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Using the density functional theory, we conducted a study on the electrification upon contact between hydrophobic liquid molecules and water molecules, revealing localized characteristics of contact-electrification. These "localized features" refer to the specific microscale characteristics where electron transfer predominantly occurs at the contact regions, influenced by factors such as atomic distances and molecular orientations. Although the electrostatic potential and the highest occupied molecular orbital–lowest unoccupied molecular orbital gap offer substantial predictive insights for electron transfer across polymer interfaces, they fall short in capturing the complexities associated with the interaction between hydrophobic liquids and water molecules. The electronegativity of elements at the interface and the localization of molecular orbitals play a decisive role in electron transfer. Simultaneously, for liquid molecules with irregular structures, there is no correlation between the "contact area" and the amount of electron transfer. The "contact area" refers to the surface region where two different liquid molecules come into close proximity. It is defined by the surface area of atoms with interatomic distances smaller than the van der Waals radius. This study challenges traditional assumptions about contact-electrification, particularly in liquid–liquid interfaces, providing new insights into the localized nature of this phenomenon. [ABSTRACT FROM AUTHOR]

Fiber zinc‐air batteries are explored as promising power systems for wearable and portable electronic devices due to their intrinsic safety and the use of ambient oxygen as cathode material. However, challenges such as limited zinc anode reversibility and sluggish cathode reaction kinetics result in poor cycling stability and low energy efficiency. To address these challenges, we design a polydopamine‐based all‐in‐one gel electrolyte (PAGE) that simultaneously regulates the reversibility of zinc anodes and the kinetics of air cathodes through polydopamine interfacial and redox chemistry, respectively. The intrinsic catechol and carboxylate groups in PAGE regulate the transport and solvation structure of Zn2+, facilitating dendrite‐free zinc deposition with a lamellar stacking morphology. Additionally, the oxidation of redox‐active catechol groups in PAGE replaces the sluggish oxygen evolution reaction on the air cathode and reduces the energy barrier for charging, enabling fiber zinc‐air batteries to achieve a significantly improved energy efficiency of 95 % and a longer lifespan of 40 hours. Further integration into self‐powered electronic textiles underscores its potential for next‐generation wearable systems. [ABSTRACT FROM AUTHOR]

The variable pressure source system is widely used in renewable energy recovery scenarios. However, the instability of the new energy input and the nonlinearity of the power generation system can lead to problems such as more difficult tracking and control of the maximum power point and poor power generation quality. To address the problem of lower efficiency under varying inputs, which is prevalent in renewable energy generation, this paper establishes an energy recovery system model based on power conversion rectifier topology, designs a speed current double closed‐loop control strategy, proposes an online variable‐step maximum efficiency point tracking method based on experience curves, and tests the overall energy recovery effect through system simulation and comparative experiments. The simulation results show that the maximum efficiency point tracking method proposed in this paper reduces the number of optimization searches by 50% and improves optimization speed. The experiment results show that, under the drastic changes of the input, the method proposed in this paper could reduce the total harmonic distortion to 5.65%, improve the energy recovery efficiency by 10.976%, and reduce the fluctuation ratio of the voltage to 2.43%. This study can provide an important reference for the collection and utilization of new energy sources. [ABSTRACT FROM AUTHOR]

Altermagnets, an emerging class of magnetic materials distinguished by a significant non-relativistic spin splitting band structure but zero net macroscopic magnetization, have recently received considerable attention. Here, we present a theoretical study focusing on the orientation-dependent conductance induced by Andreev reflection (AR) at an altermagnet/altermagnet/superconductor junction. Conventional and equal-spin AR processes occur when the Néel vector directions of the AMs are non-collinear and controllable by the altermagnet's orientation θ and Néel vector direction α. The conductance spectra resemble ferromagnet/ferromagnet/superconductor junctions with parallel or antiparallel magnetization configurations, depending on θ and α. Both the anisotropic altermagnetic state and the equal-spin AR signature can be probed by studying conductance spectra. These findings suggest that altermagnet/superconductor junctions are promising platforms for future superconducting spintronics applications. [ABSTRACT FROM AUTHOR]

A two-way fluid–structure interaction (FSI) method for the water-entry process of a structure colliding with the floating ice is established. The two-way FSI method is validated by a collision experiment between an ice floe and a cylinder. Subsequently, the cavity evolution, hydrodynamic load, and motion characteristics during the water-entry process of the structure colliding with the floating ice are investigated. In addition, the influence of different distances between the axis of the structure and the edge of the floating ice on the water-entry characteristics is conducted. The results show that after the collision, the outward flipping motion of the floating ice forms the floating ice cavity, promotes the expansion of the structure cavity, and delays the closure time of the cavity, resulting in a significant increase in the size of the structure cavity compared to the ice-free environment; the effect is further exacerbated by an increase in the distance between the structure and the floating ice. Moreover, under the floating ice environment, the fluctuation and amplitude of the hydrodynamic load on the structure and the total horizontal displacement of the structure are reduced. The interaction force generated by the collision between the structure and floating ice becomes the main reason affecting the motion trajectory. As a result of the collision with the floating ice, the velocity attenuation is faster than that under the ice-free environment. [ABSTRACT FROM AUTHOR]

Over the past 20 years, we have designed various types of expanded cervical flaps for large facial defects and achieved excellent tissue matching. This study was performed to propose a treatment strategy for flap selection for the reconstruction of different facial units. The authors retrospectively reviewed the application of cervical expanded flaps for facial rehabilitation in our department between January 2003 and January 2023. The study included 122 patients with unilateral (62.3%) and bilateral (37.7%) facial deformities ranging from the zygomatic arch to the chin. The median area of the tissue defect was 15.2 × 8.5 cm 2 (ranging from 6 × 4 cm 2 to 27 × 12 cm 2). The expansion period ranged from 61 to 175 days (mean: 86.5 days). Maximum and minimum sizes of pre-expanded cervical flaps were 30 × 13 cm 2 to 7 × 5 cm 2. All the flaps could be summarized into type 1, an advanced expanded cervical flap; type 2, a wing-shaped expanded cervical flap with overlapping tissue expansion; and type 3, an expanded single-lobed transposition flap rotated based on the anterior neck. Cervical flaps reliably meet the reconstructive requirements for different facial units, especially for large cutaneous defects in the clinic. The selection of these flaps can be planned preoperatively according to the location and size of the defect or lesion. [ABSTRACT FROM AUTHOR]

The application of air-core reactors in power systems is extensive and primarily aimed at enhancing system stability, limiting short-circuit currents, and providing reactive power compensation. Currently, the type most commonly used in power systems is the cylindrical-shaped air-core reactor (CAR), known for its stable mechanical structure and mature manufacturing process. However, the external magnetic field generated by this reactor propagates over a considerable distance in the air, which can interfere with the normal operation of many power electronic devices. This paper presents a comparative analysis between a novel annular-shaped air-core bridge arm reactor (AABAR) and the widely used cylindrical-shaped air-core bridge arm reactor (CABAR) within a DC transformer system. The comparison focuses on the magnetic field distribution, including magnetic flux density, magnetic field radiation range, and magnetic field energy, as well as the attenuation characteristics of these physical quantities. The concept of magnetic clearance (MC) is introduced as a quantitative metric. Through finite element simulation software (AEDT 2021 R1), it is demonstrated that the annular-shaped air-core reactor design can significantly improve spatial utilization and reduce the actual usage space of the reactors in DC transformer systems. [ABSTRACT FROM AUTHOR]

