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Intrauterine adhesion (IUA), a major cause of uterine infertility, is pathologically characterized by endometrial fibrosis. Current treatments for IUA have poor efficacy with high recurrence rate, and restoring uterine functions is difficult. We aimed to determine the therapeutic efficacy of photobiomodulation (PBM) therapy on IUA and elucidate its underlying mechanisms. A rat IUA model was established via mechanical injury, and PBM was applied intrauterinely. The uterine structure and function were evaluated using ultrasonography, histology, and fertility tests. PBM therapy induced a thicker, more intact, and less fibrotic endometrium. PBM also partly recovered endometrial receptivity and fertility in IUA rats. A cellular fibrosis model was then established with human endometrial stromal cells (ESCs) cultured in the presence of TGF‐β1. PBM alleviated TGF‐β1‐induced fibrosis and triggered cAMP/PKA/CREB signaling in ESCs. Pretreatment with the inhibitors targeting this pathway weakened PBM's protective efficacy in the IUA rats and ESCs. Therefore, we conclude that PBM improved endometrial fibrosis and fertility via activating cAMP/PKA/CREB signaling in IUA uterus. This study sheds more lights on the efficacy of PBM as a potential treatment for IUA. [ABSTRACT FROM AUTHOR]

Topical timolol is not effective in the treatment of some superficial infantile hemangiomas (IHs). This is a prospective study aiming to investigate the predictors of treatment response of superficial IHs to topical timolol. Patients with superficial IHs were prescribed timolol 0.5% cream four times daily and followed up every 2–3 months until 1 year of age. IH thickness was objectively measured by ultrasound, and the proportional change was calculated as a regression rate. In total, 193 patients (211 lesions) were enrolled. Topical timolol was initiated at an average age of 3.1 (0–6) months for 7.4 (2–11) months. The average regression rate of all lesions was 41.8% (−137.5%–100%). Lesion thickness (p = 0.000) and patient age at initial treatment (p = 0.001) were major variables that predicted the treatment response. On average, an increase in lesion thickness of 1 mm decreased the regression rate by 22.1%, and lesions thicker than 1.9 mm were unlikely to respond (average regression rate = −0.27%). Available results did not show a significant effect of sex (p = 0.659), lesion size (p = 0.311), or location (p > 0.05) on regression. Treatment for superficial IHs should be individualized according to lesion thickness and patient age. [ABSTRACT FROM AUTHOR]

As an emerging foundation structure for offshore wind turbines, bucket foundations with superior bearing capacities and efficient construction procedures have attracted significant attention in China. Thick-walled bucket foundations with concrete skirts can effectively reduce the cost and prevent the buckling problem of steel skirts during construction, transportation, and installation. However, great challenges are encountered during the sinking process, and the accurate calculation of sinking resistance is a critical process. Static-pressure tests of thin-walled and thick-walled models in sand were performed to measure the penetration resistance and soil pressure at the sidewalls and ends. The horizontal-soil-pressure coefficients of different models were calculated, and the end and skin-friction coefficients in the cone-penetration test method are recommended. The drag-reduction effects of the anti-drag ring and pressure-pull-out loading method were examined, and the drag-reduction effect was evident for the bucket foundation. The drag-reduction effect of the pressure-pull-out loading method is mainly reflected in the end zone. [ABSTRACT FROM AUTHOR]

To evaluate the effects of two different reconstruction routes (the posterior mediastinal route (PR) and the retrosternal route (RR)) on the surgical outcomes of patients after esophagectomy for esophageal carcinoma. PubMed, Embase, Web of Science and Scopus were searched from database inception to March 2021. Randomized controlled trials (RCTs) and case–control trials on the surgical outcomes of patients undergoing esophagectomy via one of the two routes were included. RevMan 5.3 software was used for the meta-analysis. In total, 19 studies were included, 8 were RCTs and 11 were case–control studies. The meta-analysis showed that among the case–control trials, the PR had reduced rates of anastomotic leakage [odds ratio (OR) = 0.56, 95% confidence interval (CI) (0.43, 0.74), P  < 0.01]. In addition, it had reduced rates of anastomotic stenosis [OR = 0.42, 95% CI (0.30, 0.59), P  < 0.01] and pulmonary complications [OR = 0.63, 95% CI (0.47, 0.84), P  < 0.01]. However, there was no significant difference in cardiac complications [RCTs, relative risk (RR) = 0.57, 95% CI (0.29, 1.11), P  = 0.10; case–control trials, OR = 1.06, 95% CI (0.70, 1.62), P  = 0.78] or postoperative mortality [RCTs, RR = 0.47, 95% CI (0.19, 1.16), P  = 0.10; case–control trials, OR = 0.68, 95% CI (0.32, 1.44), P  = 0.31]. Compared with the RR, the PR had reduced rates of anastomotic leakage, anastomotic stenosis and pulmonary complications. [ABSTRACT FROM AUTHOR]

