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Quantum computing and machine learning convergence enable powerful new approaches for optimizing mobile edge computing (MEC) networks. This paper uses Lyapunov optimization theory to propose a novel quantum machine learning framework for stabilizing computation offloading in next-generation MEC systems. Our approach leverages hybrid quantum-classical neural networks to learn optimal offloading policies that maximize network performance while ensuring the stability of data queues, even under dynamic and unpredictable network conditions. Rigorous mathematical analysis proves that our quantum machine learning controller achieves close-to-optimal performance while bounding queue backlogs. Extensive simulations demonstrate that the proposed framework significantly outperforms conventional offloading approaches, improving network throughput by up to 30% and reducing power consumption by over 20%. These results highlight the immense potential of quantum machine learning to revolutionize next-generation MEC networks and support emerging applications at the intelligent network edge. [ABSTRACT FROM AUTHOR]

ABSTRACT Acrylamide (AA) and 5‐hydroxymethylfurfural (HMF) are the byproducts of the Maillard reaction that pose health risks due to their high exposure to the Western diet. Current study examines the impact of yeast fermentation on AA, HMF formation, and chemical composition of French fries. Fermentation, known for enriching food with beneficial probiotics, vitamins, and minerals, is coupled with blanching, a technique used to inactivate enzymes and reduce microbial load, thus preserving color and extending shelf life. Fermentation reduced HMF and AA levels in French fries by approximately 86.5% and 54.78%, respectively. Furthermore, combining fermentation with blanching treatment further decreased HMF and AA levels by 88.62% and 59.81%, respectively. This research suggests that yeast fermentation, particularly when combined with blanching treatment, can effectively mitigate the formation of AA and HMF in French fries, thereby potentially reducing their health risks. This pioneering research opens avenues for additional inquiries, laying the groundwork for future advancements in enhancing food safety. [ABSTRACT FROM AUTHOR]

The electrochemical C‐N coupling process, facilitating the production of organic nitrogen substances (such as urea, methylamine, formamide, and ethylamine) via the simultaneous reduction of carbon dioxide (CO2) and small nitrogen‐based substances, stands at the forefront of advancing carbon neutrality and the artificial nitrogen cycle. This method has garnered substantial interest due to its potential economic and environmental benefits. Although considerable progress has been achieved in this emerging field, it still faces challenges, including slow reactant adsorption, competing side reactions, and complex multi‐step pathways, resulting in low yields and selectivity. Strategically designing and developing low‐cost and exceptionally performant catalysts is crucial for cost‐effective and precise electrochemical C─N bonding. This article offers an in‐depth review of the electrosynthesis of valuable organic nitrogen compounds at ambient conditions from earth‐abundant resources/wastes, such as CO2 and small nitrogenous molecules (nitrogen: N2, nitrite: NO2−, nitrate: NO3−, ammonia: NH3, etc.), via electrochemical C─N bond formation reactions, especially using carbon‐based catalysts. The relevant electrochemical C─N bond formation mechanisms, the design principles of advanced carbon‐based electrocatalysts, and the impact of different electrolyser designs are discussed, along with the present obstacles and upcoming prospects in this dynamic field. [ABSTRACT FROM AUTHOR]

Beard and moustache reconstruction has gained more popularity and acceptance over the last decade. The procedure is done for the correction of facial areas with hair density deficit and also for the cosmetic enhancement of pre-existing facial hair. The surgical technique includes the harvesting of grafts from the scalp by the follicular unit excision (FUE) or follicular unit transplantation (FUT) technique and then placing them in either premade slits or by stick and place method. The advancement and refinement of procedure over the years has aided in achieving the optimal aesthetic results, with minimal side effects. [ABSTRACT FROM AUTHOR]

