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Simple Summary: The objective of this study was to assess the effects of supplementing 1.0% of isoflavone in a dry extruded diet for neutered adult cats on energy requirements, body composition, and satiety. Isoflavones are natural compounds found in certain plant products, such as soybeans. Previous research has indicated that these compounds may reduce body fat, decrease caloric intake, and enhance satiety. However, in this study, the administered dose did not lead to significant changes in the evaluated variables in domestic felines. Isoflavones are composed of phytoestrogens (genistein and daidzein), which can be metabolized by cats. These compounds can promote the maintenance of lean body mass and control food intake. These effects are desirable in neutered animals, as they are predisposed to obesity. The objective of this study was to evaluate the effects of dietary supplementation of 1.0% isoflavone on the metabolizable energy intake, serum concentrations of satiety-related hormones and peptides, and body composition of neutered cats. Sixteen neutered adult cats were blocked by gender and divided into two groups (n = 8): the control group (CG) received a commercial diet, while the isoflavone group (IG) received the same diet supplemented by 1% of isoflavone for 99 days. Computed tomography was performed on the first and last experimental days to assess the animals' body composition. Satiety challenges were conducted on days 19 and 44. In the last day of the study, blood samples were collected to determine the concentration of insulin, ghrelin, leptin, peptide YY, and GLP-1. A statistical analysis was conducted using R software 3.5.2, considering both the interaction and individual effects of group and time (p < 0.05). The average intake of genistein in the IG was 0.75 ± 0.10 mg/kg body weight, and daidzein intake was 51.73 ± 7.05 mg/kg. No significant individual or interaction effects were observed for any of the analyzed variables. Therefore, the inclusion of 1.0% isoflavone in the diet did not affect the energy requirements, satiety responses, or body composition of neutered adult cats. [ABSTRACT FROM AUTHOR]

From both economic and environmental points of view, the reuse of dredged sediments in the direct onsite casting of concrete represents a promising method for replacing sand. The aim of this study was to develop a cementitious material that (i) reuses the thin particles of sediments; (ii) has a low density due to the incorporation of air foam in the material; and (iii) achieves a minimum mechanical strength of 0.5 MPa for embankment applications. This study focused on the characterization of a non-standard "concrete", which is a mixture of a synthetic soil (80% montmorillonite and 20% calibrated sand) and cement. To reduce its density, air foam was incorporated into the material during the manufacturing process (air-foamed lightweight clay concrete—AFLCC). The study results highlight that a density around 1.2 (unit: g/cm3/1 g/cm3) can be obtained. This density reduction can be obtained with a certain degree of workability when the material is in a fresh state. To obtain this workability, a certain amount of water must be added; however, the addition of water has a significant impact on the compressive strength of the AFLCC. As such, a mathematical equation correlating the compressive strength, the density, and the percentage of cement is proposed in this study. The mechanical strength results of the AFLCC at different times, in conjunction with the Vicat results, show that the porosity created by the air foam has the effect of slowing down the hydration mechanism of the cement. The porosities obtained are consistent with the density results. The characteristic radii indicate large pore sizes for formulations with low fluidity in the fresh state when air bubbles are incorporated. [ABSTRACT FROM AUTHOR]

Let ω be a closed, non-degenerate differential form of arbitrary degree. Associated to it there are an L∞-algebra of observables, and an L∞-algebra of sections of the higher Courant algebroid twisted by ω. Our main result is the existence of an L∞-embedding of the former into the latter. We display explicit formulae for the embedding, involving the Bernoulli numbers. When ω is an integral symplectic form, the embedding can be realized geometrically via the prequantization construction, and when ω is a 3-form the embedding was found by Rogers in 2010. Further, in the presence of homotopy moment maps, we show that the embedding is compatible with gauge transformations. [ABSTRACT FROM AUTHOR]

We investigate the variability of the power emission of Io's hotspots by using recent Juno/JIRAM infrared observations. The Jovian Infrared Auroral Mapper (JIRAM) is an imaging spectrometer which began observing Jupiter in August 2016. Although observing Jupiter's moons is not its primary objective, JIRAM can use the frequent opportunities to observe Io (up to once per orbit) to gather infrared images and spectra of its surface. The present study uses the data acquired by JIRAM during the last 2 years, including the location and morphology of Io's hotspots, and the temporal variability of the total output. A new photometric model for the hotspots and the dayside surface has been developed, which permits us to disentangle the temporal variability from the changes in the observation geometry. While the latitudinal dependence of the power output is not well constrained, low-latitude hotspots show a significantly more intense temporal variability and greater temperature. [ABSTRACT FROM AUTHOR]

