional sport concussion center. Participants: High-school football athletes ages 14 to 19-years old who sustained an SRC from 11, 2017 to 04, 2022. Intervention: Athletes were divided into 3 groups based on seasonality: early, middle, and late season. Main Outcome Measures: The primary outcomes were initial Post-Concussion Symptom Scale score and recovery, as defined by time to return-tolearn (RTL), symptomresolution, and return-to-play (RTP).Descriptive statistics, analysis-of-variance, t tests, andmultivariable regressions were performed. Results: Of our cohort of 273 high-school football playerswho sustained an SRC, 97 (35.5%) sustained anSRCduring early season, 107 (39.2%) during middle season, and 69 (25.3%) during late season. Compared with late-season concussions, early-season concussions took less days to symptom resolution (early = 11.5 ± 12.9 vs late = 25.5 ± 27.0, P = .03), but no differences were found in days to RTL (early = 5.3 ± 4.8 vs late = 7.2 ± 15.8, P = 0.51) and RTP (early = 13.5 ± 11.8 vs late = 23.0 ± 22.8, P = 0.08). Seasonality was not a significant predictor for any recoverymetric inmultivariable regressions. Conclusion: Sport-related concussions occurring in the early third of the season took significantly less time to symptom resolution than those occurring in the later third of the season; however, thiswas not statistically significant inmultivariable analyses.No association was observed between seasonality and time to RTL and RTP. A trend of worse recovery with concussions later in the season may be present. [ABSTRACT FROM AUTHOR]

Current accounts of the production effect suggest that production leads to the encoding of additional production-associated features and/or better feature encoding. Thus, if it is the act of production that leads to the storage and/or enhanced encoding of these features, then less of this act should reduce the resulting production effect. In two experiments, we provide a direct test of this idea by manipulating how much of a given item is produced within a single mode of production (typing). Results demonstrate that such partial production can yield a significant production effect that is smaller than the effect that emerges from producing the entire item. These results suggest that how much of an item is produced can moderate the size of the production effect and are considered in the context of recent modelling efforts. [ABSTRACT FROM AUTHOR]

Authentic Lavandula angustifolia (lavender) essential oil samples (n = 41) were procured from six producing countries. Essential oils were analyzed to determine physical properties and to determine profiles and related data by GC/MS, GC/FID, enantioselective GC, and GC/IRMS. The current study identified 43 volatile compounds that were detected in all authentic lavender samples (n = 41), and which can be considered authentic markers. Enantiomeric ranges for 15 volatile compounds and stable isotope ranges for four prominent compounds were determined in authentic lavender. Authentic samples and associated data were used to assess the quality of commercially available lavender essential oil samples (n = 12). 75% of the commercial samples studied were adulterated,and 17 volatile compounds were detected in these samples which can be considered markers for adulteration. This study establishes the utility and importance of using a multifaceted analytical approach to differentiate quality and determine authenticity of lavender essential oil. [ABSTRACT FROM AUTHOR]

We report herein the synthesis and characterization of nickel complexes supported by tridentate and bidentate phosphino(silyl) ancillary ligands, along with the successful application of these complexes as precatalysts for the hydroboration of terminal and internal alkenes using pinacolborane (HBPin). These reactions proceeded with low nickel loadings of 2.5‐5 mol % in the absence of co‐solvent, and in some cases at room temperature. Isomerization to afford exclusively the terminal hydroboration product was obtained across a range of internal alkenes, including tri‐ and tetra‐substituted examples. This reactivity is unprecedented for nickel and offers a powerful means of achieving functionalization at a C−H position remote from the C=C double bond. Nickel‐catalyzed deuteroboration experiments using DBPin support a mechanism involving 1,2‐insertion of the alkene and subsequent chain‐walking, which results in isotopic scrambling. [ABSTRACT FROM AUTHOR]

Dead plant biomass from foundation plant species is fundamental for the survival of coastal salt marshes because dead biomass aids in the vertical accretion of the ecosystem. Fungi regulate the decomposition of dead biomass, and thus play an essential role for marsh survival. Despite their importance, little is known about the compositional and functional changes of fungal communities in plant matter throughout senescence and litter decomposition. Here, we analyzed how fungal communities and their functionality change in the foundation plant species Spartina patens, which builds vast amounts of dead plant biomass (thatch) on the soil surface. We analyzed the chemical and fungal properties of live biomass, standing dead biomass (dead biomass shortly after senescence), upper thatch (top layer of litter on the soil surface), and lower thatch (bottom layer of litter on the soil surface) during September and November of 2021. We found that the chemical and fungal properties of different S. patens biomass types followed a predictable litter decomposition pattern. Notably, live biomass, standing dead biomass, upper thatch, and lower thatch all hosted unique fungal communities and litter chemistry. Functional groups present in live biomass (pathogens, epiphytes, and mycoparasites) were lost during senescence and later replaced by diverse saprotrophs. The abundance of lignocellulose saprotrophs increased throughout decomposition, with the highest abundance occurring in lower thatch. These results suggest a predictable succession of fungal communities through the senescence and decomposition of the foundation species S. patens. Our study highlights the diversity of fungal communities in a disappearing foundation species. [ABSTRACT FROM AUTHOR]