Pitch-based soft carbons, with tunable microstructure and low cost, hold great potential as anodes for potassium-ion batteries (PIBs). However, the sluggish storage kinetics and unsatisfying cycle life hinder their practical applications. In addition, low softening point pitch has been seldom used to fabricate carbon microspheres due to its thermoplasticity. Herein, P and O enriched pitch-based carbon microspheres were directly synthesized via coordinated emulsification and pre-oxidation, and followed carbonized with NaH 2 PO 2. This template-free method can avoid the coalescence of the coal tar pitch without extra post-stabilization. And NaH 2 PO 2 acts as a P doping source and generates modest mesopores. The prepared P and O enriched carbon microspheres manifest a high P content of 4.0 at%, expanded interlayer distance of 0.401 nm, and abundant reversible K+ storage sites. As a result, it delivers considerable discharge capacity of 352 mAh g−1, impressive rate capacity of 114 mAh g−1 at 5 A g−1, and long lifespan of 181 mAh g−1 at 1 A g−1 after 1000 cycles. The present work develops a new avenue for heteroatoms doped carbon microspheres to innovative potassium storage and beyond. P and O enriched carbon microspheres were directly synthesized via coordinated emulsification and pre-oxidation, and followed carbonized with NaH 2 PO 2 to yield expanded interlayer distance, abundant defects and reversible K+ storage sites. [Display omitted] • P/O enriched pitch-based carbon microspheres were successfully fabricated. • Simultaneous emulsification and oxidation prevent pitch from coalescence during carbonization. • The generated PH 3 steam creates abundant defects and acts as P source for the uniform doping. • The effect of microstructure on high-rate performance was systematically investigated. [ABSTRACT FROM AUTHOR]

Iodine crosslinks planar aromatics by alkyl-bridged linkages, yielding an ordered-in-disordered microstructure with enlarged interlayer spacing and abundant intrinsic defects. [Display omitted] Soft carbon has been regarded as one of the most promising anode materials for potassium-ion batteries. However, the rearrangement of planar aromatics at high carbonization temperature usually yields a highly graphitized structure, which generally leads to inferior rate and cycle performance. In addition, the role of intrinsic carbon defects on potassium storage has not been well reported yet. In this work, crosslinked pitch-based soft carbon nanosheets have been synthesized through the iodination/dehydroiodination process at low temperature and carbonization with NaCl template. The iodine-treatment efficiently crosslinks the planar aromatics to three-dimensional framework by alkyl-bridged linkages, and reduces the strong π-π interaction during carbonization. This unique microstructure yields an ordered-in-disordered carbon microstructure, enlarged interlayer spacing, and abundant intrinsic defect sites. Benefited from these merits, the optimal sample displays 140% increase of reversible capacity to the pristine pitch-based carbon at 5 A g−1. Particularly, it also presents 87.4% capacity retention after 1000 cycles at 1 A g−1. This facile but simple strategy is expected to expand to other high-performance carbon materials and further understand the effect of intrinsic defects for potassium storage and beyond. [ABSTRACT FROM AUTHOR]

