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1. Synthesis of Anthraquinone Oligonucleotides for Triplex Stabilization.

Author

Zhao, Zhengyun, Peng, Guomei, Michels, Jan, Fox, KeithR., and Brown, Tom

Subjects
*PHOSPHORUS, *QUINONE, *URACIL, *OLIGONUCLEOTIDES, *ANTHRAQUINONES
Abstract

The synthesis of two anthraquinone phosphoramidites is described. In both cases the anthraquinone moiety is attached via a linker to the 5-position of a uracil base, allowing incorporation at any thymidine position in an oligonucleotide sequence. Anthraquinone-modified oligonucleotides have potential applications as triplex stabilizers and fluorescence quenchers. [ABSTRACT FROM AUTHOR]

Published
2007
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