The shuttle effect and slow oxidation‐reduction reactions of the cathode in lithium‐sulfur batteries limit its practical application and development. Herein, porous carbon derived from pollen modified by black phosphorus nanosheets (BP/N−C) have been synthesized and utilized as a sulfur host in Li−S batteries. From the compositional outlook, the biomass‐derived carbon forms a unique three‐dimensional skeleton structure, exhibiting excellent properties, such as high porosity and high conductivity. Upon modified with black phosphorus, the BP/N−C composite materials demonstrate enhanced adsorption ability and catalytic activity toward lithium polysulfides (LiPSs). The BP/N−C/S cathode electrode presents a high initial specific discharge capacity of 1009.6 mAh g−1 and a low capacity decay rate of 0.08% per cycle during 150 cycles at 0.2 C rate. Besides, the BP/N C/S cathode electrode exhibits the superior rate performance (508 mAh g−1 at 5 C). [ABSTRACT FROM AUTHOR]

Background: Diabetic skin wound is a complex problem due to the disruption of normal repairing program and lack of effective remedy. Lucilia sericata larvae (maggot) is a folk method to treat chronic skin wound, while its therapeutic effects on that caused by diabetic remains unknown. Objective: This study aims to investigate the therapeutic effects of maggot extract (M.E.) on diabetic skin wound and its molecular mechanism by establishing the skin wound model of diabetic Sprague Dawley (SD) rats. Methods: Diabetic model was established by injecting intraperitoneally streptozotocin in SD rats under specific pathogen-free (SPF) conditions. The rat fasting blood glucose values were ≧16.7 mmol/L 72 hours after intraperitoneal streptozotocin (60mg/kg body weight) injection. The rats were divided into five groups (n = 10/group): normal group: normal SD rats without any treatment, diabetic blank group: the diabetic rats without any treatment, Vaseline group: the diabetic rats dressed with Vaseline, recombinant human epidermal-growth-factor (rhEGF) group: the diabetic rats dressed with a mixture of Vaseline and 200 μg/g rhEGF, M.E. group: the diabetic rats dressed with a mixture of Vaseline and 150 μg/ml maggot extract. The round open wounds (1.0 cm in diameter) down to the muscle fascia were made on both sides of rat dorsa by removing the skin layer (epidermis and dermis) and were daily photographed for calculating their healing rates. Hematoxylin-eosin (HE) and Masson's trichrome staining were performed on skin wound sections to analyze re-epithelialization and granulation tissue formation. Immunohistochemical (IHC), immunofluorescent (IF) stainings and Western blotting were conducted to analyze the statuses of STAT3 signaling. Results: The average wound healing rates on the 14th day were 91.7% in the normal, 79.6% in M.E., 71% in rhEGF, 55.1% in vaseline and 43.3% in the diabetes blank group. Morphological staining showed more active granulation tissue formation, re-epithelialization and neovascularization in M.E.-group than those in the blank and the vaseline-treated groups. Decreased p-STAT3 nuclear tranlocation and down-regulated Bcl-2, CyclinD1 and vascular endothelial growth factor (VEGF) expression were evidenced in the diabetic rats, which could be improved by rhEGF and especially M.E. Conclusion: Maggot extract would be an alternative and/or adjuvant candidate for the better management of diabetic skin wounds because of its activity in enhancing STAT3 activation. [ABSTRACT FROM AUTHOR]

In the present study, we experimentally investigated the oblique impinging process of an ice particle on a water film. A parameter study of the impact velocity, impact angle, and water film thickness was carefully carried out. The results showed that three impact categories occurred, namely uprising liquid sheet, crown with a notch, and complete crown. The uprising liquid sheet only occurred in the case when the dimensionless water film thickness was 0.1, which appeared to be independent of the impact velocity and the impact angle. The crown with a notch only occurred in the case when the impact velocity was 23.0 m/s. The left tilt angles of uprising liquid sheet, crown with a notch, and complete crown all increased first and then decreased with the dimensionless time. Among the three experimental parameters investigated in the present study, the dimensionless water film thickness had the most significant effect on the evolutions of the left tilt angles. The dimensionless spreading lengths in x- and y-direction all increased with the increase in dimensionless water film thickness. In addition, the correlations of dimensionless spreading lengths in x- and y-direction were proposed. In addition, the lifetime of complete crown generally increased with the increase in the impact velocity and the dimensionless water film thickness. Within the scope of the present study, the dimensionless maximum height of uprising liquid sheet generally ranged from 3.0 to 3.5. When the impact angle was 30.0°, the dimensionless maximum height of the crown with a notch increased with the increasing dimensionless water film thickness. The present work not only provides a new insight into the study of the ice crystal icing but also offers effective support for the development of efficient anti/de-icing methods. [ABSTRACT FROM AUTHOR]

Backgrounds: Giant neurofibromas occurring in individuals diagnosed with neurofibromatosis type 1 (NF1) often result in considerable disfigurement, functional impairment, and diminished quality of life. Although debulking surgery poses inherent risks of complications, it remains the most efficacious approach to address these issues. The primary objective of this study was to share our surgical experience with giant neurofibromas in the extremities and trunk wall of NF1 patients which may help surgeons to minimize intraoperative bleeding and facilitate tumor excision. Methods: A retrospective review was conducted at a single center, encompassing 36 NF1 patients with giant neurofibromas in the extremities and trunk wall who underwent debulking surgery from July 2010 to July 2022. Results: Twenty‐one male and fifteen female NF1 patients who received one to four surgical interventions were evaluated. The average age at the time of surgery was 17.8 years. The median follow‐up time was 52 months. Our findings revealed relatively low rates of complications and recurrence. Notably, patients expressed satisfaction with both the aesthetic and functional results. Conclusions: Debulking surgery of giant neurofibromas in the extremities and trunk wall of NF1 patients can effectively reduce the tumor burden, leading to improvements in both the appearance and function. [ABSTRACT FROM AUTHOR]

Surface movement exploration techniques are an important approach to further the understanding of small celestial bodies. Hopping movement is employed to take advantage of the weak gravitational field of small celestial bodies, facilitating long-distance mobility of the rover. The rover exhibits a strong attitude-orbit coupling characteristic during the hopping movement. Different contact attitudes contribute to the challenge of determining the rebound trajectory, rendering it difficult for the rover to maintain continuous movement towards the target position along the nominal trajectory. In this paper, a dual-stage control method for continuous surface hopping movement is developed, wherein the control is applied separately during the flight stage and the collision stage. During the flight stage, applying attitude control enables the rover to establish contact with the surface in a specific attitude, ensuring accuracy in movement direction and creating favorable conditions for the control process in the collision stage. The flywheel is controlled in the collision stage to correct the state change and energy loss due to the collision, enabling the rover to attain the desired hopping state. Considering the energy consumption of the rover, the minimum hopping velocity sequence and angular velocity sequence are designed based on the hopping angle and heading angle. The intricacies and uncertainties inherent in the surface environment of small celestial bodies pose challenges for the rover during hopping and flying. In response to the issue, a finite-time adaptive sliding-mode control law is devised. The control law facilitates the rapid adjustment of the rover to the target attitude in flight, demonstrating strong robustness. In addition, by integrating the changes in contact point velocity with the impulse contact model, the accuracy of the rover's rebound state updates is enhanced. Finally, a set of simulations is performed, and simulation results indicate that the dual-stage control method can achieve a final landing position error of less than 0.2 m for a continuously hopping. The finite-time adaptive sliding-mode control law can stabilize the rover's attitude within 10 s. Conducting 500 Monte Carlo simulations of the continuously hopping rover in three small celestial body surface simulation environments shows that the position endpoint error is within 0.3 m. • An innovative control method for continuous hopping on the surface of small celestial bodies with low gravity is proposed. • The attitude-orbit coupling challenge is addressed through a staged control. • A sequence of hopping states with minimum velocities is devised. • A finite-time adaptive sliding-mode control law is designed to effectively address unknown disturbances. • A corrected sliding-mode control law is developed for precise hopping state updates. [ABSTRACT FROM AUTHOR]