The availability of remote sensing imagery at high spatiotemporal resolutions presents the opportunity to monitor the surface motion of rock glaciers, a key constraint for characterizing the dynamics of their evolution. In this paper, we investigate four North American rock glaciers by automatically measuring their horizontal surface displacement using photogrammetric data acquired with crewed and uncrewed aircraft along with orbital spacecraft over monitoring periods of up to eight years. We estimate vertical surface changes on these rock glaciers with photogrammetrically generated digital elevation models (DEM) and digitized topographic maps. Uncertainty analysis shows that the imagery with the highest resolution and most precise positioning have the best performance when used with the automated change detection algorithm. This investigation produces gridded velocity fields over the entire surface area of each study site, from which we estimate the age of rock glacier formation using along-flow velocity integration. Though the age estimates vary, the ice within the modern extent of these landforms began flowing between 3000 and 7000 years before present, postdating the last glacial maximum. Surface elevation change maps indicate present-day thinning at the lower latitude/higher elevation sites in Wyoming, while the higher latitude/lower elevation sites in Alaska exhibit relatively stable surface elevations. [ABSTRACT FROM AUTHOR]

Objectives: Data from neurocognitive assessments may not be accurate in the context of factors impacting validity, such as disengagement, unmotivated responding, or intentional underperformance. Performance validity tests (PVTs) were developed to address these phenomena and assess underperformance on neurocognitive tests. However, PVTs can be burdensome, rely on cutoff scores that reduce information, do not examine potential variations in task engagement across a battery, and are typically not well-suited to acquisition of large cognitive datasets. Here we describe the development of novel performance validity measures that could address some of these limitations by leveraging psychometric concepts using data embedded within the Penn Computerized Neurocognitive Battery (PennCNB). Methods: We first developed these validity measures using simulations of invalid response patterns with parameters drawn from real data. Next, we examined their application in two large, independent samples: 1) children and adolescents from the Philadelphia Neurodevelopmental Cohort (n = 9498); and 2) adult servicemembers from the Marine Resiliency Study-II (n = 1444). Results: Our performance validity metrics detected patterns of invalid responding in simulated data, even at subtle levels. Furthermore, a combination of these metrics significantly predicted previously established validity rules for these tests in both developmental and adult datasets. Moreover, most clinical diagnostic groups did not show reduced validity estimates. Conclusions: These results provide proof-of-concept evidence for multivariate, data-driven performance validity metrics. These metrics offer a novel method for determining the performance validity for individual neurocognitive tests that is scalable, applicable across different tests, less burdensome, and dimensional. However, more research is needed into their application. [ABSTRACT FROM AUTHOR]

This qualitative study explored MSW students' perceived facilitators and barriers to self-care. Research suggests MSW students experience high stress from heavy course workloads, internship, and exposure to human suffering. MSW students report difficulty engaging in self-care, even when provided by their programs. Hence, it is important to gain insights into what promotes and prohibits MSW student self-care. MSW students participated in four semi-structured focus groups (N = 27, x-age = 27.8 years, 85.2% female, 55.6% white, 44.4% students of color). Analysis followed a combination of constant comparison and template analysis. Five themes underscore barriers and facilitators to self-care. Findings suggest importance of fostering a culture of self-care in MSW programs and assisting students to alter cognitive roadblocks to self-care. [ABSTRACT FROM AUTHOR]

Breast implant illness (BII) is a poorly understood disease in which patients develop symptoms typical of autoimmune conditions following breast implantation. There is no known underlying cause, and patients often resort to breast implant removal and capsulectomy to alleviate symptoms. In this issue of the JCI, Khan and colleagues examined 86 breast explants from patients that reported BII symptoms and 55 control explants. The BII group showed a disproportionally high degree of biofilm, which was associated with oxylipin (10-HOME) on the implant surfaces. Injections of 10-HOME in the mammary fat pad of a murine model recapitulated BII symptoms and increased Th1 cell populations. Notably, macrophages in the periprosthetic tissue from BII patients were more likely to exhibit a proinflammatory phenotype, and naive T cells exposed to 10-HOME caused naive macrophages to differentiate to a proinflammatory phenotype. This work provides a pathophysiologic mechanism for a currently understudied and poorly characterized disease. [ABSTRACT FROM AUTHOR]

Weather conditions, such as temperature and precipitation, likely influence white‐tailed deer (Odocoileus virginianus) activity and hunter participation, both of which are major factors contributing to deer harvest. Because harvest is often used to manage white‐tailed deer population trends and guide management decisions, understanding how certain abiotic factors may bias such data is important. We examined the effects of weather on deer harvest during the Iowa, USA, firearms seasons from 2006–2021 using a generalized mixed‐effects linear model. Weather conditions during the hunting season were related to overall deer harvest. Specifically, deer harvest was positively correlated with snowfall on opening day and negatively correlated with average minimum temperature, average snow depth, rainfall on opening day, and number of rainfall and snowfall days. Abiotic factors have the ability to substantially influence deer harvest. Because many white‐tailed deer population models use harvest data, incorporating the effects of weather variability into such models may substantially improve population estimates. Our study provides a compelling case for considering hunting season weather conditions when interpreting harvest data as a population index for white‐tailed deer. The results of this study also demonstrate potential for retrospective modeling of past harvest rates and incorporating the effects of abiotic factors on harvest into future age‐based population models. [ABSTRACT FROM AUTHOR]