The list of standard abbreviations for JDS is available at adsa.org/jds-abbreviations-24. Nonstandard abbreviations are available in the Notes. Dairy cows experiencing heat stress (HS) during the precalving portion of the transition period give birth to smaller calves and produce less milk and milk protein. Supplementation of rumen-protected methionine (RPM) has been shown to modulate protein, energy, and placenta metabolism, making it a potential candidate to ameliorate HS effects. We investigated the effects of supplementing RPM to transition cows under HS induced by electric heat blanket (EHB) on cow-calf performance. Six weeks before expected calving, 53 Holstein cows were housed in a tiestall barn and fed a control diet (CON, 2.2% Met of MP) or a CON diet supplemented with SmartamineM (MET, 2.6% Met of MP, Adisseo Inc., France). Four weeks precalving, all MET and half CON cows were fitted with an EHB. The other half of the CON cows were considered thermoneutral (TN), resulting in 3 treatments: CONTN (n = 19), CONHS (n = 17), and METHS (n = 17). Respiratory rate (RR), skin temperature (ST), and rectal temperature (RT) were measured thrice weekly and core body temperatures recorded biweekly. Postcalving BW and BCS were recorded weekly, and DMI was calculated and averaged weekly. Milk yield was recorded daily and milk components were analyzed every third DIM. Biweekly AA and weekly nonesterified fatty acids (NEFA), BHB, insulin, and glucose were measured from plasma. Calf birth weight and 24 h growth, thermoregulation, and hematology profile were measured and apparent efficiency of absorption (AEA) of immunoglobulins was calculated. Data were analyzed using the MIXED procedure of SAS with 2 preplanned orthogonal contrasts: CONTN versus the average of CONHS and METHS (C1) and CONHS versus METHS (C2). Relative to TN, EHB cows had increased RT during the postcalving weeks and increased RR and ST during the entire transition period. Body weight, BCS, DMI, and milk yield were not affected by the EHB or RPM. However, protein percentage and SNF were lower in CONHS, relative to METHS cows. At calving, METHS dams had higher glucose concentrations, relative to CONHS, and during the postcalving weeks, the EHB cows had lower NEFA concentrations than TN cows. Calf birthweight and AEA were reduced by HS, whereas RR was increased by HS. Calf withers height tended to be shorter and RT were lower in CONHS, compared with METHS heifers. Overall, RPM supplementation to transition cows reverts the negative effect of HS on blood glucose concentration at calving and milk protein percentage in the dams and increases wither height while decreasing RT in the calf. [ABSTRACT FROM AUTHOR]

We investigate the variability of the power emission of Io's hotspots by using recent Juno/JIRAM infrared observations. The Jovian Infrared Auroral Mapper (JIRAM) is an imaging spectrometer which began observing Jupiter in August 2016. Although observing Jupiter's moons is not its primary objective, JIRAM can use the frequent opportunities to observe Io (up to once per orbit) to gather infrared images and spectra of its surface. The present study uses the data acquired by JIRAM during the last 2 years, including the location and morphology of Io's hotspots, and the temporal variability of the total output. A new photometric model for the hotspots and the dayside surface has been developed, which permits us to disentangle the temporal variability from the changes in the observation geometry. While the latitudinal dependence of the power output is not well constrained, low-latitude hotspots show a significantly more intense temporal variability and greater temperature. [ABSTRACT FROM AUTHOR]