• An efficient parallel approach for multi-GNSS real-time precise orbit determination is proposed. • The proposed method improves computational efficiency by 70% compared with the traditional method. • Quad-system real-time POD with 90 stations can be completed within 5 s. Real-time Global Navigation Satellite System (GNSS) precise orbits are essential prerequisites for real-time GNSS-based applications. However, the high computational demands of filter-based real-time multi-GNSS POD methods present a significant challenge for practical utilization. This study introduces an efficient parallel approach for quad-constellation GNSS real-time POD using the square root information filter (SRIF). In the proposed approach, parallel QR factorization algorithms are implemented to expedite parameter estimation based on SRIF, while parallel processing model is designed for real-time POD to enhance its computational efficiency. Validation experiments show that the computation time for measurement and time update in SRIF can be reduced by 78.5% and 80.5%, respectively, compared to the traditional serial approach. Additionally, parallel computing improves the computational efficiency of GNSS processing algorithms in real-time POD by approximately 70%. The proposed approach enables the completion of quad-system real-time POD solutions with 90 stations within 5 s, representing an impressive 73.0% reduction. [ABSTRACT FROM AUTHOR]

Oil‐filled power transformers play an important role in modern network systems. Stable power supply can be achieved by early detection of power transformer faults and continuous monitoring of equipment. In recent years, dissolved gas analysis (DGA) has been widely used to diagnose faults in power transformers. Although DGA is an easier and simpler method for the fault diagnosis of transformers, different techniques usually provide different results with real‐world data. In fact, conventional diagnosis approaches for power transformers depend on human experience and available technology of human experts. Therefore, we propose using an artificial intelligence (AI) technique called multilayer perceptron (MLP) for the intelligent diagnosis of power transformer faults. In this work, the MLP model is constructed using the Keras library. The method is tested using two public databases: one based on the Electric Technology Research Association of Japan (ETRA) database and another based on the IEC TC10 database. Results indicate that high‐prediction accuracy is achieved. © 2020 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC. [ABSTRACT FROM AUTHOR]

Multigrid and domain-decomposition methods are now widely used in large-scale simulation studies. Meanwhile, many types of preconditioners are available for speeding the convergence. Users of analysis models are interested in the method or preconditioner that minimizes the computing time. In this paper, we analyze a thermal problem and a solid problem using two free, open-source software programs—the UG4 framework and the ADVENTURE system—based on geometric multigrid (GM) solvers and balancing domain-decomposition (BDD) solvers. We examine and report the computing times and iteration numbers to convergence of the two programs, and generate a common software interface between the UG4 framework and ADVENTURE system. Through this software interface, we can compare the solvers of the two software systems using the same mesh data. The results were presented on the CX400 system at the Information Technology Center of Nagoya University, Japan. The convergence rate of GM solver improved after suitable smoothing and scaling to finer grids. The BDD solver is suitable for large-scale analyses of structures with detailed and complex geometries. [ABSTRACT FROM AUTHOR]

Abstract: Enantioselective hydrosilylation of N-aryl and N-benzyl ketimines with trichlorosilane catalyzed by readily accessible chiral N-picolinoylaminoalcohols proceeded smoothly furnishing chiral secondary amines in good yields (up to 93%) and moderate to excellent enantioselectivities (up to 95% ee). [Copyright &y& Elsevier]

Video-assisted thoracoscopic surgery (VATS) has been used for thoracic surgery for about two decades. As the trend in VATS is to use fewer ports to decrease postoperative complications, we compared the results of our experience with single-port and two-port VATS for primary spontaneous pneumothorax (PSP). This is a non-randomized retrospective study. From January 2017 to December 2018, 104 patients with PSP underwent VATS. Fifty-six patients received single-port VATS and 48 patients received two-port VATS. Operation time, blood loss, number of staplers used, drainage time, postoperative hospital stay, complications, chest wall paresthesia, visual analog scale (VAS) pain scores, and patient satisfaction scale scores were compared between the two groups. There was no difference in age, gender, body mass index (BMI), smoking status, surgical indication, and involved side between the two groups. The procedures performed in the single-port group were similar to those performed in the two-port group. No significant difference was found in operation time, blood loss, number of staplers used, drainage time, and recurrence rate. The rate of chest wall paresthesia was lower in the single-port group than in the two-port group (28.6 vs. 52.1%, p =.014). The VAS scores in the single-port group were lower than those in the two-port group at 24 and 48 h (p =.032 and p =.004). Compared with two-port VATS, single-port VATS for PSP showed more favorable results in terms of postoperative paresthesia and pain. The single-port procedure may be considered a good alternative to the standard thoracoscopic treatment of PSP. Abbreviations: VATS: Video-assisted thoracic surgery; PSP: primary spontaneous pneumothorax [ABSTRACT FROM AUTHOR]