Background: A lack of consensus exists regarding acute flare management in hidradenitis suppurativa (HS). Intramuscular triamcinolone (IMTAC) therapy is useful in numerous inflammatory conditions; however, it has not been investigated for acute HS flares. Objective: To evaluate the efficacy and patient experience associated with IMTAC therapy for acute, severe HS flares. Methods: Retrospective analysis and surveys of 45 HS patients were conducted at Albert Einstein College of Medicine/ Montefiore HS Center, Bronx, NY, USA. Results: Follow-up visits 6.77 (4.45) weeks after IMTAC therapy revealed significant reductions in mean HS-Physician Global Assessment (PGA) (P <.001), C-Reactive Protein (CRP) (P =.03), increased hemoglobin (P =.004), and improved pain scores (P <.001). Adjusting for age, sex and concomitant medications, multivariate analysis yielded significantly reduced pain (P =.02) and increased hemoglobin (P =.03). Patient surveys indicate that IMTAC was well-tolerated, as reflected in positive mean responses for satisfaction (29 [64%]) and willingness to receive IMTAC injections again (42 [93%]). Conclusions: These novel findings demonstrate that IMTAC is a safe, effective, and well accepted adjunct for acute HS management. [ABSTRACT FROM AUTHOR]

To investigate COVID-19's impact on college student health behaviors. 189 college students. Participants completed an online survey on behaviors relating to sleep, sedentary activities, and physical activity before and during the COVID-19 pandemic. Comparisons utilized Students' dependent t-test or Wilcoxon signed-rank tests. There was an increase in time to fall asleep (before: 23.4 ± 18.0 vs. during: 42.8 ± 44.3 min·day−1, p < 0.001), time spent in bed (before: 7.8 ± 1.5 vs. during: 8.5 ± 1.5 hr·day−1, p < 0.001), as well as shifts in later bed and awake time (p < 0.001). Total sedentary time increased during the pandemic (before: 9.0 ± 3.8 vs. during: 9.9 ± 4.1 hr·day−1, p = 0.016); and time spent using a TV, computer, or phone (before: 3.1 ± 1.9 vs. during: 4.2 ± 2.3 hr·day−1, p < 0.001). There was a significant decrease in moderate-vigorous activity (before: 123.8 ± 96.0 vs. during: 108.9 ± 75.5 min·week−1, p = 0.028) and resistance training days (before: 2.4 ± 2.1 vs. during: 1.7 ± 2.1 days·week−1, p < 0.001). COVID-19 negatively influenced health behaviors in college students. [ABSTRACT FROM AUTHOR]

In recognition, context effects often manifest as higher hit and false-alarm rates to probes tested in an old context compared with probes tested in a new context; sometimes, this concordant effect is accompanied by a discrimination advantage. According to the cue-overload account of context effects (Rutherford, 2004), context acts like any other cue, and thus context effects should be larger with lighter context loads. Conversely, the Item, Associated Context, and Ensemble (ICE) account (Murnane et al., 1999) attributes context effects to two factors: subjects erroneously attributing context familiarity to the probe, and the formation of ensembles (mnemonic combinations of item and context). Context familiarity increases as exposure at study increases, and thus ICE predicts larger effects of context as context load increases. Relatedly, ICE predicts larger effects of context as context meaningfulness increases, as meaningful contexts are more likely to be bound to the target in an ensemble. In Experiments 1 and 2, rather than manipulate context load during the study phase, we relied on subjects' preexperimental context exposure to manipulate context load. Subjects studied words superimposed on photographs of their university campus or another university campus. At test, targets and distractors were evenly divided between study and novel contexts and between familiar and unfamiliar contexts. In Experiment 3, we manipulated context familiarity within the experimental session. Results supported ICE, suggesting that context does not act as a retrieval cue in recognition. [ABSTRACT FROM AUTHOR]

This article discusses a second opinion case of a 59-year-old African American male who was recently diagnosed with prostate cancer. The patient had an elevated PSA and a bone scan revealed a single sacral lesion. Further imaging confirmed the presence of metastatic disease. The case highlights the importance of multidisciplinary care and the use of PSMA PET for detecting metastases. Treatment options, including radiation therapy and systemic therapy, are also discussed. The article emphasizes the need for ongoing clinical trials to provide more evidence for optimal treatment approaches. [Extracted from the article]

Grass carp Ctenopharyngodon idella, is an herbivorous fish originally brought to North America from Asia in 1963 to control nuisance aquatic vegetation. Since their arrival, detrimental alterations to aquatic ecosystems have sometimes occurred in waterways where they were initially stocked and into which they have escaped. The movements of grass carp from lentic systems into tributaries required for spawning is poorly understood, and understanding environmental conditions associated with upstream migrations may aid in management of the species. We stocked 43 fertile diploid and 43 sterile triploid grass carp implanted with acoustic transmitters into Truman Reservoir, Missouri, USA between January 2017 and October 2018 to characterize movements during spring and summer when spawning conditions occur. Twenty fish (11 diploid/9 triploid) exhibited upstream migration behavior in the Osage River, a major tributary, in 2018 and 2019. Migration primarily occurred in April and May, during high discharge events associated with increasing river stage when water temperatures were between 15 and 28°C. Observed migrations ranged from 3.0–108 river km in length, and six individuals were observed making multiple upstream migrations in one season. Eleven fish initiated upstream migrations while in the lentic main body of the reservoir. These findings provide some evidence for upstream migrations by diploid and triploid grass carp as well both lake and river residents. Evidence of similar upstream migration behavior by both diploid and triploid grass carp suggests that triploids may be suitable surrogates for diploids for study of movement ecology. Removal efforts in tributaries targeting periods of increasing river stage during spring may provide the best opportunity of encountering large concentrations of grass carp. [ABSTRACT FROM AUTHOR]