Geological maps of Earth typically incorporate field observations of rock lithology, structure, composition, and more. In contrast, conventional planetary geological maps are often made using primarily qualitative morphostratigraphic remote sensing observations of planetary surfaces. However, it is possible to define independent quantitative spectral units (SUs) of planetary surfaces, which potentially contain information about surface composition, grain size, and space weathering exposure. Here, we demonstrate a generic method to combine independently derived geomorphic and SUs, using the Rachmaninoff basin, Mercury, as an example to create a new geostratigraphic map. From this geostratigraphic map, we can infer some compositional differences within geomorphic units, which clarifies and elaborates on the geological evolution of the region. Plain Language Summary: Geological maps of rocks on Earth include information about what landforms the rocks exhibit, what they are made from, their orientation, and more. Many such details require ground observations, but these are generally not available for planetary geological maps, which rely on spacecraft data. Spacecraft images can be used to map planetary surface textures (geomorphology), but they can also be used to measure surfaces' responses to light (reflectance or emission spectra), which contain information about what the surface rocks are made from, their physical properties (e.g., grain size, roughness, porosity), and how long they have been exposed at the surface. We have combined earlier, independent geomorphic and spectral maps of the Rachmaninoff impact basin on Mercury to create a new "geostratigraphic" map that is more like a geological map that could be made of Earth. The new map highlights places that in the original geomorphic map would have been mapped all as a single unit, but are divisible based on spectral variations, attributable to differences in what the rocks are made from. This allows us to reconstruct a more detailed geological history of the region. Our method can be applied to other regions on Mercury and to other planetary surfaces. Key Points: We combine independent morphostratigraphic and spectral units of Rachmaninoff basin to create geostratigraphic unitsGeostratigraphic units can distinguish volcanic plains and impact melt in contact with each otherGeostratigraphic units imply a wider distribution of (LRM‐composition) impact melt than previously recognized [ABSTRACT FROM AUTHOR]

Severe droughts, water-use conflicts, and minimum outflow requirements have caused infeasibilities in modeling large-scale complex hydrothermal systems. This paper presents and discusses a new formulation of objective function and constraints to better represent multiple water uses and deal with infeasibilities in the HIDROTERM model, a nonlinear programming (NLP) model developed to optimize the operation of the Brazilian interconnected hydrothermal system. The system is one of the largest in the world. In the last 10 years, approximately 72% of electricity consumed in Brazil has been supplied by hydropower plants, but with increasing shares from thermal, wind, and, more recently, solar power generation. Because of hydrological changes in recent years and the additional operational constraints imposed by environmental agencies, the use of models for decision making, such as HIDROTERM, frequently encounters the problem of infeasibility. To avoid this problem, a new objective function is proposed in HIDROTERM that incorporates economic penalties when the preset requirements are not met. Based on economic considerations, some hard constraints are removed from the constraint set and added to the objective function as penalty terms. These constraints are tightly linked with multiple water uses, including environmental protection, flood control, consumptive uses, and navigation purposes. The proposed change in the objective function and constraints avoids the problem of infeasibilities and makes it possible to apply the model to extreme conditions. Additionally, this formulation helps identify and minimize the risk, duration, and intensity of unavoidable non-compliance occurrences related to multiple water uses. The presented new version of the HIDROTERM model can be used to study and support decision making in the management and operation of large-scale hydrothermal systems. These systems can be formed by a set of hydraulically connected individual hydropower plants and reservoirs, located within a set of electrically connected subsystems. Each subsystem contains demands and other power plants, including thermal, wind, nuclear, and solar plants, and exchanges. The model has been developed with continued improvements since 2008 and applied to large systems such as the Brazilian Interconnected Power System (BIPS) with over 150 reservoirs. A graphical user interface is provided. The objective function is to minimize the total costs of additional thermal dispatch and exchanges, as well as avoid or minimize deficits in energy supply in subsystems, minimum releases, consumptive uses, and minimum storages in reservoirs. The decision variables are the power and nonpower releases for each hydropower plant and the thermal dispatches and exchanges for each subsystem. Some typical applications include (1) monthly planning operation of the system, considering a planning horizon from 3 to 5 years; (2) diagnostic studies about reliability and resilience of existing systems, processing the same system configuration to a set of different hydrological or energy demand scenarios; (3) impact analysis of changes in operational rules and constraints related to multiple uses of water; and (4) planning and evaluation of expansion alternatives. The model can be applied to a complete hydrothermal system or subsets of it, including subsystems, basins, cascades, or a single hydropower plant. [ABSTRACT FROM AUTHOR]