Introduction: The regularity of menstrual cycle depends on many factors like genetic makeup, hormonal balance, weight and height, chronic medical illness and psychological problems. Life of medical students is very stressful, their food habits and sedentary lifestyle make them more prone for many menstrual abnormalities. Aim: This study was conducted to find out the menstrual abnormalities and its association with different biological variables like BMI, food habits and physical activity. Materials and Methods: This was a cross-sectional study conducted at U.P.U.M.S. Saifai, Etawah between July- August 2019 on 150 Female medical students. All the willing female medical students were asked to fill preformed selfstructured questionnaire (weight, height, menstrual pattern and abnormalities, food habits, addiction, physical activity, relevant medical and surgical history) and association was sought between menstrual abnormalities and different demographic factors by using Pearson chi-square test. Results: The mean age of students were 21.9 years. Mean age at menarche was 13.4 years. A total of 2.7% students ate junk food daily; 18% (27) girls had irregular cycles out of which only five girls had taken treatment for this. Amount of blood loss during menstruation was found to be increased in 5.8% girls that consumed junk food (p=0.13). There was no significant correlation found between pattern of menstrual cycle and BMI, physical activity, addiction. Dysmenorrhea and PMS was less in the girls that were on restricted diet for weight reduction (46.1% and 61.5%, respectively) but this difference was not statistically significant. There was significant association between dysmenorrhea and regular consumption of junk food. Dysmenorrhea and PMS was also less in the girls that exercised regularly (45.2% and 69% respectively) (p=0.4). PMS was significantly associated with addiction to tea or coffee (p=0.04). Conclusion: In this study dysmenorrhea and PMS was the most common menstrual abnormalities. Medication was being taken mostly for dysmenorrhea. Most of the parameters did not show a significant association so a larger study or multicentric study is required. [ABSTRACT FROM AUTHOR]

Introduction: Preterm labour and delivery have a major contribution to perinatal mortality and morbidity. Tocolytic therapy reduces neonatal mortality and morbidity by prolonging gestation, allowing for corticosteroid administration and inutero transfer to a tertiary care centre. There is a need to find out better tocolytic agent that is most effective and with the least side-effects. Aim: To compare oral Nifedipine and transdermal Nitroglycerine patch to achieve tocolysis in preterm labour. Materials and Methods: A prospective interventional study was conducted in the Department of Obstetrics and Gynaecology at Uttar Pradesh University of Medical Sciences, Saifai, Etawah, from January 2020 to June 2021. A total of 100 women presenting with signs and symptoms of preterm labour with live singleton pregnancy and intact membranes were included. All the women were divided into Group-A (n=50) and Group-B (n=50). Group-A received oral Nifedipine 20 mg of oral initially and 10 mg Nifedipine repeated after 30 minutes if the contractions persisted. Oral Nifedipine 10 mg was repeated every six hours till contractions subsided, and a transdermal Nitroglycerin patch (25 mg) was directly applied to the skin of the abdomen in Group-B. Demographic profile, the number of patients in which tocolysis was successful, improvement in Bishop score, prolongation in gestational age, maternal sideeffects, and foetal outcomes in the form of birth weight, APGAR score, and NICU admission were recorded in both the groups on Excel sheet. Chi-square test and t-test were used to test the significance of the difference between categorical and continuous variables respectively. A p-value less than 0.05 were taken as significant. Results: In Group-A 94% (47 out of 50) achieved tocolysis while in Group-B 86% (43 out of 50) achieved tocolysis (p value-0.182). The mean prolongation of pregnancy was 17.70±13.04 and 13.14±11.03 in Groups A and B, respectively. The maternal complication was significantly higher in Group-B as compared to Group-A (22% Vs 6%, p-value-0.0097). In Group-A mean birth weight was 2.422 kg ±0.34 whereas in Group-B mean birth weight was 2.204±0.38 Kg (p-value-0.0032). Conclusion: Both drugs oral Nifedipine and transdermal Nitroglycerine were found to be effective in the treatment of preterm labour. [ABSTRACT FROM AUTHOR]

Introduction: Demographic transition with ageing of the population is a global phenomenon which demands international, national, regional and local action. The percentage of the elderly population in India increased from 5.4 percent in 1950 to be about 8.7 percent in 2015 and expected to be 12.4 percent in 2030 and 19.6 percent in 2050. Several forces are driving India's changing age structure, including an upward trend in life expectancy and falling fertility. The aging populations is a sign of successful development in medical sciences and technology, living standards and education, but also raise unique social, economic and clinical challenges, including a growing demand for increasingly complex healthcare service. Materials and Methods: This cross-sectional study was conducted period of one year (August 2014 to July 2015) in Allahabad districts on elderly population only. Data was collected by house to house visits. Informed consent was obtained. Morbidity was assessed by taking history, doing a clinical examination, reviewing past medical records (musculoskeletal disorders, hearing problems, eye problems, hypertension and diabetes) and medicines taken by the study subject. Chi-square test was used to find out associated with morbidity in elderly population. Results: We were found mean age of study participant was 68.86 years. Majority of subjects (31.8%) were suffering from two chronic conditions, followed by 15.5% were having three chronic conditions, 4.8% having four chronic diseases and 1% were found to be suffering from five chronic diseases conditions. Conclusion: The preventive programme and strategies should be focused on more frequent and periodic screening of elderly with special focus to elderly female, Health education and health service provision near the dwelling place through mobile health team and by peripheral workers. [ABSTRACT FROM AUTHOR]