Background: Emerging research suggests using resistance exercises to interrupt prolonged sitting may increase physical activity and reduce fatigue, sleepiness, and muscular discomfort, yet it is unclear if these improvements occur in college students. Methods: Twenty-four students (age 23.1 ± 3.4 years, BMI 27.4 ± 5.0 kg∙m−2) completed two 7-day assessments of discomfort, physical fatigue, mental fatigue, and sleepiness while wearing an ActivPAL. Each week (CON vs REX) followed normal activities while completing assessments in the morning (M), mid-day (MD), and evening (E). During REX, hourly resistance exercise breaks (1 exercise per break, 8 breaks per day) for 2 sets of 15 repetitions. Paired t-tests evaluated difference in physical activity variables. Repeated measures ANOVA (0 between, 3 within) evaluated differences in discomfort, physical fatigue, mental fatigue, and sleepiness variables across treatment (CON vs. REX). Results: Comparison of physical activity resulted in no statistical significance between treatments for all outcomes (p ≥ 0.05). A main effect for treatment was observed for overall discomfort (CON: 2.97, REX: 1.72; p =.042) and for sleepiness (CON: 4.38, REX: 3.89; p =.011). Conclusion: Hourly simple resistance breaks resulted in no compensation in steps or sedentary time while reducing muscular discomfort and sleepiness in a relatively healthy and active population. [ABSTRACT FROM AUTHOR]

Two species within the Lamiaceae (mint) family, Agastache urticifolia and Monardella odoratissima, are aromatic plants that are native to the Intermountain Region (USA). Essential oil produced through steam distillation was examined to establish the essential oil yield and both the achiral and chiral aromatic profiles of both plant species. The resulting essential oils were analyzed by GC/MS, GC/FID, and MRR (molecular rotational resonance). For A. urticifolia and M. odoratissima, achiral essential oil profiles were largely composed of limonene (71.0%, 27.7%), trans-β-ocimene (3.6%, 6.9%), and pulegone (15.9%, 4.3%), respectively. Between the two species, eight chiral pairs were analyzed and, interestingly, the dominant enantiomer (calculated as ee%) of limonene and pulegone switched between the two species. Where enantiopure standards were not commercially available, MRR was used as a reliable analytical technique for chiral analysis. This study verifies the achiral profile for A. urticifolia and, for the first time to the authors' knowledge, establishes the achiral profile for M. odoratissima and chiral profile for both species. Additionally, this study confirms the utility and practicality of using MRR for determining chiral profiles in essential oils. [ABSTRACT FROM AUTHOR]

This study used integrative review methodology to synthesize research on the relationship between school-based restorative practices and exclusionary discipline outcomes in the United States. Exclusionary discipline outcomes were defined as out-of-school suspensions, expulsions, and referrals to law enforcement. A literature search produced 5,764 publications, and 11 studies were included in the final sample. Peacemaking circles were the most common restorative practice implemented, and secondary analysis of school records was the most common method utilized. Findings indicated that restorative practices are associated with reduced suspension rates, which suggest that school-based restorative practices are a promising approach to reducing exclusionary discipline outcomes. [ABSTRACT FROM AUTHOR]

Our purpose in this article is to forward a narrative of valued thinking in education—a narrative that has long been strongly influenced by Western philosophy and scientific psychology. Specifically, we begin by examining the philosophical forebearers of valued thinking, including theories such as rationalism, empiricism, and pragmatism. We follow these philosophical roots into the burgeoning mid-life of introspection, positivism, and the cognitive revolution that made way for mental-focused conceptualizations of valued thinking (e.g., higher-order thinking, critical thinking, or critical-analytic thinking). In sharing this narrative, we also hope to draw attention to the ways in which the voices of White, predominantly male scholars, past and present, have dominated understandings of valued thinking. As we turn to the final section and the possible future of valued thinking, we humbly overview two theoretical perspectives that liberate prevailing epistemic notions and center critical aspects of valued thinking. [ABSTRACT FROM AUTHOR]