Shear wave velocity is an essential parameter in reservoir characterization and evaluation, fluid identification and prestack inversion. However, conventional data‐driven or model‐driven shear wave velocity prediction methods exhibit several limitations, such as lack of training data sets, poor model generalization and weak model robustness. In this study, a model‐ and data‐driven approach is presented to facilitate the solution of these problems. We develop a theoretical rock physics model for fractured limestone reservoirs and then use the model to generate synthetic data that incorporates geological and geophysical knowledge. The synthetic data with random noise is utilized as the training data set for the artificial neural network, and a well‐trained shear wave velocity prediction model, random noise shear wave velocity prediction neural network, is established by parameter tuning, which fits the synthetic data with noise well. The neural network is applied directly to the real field area. Compared with conventional shear wave prediction methods, such as empirical formulas and the improved Xu–White model, the prediction results show that the random noise shear wave velocity prediction neural network has better prediction performance and generalization. Furthermore, the prediction results demonstrate the efficacy of the proposed approach, and the approach has the potential to perform shear wave velocity prediction in real areas where training data sets are unavailable. [ABSTRACT FROM AUTHOR]

Accurately calculating winding losses has always been a significant challenge in the design of large-capacity medium-frequency transformers. This paper presents an accurate design algorithm for calculating the winding losses of a large-capacity medium-frequency distribution transformer. First, the peculiarities of winding losses in medium-frequency distribution transformers are analyzed. Various commonly used winding conductor types for medium-frequency transformers are introduced. The mechanisms of and differences between AC and DC winding losses in medium-frequency transformers are explained, and an effective analytical method for calculating the AC-to-DC resistance ratio is provided. Finally, the analytical calculation results of different types of winding losses are compared with those obtained through finite element simulations and experimental methods applied to a real transformer prototype. The discrepancies between the analytical results and those obtained using the other two methods were found to be within acceptable error margins, thereby validating the accuracy and effectiveness of the proposed algorithm. [ABSTRACT FROM AUTHOR]

Background: AGTPBP1 is a cytosolic carboxypeptidase that cleaves poly-glutamic acids from the C terminus or side chains of α/β tubulins. Although its dysregulated expression has been linked to the development of non-small cell lung cancer, the specific roles and mechanisms of AGTPBP1 in pancreatic cancer (PC) have yet to be fully understood. In this study, we examined the role of AGTPBP1 on PC in vitro and in vivo. Methods: Immunohistochemistry was used to examine the expression of AGTPBP1 in PC and non-cancerous tissues. Additionally, we assessed the malignant behaviors of PC cells following siRNA-mediated AGTPBP1 knockdown both in vitro and in vivo. RNA sequencing and bioinformatics analysis were performed to identify the differentially expressed genes regulated by AGTPBP1. Results: We determined that AGTPBP1 was overexpressed in PC tissues and the higher expression of AGTPBP1 was closely related to the location of tumors. AGTPBP1 inhibition can significantly decrease cell progression in vivo and in vitro. Moreover, the knockdown of AGTPBP1 inhibited the expression of ERK1/2, P-ERK1/2, MYLK, and TUBB4B proteins via the ERK signaling pathway. Conclusion: Our research indicates that AGTPBP1 may be a putative therapeutic target for PC. [ABSTRACT FROM AUTHOR]

Various environmental stresses induce the production of reactive oxygen species (ROS), which have deleterious effects on plant cells. Glutathione (GSH) is an antioxidant used to counteract reactive oxygen species. Glutathione is produced by glutamylcysteine synthetase (GCS) and glutathione synthetase (GS). However, evidence for the GCS gene in sweetpotato remains scarce. In this study, the full-length cDNA sequence of IbGCS isolated from sweetpotato cultivar Xu18 was 1566 bp in length, which encodes 521 amino acids. The qRT-PCR analysis revealed a significantly higher expression of the IbGCS in sweetpotato flowers, and the gene was induced by salinity, abscisic acid (ABA), drought, extreme temperature and heavy metal stresses. The seed germination rate, root elongation and fresh weight were promoted in T3 Arabidopsis IbGCS-overexpressing lines (OEs) in contrast to wild type (WT) plants under mannitol and salt stresses. In addition, the soil drought and salt stress experiment results indicated that IbGCS overexpression in Arabidopsis reduced the malondialdehyde (MDA) content, enhanced the levels of GCS activity, GSH and AsA content, and antioxidant enzyme activity. In summary, overexpressing IbGCS in Arabidopsis showed improved salt and drought tolerance. Headings: •IbGCS gene was cloned from the sweetpotato cultivar Xu18. • The multiple abiotic stresses significantly increased the expression of IbGCS gene. • Overexpression of IbGCS significantly improved the salt and drought stress tolerance [ABSTRACT FROM AUTHOR]

It is crucial for the water-entry stability and safety of the polar ocean equipment to study the process of the cylinder entering the water and passing through ice holes. In this study, based on the volume of fluid model and Schnerr–Sauer cavitation model, the influences of the ice-hole constraint on the cavity evolution process, the flow field characteristics, and the motion characteristics of the oblique water-entry process of the cylinder under different ice-hole diameter conditions are investigated numerically. The numerical method is verified. Results show that the influence of the ice-hole constraint on cavity evolution is mainly reflected in three aspects: surface splash, cavity wall, and cavity surface closure time. The ice-hole constraint changes the flow range of the water near the free surface, affecting the direction and shape of the surface splashing. The ice-hole inhibits the cavity expansion near the free surface. Under the smaller ice-hole diameter condition, the left-sided cavity wall directly collides with the inner wall of the ice-hole, which causes the curvilinearity of the left wall of the cavity near the free surface. Simultaneously, under the ice-hole condition, the surface closure time of the cavity is altered, and the distribution of the air and vapor inside the cavity is changed. A larger shear deformation region appears near the free surface, and there are more large-scale vortices inside the cavity, which leads to the acceleration of the velocity of the fluid and the decrease in the pressure near the free surface. Moreover, the impact force is changed at the initial stage of the cylinder passing through the ice-hole. The ice-hole condition leads to a faster velocity attenuation and a greater deflection during the oblique water-entry process of the cylinder. [ABSTRACT FROM AUTHOR]

Background: This study developed a nomogram model using CT-based delta-radiomics features and clinical factors to predict pathological complete response (pCR) in esophageal squamous cell carcinoma (ESCC) patients receiving neoadjuvant chemoradiotherapy (nCRT). Methods: The study retrospectively analyzed 232 ESCC patients who underwent pretreatment and post-treatment CT scans. Patients were divided into training (n = 186) and validation (n = 46) sets through fivefold cross-validation. 837 radiomics features were extracted from regions of interest (ROIs) delineations on CT images before and after nCRT to calculate delta values. The LASSO algorithm selected delta-radiomics features (DRF) based on classification performance. Logistic regression constructed a nomogram incorporating DRFs and clinical factors. Receiver operating characteristic (ROC) and area under the curve (AUC) analyses evaluated nomogram performance for predicting pCR. Results: No significant differences existed between the training and validation datasets. The 4-feature delta-radiomics signature (DRS) demonstrated good predictive accuracy for pCR, with α-binormal-based and empirical AUCs of 0.871 and 0.869. T-stage (p = 0.001) and differentiation degree (p = 0.018) were independent predictors of pCR. The nomogram combined the DRS and clinical factors improved the classification performance in the training dataset (AUCαbin = 0.933 and AUCemp = 0.941). The validation set showed similar performance with AUCs of 0.958 and 0.962. Conclusions: The CT-based delta-radiomics nomogram model with clinical factors provided high predictive accuracy for pCR in ESCC patients after nCRT. [ABSTRACT FROM AUTHOR]