Neuromuscular diseases encompass a heterogeneous array of disorders characterized by varying onset ages, clinical presentations, severity, and progression. While these conditions can stem from acquired or inherited causes, this review specifically focuses on disorders arising from genetic abnormalities, excluding metabolic conditions. The pathogenic defect may primarily affect the anterior horn cells, the axonal or myelin component of peripheral nerves, the neuromuscular junction, or skeletal and/or cardiac muscles. While inherited neuromuscular disorders have been historically deemed not treatable, the advent of gene-based and molecular therapies is reshaping the treatment landscape for this group of condition. With the caveat that many products still fail to translate the positive results obtained in pre-clinical models to humans, both the technological development (e.g., implementation of tissue-specific vectors) as well as advances on the knowledge of pathogenetic mechanisms form a collective foundation for potentially curative approaches to these debilitating conditions. This review delineates the current panorama of therapies targeting the most prevalent forms of inherited neuromuscular diseases, emphasizing approved treatments and those already undergoing human testing, offering insights into the state-of-the-art interventions. [ABSTRACT FROM AUTHOR]

The document is a corrigendum for an article on Io's hotspots, correcting references to various studies and authors. The corrections ensure accurate citations and do not impact the scientific conclusions of the original article. The authors are from various institutions in Italy, the United States, and other countries, emphasizing international collaboration in space research. [Extracted from the article]

Objectives: Pathogenic variants in AIFM1 have been associated with a wide spectrum of disorders, spanning from CMT4X to mitochondrial encephalopathy. Here we present a novel phenotype and review the existing literature on AIFM1‐related disorders. Methods: We performed EEG recordings, brain MRI and MR Spectroscopy, metabolic screening, echocardiogram, clinical exome sequencing (CES) and family study. Effects of the variant were established on cultured fibroblasts from skin punch biopsy. Results: The patient presented with drug‐resistant, electro‐clinical, multifocal seizures 6 h after birth. Brain MRI revealed prominent brain swelling of both hemispheres and widespread signal alteration in large part of the cortex and of the thalami, with sparing of the basal nuclei. CES analysis revealed the likely pathogenic variant c.5T>C; p.(Phe2Ser) in the AIFM1 gene. The affected amino acid residue is located in the mitochondrial targeting sequence. Functional studies on cultured fibroblast showed a clear reduction in AIFM1 protein amount and defective activities of respiratory chain complexes I, III and IV. No evidence of protein mislocalization or accumulation of precursor protein was observed. Riboflavin, Coenzyme Q10 and thiamine supplementation was therefore given. At 6 months of age, the patient exhibited microcephaly but did not experience any further deterioration. He is still fed orally and there is no evidence of muscle weakness or atrophy. Interpretation: This is the first AIFM1 case associated with neonatal seizures and diffuse white matter involvement with relative sparing of basal ganglia, in the absence of clinical signs suggestive of myopathy or motor neuron disease. [ABSTRACT FROM AUTHOR]

The purpose of this paper is to extend the store of models able to support integrable defects by investigating the two-dimensional Boussinesq nonlinear wave equation. As has been previously noted in many examples, insisting that a defect contributes to energy and momentum to ensure their conservation, despite the presence of discontinuities and the explicit breaking of translation invariance, leads to sewing conditions relating the two fields and their derivatives on either side of the defect. The manner in which several types of soliton solutions to the Boussinesq equation are affected by the defect is explored and reveals new effects that have not been observed in other integrable systems, such as the possibility of a soliton reflecting from a defect or of a defect decaying into one or two solitons. [ABSTRACT FROM AUTHOR]

The performance of Bioactive Mesoporous Glasses (MBGs) as tissue regeneration scaffolds can be enhanced by the addition of therapeutic inorganic ions (TIIs) or organic molecules. In order to maximise the benefits conferred by different TIIs and organic molecules on bioactive glasses, we investigated the behavior of a 1:1 mixture (wt.%) of MBGs doped with cerium and loaded separately with gentamicin (Gen) and polyphenols (POLY). The resulting admixed material preserves bioactivity of the unloaded cerium-doped MBGs, assessed by evaluating the formation of an apatitic layer. Furthermore, it shows both antioxidant properties, evaluated by the reduction of Reactive Oxygen Species (ROS) measured by enzymatic assays, conferred by cerium POLY loadings and antibacterial properties conferred by Gen, and estimated by a modification of the Kirby-Bauer agar diffusion method. Ce-MBGs can thus be applied as a useful dual drug delivery system (DDS) with hard tissue regeneration capabilities. [ABSTRACT FROM AUTHOR]

Given an L ∞ -algebra V and an L ∞ -subalgebra W, we give sufficient conditions for all small Maurer–Cartan elements of V to be equivalent to Maurer–Cartan elements lying in W. As an application, we obtain a stability criterion for fixed points of a Dirac structure in an arbitrary Courant algebroid of split signature (for instance a twisted Poisson structure), i.e., points where the corresponding leaf is zero-dimensional. The criterion guarantees that any nearby Dirac structure also has a fixed point. [ABSTRACT FROM AUTHOR]