• The software supports space geodetic data processing, precise positioning and orbit determination, and multi-source fusion navigation. • The core computational engines are written using C++ language and apply efficiency optimization algorithms such as parallel computing, with modular structure, cross-platform capabilities and efficient performance. • The software provides both client and server functions for high-precision navigation services, and centimeter-level multi-source fusion navigation can be achieved in urban scenarios though the integrated system of PPP-RTK/MEMS/VIS/LiDAR. The software platform named GNSS + REsearch, Application and Teaching (GREAT) has been designed and developed by Wuhan University for satellite geodesy and multi-source fusion navigation. GREAT is a comprehensive software platform based on C++ language, with modular structure, cross-platform capabilities and efficient performance. The software mainly focuses on space geodetic data processing, precise positioning and orbit determination, and multi-source fusion navigation. With the integration of multiple space geodetic techniques at observation level, GREAT can achieve the determination of global geodetic parameters. Meanwhile, GREAT can also achieve real-time precise orbit and clock determination by processing GNSS data from globally distributed stations, and the accuracies are about 3–6 cm for orbit and 0.1–0.4 ns for clock. Based on high-precision orbit and clock products, centimeter-level onboard positioning accuracies can be achieved with PPP-RTK in open-sky scenarios. Furthermore, centimeter-level multi-source fusion navigation can be achieved in urban scenarios though the integrated system of PPP-RTK/MEMS/VIS/LiDAR. Additionally, efficiency optimization algorithms such as parallel computing are applied to enable the software to handle the data-intensive and calculation-intensive situations. [ABSTRACT FROM AUTHOR]

Background: Our previous study proved that nanofat could enhance fat graft survival by promoting neovascularization. Fat extract (FE), a cell-free component derived from nanofat, also possesses proangiogenic activity. Objectives: The aim of this study was to investigate whether FE could improve fat graft survival and whether FE and nanofat could work synergistically to promote fat graft survival. The underlying mechanism was also investigated. Methods: In the first animal study, human macrofat from lipoaspirate was co-transplanted into nude mice with FE or nanofat. The grafts were evaluated at 2, 4 and 12 weeks post-transplantation. In the second animal study, nude mice were transplanted with a mixture of macrofat and nanofat, followed by intra-graft injection of FE at days 1, 7, 14, 21 and 28 post-transplantation. The grafts were evaluated at 12 weeks post-transplantation. To detect the mechanism by which FE impacts graft survival, the proangiogenic, anti-apoptotic and pro-proliferative activities of FE were analysed in grafts in vivo and in cultured human vascular endothelial cells (HUVECs), adipose-derived stem cells (ADSCs) and fat tissue in vitro. Results: In the first animal study, the weights of the fat grafts in the nanofat- and FE-treated groups were significantly higher than those of the fat grafts in the control group. In addition, higher fat integrity, more viable adipocytes, more CD31-positive blood vessels, fewer apoptotic cells and more Ki67-positive proliferating cells were observed in the nanofat- and FE-treated groups. In the second animal study, the weights of the fat grafts in the nanofat+FE group were significantly higher than those of the fat grafts in the control group. In vitro, FE showed proangiogenic effects on HUVECs, anti-apoptotic effects on fat tissue cultured under hypoxic conditions and an ability to promote ADSC proliferation and maintain their multiple differentiation capacity. Conclusions: FE could improve fat graft survival via proangiogenic, anti-apoptotic and pro-proliferative effects on ADSCs. FE plus nanofat-assisted fat grafting is a new strategy that could potentially be used in clinical applications. [ABSTRACT FROM AUTHOR]