Both rare pathogenic germline mutations and common variants are strongly associated with the risk of aggressive prostate cancer. Men with a high genetic risk can be considered for cancer screening and encouraged to adhere to a healthy lifestyle. Prostate cancer (PCa) is a leading cause of death and partially heritable. Genetic risk prediction might be useful for strategies to reduce PCa mortality through early detection and prevention. To review evidence for genetic risk prediction for PCa. A collaborative literature review was conducted using PubMed and Google Scholar. Search terms included genetic, risk, prediction, and "prostate cancer". Articles addressing screening, early detection, or prevention were prioritized, as were studies involving diverse populations. Rare pathogenic mutations (RPMs), especially in DNA damage repair genes, increase PCa risk. RPMs in BRCA2 are most clearly deleterious, conferring 2–8.6 times higher risk of PCa and a higher risk of aggressive disease. Common genetic variants can be combined into genetic risk scores (GRSs). A high GRS (top 20–25% of the population) confers two to three times higher risk of PCa than average; a very high GRS (top 1–5%) confers six to eight times higher risk. GRSs are not specific for aggressive PCa, possibly due to methodological limitations and/or a field effect of an elevated risk for both low- and high-grade PCa. It is challenging to disentangle genetics from structural racism and social determinants of health to understand PCa racial disparities. GRSs are independently associated with a lethal PCa risk after accounting for family history and race/ancestry. Healthy lifestyle might partially mitigate the risk of lethal PCa. Genetic risk assessment is becoming more common; implementation studies are needed to understand the implications and to avoid exacerbating healthcare disparities. Men with a high genetic risk of PCa can reasonably be encouraged to adhere to a healthy lifestyle. Prostate cancer risk is inherited through rare mutations and through the combination of hundreds of common genetic markers. Some men with a high genetic risk (especially BRCA2 mutations) likely benefit from early screening for prostate cancer. The risk of lethal prostate cancer can be reduced through a healthy lifestyle. [ABSTRACT FROM AUTHOR]

Purpose: Bursitis is a common musculoskeletal cause of shoulder pain and treatment varies, thus correctly diagnosing and grading bursitis is paramount in deciding management. Our aim was to assess reliability in grading shoulder bursitis on ultrasonography among fellowship trained musculoskeletal radiologists at our institution. Methods: Retrospective study of patients diagnosed with bursitis on ultrasonography. Single-sonographic images of the subacromial-subdeltoid bursa were collected for each patient and randomized to form a test-bank of varying degrees of bursitis. Three months after the test was administered, the cases were randomized and readministered. The radiologists graded each case as: within normal limits, mild, moderate or severe. Intraobserver variability was measured using Cohen's kappa coefficient. Linear regression model was performed to assess correlation between years of experience and kappa. Results: 10 radiologists reviewed 70 cases of bursitis. Kappa values ranged from.53 to.91, indicating 'moderate' to 'almost perfect' variability amongst radiologists. A moderate positive correlation of improving variability (r =.69) with increasing years of experience exists. Conclusion: Fellowship trained musculoskeletal radiologists were able to grade shoulder bursitis with moderate to almost perfect variability, with a positive correlation of improved variability with increasing experience. This may help clinicians choose the correct treatment more confidently in their patients with shoulder pain. [ABSTRACT FROM AUTHOR]

Lizards engage in push-up displays to signal dominance and to secure access to important resources. The rate and patterns of push-up displays have been shown to vary based on both biotic and abiotic factors. We investigated push-up display rate in tree lizards, Urosaurus ornatus , to determine contributions from potentially conflicting factors including sex, throat colour, microhabitat usage, social context, and thermal traits. We found that display rate was best described by an interaction between microhabitat and body temperature (T b). The relationship between display rate and T b was significantly different between three microhabitats: sunny dead trees, the inner branches of trees, and tree trunks. We suggest that this variation in display rate is driven by shifts in microhabitat temperature over the course of the day and spatial and temporal adjustments being made depending on the probabilities of being detected by both conspecifics and predators. [ABSTRACT FROM AUTHOR]

Aim: The Pennsylvania first episode psychosis program evaluation (PA‐FEP‐PE) core assessment battery was developed as a standard and comprehensive clinical assessment and data collection tool in Pennsylvania coordinated specialty care programs (CSC). To reduce administrative time and maximize clinical utility by maintaining acceptable levels of precision, we aimed to generate a short form using item response theory (IRT)‐based computer‐adaptive test (CAT) simulation and analyse the implementation and acceptability of the short form among providers from PA‐CSC. Methods: FEP participants (n = 759; age 14–36) from nine coordinated specialty care programs completed 156 items drawn from the PA‐FEP‐PE battery. Multidimensional IRT‐based CAT simulations were used to select the best PA‐FEP‐PE items for abbreviated forms. Results: A 67‐item PA‐FEP‐PE short form was developed to capture six factors: (1) positive affect and surgency (with negative loadings on Anxious‐Misery items); (2) psychiatric services satisfaction; (3) antipsychotic side effect severity; (4) family turmoil and associated traumas; (5) trauma load; and (6) psychosis. The total number of items was reduced more than 50% in the PA‐FEP‐PE shortened forms. The short form demonstrated good psychometric properties, and it was well accepted by our providers in the implementation. Conclusions: The empirical derivation and implementation of abbreviated measures of key domains and constructs in FEP care have streamlined and facilitated PA‐FEP program evaluation. Our work supports potential application of IRT based methods to empirically reduce core assessment battery measures in large‐scale data collection efforts such as in the Early Psychosis Intervention Network. [ABSTRACT FROM AUTHOR]

We report an 80‐year‐old male developing linear IgA bullous dermatosis (LAD) in the setting of angioimmunoblastic T‐cell lymphoma (AITL). This phenomenon is rare, as only three cases have been described in the literature. The pathophysiologic process can be attributed to dysregulation in somatic hypermutation and the expression of chemokine receptor 5 in AITL, contributing to increased IgA. Immunoglobulin production resulting from clonal plasma cell expansion may be because of the B‐cell promotional effect by neoplastic follicular helper T‐cells. Beyond providing a pathophysiologic platform for AITL‐associated LAD, we also briefly summarized prior cases. This report demonstrates the importance of considering LAD in the differential diagnosis for patients with a bullous eruption in the setting of AITL. [ABSTRACT FROM AUTHOR]

