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The newly released 'Snow White' (SW), a white-fleshed loquat (Eriobotrya japonica Lindl.) cultivar, holds promise for commercial production. However, the specifics of the phenolic composition in white-fleshed loquats, along with the antioxidant substances and their regulatory mechanisms, are not yet fully understood. In this study, we examined the dynamic changes in the phenolic compounds, enzyme activities, antioxidant capacity, and gene expression patterns of SW during the key stages of fruit development and ripening. A total of 18 phenolic compounds were identified in SW, with chlorogenic acid, neochlorogenic acid, and coniferyl alcohol being the most predominant. SW demonstrated a stronger antioxidant capacity in the early stages of development, largely due to total phenolics and flavonoids. Neochlorogenic acid may be the most significant antioxidant contributor in loquat. A decline in enzyme activities corresponded with fruit softening. Different genes within a multigene family played distinct roles in the synthesis of phenolics. C4H1, 4CL2, 4CL9, HCT, CCoAOMT5, F5H, COMT1, CAD6, and POD42 were implicated in the regulation of neochlorogenic acid synthesis and accumulation. Consequently, these findings enhance our understanding of phenolic metabolism and offer fresh perspectives on the development of germplasm resources for white-fleshed loquats. [ABSTRACT FROM AUTHOR]

Luku alkali syenite is distributed throughout the southern end of the Hongge basic‐ultrabasic intrusion in Panzhihua, Sichuan, SW China. Using LA‐ICP‐MS, the alkali syenite intrusion yielded a zircon U‐Pb age of 264.5 ± 1.6 Ma, concordant with the ages of the E'meishan large igneous province (260 Ma). The intrusion displayed silica‐saturated, Al‐adequate and alkali‐rich signatures, with SiO2 62.07%–64.04%, Al2O3 16.26%–16.79% and Na2O + K2O 9.17%–9.91% (averaging 9.31%). The rock falls into the alkaline zone on the SiO2‐A.R. diagram, as well as in the potassium zone on the K2O‐Na2O diagram, indicating a potassium alkaline rock. The rock has a low total REE concentration and showed enrichment in LREE (LREE/HREE = 7.06–7.95), typical negative Eu anomalies (δEu = 0.73–0.80), trace element deficiencies in LILEs (Ba, K, Sr, Zr) and enrichment in HFSEs (Th, U, Nd, Sm, Ta and Nb), displaying crust and mantle element information. Zircons show a strong positive Ce anomaly and negative Eu anomaly, similar to the characteristics of crustal source magmatic zircon, however the (Lu/Gd)N ratio ranges from 1.48 to 3.17, and the (Yb/Sm)N ratio ranges from 38.49 to 77.15, which are similar to the characteristics of mantle‐derived magmatic zircon. In the La/Yb‐δEu correlation diagram, the data plots near the boundary between crust type and crust‐mantle type. From the combined 'trinity' spatiotemporal relationship of Indosinian intermediate‐acid alkali intrusive rocks in the Panxi area with E'meishan basalt and basic‐ultrabasic intrusive rocks, the regional tectonic evolution and the partial melting model of the most intraplate magma sources, we believe that the Luku alkali syenite in Sichuan was formed from the partial melting of a crust‐mantle source material, due to underplating of the mantle plume basic magma. [ABSTRACT FROM AUTHOR]

We aimed to analyze the changes in plasma leptin, serum inflammatory factors and urinary protein in children with nephrotic syndrome before and after treatment and their clinical significance. A total of 28 children treated and diagnosed with nephrotic syndrome between November 2015 and October 2016 were selected as treatment group, while 25 healthy children were selected as control group. There were no statistically significant differences in age, sex, body mass index (BMI), serum albumin and other general data between treatment group and control group (P>0.05). There was a positive correlation between serum high-sensitivity C-reactive protein (hs-CRP) level and 24 h urinary protein level in children with nephrotic syndrome before treatment (r=0.408, P=0.005). Twenty-four hours urinary protein, urea nitrogen (BUN) and serum creatinine (SCr) levels in children with nephrotic syndrome before treatment were significantly higher than those in normal children, and these indexes were significantly decreased after treatment. The levels of plasma leptin and serum inflammatory factors (hs-CRP and IL-18) in children with nephrotic syndrome before treatment were obviously higher than those in normal children, and these indexes were obviously decreased after treatment. In conclusion, the detection of changes in plasma leptin, serum inflammatory factors (hs-CRP and IL-18) and urinary protein in children with nephrotic syndrome before and after treatment has important reference value for reflecting the severity of disease and evaluating the prognosis of children with nephrotic syndrome. [ABSTRACT FROM AUTHOR]