The prognosis of HCC patients without MVI (so called M0) is highly heterogeneous and the need for adjuvant therapy is still controversial. Patients with HCC with M0 who underwent liver resection (LR) or liver transplantation (LT) as an initial therapy were included. The Eastern Hepatobiliary Surgery Hospital (EHBH)-M0 score was developed from a retrospective cohort to form the training cohort. The classification which was developed using multivariate cox regression analysis was externally validated. The score was developed using the following factors: α-fetoprotein level, tumour diameter, liver cirrhosis, total bilirubin, albumin and aspartate aminotransferase. The score differentiated two groups of M0 patients (≤3, >3 points) with distinct long-term prognoses outcomes (median overall survival (OS), 98.0 vs. 46.0 months; p < 0.001). The predictive accuracy of the score was greater than the other commonly used staging systems for HCC. And for M0 patients with a higher score underwent LR. Adjuvant transcatheter arterial chemoembolization (TACE) was effective to prolong OS. The EHBH M0 scoring system was more accurate in predicting the prognosis of HCC patients with M0 after LR or LT. Adjuvant therapy is recommended for HCC patients who have a higher score. [ABSTRACT FROM AUTHOR]

Manipulating elastic waves propagating in the desired manner has attracted substantial attention, and the metasurfaces offer the important ideas to achieve this goal. In particular, it will be more advantageous if wave function switching can be achieved without changing the microstructure of the metasurface. In the paper, a knob elastic metasurface is designed to realize the regulation of flexural wave covering the 0–2π range of phase shift by rotating the angle of the knob. When the metasurface is in the turn-on state, the angles of the knob at different positions can be adjusted reasonably though the generalized Snell's law to achieve several phenomena of anomalous refraction, beam focus, and non-paraxial self-acceleration of flexural wave in a wide frequency. And when the metasurface is placed in the turn-off state, the total reflection of the flexural wave can be realized, and then bidirectional vibration isolation can be achieved. [ABSTRACT FROM AUTHOR]

Regular blood glucose monitoring and control is necessary for people with type 1 or advanced type 2 diabetes, yet diagnosing and treating patients with diabetes in an accurate, sustained and patient‐friendly manner remains limited. Here, a glucose‐responsive bifunctional nanosystem (PGOxMns) is constructed via one‐pot biomineralisation of manganese dioxide with glucose oxidase and ε‐poly‐L‐lysine. Under hyperglycaemic conditions, the cascade reactions that occur when glucose interacts with PGOxMns can trigger the production of Mn(II), which enhances the magnetic resonance imaging signal. Simultaneously, manganese dioxide catalyses the decomposition of toxic hydrogen peroxide into oxygen, which also maintains glucose oxidase (GOx) activity. In an in vivo model of diabetes, PGOxMns is used to monitor glucose levels (0–20 mm) and allowed identification of diabetic mice via T1‐weighted MRI. Furthermore, PGOxMns is found to have a high insulin‐loading capacity (83.6%), likely due to its positive charge. A single subcutaneous injection of insulin‐loaded nanosystem (Ins‐PGOxMns) into diabetic mice resulted in a rapid and efficient response to a glucose challenge and prolonged blood glucose level control (< 200 mg dL−1) for up to 50 h. Overall, this proof‐of‐concept study demonstrates the feasibility of using biomineralised nanosystems to develop patient‐friendly strategies for glucose monitoring and control. [ABSTRACT FROM AUTHOR]

In this study, a novel molecularly imprinted polymer (MIP) was synthesized with attapulgite (ATP) and acrylamide (AM) and ethyl methacrylate (MMA) for controlled release carrier of 5-fluorouracil (5-FU). The MIPs (PAM-PMMA) were characterized by XRD, FESEM, HRTEM, and FTIR. The drug loading and in vitro controlled release ability of MIP on 5-FU was investigated by adsorption property analysis and in vitro release analysis. MIPs (PAM-PMMA) reached a maximum drug loading of 12 mg/g and a maximum release of 80% at an ATP dosage of 0.2 g (0.4%), an initial concentration of 5-FU of 100 mg/L, and an adsorption time of 240 min. Cytotoxicity analysis showed that the maximum inhibition of cells could reach 25% at 72 h of cell culture time under the above conditions. The results showed that MIPs synthesized with ATP as the substrate and AM and MMA as the functional monomers were successfully synthesized and could be used as a drug delivery system for 5-FU. [ABSTRACT FROM AUTHOR]

In the karst area, the epikarst increases the infiltration of rainfall and the depressions and conduits make water exchange frequently between surface rivers and karst aquifers. To improve simulation accuracy, we proposed the Soil and Water Assessment Tool-Genetic Algorithm-Back Propagation (SWAT-GA-BP) model. Also, the SWAT-tank model was created to elaborate the runoff processes in different karst systems. Furthermore, we designed three scenarios to study the influence of land use changes on runoff. The Zuo River Basin was selected as a case study. Compared to SWAT, the determination coefficient of the SWAT-GA-BP increased by 4.8% and the Nash-Sutcliffe efficiency increased by 4.9%; the rapid flow accounted for more than 50% of the total runoff, and the slow flow for less than 10%; the contribution of the land use changes was 10.80% from 2008 to 2012 and 5.57% from 2013 to 2017. Therefore, the effect of land use change on runoff should not be ignored. [ABSTRACT FROM AUTHOR]

[Display omitted] Due to lack of effective, early and non-invasive diagnostic as well as treatment tools, the surgical treatment opportunities for lung squamous cell carcinoma (SCC) are limited, resulting in high mortality rates. Therefore, the combination of targeted recognition and precise treatment of lung SCC is of great significance. In this study, a multifunctional nanoparticle is designed and synthesized, which specifically identifies lung SCC cells for target imaging and therapy. Desmoglein-3 (Dsg-3), a transmembrane glycoprotein found in desmosomes, is highly expressed in lung SCC cells. Gold nanoclusters (AuNCs) conjugated with Dsg-3 antibodies to form Au-Dsg-3 through coupling reaction. The results showed that the fluorescence imaging (FI) intensity and computed tomography (CT) signal of Au-Dsg-3 significantly increased within 6 h in vitro and in vivo , achieving dual-modal imaging to detect lung SCC effectively. Besides, Au-Dsg-3 even integrates targeted photothermal therapy (PTT) characteristics in a single nanoparticle. When exposed to near-infrared radiation (NIR), the temperature of the tumor site increased rapidly and reached a high temperature of 53.3 °C after 600 s, causing tumor ablation and growth inhibition. In summary, Au-Dsg-3 provides a key platform for targeted biological imaging and collaborative PTT, which demonstrates good performance on lung SCC. [ABSTRACT FROM AUTHOR]

Single-cell RNA-sequencing (scRNA-seq) has emerged as a powerful technique to identify novel cell markers, developmental trajectories, and transcriptional changes during cell differentiation and disease onset and progression. In this review, we highlight recent scRNA-seq studies of the gastric corpus in both human and murine systems that have provided insight into gastric organogenesis, identified novel markers for the various gastric lineages during development and in adults, and revealed transcriptional changes during regeneration and tumorigenesis. Overall, by elucidating transcriptional states and fluctuations at the cellular level in healthy and disease contexts, scRNA-seq may lead to better, more personalized clinical treatments for disease progression. [ABSTRACT FROM AUTHOR]