Context: In folk medicine, the stem bark ofStreblus asperLour. (Moraceae) has been reported to possess anticonvulsant activity. However, no systematic/scientific validation is available. ObjectiveThis study explores the constituents in the stem bark, their biosassy-guided isolation and their efficacy in neuro-pharmacological disorders, for validating the traditional claims. Materials and methods: Microwave-assisted extraction (MAE) technique was employed to obtain the crude extract. Then-hexane, dichloromethane and aqueous fractions were prepared and phytoconstituents were ascertained by phytochemical tests. The isolated compound, betulin, was characterized by different physicochemical and spectral methods, including HPTLC. Finally, neuro-pharmacological evaluations were conducted at 100, 200, 400 mg/kg b.w., p.o. (25, 50, 100 mg/kg b.w. for betulin) doses in BALB/c mice. Results: Then-hexane fraction (400 mg/kg), and isolated compound betulin (100 mg/kg), showed maximum anticonvulsant activity in maximal electroshock (87.84% and 85.14% seizure inhibition), and isoniazid induced convulsion models (88.85% and 83.18% seizure inhibition), respectively. A dose-dependent attenuation of epileptic seizures was observed, probably through GABArgic mechanism of anticonvulsant action. Moreover, the antidepressant study was also conducted using behavioural models and the results expound thatn-hexane and dichloromethane fractions (400 mg/kg) significantly reduced the duration of immobility, as compared to the control. Discussion and conclusion: This study reports some novel aspects like applying an environmentally benign/green approach of MAE, neuro-pharmacological screening and use of docking studies, for the first time, on the plantS. asper. The findings present a rational explanation for its use in traditional medicine, for the management of neuro-pharmacological disorders. [ABSTRACT FROM AUTHOR]

In this study, deep fat frying, microwave frying, air frying, and vacuum frying processes were used to mitigate acrylamide (AA) and hydroxymethylfurfural (HMF) formation during the frying of French fries. The highest reduction of AA and HMF range was found in vacuum frying (61.42–81.14%), followed by air frying (59.2–78.7%), as compared to deep fat frying and microwave frying. Both these method samples also showed significantly (p < 0.05) lower browning index (BI) and CIE a* values. Principal component analysis (PCA) was used to visualize the effects of the different frying methods on AA and HMF content. Vacuum frying and air frying were found to be alternative frying technologies to minimize AA and HMF content in French fries. • Effect of deep fat, air, vacuum, and microwave frying on the formation of AA. • Air frying and vacuum frying both methods showed less oil absorption. • The advanced frying method improved the taste, color, and texture of french fries. • Reducing sugar, asparagine & browning index is strongly correlated with AA and HMF. [ABSTRACT FROM AUTHOR]

Condyloma Acuminata (CA) or wart is a benign lesion which is caused by Human Papillomavirus (HPV) type-6 or type-11 infection. During pregnancy, condyloma has a tendency to proliferate and may have recurrence. This is because during pregnancy physiological changes takes place to the external genitalia and immunological effects during pregnancy promote HPV replication, and increased vaginal secretions contacting the skin and mucous membranes in pregnancy also lead to proliferation of CA in pregnancy. A 25-year-old primigravida presented to our hospital at 36 weeks pregnancy with extensive genital warts. These lesions regressed itself one month postpartum and remained only on vulva. Podophyllum resin application was planned for remaining lesions two months postpartum. The few treatments that have been tested and recommended for use in pregnancy are Bi and Tri Chloro Acetic Acid (BCA/TCA) application, cryotherapy, electrocautery and surgical excision, including laser treatment. [ABSTRACT FROM AUTHOR]

Abstract: Many cell signalling pathways are driven by changes in cytosolic calcium. We studied the effects of a range of inhibitors of connexin channels on calcium signalling in cardiac cells and HeLa cells expressing connexins. Gap 26 and 27, peptides that mimic short sequences in each of the extracellular loops of connexin 43, and anti-peptide antibodies generated to extracellular loop sequences of connexins, inhibited calcium oscillations in neonatal cardiac myocytes, as well as calcium transients induced by ATP in HL-1 cells originating from cardiac atrium and HeLa cells expressing connexin 43 or 26. Comparison of single with confluent cells showed that intracellular calcium responses were suppressed by interaction of connexin mimetic peptides and antibodies with hemichannels present on unapposed regions of the plasma membrane. To investigate how inhibition of hemichannels in the plasma membrane by the applied reagents was communicated to calcium store operation in the endoplasmic reticulum, we studied the effect of Gap 26 on calcium entry into cells and on intracellular IP3 release; both were inhibited by Gap 26. Calcium transients in both connexin 43- and connexin 26-expressing HeLa cells were inhibited by the peptides suggesting that the extended cytoplasmic carboxyl tail domain of larger connexins and their interactions with intracellular scaffolding/auxiliary proteins were unlikely to feature in transmitting peptide-induced perturbations at hemichannels in the plasma membrane to IP3 receptor channel central to calcium signalling. The results suggest that calcium levels in a microenvironment functionally connecting plasma membrane connexin hemichannels to downstream IP3-dependent calcium release channels in the endoplasmic reticulum were disrupted by the connexin mimetic peptide, although implication of other candidate hemichannels cannot be entirely discounted. Since calcium signalling is fundamental to the maintenance of cellular homeostasis, connexin hemichannels emerge as therapeutic targets open to manipulation by reagents interacting with external regions of these channels. [Copyright &y& Elsevier]