Objectives Skull base chordomas are locally aggressive malignant tumors derived from the notochord remnant. There are limited large-scale studies examining the role and extent of surgery and radiation therapy. Design Analysis of the National Cancer Database (NCDB) was performed to evaluate the survival outcomes of various treatments, and to assess for predictors of overall survival (OS). Participants This is a retrospective, population-based cohort study of patients diagnosed with a clival/skull base chordoma between 2004 and 2015 in the NCDB. Main Outcome Measures The primary outcome was overall survival (OS). Results In all, 468 cases were identified. Forty-nine percent of patients received surgery and 20.7% had positive margins. Mean age at diagnosis was 48.4 years in the surgical cohort, and 55% were males. Of the surgical cohort, 33.8% had negative margins, 20.7% had positive margins, and 45.5% had unknown margin status. Age ≥ 65 (hazard ratio [HR]: 3.07; 95% confidence interval [CI]: 1.63–5.76; p < 0.001), diagnosis between 2010 and 2015 (HR: 0.49; 95% CI: 0.26–0.90; p = 0.022), tumor size >5 cm (HR: 2.29; 95% CI: 1.26–4.15; p = 0.007), and government insurance (HR: 2.28; 95% CI: 1.24–4.2; p = 0.008) were independent predictors of OS. When comparing surgery with or without adjuvant radiation, no survival differences were found, regardless of margin status (p = 0.66). Conclusion Surgery remains the mainstay of therapy. Advanced age (>65 years), large tumor size, and government insurance were predictors of worse OS. Whereas negative margins and the use of adjuvant radiation did not appear to impact OS, these may very well reduce local recurrences. A multidisciplinary approach is critical in achieving optimal outcomes in this challenging disease. [ABSTRACT FROM AUTHOR]

Litter decomposition is a central ecosystem function because dead plant biomass plays a critical role in carbon storage, the nitrogen (N) cycle, and as food/habitat for animals and microorganisms. In the face of global change, interactions between organisms that participate in litter decomposition are likely to change due to species loss and N pollution. To understand how these global change factors may interact to alter litter decomposition, we manipulated the detritivore community and N concentrations in a coastal salt marsh for 2 years. We chose to manipulate densities of a dominant, detritivorous snail (Melampus bidentatus) because its population size is expected to decline due to climate change, yet its impact on litter decomposition has not been tested in the field. We measured litter decomposition rates, detritivore densities, and the N concentrations of sediment and litter. We found that endogenous N enrichment (N added live plants before decomposition), exogenous N enrichment (N added to decomposing plants) and higher densities of Melampus increased litter decomposition rates. Linear mixed models further revealed that snails, other detritivores, and soil NH4+ were the best predictors of litter mass loss in the middle stages of decomposition. Notably, exogenous N added to litter already enriched with N further increased mass loss but did not increase litter %N. Our study reveals how global change in the form species loss and N pollution can have palpable impacts on carbon cycling and ecosystem function. [ABSTRACT FROM AUTHOR]

Objective: Cytomegalovirus (CMV) infection is associated with age‐related chronic disease, and co‐infection with Epstein‐Barr virus (EBV) may compound disease risk. We aimed to assess the frequency of CMV infection and its relationship with age among EBV seropositive individuals in an Indigenous Amazonian population. Methods: We report concentrations of CMV and EBV antibodies in dried blood spot samples collected from 157 EBV positive Shuar participants aged 15–86 years (60.5% female) to assess CMV infection rate. We used logistic and linear regression models to examine associations among CMV, EBV, and age, adjusting for sex, geographic region, and body mass index. Results: Nearly two‐thirds (63.1%) of EBV seropositive participants were also CMV seropositive. A 1‐year increase in age was associated with 3.4% higher odds of CMV infection (OR [95% CI]: 1.034 [1.009–1.064], p =.012), but CMV antibody concentration was not significantly associated with age or EBV antibody concentration among co‐infected individuals. Conclusions: Herpesvirus‐related immunosenescence may be important to understanding chronic disease risk among Shuar. Future studies should further explore the role of co‐infection in shaping age‐related changes in immune function. [ABSTRACT FROM AUTHOR]

Background: Assessment of risks of illnesses has been an important part of medicine for decades. We now have hundreds of 'risk calculators' for illnesses, including brain disorders, and these calculators are continually improving as more diverse measures are collected on larger samples. Methods: We first replicated an existing psychosis risk calculator and then used our own sample to develop a similar calculator for use in recruiting 'psychosis risk' enriched community samples. We assessed 632 participants age 8–21 (52% female; 48% Black) from a community sample with longitudinal data on neurocognitive, clinical, medical, and environmental variables. We used this information to predict psychosis spectrum (PS) status in the future. We selected variables based on lasso, random forest, and statistical inference relief; and predicted future PS using ridge regression, random forest, and support vector machines. Results: Cross-validated prediction diagnostics were obtained by building and testing models in randomly selected sub-samples of the data, resulting in a distribution of the diagnostics; we report the mean. The strongest predictors of later PS status were the Children's Global Assessment Scale; delusions of predicting the future or having one's thoughts/actions controlled; and the percent married in one's neighborhood. Random forest followed by ridge regression was most accurate, with a cross-validated area under the curve (AUC) of 0.67. Adjustment of the model including only six variables reached an AUC of 0.70. Conclusions: Results support the potential application of risk calculators for screening and identification of at-risk community youth in prospective investigations of developmental trajectories of the PS. [ABSTRACT FROM AUTHOR]

