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The aim of this study was to compare the effects of caffeine ingestion on muscular performance during the early-follicular and mid-luteal phases of the menstrual cycle. Fourteen resistance-trained naturally menstruating women performed countermovement jump (CMJ), maximal voluntary isometric contraction (MVIC), one-repetition maximum (1-RM), and repetitions-to-failure (RF) at 80% of 1-RM in the half-squat exercise, in early-follicular and mid-luteal phases, after placebo or caffeine ingestion. The early-follicular and mid-luteal phases were identified via calendar-based counting method. The MVIC was lower in the early-follicular than mid-luteal phase (–6.2 ± 15.2 N, p < 0.05) and higher with caffeine than placebo ingestion regardless of the menstrual cycle phase (+16.8 ± 26.7 N, p < 0.05). The magnitude of gains (supplement x phase interaction, p < 0.026) in 1-RM, CMJ, and RF with caffeine ingestion was higher in the early-follicular (+16.6 ± 7.1 kg, +2.5 ± 1.6 cm, and +4.5 ± 2.6 repetitions, respectively) than in the mid-luteal phase (+7.7 ± 4.8 kg, +1.5 ± 2.0 cm, and +2.4 ± 3.1 repetitions, respectively). In conclusion, the greater ergogenic effect of caffeine during the early-follicular phase supports its use to mitigate the decline in muscular performance in this phase of the menstrual cycle. [ABSTRACT FROM AUTHOR]

Purpose: To compare the development of fatigability during a moderate-intensity cycling exercise between women with fibromyalgia (FM) and control women (CON) after acute ingestion of caffeine and placebo. Methods: Ten FM and 10 CON women performed a 30-min moderate-intensity cycling exercise 1 h after the ingestion of a capsule containing either caffeine or a placebo. Fatigability and its central and peripheral determinants were determined via changes from pre- to post-15 and post-30 min of exercise in maximal voluntary isometric contractions, voluntary activation (VA), and quadriceps potentiated twitch torque (Qtw-pot), respectively. Heart rate, muscle oxygen saturation, perceptive responses, mood state, localized and widespread pain, and sleepiness were also monitored during and after exercise. Results: There was a time versus group interaction for maximal voluntary isometric contraction and VA (P < 0.001) but not for Qtw-pot (P = 0.363), indicating a greater rate of fatigability development, mainly caused by central mechanisms, in the FM than in the CON group. There was also a main effect of condition for VA (P = 0.011), indicating that caffeine attenuates central mechanisms of fatigability in both groups. Caffeine ingestion also increased muscle oxygenation, perceived vigor, and energy, and decreased leg muscle pain, sleepiness, and perceived fatigue in both groups. However, caffeine improved perceived pleasure/displeasure and exercise adherence likelihood only in the FM group. Conclusions: Compared with CON, women with FM present a greater rate of fatigability during exercise, mainly of central origin. Caffeine seems to be a promising bioactive to counteract the central mechanisms of fatigability and improve the exercise experience among FM women. [ABSTRACT FROM AUTHOR]