Nanomaterials are increasingly being employed for biomedical applications, necessitating a comprehensive understanding of their degradation behavior and potential toxicity in the biological environment. This study utilizes a continuous flow system to simulate the biologically relevant degradation conditions and investigate the effects of pH, protein, redox species, and chelation ligand on the degradation of iron oxide nanoparticles. The morphology, aggregation state, and relaxivity of iron oxide nanoparticles after degradation are systematically characterized. The results reveal that the iron oxide nanoparticles degrade at a significantly higher rate under the acidic environment. Moreover, incubation with bovine serum albumin enhances the stability and decreases the dissolution rate of iron oxide nanoparticles. In contrast, glutathione accelerates the degradation of iron oxide nanoparticles, while the presence of sodium citrate leads to the fastest degradation. This study reveals that iron oxide nanoparticles undergo degradation through various mechanisms in different biological microenvironments. Furthermore, the dissolution and aggregation of iron oxide nanoparticles during degradation significantly impact their relaxivity, which has implications for their efficacy as magnetic resonance imaging contrast agents in vivo. The results provide valuable insights for assessing biosafety and bridge the gap between fundamental research and clinical applications of iron oxide nanoparticles. [ABSTRACT FROM AUTHOR]

The 5′-open reading frame (ORF) acts as an upstream ORF to restrict overaccumulation of the 3′-ORF encoding protein of the Reduced height-B1b gene to moderately reduce plant height in wheat. [ABSTRACT FROM AUTHOR]

Background: Gemcitabine is a cornerstone drug for the treatment of all stages of pancreatic cancer and can prolong the survival of patients with pancreatic cancer, but resistance to gemcitabine in pancreatic cancer patients hinders its efficacy. The overexpression of Early growth response 1(EGR1) in pancreatic ductal adenocarcinoma as a mechanism of gemcitabine chemoresistance in pancreatic cancer has not been explored. The major mechanisms of gemcitabine chemoresistance are related to drug uptake, metabolism, and action. One of the common causes of tumor multidrug resistance (MDR) to chemotherapy in cancer cells is that transporter proteins increase intracellular drug efflux and decrease drug concentrations by inducing anti-apoptotic mechanisms. It has been reported that gemcitabine binds to MDR1 with high affinity. The purpose of this research was to investigate the potential mechanisms by which EGR1 associates with MDR1 to regulate gemcitabine resistance in pancreatic cancer cells. Methods: The following in vitro and in vivo techniques were used in this research to explore the potential mechanisms by which EGR1 binds to MDR1 to regulate gemcitabine resistance in pancreatic cancer cells. Cell culture; in vitro and in vivo study of EGR1 function by loss of function analysis. Binding of EGR1 to the MDR1 promoter was detected using the ChIP assay. qRT-PCR, Western blot assays to detect protein and mRNA expression; use of Annexin V apoptosis detection assay to test apoptosis; CCK8, Edu assay to test cell proliferation viability. The animal model of pancreatic cancer subcutaneous allograft was constructed and the tumours were stained with hematoxylin eosin and Ki-67 expression was detected using immunohistochemistry. Findings: We revealed that EGR1 expression was increased in different pancreatic cancer cell lines compared to normal pancreatic ductal epithelial cells. Moreover, gemcitabine treatment induced upregulation of EGR1 expression in a dose- and time-dependent manner. EGR1 is significantly enriched in the MDR1 promoter sequence.Upon knockdown of EGR1, cell proliferation was impaired in CFPAC-1 and PANC-1 cell lines, apoptosis was enhanced and MDR1 expression was decreased, thereby partially reversing gemcitabine chemoresistance. In animal experiments, knockdown of EGR1 enhanced the inhibitory effect of gemcitabine on tumor growth compared with the sh-NC group. Conclusions: Our study suggests that EGR1 may be involved in the regulation of MDR1 to enhance gemcitabine resistance in pancreatic cancer cells. EGR1 could be a novel therapeutic target to overcome gemcitabine resistance in pancreatic cancer. [ABSTRACT FROM AUTHOR]

The boom of microelectronic devices and their diverse applications has heightened the demand for innovative and effective energy supply strategies. The longevity of contemporary microelectronic devices predominantly depends on direct human intervention power supply methods, encompassing battery replacement or recharging. However, these methods may falter in specific scenarios, such as when facing liquid conditions in vivo. Here, a concept of swimmable micro‐batteries (MBs) for targeted power delivery is presented. This is achieved through the design of a flexible polydimethylsiloxane/Fe3O4 soft‐magnetic substrate for actuation, polydimethylsiloxane/neodymium‐iron‐boron (NdFeB) hard‐magnetic tabs for precise targeting, and quasi‐solid‐state Zn//MnO2 battery for power generation. These swimmable MBs exhibit an impressive areal capacity of 102.3 µAh cm‐2, remarkable waterproofing, adjustable output voltage or capacity, rapid response, and accurate remote magnetic field manipulation, enabling targeted power supply available. This novel swimmable MB design broadens the function of MBs and may open a new avenue for their future development. [ABSTRACT FROM AUTHOR]

Background: Acetyl-CoA acetyltransferase 2 (ACAT2) is a lipid metabolism enzyme and rarely was researched in epithelial ovarian cancer (EOC). Methods: ACAT2 expressions were confirmed in two pairs of cell lines (A2780 and A2780/DDP, OVCAR8 and OVCAR8/DDP) from Gene Expression Omnibus database by bioinformatics analysis, and in A2780 and A2780/DDP cell lines by quantitative real-time polymerase chain reaction and western blotting. Tissue samples were stained by immunohistochemistry and scored for ACAT2 expression. The relationships between ACAT2 expression and clinicopathological characteristics were analyzed by χ2 test. The prognosis of ACAT2 was analyzed by the log-rank tests and Cox regression models. Results: ACAT2 was remarkably upregulated in the above drug-resistant cell lines by mRNA (all P < 0.05) and protein expression (P = 0.026) than those in sensitive ones. Patients were classified as ACAT2-high (n = 51) and ACAT2-low (n = 26) according to immunohistochemical score. ACAT2 expression had a significantly inverse correlation with FIGO stage (P = 0.030) and chemo-response (P = 0.041). A marginal statistical significance existed in ACAT2 expression and ascites volume (P = 0.092). Univariate analysis suggested that high-expressed ACAT2 was associated with decreased platinum-free interval (PFI) (8.57 vs. 14.13 months, P = 0.044), progression-free survival (PFS) (14.12 vs. 19.79 months, P = 0.039) and overall survival (OS) (36.89 vs. 52.40 months, P = 0.044). Multivariate analysis demonstrated that ACAT2 expression (hazard ratio = 2.18, 95% confidence interval: 1.15–4.11, P = 0.017) affected OS independently, rather than PFI and PFS. Conclusion: The expression of ACAT2 in A2780/DDP and OVCAR8/DDP was higher than the corresponding A2780 and OVCAR8. High-expressed ACAT2 was associated with advanced FIGO stage, chemo-resistance, and decreased PFI, PFS and OS. It was an independent prognostic factor of OS in EOC. [ABSTRACT FROM AUTHOR]

The accurate preoperative diagnosis and tracking of lung adenocarcinoma is hindered by non-targeting and diffusion of dyes used for marking tumors. Hence, there is an urgent need to develop a practical nanoprobe for tracing lung adenocarcinoma precisely even treating them noninvasively. Herein, Gold nanoclusters (AuNCs) conjugate with thyroid transcription factor-1 (TTF-1) antibody, then multifunctional nanoprobe Au-TTF-1 is designed and synthesized, which underscores the paramount importance of advancing the machine learning diagnosis and bioimaging-guided treatment of lung adenocarcinoma. Bright fluorescence (FL) and strong CT signal of Au-TTF-1 set the stage for tracking. Furthermore, the high specificity of TTF-1 antibody facilitates selective targeting of lung adenocarcinoma cells as compared to common lung epithelial cells, so machine learning software Lung adenocarcinoma auxiliary detection system was designed, which combined with Au-TTF-1 to assist the intelligent recognition of lung adenocarcinoma jointly. Besides, Au-TTF-1 not only contributes to intuitive and targeted visualization, but also guides the following noninvasive photothermal treatment. The boundaries of tumor are light up by Au-TTF-1 for navigation, it penetrates into tumor and implements noninvasive photothermal treatment, resulting in ablating tumors in vivo locally. Above all, Au-TTF-1 serves as a key platform for target bio-imaging navigation, machine learning diagnosis and synergistic PTT as a single nanoprobe, which demonstrates attractive performance on lung adenocarcinoma. [ABSTRACT FROM AUTHOR]

