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3 results on '"Vijayakumar, Vipin"'

1. Design and Analysis of Multiple Radius Pipe Bending Machine.

Author

Chandran, Maneesh, Mullathody, Thushar, Vijayakumar, Vipin, and Rajasekharan, Sambhu

Subjects
*PIPE bending, *BENDING machines, *ELECTRIC conduits, *DESIGN, *RADIUS (Geometry)
Abstract

In this work a low cost and easy to manufacture multiple radius pipe bending machine is designed to bend a given diameter conduit pipe in a required bending radius. In most of the industries, pipe bending is a salient requirement. In market there are different types of pipe bending machines available. But most of them can bend only a particular diameter pipe into a specified bending radius. To bend into different bending radius the die and other related parts need to be changed. Even some pipe bending machines are available to bend a particular diameter pipe into any bending radius but either they are very expensive or difficult to manufacture. So this project is to design a machine to satisfy our requirement. The working of this machine is simple and also the cost of manufacturing is comparatively cheaper than what is available in the current market. This machine can bend a pipe up to 32mm diameter to a minimum bending radius of 150mm. The material of the machine used is mild steel and hydraulics with piston-cylinder is used as power source. Static analysis of different parts is also carried out in ANSYS and finally a prototype is fabricated in order to test the machine and it is successful by all means. [ABSTRACT FROM AUTHOR]

Published
2019
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2. CK-2127107 amplifies skeletal muscle response to nerve activation in humans.

Author

Andrews, Jinsy A., Miller, Timothy M., Vijayakumar, Vipin, Stoltz, Randall, James, Joyce K., Meng, Lisa, Wolff, Andrew A., and Malik, Fady I.

Subjects
*COMPARATIVE studies, *CROSSOVER trials, *DOSE-effect relationship in pharmacology, *ELECTROCARDIOGRAPHY, *ELECTROMYOGRAPHY, *RESEARCH methodology, *MEDICAL cooperation, *MUSCLES, *NEUROLOGIC examination, *PHARMACOKINETICS, *RESEARCH, *EVALUATION research, *RANDOMIZED controlled trials, *HUMAN research subjects, *BLIND experiment, *SKELETAL muscle, *TROPONIN
Abstract

Introduction: Three studies evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics of CK-2127107 (CK-107), a next-generation fast skeletal muscle troponin activator (FSTA), in healthy participants. We tested the hypothesis that CK-107 would amplify the force-frequency response of muscle in humans.Methods: To assess the force-frequency response, participants received single doses of CK-107 and placebo in a randomized, double-blind, 4-period, crossover study. The force-frequency response of foot dorsiflexion following stimulation of the deep fibular nerve to activate the tibialis anterior muscle was assessed.Results: CK-107 significantly increased tibialis anterior muscle response with increasing dose and plasma concentration in a frequency-dependent manner; the largest increase in peak force was ∼60% at 10 Hz.Discussion: CK-107 appears more potent and produced larger increases in force than tirasemtiv-a first-generation FSTA-in a similar pharmacodynamic study, thereby supporting its development for improvement of muscle function of patients. Muscle Nerve 57: 729-734, 2018. [ABSTRACT FROM AUTHOR]

Published
2018
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3. Tirasemtiv amplifies skeletal muscle response to nerve activation in humans.

Author

Hansen, Richard, Saikali, Khalil G., Chou, Willis, Russell, Alan J., Chen, Michael M., Vijayakumar, Vipin, Stoltz, Randall R., Baudry, Stephane, Enoka, Roger M., Morgans, David J., Wolff, Andrew A., and Malik, Fady I.

Abstract

ABSTRACT Introduction: In this study we tested the hypothesis that tirasemtiv, a selective fast skeletal muscle troponin activator that sensitizes the sarcomere to calcium, could amplify the response of muscle to neuromuscular input in humans. Methods: Healthy men received tirasemtiv and placebo in a randomized, double-blind, 4-period, crossover design. The deep fibular nerve was stimulated transcutaneously to activate the tibialis anterior muscle and produce dorsiflexion of the foot. The force-frequency relationship of tibialis anterior dorsiflexion was assessed after dosing. Results: Tirasemtiv increased force produced by the tibialis anterior in a dose-, concentration-, and frequency-dependent manner with the largest increases [up to 24.5% (SE 3.1), P < 0.0001] produced at subtetanic nerve stimulation frequencies (10 H z). Conclusions: The data confirm that tirasemtiv amplifies the response of skeletal muscle to nerve input in humans. This outcome provides support for further studies of tirasemtiv as a potential therapy in conditions marked by diminished neuromuscular input. Muscle Nerve 50: 925-931, 2014 [ABSTRACT FROM AUTHOR]

Published
2014
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