Abstract: The Mianning–Dechang (MD) rare earth element (REE) belt, located in the northern Kangdian axis (KDA) in the western margin of the Yangtze platform, is one of the most economically significant REE mineral belts in China. REE mineralization is associated with Himalayan carbonatite–alkaline complexes. The Lizhuang nordmarkite occurred in the northern part of the MD REE belt. The majority of zircons from the Lizhuang nordmarkite are characterized by pronounced positive Ce yet slightly negative Eu anomalies and high U/Yb. Moreover, all zircons have stable Hf isotopic compositions with initial 176Hf/177Hf ratios ranging from 0.282739 to 0.282808 and an average value of 0.282773. The negative Lu/Hf and positive εHf(t) range from −0.98 to −0.94 (average value of −0.96) and from −0.56 to 1.89 (the majority is positive, with an average of 0.66), respectively. These characteristics indicate that the rock is derived from an enriched mantle and subducted material. LA‐ICP‐MS analysis of the zircons from the intrusion yields a weighted mean 206Pb/238U age of 28.57±0.61Ma. During this period, the tectonic activity in the KDA is not plate subduction but an intraplate tectonic exhibiting fold–thrust and strike–slip behaviors in the western marginal zone of the Yangtze platform (WMYB). We suggest the possibility of an existing eastward old slab subduction under WMYB combined with a regional tectonic evolution. The Lizhuang nordmarkite may be derived from an enriched mantle beneath the western part of the Yangtze craton, which originated from the remelting of the Tethys subducting slab, because of the Himalayan strike–slip that formed a special type of REE deposit called strike–slip‐type REE deposits. [ABSTRACT FROM AUTHOR]

α-Synuclein (α-syn) is a hallmark protein of Parkinson's disease (PD). The aggregation process of α-syn has been heavily associated with the pathogenesis of PD. With the exponentially growing number of potential therapeutic compounds that can inhibit the aggregation of α-syn, there is now a significant demand for a high-throughput analysis system. Herein, a novel flow injection analysis system with an electrochemical biosensor as the detector was developed to study the interaction of a well-described antioxidant and amyloid inhibitor, pyrroloquinoline quinone (PQQ) with α-synuclein peptides. Screen-printed gold electrodes (SPEs) were modified using heptapeptides from α-syn wild-type (WT) and mutants such as lysine knock-out (ETEE) and E46K. Affinity binding events between these peptides and PQQ were analyzed by electrochemical impedance spectroscopy (EIS) and further confirmed by high-performance liquid chromatography (HPLC), liquid chromatography/mass spectrometry (LC/MS), and nuclear magnetic resonance (NMR) spectroscopy. HPLC and LC/MS results revealed that PQQ formed a stable complex with α-syn. NMR results confirmed that the α-syn–PQQ complex was formed via a Schiff base formation-like process. In addition, results showed that lysine residues influenced the binding event, in which the presence of an extra lysine stabilized the α-syn–PQQ complex, and the absence of a lysine significantly decreased the interaction of α-syn with PQQ. Therefore, we concluded that EIS is a promising technique for the evaluation of the interaction between PQQ-based amyloid inhibitors and α-syn. The electrochemical flow injection analysis assembly provided a rapid and low-cost drug discovery platform for the evaluation of small molecule–protein interactions. [ABSTRACT FROM AUTHOR]

The article presents a study that investigates genesis of carbonatites in the Mianning-Dechang rare earth element (REE) belt in Western Sichuan, China. The study shows that the deposits related to carbonatite alkaline complex are divided into magmatic type and hydrothermal type. Also the study mentions that there are four types of REE deposits including carbonatite type, carbonatite predominates type, alkaline type and alkaline predominates type.

An abstract of the article regarding the case study of potash formation event and sea-level eustatic cycles in Triassic Sichuan Basin in China is presented.

The environment supplies water, land, biological resources, and climate resources for people's daily life and development, dramatically affecting the subsistence and development of human beings. Panzhihua City is a representative resource-based industrial city of southwestern China. The abundant mineral resources provide the material basis for the city's development. However, while the overdevelopment of the past decades has provided the preconditions for its rapid economic growth, it has also inevitably had a huge impact on its environmental quality and land use structure. In this study, the landsat remote sensing images, terrain data, socio-economic data, and mining resources exploitation data of Panzhihua were used to extract the NDVI (Normalized Difference Vegetation Index), NDBSI (Normalized Difference Build and Soil Index) and LST (Land Surface Temperature) of the past 20 years at 5-year intervals. We normalized four indicators by Principal Component Analysis to derive a remote sensing ecological index of each factor and build the Remote Sensing-based Ecological Index evaluation model. This research quantified the changes in environmental quality in the past 20 years through the range method, showing that the environmental quality of Panzhihua City first declined and then increased slowly. This research also analyzed the influence of land use types, terrain, mining area, and socio-economy on the environmental quality of Panzhihua City by grey relational analysis and buffer analysis. It is found that with the influence of its unique topographical factors and economic aspects, the environmental quality of Panzhihua City changed to varying degrees. The results provide a reliable basis for the future environmental planning of Panzhihua City and a reference for the ecological restoration of mining areas with different mineral species accurately. [ABSTRACT FROM AUTHOR]

