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It has been found that the topology effect and the possible emergent hidden scale and hidden local flavor symmetries at high density reveal a novel structure of compact star matter. When N f ≥ 2 , baryons can be described by skyrmions when the number of color N c is regarded as a large parameter and there is a robust topology change—the transition from skyrmion to half-skyrmion—in the skyrmion matter approach to dense nuclear matter. The hidden scale and local flavor symmetries, which are sources introducing the scalar meson and vector mesons, are significant elements for understanding the nuclear force in nonlinear chiral effective theories. We review in this paper how the robust conclusions from the topology approach to dense matter and emergent hidden scale and hidden local flavor symmetries figure in generalized nuclear effective field theory (GnEFT), which is applicable to nuclear matter from low density to compact star density. The topology change encoded in the parameters of the effective field theory is interpreted as the hadron-quark continuity in the sense of the Cheshire Cat Principle. A novel feature predicted in this theory that has not been found before is the precocious appearance of the conformal sound velocity in the cores of massive stars, although the trace of the energy-momentum tensor of the system is not zero. That is, there is a pseudoconformal structure in the compact star matter and, in contrast to the usual picture, the matter is made of colorless quasiparticles of fractional baryon charges. A possible resolution of the longstanding g A quench problem in nuclei transition and the compatibility of the predictions of the GnEFT with the global properties of neutron star and the data from gravitational wave detections are also discussed. [ABSTRACT FROM AUTHOR]

A new isoflavone derivative compound 1 (psoralenone) was isolated from soybean inoculated with a marine fungus Aspergillus terreus C23-3, together with seven known compounds including isoflavones 2–6, butyrolactone I (7) and blumenol A (8). Their structures were elucidated by MS, NMR, and ECD. Psoralenone displayed moderate in vitro anti-inflammatory activity in the LPS-induced RAW264.7 cell model. Compound 2 (genistein) showed moderate acetylcholinesterase (AChE) inhibitory activity whereas compounds 2, 5 (biochanin A), 6 (psoralenol), and 7 exhibited potent larvicidal activity against brine shrimp. Compounds 3 (daidzein), 4 (4ʹ-hydroxy-6,7-dimethoxyisoflavone), and 5–7 showed broad-spectrum anti-microbial activity, and compound 7 also showed moderate 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity. An anti-inflammatory isoflavone from soybean fermented by a marine fungus Aspergillus terreus C23-3 [ABSTRACT FROM AUTHOR]