Current treatment modalities for postinflammatory hyperpigmentation (PIH) often fall short in delivering satisfactory results for some patients. Therefore, this study aimed to assess the efficacy and tolerability of autologous cell-free fat extract (CEFFE) in the treatment of PIH. We enrolled 15 patients with PIH and administered them with five intracutaneous CEFFE injections, each at a two-week interval. Evaluation included efficacy assessment using objective (standard two-dimensional photos, VISIA®-photos, brown spot (BS) index, lesion lightness, lesion color, and trans-epidermal water loss) and subjective (Global Aesthetic Improvement Scale and Likert satisfaction scale) parameters and tolerance assessment. Following CEFFE treatment, significant reductions were observed in the BS index (p < 0.05) and transepidermal water loss (p < 0.05), while skin lightness and lesion color showed significant improvements (p < 0.05) at the 12-month follow-up. Subjectively, 93.33% of patients reported improved or greatly improved conditions after 12 months of treatment. Transient local bruising and stinging were the only observed treatment-related adverse events, with no serious complications reported. These findings demonstrate that intradermal injections of CEFFE are well-tolerated and effective for the treatment of PIH. This trial is registered with ChiCTR2000039381. [ABSTRACT FROM AUTHOR]

The role of long noncoding RNAs (lncRNAs) has been verified by more and more researches in recent years. However, there are few reports on cellular senescence-associated lncRNAs in lung adenocarcinoma (LUAD). Therefore, to explore the prognostic effect of lncRNAs in LUAD, 279 cellular senescence-related genes, survival information and clinicopathologic parameters were derived from the CellAge database and The Cancer Genome Atlas (TCGA) database. Then, we constructed a novel cellular senescence-associated lncRNAs predictive signature (CS-ALPS) consisting of 6 lncRNAS (AC026355.1, AL365181.2, AF131215.5, C20orf197, GAS6-AS1, GSEC). According to the median of the risk score, 480 samples were divided into high-risk and low-risk groups. Furthermore, the clinicopathological and biological functions, immune characteristics and common drug sensitivity were analyzed between two risk groups. In conclusion, the CS-ALPS can independently forecast the prognosis of LUAD, which reveals the potential molecular mechanism of cellular senescence-associated lncRNAs, and provides appropriate strategies for the clinical treatment of patients with LUAD. [ABSTRACT FROM AUTHOR]

Soft carbon has been considered as one of the most promising high-performance potassium-ion battery anodes owing to the advantages of high carbon crystallinity and conductivity. Nevertheless, the lack of microstructure tunning strategy for soft carbon generally leads to low interlayer spacing and limited active sites, which results in relatively low storage capacity and sluggish kinetics. Herein, sulfur doped quinoline oligomer derived soft carbon nanosheets (SNC) have been successfully fabricated with expanded interlayer spacing, modest defects, and relatively ordered carbon clusters. These favorable characteristics can not only contribute to a high potassium storage capacity, but also shorten the diffusion spacing for both electrons and ions. Hence, SNC displays an extremely high capacity (456 mA h g−1 at 0.05 A g−1) and long cyclability (189 mA h g−1 at 2.0 A g−1 after 1000 cycles), superior to most of recently reported carbon anodes. Kinetic analyses demonstrate that sulfur doped quinoline oligomer derived soft carbon can significantly boost the potassium diffusion. Additionally, the enlarged interlayer spacing and modest defect sites benefitted from high sulfur doping could further enhance potassium storage properties. This study provides a facile molecular tuning and large-scale production strategy for soft carbon anodes with high capacity and long life. [Display omitted] • The sulfur-doped quinoline oligomer derived soft carbon nanosheets have been successfully fabricated via a facile ball milling-thermal treatment method. • Molecular crosslinking optimizes the microstructure of soft carbon precursor with expanded interlayer spacing and more defects. • The influence of sulfur on electrochemical performance was systematically investigated. • The soft carbon nanosheets present high capacity and excellent rate performance. [ABSTRACT FROM AUTHOR]