This work aimed to verify the relationships between the total factor productivity (TFP) of the Brazilian states and their public expenditures by functions, namely: judiciary; legislative; administration/planning; education and culture; industry, commerce and services; science and technology; social assistance and pension; and, health. The analyzes covered the period from 2003 to 2018, and, for the econometric estimates, the panel data methodology was adopted. Control variables were used to give robustness to the results. The results reveal that most expenditures did not have significant relations on total factor productivity, with the exception of expenditures on health and the judiciary, but which had relatively small correlations. [ABSTRACT FROM AUTHOR]

Mitochondrial leukodystrophies constitute a group of different conditions presenting with a wide range of clinical presentation but with some shared neuroradiological features. Genetic defects in NUBPL have been recognized as cause of a pediatric onset mitochondrial leukodystrophy characterized by onset at the end of the first year of life with motor delay or regression and cerebellar signs, followed by progressive spasticity. Early magnetic resonance imagings (MRIs) show white matter abnormalities with predominant involvement of frontoparietal regions and corpus callosum. A striking cerebellar involvement is usually observed. Later MRIs show spontaneous improvement of white matter abnormalities but worsening of the cerebellar involvement evolving to global atrophy and progressive involvement of brainstem. After the 7 cases initially described, 11 more subjects were reported. Some of them were similar to patients from the original series while few others broadened the phenotypic spectrum. We performed a literature review and report on a new patient who further expand the spectrum of NUBPL-related leukodystrophy. With our study we confirm that the association of cerebral white matter and cerebellar cortex abnormalities is a feature commonly observed in early stages of the disease but beside the original and so far prevalent presentation, there are also uncommon phenotypes: clinical onset can be earlier and more severe than previously thought and signs of extraneurological involvement can be observed. Brain white matter can be diffusely abnormal without anteroposterior gradient, can progressively worsen, and cystic degeneration can be present. Thalami can be involved. Basal ganglia can also become involved during disease evolution. [ABSTRACT FROM AUTHOR]

Historical-genetic analysis on the origin of the Superior Institutes of Religious Sciences in Italy. Religious sciences are somehow presented as a course for laypeople and they are considered as a second level when compared to theological studies leading to a scientific research and opening to the achievement of all academic graduations. A short research shows that in Italy "religious sciences" were originally thought as a theological formation for laypeople who could not attend theological studies in seminars. A short historical survey found their academic raison d'être in studying the relationship "faith and culture" and the religious phenomena with an interdisciplinary method in the light of the Revelation. Afterwards a course of studies with a feeble epistemological path focused on the theological and ministerial formation of laypeople and future religion teachers. May religious sciences have lost their original vocation? [ABSTRACT FROM AUTHOR]

Micropropagated Catharantus roseus plants infected with 'Candidatus Phytoplasma asteris' showed virescence symptoms, witches' broom symptoms, or became asymptomatic after their planting in pots. Nine plants were grouped into three categories according to these symptoms, which were then employed for investigation. The phytoplasma concentration, as determined by qPCR, correlated well with the severity of symptoms. To reveal the changes in the small RNA profiles in these plants, small RNA high-throughput sequencing (HTS) was carried out. The bioinformatics comparison of the micro (mi) RNA and small interfering (si) RNA profiles of the symptomatic and asymptomatic plants showed changes, which could be correlated to some of the observed symptoms. These results complement previous studies on phytoplasmas and serve as a starting point for small RNA-omic studies in phytoplasma research. [ABSTRACT FROM AUTHOR]

Hereditary motor neuropathies (HMN) were first defined as a group of neuromuscular disorders characterized by lower motor neuron dysfunction, slowly progressive length-dependent distal muscle weakness and atrophy, without sensory involvement. Their cumulative estimated prevalence is 2.14/100.000 and, to date, around 30 causative genes have been identified with autosomal dominant, recessive, and X-linked inheritance. Despite the advances of next generation sequencing, more than 60% of patients with HMN remain genetically uncharacterised. Of note, we are increasingly aware of the broad range of phenotypes caused by pathogenic variants in the same gene and of the considerable clinical and genetic overlap between HMN and other conditions, such as Charcot-Marie-Tooth type 2 (CMT2; axonal), spinal muscular atrophy with lower extremities predominance (SMA-LED), neurogenic arthrogryposis multiplex congenita (AMC), and juvenile amyotrophic lateral sclerosis (ALS). Considering that most HMN present during childhood, in this review we primarily aim to summarise key clinical features of paediatric forms, including recent data on novel phenotypes, to help guide differential diagnosis and genetic testing. Secondly, we describe newly identified causative genes and molecular mechanisms, and discuss how the discovery of these is changing the paradigm through which we approach this group of conditions. [ABSTRACT FROM AUTHOR]