Tumor necrosis factor-α converting enzyme (TACE) is an ADAM (a disintegrin and metalloproteinases) that comprises an active catalytic domain and several C-terminal domains. We compare the binding affinity and association rate constants of the N-terminal domain form of wild-type tissue inhibitor of metalloproteinase (TIMP-3; N-TIMP-3) and its mutants against full-length recombinant TACE and the truncated form of its catalytic domain. We show that the C-terminal domains of TACE substantially weaken the inhibitory action of N-TIMP-3. Further probing with hydroxamate inhibitors indicates that both forms of TACE have similar active site configurations. Our findings highlight the potential role of the C-terminal domains of ADAM proteinases in influencing TIMP interactions. [Copyright &y& Elsevier]

Leiomyoma is a very rare benign tumour to be found in ovary. Here, we report a case of 40-year-old perimenopausal women with large left ovarian mass. The Computerised Tomography (CT) showed left ovarian solid mass without ascites, right ovary was normal. Her CA125 level was 46 units/mL. Total abdominal hysterectomy with bilateral salpingo-oophrectomy was done. Histopathological findings were suggestive of ovarian leiomyoma. Since, it is very rare to be found in ovary so immunohistochemistry was done to confirm the diagnosis. Symptomatic ovarian leiomyoma is very rare but it should always be considered in the differential diagnosis of ovarian mass. [ABSTRACT FROM AUTHOR]

Introduction: Cervical cancer is the primary malignancy in Indian women. The most significant method for untimely diagnosis of cancer cervix is cytology screening, but it is not possible to launch nationwide cytology screening programme of cervical cancer. So, this has lead to the development of low cost technology e.g., visual inspection of the cervix after application of acetic acid. Aim: To compare Visual Inspection using Acetic Acid (VIA) and Liquid Based Cytology (LBC) in evaluation of abnormal cervical lesions. Materials and Methods: This was a cross-sectional study conducted on 1600 women who fulfill selection criteria. Patients attending Gynaecology Outpatient Department (OPD) with the following signs and symptoms like vaginal discharge, abnormal uterine bleeding, lowback pain, contact bleeding, and lower abdominal pain were included. After taking informed consent, the participant was subjected to detailed history, physical examination, LBC, VIA and Colposcopy followed by biopsy (if required). The sensitivity and specificity of each test are determined and compared. Data entry and analysis were done using SPSS Inc., version 11.0. Results: In present study, VIA was more sensitive (92.06%) than the LBC (68.25%) for the detection of dysplasia. However, the specificities of VIA (56.76%) and LBC (54.05%) had not much difference. Positive Pedictive Value (PPV) of VIA was 78.38% and Negative Predictive Value (NPV) of VIA was 80.77% while PPV of LBC was 71.67% and NPV of LBC was 50%. The accuracy of VIA (79%) is higher than LBC (63%). Conclusion: The VIA is more sensitive screening modality than LBC. The accuracy of VIA is higher than LBC in detecting premalignant lesion which makes it a suitable and valuable alternative screening method to cytology in poor resource setting. [ABSTRACT FROM AUTHOR]

Light enables vision and exerts widespread effects on physiology and behavior, including regulating circadian rhythms, sleep, hormone synthesis, affective state, and cognitive processes. Appropriate lighting in animal facilities may support welfare and ensure that animals enter experiments in an appropriate physiological and behavioral state. Furthermore, proper consideration of light during experimentation is important both when it is explicitly employed as an independent variable and as a general feature of the environment. This Consensus View discusses metrics to use for the quantification of light appropriate for nonhuman mammals and their application to improve animal welfare and the quality of animal research. It provides methods for measuring these metrics, practical guidance for their implementation in husbandry and experimentation, and quantitative guidance on appropriate light exposure for laboratory mammals. The guidance provided has the potential to improve data quality and contribute to reduction and refinement, helping to ensure more ethical animal use. Lighting conditions for laboratory mammals is currently set according to the sensitivity of human vision. This Consensus View defines alternative 'animal-centric' metrics and provides guidance for their application to standardize experimental conditions, improve animal welfare and the quality of animal research. [ABSTRACT FROM AUTHOR]