Against the backdrop of the judicialization transformation of global climate governance, China's judicial system has shown a comprehensive and positive attitude towards addressing climate change. It is urgent to form a systematic localization plan for climate justice as a new specialized field of environmental justice. The localization of climate justice emphasizes its subjectivity, the understanding of which requires placing the concept system, function orientation, trial mechanism, adjudication system, and rules of climate justice in the specific background and social structure of the modernization of China's rule of law, and its internal logic is a dynamic system encompassing normative system, value sequence, and function orientation. Currently, the multi-level legislation in China's system of climate judicial norms presents indirect and principled characteristics, coupled with the insufficient creation of diversified judicial norms and the unfinished task of systematization, inducing circumscribed dilemmas and coherent problems in climate judicial norms. Under such circumstances, the identification and core value of the legal interests protected by climate justice have not been clearly defined, and many external factors, such as scientific uncertainty, policy trade-offs, and economic incentives, limit the value judgment of climate change cases. These issues profoundly affect the function orientation and development direction of climate justice as public welfare and governance justice. Therefore, the approaches and paths for the localization of climate justice should be based on the triple logic of norm, value, and function as well as the problems or requirements presented. Firstly, it is necessary to strengthen the shaping of an order incorporating multiple norms. The specific path is to promote the systematization of climate change legislation through the synergy of public and private laws, to consolidate consensus by strengthening secondary climate judicial norms, and to enhance the compatibility of the climate judicial normative system using diversified legal interpretation methods. Secondly, there is a need to establish the authority of legal argument with interests as the core, to strengthen the substantive reasons of the judgment by assessing carbon-related interests, to reinforce the openness of the judgment through the multi-dimensional protection of climate and environmental interests, and to enhance the authoritative reasons for the judgment through the balance of external and legal factors. Finally, it is necessary to shape the dual functions of climate justice precisely, with the principle of risk prevention to build preventive public interest climate justice and policy judicialization to build governance climate justice that serves the ' dual carbon' goals. [ABSTRACT FROM AUTHOR]

Molecularly imprinted polymers and non‐imprinted polymers based on attapulgite and graphene composite were synthesized by coating with copolymer of acrylamide and methyl methacrylate. The adsorption results showed that the molecularly imprinted polymers and non‐imprinted polymers could reach the maximum drug loading of 2.4 and 1.6 mg/g, respectively. The in vitro release studies demonstrated that molecularly imprinted polymers and non‐imprinted polymers can control the release of 5‐fluorouracil and reach maximum release at approximately 48 h. Cytotoxicity analysis showed that 100 μg/mL of molecularly imprinted polymers loaded with 5‐fluorouracil gradually increased the inhibition rate of HeLa with increasing time and approached the maximum inhibition rate of 20 % at 72 h. [ABSTRACT FROM AUTHOR]

Background: Immune checkpoint blockade (ICB) represents a revolutionary advance in cancer treatment but remains limited success in triple-negative breast cancer (TNBC). Here we aim to explore the mechanism of RNA-binding protein (RBP) HuR in cancer immune evasion by post-transcriptionally regulating PD-L1 and evaluate the potential of HuR inhibition to improve immune response. Methods: The binding between HuR and PD-L1 mRNA was determined by ribonucleoprotein immunoprecipitation and RNA pull-down assays. The HuR knockout clones were established by CRISPR/Cas9 technology. The protein levels were assessed by Western blot, immunohistochemistry, and immunocytochemistry. The function and molecular mechanism of HuR-PD-L1 were determined by in vitro T cell activation and killing assay and in vivo efficacy assay. Results: We found that HuR directly bound to and stabilized PD-L1 mRNA. Knocking out HuR reduced PD-L1 levels and promoted T cell activation. We discovered that niclosamide reduced PD-L1 by inhibiting HuR cytoplasmic translocation, and diminished glycosylation of PD-L1. Niclosamide enhanced T cell-mediated killing of cancer cells and significantly improved the efficacy of anti-PD-1 immunotherapy in two syngeneic animal tumor models. Conclusion: We identified HuR as a novel posttranscriptional regulator of PD-L1, which plays an important role in tumor immune evasion. Niclosamide might be a promising repurposed drug to improve the patient response to immunotherapy by targeting HuR-PD-L1 axis. Our study demonstrates a novel strategy for targeting HuR/PD-L1 and provides the first proof-of-principle for repurposing niclosamide as a HuR inhibitor to overcome cancer immune evasion and improve response to ICB immunotherapy. [ABSTRACT FROM AUTHOR]

Background: Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disease, which is an important cause of female infertility worldwide. PCOS patients are in a state of chronic low‐grade inflammation, and immune imbalance is considered as a potential cause of its pathogenesis. Methods: The expression of AOC4P in PCOS and normal ovarian granulosa cells (GCs) was detected by real‐time quantitative PCR. KGN cells were induced by dihydrotestosterone at 500 ng/mL to construct the PCOS model. After lentivirus‐infected, KGN cells were constructed with AOC4P overexpression cell lines, the proliferation and apoptosis levels of KGN cells in AOC4P and NC groups were detected. Human monocyte cell line (THP‐1)‐derived macrophages and peripheral blood mononuclear cells (PBMC) were co‐cultured with KGN cells for 48 h, respectively, and the differentiation of macrophages and CD4+ T cells were detected by flow cytometry. Results: Decreased AOC4P expression was found in PCOS patients. After constructing the PCOS cell model, we observed that overexpression of AOC4P promoted KGN cell proliferation and inhibited apoptosis. After co‐culture with AOC4P overexpressed KGN cells, M1 macrophages decreased, M2 macrophages increased, T helper cells type 1 (Th1)/Th2 ratio increased, and regulatory T cell (Treg) cells increased. Finally, we found that AOC4P inhibited the activation of the nuclear factor κ B (NF‐κB) pathway in KGN cells. Conclusions: In this study, we found that AOC4P regulated the NF‐κB signaling pathway by inhibiting the phosphorylation of P65, thereby affecting the proliferation and apoptosis of GCs, altering the differentiation of macrophages and T cells, thus contributing to the pathogenesis of PCOS. [ABSTRACT FROM AUTHOR]

In this paper, we establish a social coalitional weak equilibrium existence theorem with a continuum of agents, which is an infinite-player extension of the fully cooperative version of Ichiishi (1981). As a unified approach, we obtain the weak α-core existence theorems of normal-form games and exchange economies with a continuum of agents by the social coalitional weak equilibrium existence theorem. [ABSTRACT FROM AUTHOR]

Lakes play a crucial role in the earth's ecosystems and human activities. While turbidity is not a direct biochemical indicator of lake water quality, it is relatively easy to measure and indicates trophic status and lake health. Although ocean color satellites have been widely used to monitor water color parameters, their coarse spatial resolution makes it hard to capture the fine spatial variability of turbidity in lakes. The combination of Sentinel-2 and Landsat provides an opportunity to monitor lake turbidity with high spatial and temporal resolution. This study aims to generate consistent turbidity products in Taihu Lake from 2018 to 2022 using the Multispectral Instrument (MSI) on board Sentinel-2A/B and the Operational Land Imager (OLI) on board Landsat-8/9. We first tested the performance of three atmospheric correction methods to retrieve consistent reflectance from MSI and OLI images. We found that the Rayleigh correction and a subtraction of the SWIR band from Rayleigh-corrected reflectance can generate the most consistent reflectance (the coefficient of determination (R2) > 0.84, the mean absolution percentage error (MAPE) < 7%, the median error (ME) < 0.0035, and slope > 0.92). Machine learning models outperformed an existing semi-analytical retrieval algorithm in retrieving turbidity (MSI: R2 = 0.92, MAPE = 18.78%, and OLI: R2 = 0.93, MAPE = 16.20%). The consistency of turbidity from the same-day MSI and OLI images was also satisfactory (N = 3110 and MAPE = 26.48%). The distribution of turbidity exhibited obvious spatial and seasonal variability in Taihu Lake from 2018 to 2022. The results show the potential of MSI and OLI when combined to monitor inland lake water quality. [ABSTRACT FROM AUTHOR]