In this work, we present the most updated catalog of Io hot spots based on Juno/JIRAM data. We find 242 hot spots, including 23 previously undetected. Over the half of the new hot spots identified, are located at high northern and southern latitudes (>70°). We observe a latitudinal variability and a larger concentration of hot spots in the polar regions, in particular in the North. The comparison between JIRAM and the most recent Io hot spot catalogs listing power output (Veeder et al., 2015, https://doi.org/10.1016/j.icarus.2014.07.028; de Kleer, de Pater, et al., 2019, https://doi.org/10.3847/1538-3881/ab2380), shows JIRAM detected 63% and 88% of the total number of hot spots, respectively. Furthermore, JIRAM observed 16 of the 34 faint hot spots previously identified. JIRAM data revealed thermal emission from 5 dark pateræ inferred to be active from color ratio images, thus confirming that these are hot spots. Plain Language Summary: We mapped the hot spot distribution on Io's surface by analyzing the images acquired by the JIRAM instrument onboard the Juno spacecraft. We identified 242 hot spots, including 23 not present in other catalogs. A large number of the new hot spots identified are in the polar regions, specifically in the northern hemisphere. The comparison between our work and the most recent and updated catalog reveals that JIRAM detected 82% of the most powerful hot spots previously identified and half of the intermediate‐power hot spots, thus showing that these are still active. JIRAM detected 16 out of the 34 faint hot spots previously reported. The resolution of JIRAM may not have been sufficient to detect these faint hot spots, or activity might have faded or stopped. Key Points: We produced a new Io hot spot map based on Juno/JIRAM dataWe identified 242 hot spots, including 23 previously undetectedThe latitudinal hot spot distribution is uneven with a larger concentration at the poles [ABSTRACT FROM AUTHOR]

Outstanding achievements of graph neural networks for spatiotemporal time series analysis show that relational constraints introduce an effective inductive bias into neural forecasting architectures. Often, however, the relational information characterizing the underlying datagenerating process is unavailable and the practitioner is left with the problem of inferring from data which relational graph to use in the subsequent processing stages. We propose novel, principled--yet practical--probabilistic score-based methods that learn the relational dependencies as distributions over graphs while maximizing end-to-end the performance at task. The proposed graph learning framework is based on consolidated variance reduction techniques for Monte Carlo score-based gradient estimation, is theoretically grounded, and, as we show, effective in practice. In this paper, we focus on the time series forecasting problem and show that, by tailoring the gradient estimators to the graph learning problem, we are able to achieve state-of-the-art performance while controlling the sparsity of the learned graph and the computational scalability. We empirically assess the effectiveness of the proposed method on synthetic and real-world benchmarks, showing that the proposed solution can be used as a stand-alone graph identification procedure as well as a graph learning component of an end-to-end forecasting architecture. [ABSTRACT FROM AUTHOR]

The main aim of this work was to verify the effects of credit on the economic growth of the municipalities of Espírito Santo, in the period from 2006 to 2018, using spatial econometrics for panel data. According to the results, all estimated spatial models revealed significant spatial effects, and the Durbin spatial model (SDM) presented the best fit when using the Akaike information criterion (AIC). The main results show that the variables credit supply and number of branches, without spatial lag, were significant and positively correlated with the economic growth of the municipalities. In addition, there were spatial spillover effects of the variables credit supply, number of branches and GDP per capita on the economic growth of municipalities. It is noteworthy that the variables number of branches and GDP per capita had a positive spatial relationship with economic growth, while the spatially lagged supply of credit had a negative relationship. [ABSTRACT FROM AUTHOR]