Following significant urban expansion, the ecological problems of resource-based cities are gradually exposed. It is of great significance to study the ecosystem services of resource-based cities to achieve their sustainable development goals and to alleviate the conflicts between environmental protection and the utilization of the surrounding resources. However, in the current research on resource-based cities, few scholars have combined multiple minerals and multiple ecosystem services to explore the impact of mineral resources on the ecosystem. In this study, based on the historical data spanning from 2002 to 2018, we used the CA–Markov model to project the land use of Panzhihua City to 2030. Based on future land use projection, we quantified four ecosystem services (ESs) variables, including water yield, carbon storage, habitat quality, and soil conservation, using the InVEST model from the perspective of land use evolution in Panzhihua City. In addition, we explored the trade-offs and synergies of different ecosystem services and the correlations between different mineral species and ecosystem services using Spearman's correlation coefficient. Results showed the following: (1) During 2002–2018, water yield service, habitat quality service, and carbon storage service of Panzhihua City decreased year by year, and soil conservation service showed significant fluctuations; most of the low ESs areas were distributed in the central region of Panzhihua. On the contrary, most high ESs areas were located in the forest region. (2) The trade-offs and synergistic relationships among different ecosystem services showed significant spatial variations. There were synergistic relationships among ESs and weak trade-offs between water yield services, soil conservation, and habitat quality services. There was also significant spatial variability in the trade-offs and synergies among ecosystem services, with water production services showing "east trade-offs and west synergies" with soil conservation and habitat quality services, and most of the rest showing trade-offs in urban areas. (3) ESs in mining areas showed trade-offs in general, mainly between water production services and carbon storage services, with clay as the major negative factor of mineral species, and iron ore mines that have undergone ecological protection construction showed the lowest negative impact on ecology. [ABSTRACT FROM AUTHOR]

Highlights: [•] Argon dynamics in first year sea ice are modeled. [•] Gas bubbles nucleation and rise are important to describe gas dynamics in sea ice. [•] Ice–atmosphere fluxes do not drastically change the simulated Argon in sea ice. [•] In winter, Argon is controlled by uptake, transport by brine and bubble nucleation. [•] An intense and rapid release of gas bubbles to the atmosphere occurs in spring. [ABSTRACT FROM AUTHOR]

The harsh environment of high-latitude areas with large amounts of snow and ice cover makes it difficult to carry out full geological field surveys. Uranium resources are abundant within the Ilimaussaq Complex in the Narsaq region of Greenland, where the uranium ore body is strictly controlled by the Lujavrite formation, which is the main ore-bearing rock in the complex rock mass. Further, large aggregations of radioactive minerals appear as thermal anomalies on remote sensing thermal infrared imagery, which is indicative of deposits of highly radioactive elements. Using a weight-of-evidence analysis method that combines machine-learned lithological classification information with information on surface temperature thermal anomalies, the prediction of radioactive element-bearing deposits at high latitudes was carried out. Through the use of Worldview-2 (WV-2) remote sensing images, support vector machine algorithms based on texture features and topographic features were used to identify Lujavrite. In addition, the distribution of thermal anomalies associated with radioactive elements was inverted using Landsat 8 TIRS thermal infrared data. From the results, it was found that the overall accuracy of the SVM algorithm-based lithology mapping was 89.57%. The surface temperature thermal anomaly had a Spearman correlation coefficient of 0.63 with the total airborne measured uranium gamma radiation. The lithological classification information was integrated with surface temperature thermal anomalies and other multi-source remote sensing mineralization elements to calculate mineralization-favorable areas through a weight-of-evidence model, with high-value mineralization probability areas being spatially consistent with known mineralization areas. In conclusion, a multifaceted remote sensing information finding method, focusing on surface temperature thermal anomalies in high-latitude areas, provides guidance and has reference value for the exploration of potential mineralization areas for deposits containing radioactive elements. [ABSTRACT FROM AUTHOR]