A novel process optimization was proposed by rotational vibration and structural design of flax yarns to manufacture large‐tow flax fiber prepreg filaments for 3D printing components with balanced efficiency and performance. It demonstrated that the untwisting of flax yarns generated by rotational vibration produced a dispersed yarn structure, which provided more flow channels for the polylactic acid (PLA) resin to infiltrate yarns. As for the structural design of yarns, the specific surface area increases after replacing the single yarn of large liner density with multiple fine yarns, which further shortens the impregnation time. Unidirectional continuous flax fiber‐reinforced thermoplastic (CFRTP) composites were obtained by 3D printing. The mechanical test results showed that the tensile properties of CFRTP composites were significantly increased using filaments consisting of multiple fine flax yarns and the aid of rotational vibration due to the improved impregnation of yarns with PLA resin. [ABSTRACT FROM AUTHOR]

We study the mixed-state entanglement for AdS Born-Infeld (BI) theory. We calculate the mixed-state entanglement and investigate the relationship between it and the system parameters. We find that the holographic entanglement entropy (HEE) and mutual information (MI) exhibit monotonically increasing and decreasing behavior with BI factor b. However, the entanglement wedge cross-section (EWCS) exhibits a very rich set of phenomena about system parameters. EWCS always increases with b when b is small and then monotonically decreases with b. These behaviors suggest that increasing the BI factor, which is essentially enhancing the coupling between the background geometry and the transport properties can always enhance the EWCS. The coupling between the entanglement and the transport behaviors has also been studied in condensed matter theories and is important to construct a stable quantum circuit. We also provide analytical understanding of the above phenomenon. Furthermore, we have tested two additional BI-like models and find the universality of these results, suggesting the crucial role of the BI term in governing the interplay between nonlinear electromagnetic effects and entanglement. [ABSTRACT FROM AUTHOR]

Hybrid materials of earth abundant transition metal dichalcogenides and noble metal nanoparticles, such as molybdenum sulfide (MoSx) and gold nanoparticles, exhibit synergistic effects that can enhance electrocatalytic reactions. However, most current hybrid MoSx-gold synthesis requires an energy intensive heat source of >500 °C or chemical plating to achieve deposition of MoSx on the gold surface. Herein, we demonstrate the direct overgrowth of MoSx over colloidal nanoporous gold (NPG), conducted feasibly under ambient conditions, to form hybrid particles with enhanced electrocatalytic performance toward hydrogen evolution reaction. Our strategy exploits the localized surface plasmon resonance-mediated photothermal heating of NPG to achieve >230 °C surface temperature, which induces the decomposition of the (NH4)2MoS4 precursor and direct overgrowth of MoSx over NPG. By tuning the concentration ratio between the precursor and NPG, the amount of MoSx particles deposited can be systematically controlled from 0.5% to 2% of the Mo/(Au + Mo) ratio. Importantly, we find that the hybrid particles exhibit higher bridging and an apical S to terminal S atomic ratio than pure molybdenum sulfide, which gives rise to their enhanced electrocatalytic performance for hydrogen evolution reaction. We demonstrate that hybrid MoSx-NPG exhibits >30 mV lower onset potential and a 1.7-fold lower Tafel slope as compared to pure MoSx. Our methodology provides an energy- and cost-efficient synthesis pathway, which can be extended to the synthesis of various functional hybrid structures with unique properties for catalysis and sensing applications. [ABSTRACT FROM AUTHOR]

This work proposed a hybrid modeling framework for the safety monitoring of coking rates in FCC (Fluidized Catalytic Cracking) disengager. The framework combines CFD (Computational Fluid Dynamics), coking FPM (First Principles Model), machine learning, and industrial data to establish a comprehensive and customizable approach. The FPM of the coking rate, including the UNIFAC condensation ratio model, the coking ratio model and the capture ratio model, are established by combustion experiments, gas-solid two-phase flow simulations and DPM (Discrete Phase Model) simulations. The capture ratio model is built to calculate the capture ratio of heavy oil droplets by each high-risk region, achieved by DPM simulation. By establishing a link between the simulated position and the DCS (Distributed Control System) sensor, the simulation results and the real-time DCS data are matching. An improved LSTM (Long Short-Term Memory) network was then established to predict the real-time temperature and pressure in the high-risk coking regions of the disengager using real-time DCS and LIMS (Laboratory Information Management System) data. The LSTM network can achieve online monitoring of coking rate by coupling FPM. This hybrid coking monitoring framework has been industrially applied and validated with an accuracy of over 90% in a continuous one-month online monitoring task, which is highly interpretable and extensible, providing refining companies with a scalable and customizable approach to monitor coking problems in FCC disengager. [ABSTRACT FROM AUTHOR]

Summary: Traffic congestion, air pollution, fuel wastage, and car accidents are all exacerbated by increased traffic. Thus, vehicular communications, which refer to information transmission between cars, pedestrians, and infrastructures, have lately gained popularity and been extensively explored due to their enormous potential to enable intelligent transportation and various safety applications. Manually piloted cars and automated vehicles can acquire relevant information via vehicular communications to enhance traffic security and boost entertainment services. The basic concept of automobile clouds was originally published in the literature not long ago, and several suggested structural approaches have been presented in this study thus far. Several academics have concentrated on the structural layout to address various problems and, as a result, satisfy user expectations in order to give dependable services. We examined various vehicular cloud topologies in this study. We also offered a complete summary of current network layer research on allowing efficient vehicle communications and examined specific security, architectural, and reliability concerns in vehicular clouds. Also, the taxonomy of vehicular networks was discussed in terms of the service link between vehicular networks and cloud computing. Ultimately, we discussed the research prospects available. The results showed that security and privacy challenges are among the most important challenges. [ABSTRACT FROM AUTHOR]

In this paper, we investigate the mixed-state entanglement in a model of p-wave superconductivity phase transition using holographic methods. We calculate several entanglement measures, including holographic entanglement entropy (HEE), mutual information (MI), and entanglement wedge cross-section (EWCS). Our results show that these measures display critical behavior at the phase transition points, with the EWCS exhibiting opposite temperature behavior compared to the HEE. Furthermore, we explore the behavior of thermodynamics and holographic quantum information at the zeroth-order phase transition point and find that it is opposite to that observed in the first-order phase transition. Additionally, we find that the critical exponents of all entanglement measures are twice those of the condensate. Our findings also suggest that the EWCS is a more sensitive indicator of the critical behavior of phase transitions than the HEE. Lastly, we uncover a universal inequality in the growth rates of EWCS and MI near critical points in thermal phase transitions, such as p-wave and s-wave superconductivity, suggesting that MI captures more information than EWCS when a phase transition first occurs. [ABSTRACT FROM AUTHOR]