This paper examines the dependence structure between the Brazilian stock market (IBOVESPA) and some relevant global factors. The study covers the period from January 2010 to December 2020 (daily frequency) and adopts the quantile regression approach. Regarding to existing empirical literature, this work advances in two main points: i) it uses the most recent data, including the initial phase of the COVID-19 pandemic, which significantly affected world financial markets; and ii) it checks whether the global crisis, arising from the COVID-19 pandemic, affected the dependency structure and the co-movements between the IBOVESPA index and global factors. The mean results reveal that the Brazilian stock market exhibit dependence with global factors, especially regarding to the series SP&500 (SP500), oil price (WTI) and exchange rate (CAM). The US volatility index (VIX) and the US policy uncertainty index (IIP) do not significantly impact the IBOVESPA. In addition, during the COVID-19 pandemic period, it can be seen that: a) the statistical significance of the variables was verified only in some quantiles, especially in the intermediate quantiles; b) the SP500 variable had its effects accentuated; and c) the price of oil started to show a negative correlation with the returns of the IBOVESPA. Finally, the dependency structure appears to be symmetrical with respect to the quantiles, in both scenarios (crisis and non-crisis of the COVID-19 pandemic). [ABSTRACT FROM AUTHOR]

Food safety is a widespread challenge. Every year it is estimated that almost 1 in 10 people in the world fall ill after eating contaminated food resulting in over 400,000 deaths. The risk of outbreaks is higher when consuming ready‐to‐eat (RTE) products because they are eaten without a further cooking process that could inactivate pathogenic microorganisms. Hence, food processing is essential to increase the safety of RTE products. Microbiological risk assessment (MRA) integrates food science, microbiology and data science to provide a comprehensive understanding of the safety of the food system. MRA provides qualitative and/or quantitative information to decision makers, which might promote the adoption of better food practices. In this contest, this project aims to study and implement tools for quantitative microbial risk assessment (QMRA) of food products along the food chain. A common RTE product (cured ham) from Spain was used as a case study. Following, the exposure assessment model was implemented using mathematical models and statistical software to describe the microbial behaviour along the food chain. The study presents the possibility to identify the risk exposure in different scenarios (e.g. growth during different storage conditions, inactivation induced by traditional or innovative decontamination techniques), showing the flexibility of the predictive tools developed. [ABSTRACT FROM AUTHOR]

Food safety is a widespread challenge. Every year it is estimated that almost 1 in 10 people in the world fall ill after eating contaminated food resulting in over 400,000 deaths. The risk of outbreaks is higher when consuming ready‐to‐eat (RTE) products because they are eaten without a further cooking process that could inactivate pathogenic microorganisms. Hence, food processing is essential to increase the safety of RTE products. Microbiological risk assessment (MRA) integrates food science, microbiology and data science to provide a comprehensive understanding of the safety of the food system. MRA provides qualitative and/or quantitative information to decision makers, which might promote the adoption of better food practices. In this contest, this project aims to study and implement tools for quantitative microbial risk assessment (QMRA) of food products along the food chain. A common RTE product (cured ham) from Spain was used as a case study. Following, the exposure assessment model was implemented using mathematical models and statistical software to describe the microbial behaviour along the food chain. The study presents the possibility to identify the risk exposure in different scenarios (e.g. growth during different storage conditions, inactivation induced by traditional or innovative decontamination techniques), showing the flexibility of the predictive tools developed. [ABSTRACT FROM AUTHOR]

From the perspective of successive events, chemical reactions are expressed or thought about, in terms of the cause-effect category. In this work, I will firstly discuss some aspects of causation and interaction in chemistry, argue for the interaction, and propose an alternative or complementary representation scheme called "interaction diagram", that allows representing chemical reactions through a geometric diagram. The understanding of this diagram facilitates the analysis of reactions in terms of the interaction, or reciprocal action, among the participating entities. Secondly, I will describe the model and provide examples and finally, I will discuss the scope and limitations of the current development status of the model. [ABSTRACT FROM AUTHOR]

• SMA displays a multi-systemic involvement across different tissues and organs. • Non-neuronal manifestations may contribute to SMA pathology and symptoms. • Unknown multi-system mechanisms are under investigation in preclinical studies. • Novel phenotypes in treated patients warrant refined clinical monitoring and care. • Close interaction between patients, researchers and clinicians needs to be prioritized. [ABSTRACT FROM AUTHOR]