Hedgehog signaling controls tissue patterning during embryonic and postnatal development and continues to play important roles throughout life. Characterizing the full complement of Hedgehog pathway components is essential to understanding its wide-ranging functions. Previous work has identified neuropilins, established semaphorin receptors, as positive regulators of Hedgehog signaling. Neuropilins require plexin co-receptors to mediate semaphorin signaling, but the role of plexins in Hedgehog signaling has not yet been explored. Here, we provide evidence that multiple plexins promote Hedgehog signaling in NIH/3T3 mouse fibroblasts and that plexin loss of function in these cells results in significantly reduced Hedgehog pathway activity. Catalytic activity of the plexin GTPase-activating protein (GAP) domain is required for Hedgehog signal promotion, and constitutive activation of the GAP domain further amplifies Hedgehog signaling. Additionally, we demonstrate that plexins promote Hedgehog signaling at the level of GLI transcription factors and that this promotion requires intact primary cilia. Finally, we find that plexin loss of function significantly reduces the response to Hedgehog pathway activation in the mouse dentate gyrus. Together, these data identify plexins as novel components of the Hedgehog pathway and provide insight into their mechanism of action. [ABSTRACT FROM AUTHOR]

• There is a positive association between CH and CVD in people living with HIV (PLWH). • The CH clone was identifiable years before CVD diagnosis. • CH mutations among PLWH who developed CVD have a higher growth rate. Hematopoietic stem cells (HSCs) with age-associated somatic mutations that disproportionally contribute to hematopoiesis generate the condition known as clonal hematopoiesis (CH). While CH conveys increased risk of hematologic cancer, there is also strong association between CH and cardiovascular disease (CVD). Accumulating evidence suggests that inflammation mechanistically links CH to CVD, and we hypothesized that CH may be a predictive biomarker of CVD in conditions of chronic inflammation. One such patient population comprises people living with HIV (PLWH) who also have substantially increased incidences of CVD and CH. We studied the association between CH and CVD in PLWH using samples from ACTG Study A5001 (or ALLRT), a prospective clinical trial of HIV-infected persons with long-term follow-up. We observed a positive association between CH and CVD in PLWH independent of traditional CVD risk factors. Moreover, in CVD cases, the CH clone was identifiable in the blood years before CVD diagnosis, unlike in PLWH with CH who did not have CVD. With the life span of PLWH increasing because of advances in treatment, our results indicate that the presence of CH and its clonal dynamics could be used as a prognostic biomarker of the risk for CVD in PLWH. [ABSTRACT FROM AUTHOR]

Background: Inflammatory markers and leukocyte profiles have not been longitudinally evaluated as objective signs of hidradenitis suppurativa (HS) severity. We sought to assess C‐reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin‐6 (IL‐6), and leukocyte profiles as reliable indicators of HS severity. Methods: Retrospective cohort study of 404 patients seen at the Einstein/Montefiore HS Center, Bronx, New York, between March 2019 and November 2020. Associations of disease severity (HS‐Physician Global Assessment) with inflammatory markers and leukocyte profiles were assessed by odds ratios (OR) and 95% confidence intervals (95% CI) incorporating up to four visits per patient, adjusting for baseline gender, age, BMI, and smoking status. Results: Patients with severe disease had elevated CRP (OR 1.87; 95% CI 1.49, 2.34), ESR (OR 1.04; 95% CI 1.03, 1.04), IL‐6 (OR 1.08; 95% CI 1.00, 1.16), leukocytes (OR 1.22; 95% CI 1.14, 1.31), neutrophils (OR 1.31; 95% CI 1.20, 1.42), eosinophils (OR 14.40; 95% CI 2.97, 69.74), basophils (OR 2.53; 95% CI 1.09, 5.85), monocytes (OR 5.36; 95% CI 2.49, 11.53), and neutrophil‐lymphocyte ratios (OR 1.63; 95% CI 1.35, 1.96) but decreased lymphocytes (OR 0.86; 95% CI 0.68, 1.10). Conclusions: This novel longitudinal study of inflammatory markers and leukocyte profiles offers critical laboratory measures to confirm clinically determined disease severity over time. [ABSTRACT FROM AUTHOR]