This paper deals with the facile approach to the synthesis of different metal oxide nanoparticles and their comparative study for humidity sensing application at room temperature. The synthesis of these metal oxide nanoparticles is through co-precipitation method for nickel oxide and tin ferrite and hydrothermal route for cuprous oxide. The SEM and EDX reveal the porous morphology and confirmed composition of the synthesized metal oxides. FTIR detects the presence of functional groups like –OH and confirms the inverse spinal structure in tin ferrite. The optical band gap was determined by UV spectroscopy: 3.86 eV for NiO, 4.13 eV for Cu2O, and 4.07 eV for SnFe2O4. XRD gives the information about the average crystallite size for tin ferrite 2.42 nm, cuprous oxide 12.88 nm and nickel oxide 22.51 nm as the size comes to nano range the surface area increases, which is a good indication for humidity sensing. The humidity sensing of materials was detected by electrical modes. The deposited thin films were prepared by spin coater and observed sensitivity of these films was 0.72 M Ω /%RH for NiO, 1.59 M Ω /%RH for Cu2O, and 2.07 M Ω /%RH for SnFe2O4. The experiments were repeated after few weeks and the aging effects of samples were found negligible which makes the sensor stable. [ABSTRACT FROM AUTHOR]

• Catalytic pyrolysis of macroalgae studied over mono and bimetallic catalyst. • Maximum bio-oil (49.2 wt%) was obtained with Co-Ni/ZrO 2 catalyst. • Higher % of hydrocarbon compounds was obtained with catalysts. • Advance catalyst achieved using Co-Ni impregnation to promote bio-oil quality. Catalytic pyrolysis of ulva lactuca (UL) macroalgae was studied over a series of ZrO 2 supported metal such as Co, Ni and Co-Ni metal catalysts at temperature range of 300–500 °C. Highest bio-oil yield (47.8 wt%) was found with Co-Ni/ZrO 2 (10 wt%) catalyst while non-catalytic yielded 42.5 wt% bio-oil. Moreover with increases the metal amount to 15 wt%, the bio-oil yield slightly increased (49.2 wt%). The bio-oil quality significantly improved with using the catalysts compared to the non-catalytic pyrolysis. Catalytic pyrolysis also revealed that introducing Co-Ni into the ZrO 2 could result in higher surface area and which increased active sites. Catalytic bio-oils were consisted of mainly long chain hydrocarbon in the range of C 6 -C 16. Moreover, the catalytic bio-oils were showed the higher 'high heating value' (HHV) 38.1 MJ/kg as compare to non-catalytic bio-oils (29.4 MJ/kg). Catalysts have been showed excellent recyclability on bio-oil yield and compounds selectivity. [ABSTRACT FROM AUTHOR]

Biotechnology has offered tremendous scope and potential to conventional methods of crop improvement, crop protection, crop quality management and other horticultural traits. Biotechnology extends tremendous opportunities in fruit production by providing new genotypes for breeding purpose, supply of healthy and disease free planting material, improvement in fruit quality, enhancing shelf-life, availability of biopesticides, biofertilizers, etc. Integration of specially desired traits through genetic engineering has been possible in some horticultural crops. Recent advancements in molecular biology and genetic transformation have made it possible to identify, isolate and transfer desirable genes from any living organism to plants. The introduction or enhancement of desirable traits is traditionally done by breeding. This is time consuming and also not very precise. On the other hand, genetic engineering creates plants with specific changes in the background of a proven cultivar without disturbing their genetic constitution. Expression of undesirable genes can be blocked by the application of antisense gene technology and RNAi technology. Genetic transformation provides the means for modifying horticultural traits in various horticultural crops without altering their phenotype. Biotechnological interventions that could increase the efficiency of horticultural crop improvement are essential to generate plants with several desirable traits. [ABSTRACT FROM AUTHOR]

The article provides information on the findings of a study on the stimulation of connexin 43 (Cx43) expression and gap-junctional communication in pituitary folliculostellate (FS) cells by adenosine. The expression of Cx43 in TtT/GF pituitary cells is influenced by prolactin MMQ. Cytokines and growth factors that are thought to act in a pracrine or autocrine are produced by FS cells.