Aim: To correlate the North Star Ambulatory Assessment (NSAA) and timed rise from floor (TRF) recorded at age of expected peak with age at loss of ambulation (LOA) in Duchenne muscular dystrophy (DMD). Method: Male children with DMD enrolled in the UK North Start Network database were included according to the following criteria: follow‐up longer than 3 years, one NSAA record between 6 years and 7 years 6 months (baseline), at least one visit when older than 8 years. Data about corticosteroid treatment, LOA, genotype, NSAA, and TRF were analysed. Age at LOA among the different groups based on NSAA and TRF was determined by log‐rank tests. Cox proportional hazard models were used for multivariable analysis. Results: A total of 293 patients from 13 different centres were included. Mean (SD) age at first and last visit was 5 years 6 months (1 year 2 months) and 12 years 8 months (2 years 11 months) (median follow‐up 7 years 4 months). Higher NSAA and lower TRF at baseline were associated with older age at LOA (p<0.001). Patients scoring NSAA 32 to 34 had a probability of 0.61 of being ambulant when older than 13 years compared with 0.34 for those scoring 26 to 31. In multivariable analysis, NSAA, TRF, and corticosteroid daily regimen (vs intermittent) were all independently associated with outcome (p=0.01). Interpretation: Higher functional abilities at peak are associated with older age at LOA in DMD. This information is important for counselling families. These baseline measures should also be considered when designing clinical trials. [ABSTRACT FROM AUTHOR]

Espírito Santo is nationally recognized as an example of institutional evolution and constant improvement in the quality of its public policies in recent decades, but there was still no study of this type about its municipalities. The objective of this work is to verify whether the quality of municipal institutions in Espírito Santo positively influences their growth rates, using data from 2000 and 2010. Regarding the empirical strategy, the method of Least Squares in Two Stages is adopted, making the use of regression models for cross-sectional data (specific regressions for the years 2000 and 2010) and panel data (using a panel of individual fixed effects). The results reveal that the quality of institutions had a positive impact on the growth of municipalities in Espírito Santo in both models. [ABSTRACT FROM AUTHOR]

We assessed the impact of MRI and PSA density on the probability to pursue an active surveillance of prostate cancer. We found that the use of these characteristics could improve selection of patients at diagnosis, stratifying the delayed treatment risk. During follow-up, some biopsies could be avoided with a reasonably risk and higher MRI lesion were at high-risk of treatment. Introduction: A greater selection of candidates for active surveillance (AS) of prostate cancer (PCa) may decrease the rate of delayed treatment. We aimed to study: 1) the impact of MRI and PSA density (PSAd) at baseline on the final status, and 2) the impact of bio-clinical features during the follow-up on pursuing AS. Materials and Methods: This retrospective, monocentric study between June 2013 and July 2020, included 99 patients in AS (median follow-up: 19 months [18-92]). All MRI were reviewed by a single radiologist. Lost to follow-up were 17 patients and 6 patients chose treatment by themselves. Treatment was proposed in case of upgrading (= GG2) or increasing PCa volume. Results: Impact of MRI and PSAd at baseline: Combining PSAd = 0.15 and PIRADS = 3, the probability to remain in AS was 72%. This rate reached 83% when PSAd = 0.10 was associated to normal MRI. During follow-up: One hundred fiftyseven prostatic biopsies (PBx) were performed and 38 (24%) found PCa upgrading. The association between negative MRI and PSAd = 0.10, during follow-up, had an excellent NPV to predict treatment (95%). This combination concerned 25% (37/151) of surveillance biopsies that could have been avoided at the cost of delaying upgrading in 3% (1/37). In multivariate analysis, only PIRADS = 4 before PBx was associated to a risk of treatment during follow-up (OR, 10.4 [95% CI, 4.2-25.8]; P < .0001). Conclusion: Using PSAd and MRI at baseline to select patients showed excellent performances to predict the maintenance in AS. During follow-up, MRI PIRADS = 4 was associated to an increased risk of treatment. [ABSTRACT FROM AUTHOR]

We consider homotopy actions of a Lie algebroid on a graded manifold, defined as suitable L ∞ -algebra morphisms. On the "semi-direct product" we construct a homological vector field that projects to the Lie algebroid. Our main theorem states that this construction is a bijection. Since several classical geometric structures can be described by homological vector fields as above, we can display many explicit examples, involving Lie algebroids (including extensions, representations up to homotopy and their cocycles) as well as transitive Courant algebroids. [ABSTRACT FROM AUTHOR]