Background: Zinc finger and BTB domain-containing protein 4 (ZBTB4) belongs to the zinc finger protein family, which has a role in regulating epigenetic inheritance and is associated with cell differentiation and proliferation. Previous studies have identified aberrant ZBTB4 expression in cancer and its ability to modulate disease progression, but studies on the immune microenvironment, immunotherapy and its role in cancer are still lacking. Methods: Human pan-cancer and normal tissue transcriptome data were obtained from The Cancer Genome Atlas. The pan-cancer genomic alteration landscape of ZBTB4 was investigated with the online tool. The Kaplan–Meier method was used to evaluate the prognostic significance of ZBTB4 in pancreatic cancer. In parallel, ZBTB4 interacting molecules and potential functions were analyzed by co-expression and the correlation between ZBTB4 and immune cell infiltration, immune modulatory cells and efficacy of immune checkpoint therapy was explored. Next, we retrieved the Gene Expression Omnibus database expression datasets of ZBTB4 and investigated ZBTB4 expression and clinical significance in pancreatic cancer by immunohistochemical staining experiments. Finally, cell experiments were performed to investigate changes in pancreatic cancer cell proliferation, migration and invasion following overexpression and knockdown of ZBTB4. Findings: ZBTB4 showed loss of expression in the majority of tumors and possessed the ability to predict cancer prognosis. ZBTB4 was closely related to the tumor immune microenvironment, immune cell infiltration and immunotherapy efficacy. ZBTB4 had good diagnostic performance for pancreatic cancer in the clinic, and ZBTB4 protein expression was lost in pancreatic cancer tumor tissues. Cell experiments revealed that overexpression of ZBTB4 inhibited the proliferation, migration and invasion of pancreatic cancer cells, while silencing ZBTB4 showed the opposite effect. Conclusions: According to our results, ZBTB4 is present in pancreatic cancer with aberrant expression and is associated with an altered immune microenvironment. We show that ZBTB4 is a promising marker for cancer immunotherapy and cancer prognosis and has the potential to influence pancreatic cancer progression. [ABSTRACT FROM AUTHOR]

Object detection and recognition is a very important topic with significant research value. This research develops an optimised model of moving target identification based on CNN to address the issues of insufficient positioning information and low target detection accuracy (convolutional neural network). In this article, the target classification information and semantic location information are obtained through the fusion of the target detection model and the depth semantic segmentation model. The classification and position portion of the target detection model is provided by the simultaneous fusion of the image features carrying various information and a pyramid structure of multiscale image features so that the matched image fusion characteristics can be used by the target detection model to detect targets of various sizes and shapes. According to experimental findings, this method's accuracy rate is 0.941, which is 0.189 higher than that of the LSTM-NMS algorithm. Through the migration of CNN and the learning of context information, this technique has great robustness and enhances the scene adaptability of feature extraction as well as the accuracy of moving target position detection. [ABSTRACT FROM AUTHOR]

In this paper, we consider a class of mixed duopoly games with a nonlinear demand function. We investigate the quantizations of mixed duopoly games by the Li–Du–Massar and Frackiewicz quantum schemes. By solving the quantum equilibrium quantities, profits and objectives, we find that the quantum equilibrium quantities and objectives are all monotonically increasing with respect to entanglement level, and the quantum equilibrium profits are monotonically decreasing with respect to entanglement level. Our main contribution is to consider some new quantum game models by the existing quantum schemes. [ABSTRACT FROM AUTHOR]

Converter-interfaced renewable energy sour- ces are directly integrated into the power system using power electronics, so unique fault characteristics may lead to the maloperation of traditional distance relays. In this article, to deal with this issue, a harmonic injection- based distance protection method is proposed. The controllable harmonic current is injected without revising the controller structure, and the harmonic frequency and magnitude are determined according to the grid feature. Since the proportional integral cannot track the sine component without the static error, the actual frequency response will be deduced using the transfer function. On this basis, the harmonic impedance measured at the relay point can accurately reflect the fault distance due to the disappearance of the remote infeed, so the proposed method has a strong ability to withstand the fault resistance. Meanwhile, it only needs a few modifications to the phasor extraction method in original protection devices, so it is easy for engineering applications. Furthermore, typical fault ride through requirements can be still satisfied. Simulation results in PSCAD and real-time digital simulator verify the proposed method in different fault scenarios. [ABSTRACT FROM AUTHOR]

The plasma pyrolysis and plasma catalysis of methane coupling were performed under room temperature and atmosphere. The coupling of methane through gliding arc plasma with different H 2 /CH 4 ratios and N 2 flow rates exhibited conversion from 25% to 40% and high selectivity of acetylene above 90%. Plasma emission spectra displayed lowest I Hβ /I Hα ratio at H 2 /CH 4 ratio of 3, while I Hβ /I Hα ratio decreased with increasing N 2 feed rate from 0 to 2 L/min, which had similar variation with selectivity of acetylene. X-ray photoelectron spectra for reduced catalysts demonstrated that metallic Pd species (335.4 eV) were transferred to electron-rich Pd species (334.8eV and 334.1 eV) with increasing Pd loading and Ag/Pd ratio, corresponding to red shift of linear adsorbed CO stretching frequency from 2060 to 2068 cm−1 to 2055-2015 cm−1. Superior plasma catalytic behavior over 0.1Pd0.5Ag/Al 2 O 3 catalyst has been reached with 86.5% selectivity of ethene and 36.2% conversion of methane. • Methane coupling to ethene can achieve high yield of 30.2% through plasma catalysis. • Gliding arc plasma made high gas temperature leading to more acetylene production. • Proper AgPd catalyst exhibited great suitability for plasma catalysis process. [ABSTRACT FROM AUTHOR]

The impact of droplets on moving liquid surfaces is a ubiquitous phenomenon in nature and in industry. In the present study, we experimentally investigated the impinging process of a deionized water droplet on a shear-driven water film. A parameter study of the Weber number of the primary droplet and dimensionless moving water film thickness was carefully carried out. A high-speed camera was used to record the whole impact and splashing processes of the water droplet. The results showed that the shearing air could significantly change the crown morphology, causing the crown to tilt downstream. Besides, the droplet Weber number had a significant effect on the crown evolution. With the increase of the droplet Weber number, the spreading crown length, the maximum crown height, the upstream crown angle, and the number of secondary droplets increased. Besides, under the current experimental conditions, the moving water film thickness had a minor effect on the crown maximum height. Considering the influence of droplet Weber number and moving water film thickness, we proposed empirical correlations for the maximum upstream crown height and maximum downstream crown height. And the present empirical correlations agreed well with the experimental data. [ABSTRACT FROM AUTHOR]

[Display omitted] • Pl-Si/Ag/Pc is identified as an efficient and stable catalyst for CO 2 reduction. • Functionalizing pl-Si/Ag with Pc enhances the selectivity of CO from CO 2 RR. • The CO faradaic efficiency is 90.8 % at the optimal potential of −1.5 V vs. RHE. • The Pc molecule is anchored on pl-Si/Ag through Ag-N and Si-N bonds. • Pc enriches surface CO 2 concentration and inhibits the competing HER during CO 2 RR. The photo-assisted electrochemical CO 2 reduction reaction (CO 2 RR) toward CO stands as a highly promising pathway for addressing environmental challenges and produces valuable chemicals. In this study, a novel pl-Si/Ag/Pc electrode was developed with the surface enveloped by an amorphous phthalocyanine overlayer. The pl-Si/Ag/Pc electrode has gained recognition as a catalyst of exceptional quality, displaying superior activity, selectivity toward CO, and stability. A synergistic mechanism has been revealed from experimental results that Ag served as active centers for CO 2 RR, Pc facilitated CO 2 adsorption and suppressed the competing HER reaction. Functionalizing the surface of electrode with Pc enhanced the CO selectivity (FE CO at 90.8 % under −1.5 V vs RHE) during the CO 2 RR process and reduced the cost in following product separation procedures. This study presents an uncomplicated yet effective approach for formulating durable and discerning electrocatalysts dedicated to the utilization of CO 2. [ABSTRACT FROM AUTHOR]