Anticoagulant therapy is believed to be an important component of treatment for idiopathic pulmonary arterial hypertension (IPAH). Recent data suggest that therapy that does not include anticoagulants results in no significant difference in patient survival. We sought to evaluate the effect of anticoagulants on survival in patients with IPAH. A systematic review and a random-effects meta-analysis to estimate hazard ratio (HR) and 95% confidence intervals (CI) were performed. PubMed/MEDLINE, Web of Knowledge and other databases were searched for eligible literature. Review articles and references were also screened. 8 studies with a total of 1812 patients with IPAH were included in this analysis. No randomized controlled trials (RCT) were identified. All the 8 studies had a mean complete follow-up ranging from 3 to 14 years. In this analysis, use of anticoagulants did not significantly decrease mortality risk (P = 0.07, HR = 0.77, 95% CI [0.58, 1.02]). Sensitivity analysis showed similar results (P = 0.12, HR = 0.80, 95% CI [0.60, 1.06]). Subgroup analysis showed that anticoagulants performed no significant advantages with the use of PAH-specific therapies (P = 0.82, HR = 0.95, 95% CI [0.63, 1.44]). No randomized evidence to support the use of anticoagulants in IPAH. No significant benefit for patients' survival was found in our analysis. The potential biases of included observational studies made it hard to achieve a meaningful conclusion. The necessity of anticoagulants for IPAH patients remains to be evaluated. • Pathobiological study suggested vascular thrombosis formation in IPAH. • The use of anticoagulants in IPAH patients remains controversial. • Using specific drug therapies for PAH, the effect of anticoagulants needs re-evaluation. • Well-designed RCTs are still needed for anticoagulants in IPAH. [ABSTRACT FROM AUTHOR]

Abstract: The promotional effect of cationic gemini surfactants for the hydroformylation of 1-dodecene in the organic/aqueous biphasic catalytic system is reported. Cationic gemini surfactants with a flexible spacer (G(Eth), G(But) and G(Hex)) and rigid spacer (G(Xyl)) group were used in the reaction. The critical micelle concentration (CMC) and solubilization of laurylbenzene in gemini surfactant solutions were determined. The influence of the concentration of gemini surfactants and the stirring rate on 1-dodecene hydroformylation were investigated. The reaction results showed that in the biphasic catalytic system the hydroformylation of 1-dodecene catalyzed by RhCl(CO)(TPPTS)2–TPPTS [TPPTS=tris(sodium-m-sulfonatophenyl) phosphine] in the presence of gemini surfactants occurred with higher turn over frequency (TOF) and higher regioselectivity toward linear aldehyde (L/B) than those obtained with the conventional monomeric surfactant CTAB. The phenomena could be attributed to the fact that the gemini surfactant has lower CMC and better surface tension reduction ability; moreover it could form more compact and spherocylindrical micelle in the solution. These properties would be favorable for the decrease in the phase transfer energy barrier, thereby greatly accelerating the reaction rate. Meanwhile, the more compact structure of the spherocylindrical micelle formed from gemini surfactant could construct a favorable microenvironment for the formation of linear aldehyde. The comparison of the acceleration effect of the three type surfactants (monomeric surfactant CTAB (cetyltrimethylammonium bromide), gemini surfactant G(Eth), G(But), G(Hex)), G(Xyl) as well as double chain surfactant DCMAB (di(cetylmethyl)ammonium bromide) indicated that the surfactant structure had an important effect on the reaction rate. Their promotion order is DCMAB>G(Eth)≈G(But)≈G(Hex)≈G(Xyl)>CTAB. [Copyright &y& Elsevier]

Abstract: The catalytic performance of ruthenium phosphine complexes using (1S,2S)-DPENDS [(1S,2S)-1,2-diphenyl-1,2-ethylene diamine sulfonate disodium] as a chiral modifier in the asymmetric hydrogenation of aromatic ketones was examined in a series of hydrophilic ionic liquids [RMIM]+[p-CH3C6H4SO3]− (R=ethyl, butyl, octyl, dodecyl). The synergistic effect between (1S,2S)-DPENDS and KOH significantly accelerated the reaction and enhanced the enantioselectivity. An ee value of 84.8% was obtained in the asymmetric hydrogenation of acetophenone under the optimized conditions. The products were conveniently separated with cyclohexane extraction, and both the ruthenium catalyst and (1S,2S)-DPENDS were kept in the ionic liquid and could be reused. [Copyright &y& Elsevier]