Practice is required to improve one's shooting technique in basketball or to play a musical instrument well. Learning these motor skills may be further enhanced by transcranial direct current stimulation (tDCS). We aimed to investigate whether tDCS leads to faster attainment of a motor skill, and to confirm prior work showing it improves skill acquisition and retention performance. Fifty-two participants were tested; half received tDCS with the anode on primary motor cortex and cathode on the contralateral forehead while concurrently practicing a sequential visuomotor isometric pinch force task on Day 1, while the other half received sham tDCS during practice. On Day 2, retention of the skill was tested. Results from a Kaplan-Meier survival analysis showed that participants in the anodal group attained a pre-defined target level of skill faster than participants in the sham group (χ2 = 9.117, p = 0.003). Results from a nonparametric rank-based regression analysis showed that the rate of improvement was greater in the anodal versus sham group during skill acquisition (F(1,249) = 5.90, p = 0.016), but there was no main effect of group or time. There was no main effect of group or time, or group by time interaction when comparing performance at the end of acquisition to retention. These findings suggest anodal tDCS improves performance more quickly during skill acquisition but does not have additional benefits on motor learning after a period of rest. [ABSTRACT FROM AUTHOR]

Psychiatric disorders are associated with cognitive dysfunction (CD), and reliable screening and follow-up of CD is essential both for research and clinical practice globally; yet, most assessments are in Western languages. We aimed to evaluate the test-retest reliability of the Turkish version of the Penn Computerized Neurocognitive Battery (PennCNB) to guide confident interpretation of results. Fifty-eight healthy individuals completed the PennCNB Turkish version in two sessions. After quality control, reliability analysis was conducted using Intraclass Correlation Coefficients (ICC), corrected for practice effects. Most measures were not significantly different between the sessions and had acceptable ICC values, with several exceptions. Scores were improved considerably for some memory measures, including immediate Facial Memory and Spatial Memory, and for incorrect responses in abstraction and mental flexibility, with correspondingly acceptable ICCs. Test-retest assessment of the Turkish version of the PennCNB shows that it can be used as a reliable real-time measurement of cognitive function in snapshot cross-sectional or longitudinal determinations. Preliminary validity assessment in this normative sample showed expected positive correlations with education level and negative correlations with age. Thus, the Turkish version of the PennCNB can be considered a reliable neuropsychological testing tool in research and clinical practice. Practice effects should be considered, especially when applied in short intervals. Significantly better performances in the retest, beyond practice effect, likely reflect nonlinear improvements in some participants who "learned how to learn" the memory tests or had insight on solving the abstraction and mental flexibility test. [ABSTRACT FROM AUTHOR]

Child physical activity (PA) declines during summer reducing PA-related health benefits. Summer care programs (e.g., Boys & Girls Clubs) can promote active play while providing opportunities for friendships. Sport participation is a positive influence on PA and social development. Purpose: This article investigates the role of sport participation in PA attainment, perceived skill competency, and social connection at a summer care program. Methods: Children self-reported PA, sport participation, and the names of up to five peers whom they played with most at the program at the start (T1; n = 100; M age = 9.94 years; SD = 1.34; 47% male) and end (T2; n = 77; M age = 9.83 years; SD = 1.46; 51% male) of summer. Network autocorrelation models were used to determine if child sport participation was significantly associated with those they played with at the program. Results:Children who reported sport participation reported significantly more PA than those who did not at T1, but not T2. Child sport participation was significantly related to that of the peers they said they spent time with while at the program for T1 (β = 0.07, p <.01), but not T2 (β = 0.06, p =.10). Additionally, PA (β = 0.08, p <.01; β = 0.07, p =.01) and skill competency (β = 0.11, p =.02; β = 0.15, p <.01) were significantly associated with sport participation at both time points. While sports participation was a key factor in child friendships at the start of summer, the program allowed children, regardless of sport participation, to become friends outside of sports. Conclusions: These results suggest summer care programs promote PA through play and provide opportunities for children to facilitate friendships regardless of sport participation. [ABSTRACT FROM AUTHOR]

Objective: To estimate the changes in infertility from 1995-2019 and determine the association of individual-level characteristics with fertility in the United States.Design: Cross-sectional study.Setting: Periodic data from 1995, 2002, 2006-2010, 2011-2013, 2013-2015, 2015-2017, and 2017-2019 cycles of the National Survey for Family Growth were used for this analysis. The National Survey for Family Growth comprises samples of the household-level population of women aged 15-44 years in the United States.Patient(s): Surveyed married and cohabiting women aged 15-44 years.Intervention(s): None.Main Outcome Measure(s): The primary outcomes were the rates of infertility across subgroups of married or cohabiting women. For secondary outcomes, we performed bivariable and multivariable logistic regression models using the pooled sample (N = 53,764) to determine the association of individual-level characteristics, including age, parity, pelvic inflammatory disease treatment, education, income, race or ethnicity, and receipt of sexual and reproductive health services, with the odds of 12-month infertility among married or cohabiting women.Result(s): The fluctuations in infertility over this period, with a low of 5.8% in 2006-2010 and a high of 8.1% in 2017-2019, were not found to be statistically significant. This trend was present across nearly all subgroups. The multivariable model showed that women who were older and nulliparous, had fewer years of education, had lower income, were non-Hispanic black, or were not receiving sexual and reproductive health services were more likely to be infertile.Conclusion(s): This study confirms that parity, age, race, and education level continue to have an association with infertility. Further, the results demonstrate that access to sexual and reproductive health services plays an important role in infertility. In contrast to previous studies, infertility in the United States is no longer on the decline, and Hispanic ethnicity did not have a significant relationship with infertility. Given the rise of sexually transmitted infections and the persistent lack of access to sexual and reproductive health services, particularly among already vulnerable groups, the connection between access to care and infertility is ripe for further investigation. [ABSTRACT FROM AUTHOR]