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Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. The detailed epigenomic changes during fat accumulation in liver are not clear yet. Here, we performed ChIP‐Seq analysis in the liver tissues of high‐fat diet and regular chow diet mice and investigated the dynamic landscapes of H3K27ac and H3K9me3 marks on chromatin. We find that the activated typical enhancers marked with H3K27ac are enriched on lipid metabolic pathways in fat liver; however, super enhancers do not change much. The regions covered with H3K9me3 repressive mark seem to undergo great changes, and its peak number and intensity both decrease in fat liver. The enhancers located in lost H3K9me3 regions are enriched in lipid metabolism and inflammatory pathways; and motif analysis shows that they are potential targets for transcription factors involved in metabolic and inflammatory processes. Our study has revealed that H3K9me3 may play an important role during the pathogenesis of NAFLD through regulating the accessibility of enhancers. [ABSTRACT FROM AUTHOR]

Abstract: A bismuth 3-nitro-1,2,4-triazol-5-one (Bi-NTO) complex was prepared and characterized, and its effects on the thermal behaviors, non-isothermal decomposition reaction kinetics, and burning rates of the double-base (DB) propellant containing the mixed ester of triethyleneglycol dinitrate (TEGDN) and nitroglycerin (NG) with Bi-NTO complex as a ballistic modifier were investigated by thermogravimetry and derivative thermogravimetry (TG–DTG), and differential scanning calorimetry (DSC). The results show that Bi-NTO complex can increase the decomposition heat by 140Jg−1, and it can change the decomposition reaction mechanism function, the kinetic parameters and kinetic equation of the propellant under 0.1MPa. Combustion experiment shows that Bi-NTO complex can increase the burning rate and reduce the pressure exponent of the NG/TEGDN/NC propellant effectively, with the increase of the catalysis efficiency by 40%. [Copyright &y& Elsevier]

The effects of pressure and triethyleneglycol dinitrate (TEGDN) content on the decomposition reaction mechanism and kinetics of the double-base (DB) gun propellant composed of mixed ester of TEGDN and nitroglycerin (NG), and nitrocellulose (NC) were investigated by high-pressure differential scanning calorimetry (PDSC). The results show that the high pressure can decrease the DSC peak temperature, increase the decomposition heat; with the increase in the content of TEGDN, the decomposition heat decreases below 2MPa and rises at 4MPa. The high pressure can change the decomposition reaction mechanism and the kinetics of the DB gun propellant under 0.1MPa; the high TEGDN content does not change the mechanism functions, and the kinetic equation has a little difference between the sample and the control propellant; the high pressure makes the critical temperature (T be) of thermal explosion of the sample decrease, while the high TEGDN content make it present a increasing trend, and the DB gun propellant containing high content of TEGDN has a better thermal stability. [Copyright &y& Elsevier]