Abstract: Objective:: This study compared the efficacy and safety of a single dose of oxycodone 5 mg/ibuprofen 400 mg versus its individual components and placebo in a third-molar extraction model. Methods:: In this multicenter, double-blind, double-dummy, parallel-group investigation, subjects with moderate to severe pain within 5 hours after extraction of ≥2 ipsilateral bony impacted third molars were randomized to single doses of oxycodone 5 mg/ibuprofen 400 mg, ibuprofen 400 mg, oxycodone 5 mg, or placebo. Primary efficacy variables were the sum of pain intensity difference over 6 hours (SP1D6) and total pain relief through 6 hours (TOTPAR6). The pharmacokinetics of oxycodone and ibuprofen, alone and in combination, were also determined in a subset of patients. Results:: A total of 498 subjects were randomized to treatment (187 to oxycodone 5 mg/ibuprofen 400 mg, 186 to ibuprofen 400 mg, 63 to oxycodone 5 mg, and 62 to placebo). Baseline demographics were generally similar among treatment groups, despite differences in sex (P = 0.041) and race (P = 0.023). Combination therapy was associated with greater analgesia than ibuprofen alone, oxycodone alone, or placebo (mean [SE] TOTPAR6: 13.3 [0.52], 12.2 [0.52], 4.3 [0.82], and 4.2 [0.83], respectively [P &#60; 0.001 vs oxycodone or placebo, P = 0.012 vs ibuprofen]; mean [SE] SP1D6: 6.54 [0.42], 5.41 [0.44], 0.14 [0.60], and 0.32 [0.59], respectively [P &#60; 0.001 vs oxycodone or placebo, P = 0.002 vs ibuprofen]). Combination therapy was well tolerated. Pharmacokinetic results implied no interaction between oxycodone and ibuprofen. Conclusions:: In this study, a single dose of oxycodone 5 mg/ibuprofen 400 mg was fast-acting, effective, and well tolerated in subjects with moderate to severe pain after dental surgery. Oxycodone 5 mg alone did not provide an efficacy benefit over placebo in this study. [Copyright &y& Elsevier]

Provides information on the study which compared the effects of nateglinide, glyburide and placebo on postmeal glucose excursions and insulin secretion in previously diet-treated type 2 diabetic patients. Effect of nateglinide on glucose; Relation of glyburide on insulin levels; Liquid and solid meal challenges for the patients; Methodology; Results and discussion.

Background: The proangiogenic capacity of adipose tissue and its derivatives has been demonstrated in a variety of studies. The paracrine mechanism of the cellular component is considered to play a critical role in the regenerative properties of these tissues. However, cell-based therapy for clinical application has been hindered by limitations such as safety, immunogenicity issues, and difficulties in cell preservation, transportation, and phenotype control. In the current study, we aimed to produce a cell-free extract directly from human fat tissue and evaluate its potential therapeutic efficacy. Methods: We developed a novel physical approach to produce a cell-free aqueous extract from human fat tissue (fat extract (FE)). The therapeutic potential of FE was investigated in the ischemic hindlimb model of nude mice. After establishment of hindlimb ischemia with ligation of the left femoral artery and intramuscular injection of FE, blood perfusion was monitored at days 0, 7, 14, 21, and 28. Tissue necrosis and capillary density were evaluated. Enzyme-linked immunosorbent assay was used to analyze the growth factors contained in FE. Moreover, the proliferation, migration, and tube formation ability were tested on human umbilical vein endothelial cells (HUVECs) in vitro when treated with FE. The proangiogenic ability of FE was further assessed in an in-vivo Matrigel plug assay. Results: FE was prepared and characterized. The intramuscular injection of FE into the ischemic hindlimb of mice attenuated severe limb loss and increased blood flow and capillary density of the ischemic tissue. Enzyme-linked immunosorbent assay showed that FE contained high levels of various growth factors. When added as a cell culture supplement, FE promoted HUVEC proliferation, migration, and tube formation ability in a dose-dependent manner. The subcutaneous injection of Matrigel infused with FE enhanced vascular formation. Conclusions: We developed a novel cell-free therapeutic agent, FE, produced from human adipose tissue. FE was able to attenuate ischemic injury and stimulate angiogenesis in ischemic tissues. This study indicates that FE may represent a novel cell-free therapeutic agent in the treatment of ischemic disorders. [ABSTRACT FROM AUTHOR]