Abstract: A high-efficiency inverted bulk heterojunction (BHJ) solar cell with good air stability is fabricated using annealing-free ZnO nanocrystals as an electron-transport layer and a blend of a low bandgap polymer PDTSTPD and PC71BM as an active layer. A power conversion efficiency as high as 6.7% has been achieved on the inverted devices with an active area of 1.0cm2 using nitrobenzene as a processing additive. The device is highly stable, retaining 85% of its original efficiency after being stored in air for 32 days even without encapsulation. [Copyright &y& Elsevier]

The article discusses a case study on the enclosed extent of the saline water and its constraints on the salt forming and sedimentary characteristics of the paleogene playas in Hoh Xil basin. The study is undertaken through water sampling from the lake and testing them for microbe flourish, carbonates. The results of the study show the preserved gypsum-salt layers shaped in lenticular, thin-bedded and hummocky form.

[Display omitted] • The QBMs area is becoming sustainably wetter, and the NPP is increasing significantly. • The NPP of QBMs has the strongest correlation with SPEI at the four-month time scale. • The carbon sink capacity of the vegetation of QBMs is most dependent on the water balance at July and October. • The vegetation carbon sink capacity is most sensitive to the cumulative effect of hydrothermal equilibrium at the seasonal scale. Drought can significantly affect the carbon cycle of ecosystems. The Qinba Mountains region has a high potential for developing carbon sink forestry due to its strong carbon fixation capacity. This study applied the Carnegie-Ames-Stanford approach (CASA) model calculate monthly net primary productivity (NPP) in the region from 2001 to 2018. The standardized precipitation evapotranspiration indices (SPEI1-12) at various time scales were also analyzed by the Thornthwaite method, along with the test of significance and sustainability (Sen-MK-Hurst) model, to examine the persistent characteristics of dry and wet changes in the Qinba Mountains. The results of the correlation analysis between NPP and SPEI at multiple time scales showed that regional vegetation NPP is significantly impacted by drought, with the most sensitive months being July and October. On average, there is a four-month cumulative effect of drought on NPP. About 45.49% and 19.99% of NPP in the Qinba Mountains region are extremely or heavily sensitive to drought, with grasses being the most sensitive, followed by cultivated plants, deciduous broadleaved forests, mixed forests, sparse forests, and shrublands. The study also found that 40.99% of the region is expected to become wetter and 14.9% is expected to become drier in the future. Understanding the response of NPP to drought in this region can help with the management of regional climate change for environmental regulation. [ABSTRACT FROM AUTHOR]

[Display omitted] • Hyperspectral remote sensing help reveal hidden information about vegetation health. • A new assessment framework for ecological vulnerability based on hyperspectral remote sensing has been proposed. • The policy-informed ecological restoration effectively help the vegetation recovery of Panzhihua city. • Intensive and extensive excavation activities have a substantial impact on the local ecological vulnerability. Mining cities are clusters of communities that specialized in mining and extractive industries. The extensive mining activities in these cities have stimulated widespread and substantial ecological stresses to the surrounding environment, that significantly jeopardize the health condition of vegetation and human. Given the recent recognition of remote sensing in monitoring large-scale environmental change, we incorporated Ziyuan #1-02D, a recently released hyperspectral remote sensing data, into the ecological vulnerability assessment framework, using Panzhihua city as a case study, which is recognized as one of the most representative mining cities in China. The multi-spectral imaging data was widely applied in previous research. However, with the wide bands, multi-spectral imaging data cannot depict detailed characteristics of spectral targeted. As a result, we introduce indexes from the hyperspectral imaging to ecological vulnerability assessment proposed in this study, which can depict and monitor the growth and restoration of vegetation more accurately. We used the optimum index factor method to select bands from the satellite-based Ziyuan #1-02D data for quantifying vegetation indexes and red edge. Besides, we obtained inventory data, land-use, soil type, and typography of Panzhihua city to reconstruct its ecological vulnerability index (EVI) for 2020 and 2021. Comparing to the multi-spectral data, the ecological vulnerability results from hyperspectral imaging performed better in precision and concentration in EVI values, reaching the conclusions more directly. Specifically, the mining area and the relevant hazard types and impact areas were delineated through intensive fieldwork. Results suggested that the east and west districts, and north of Renhe district suffer great ecological stress, in which we observed intensive coal and metal-related mining industry. The central region, which occupies vanadium titanomagnetite mines, also shows substantial ecological issues, while the other mining industries, such as granite ore did not significantly influence the local environment. Although the newly released satellite-based data only have two-year periods, we still observed improving ecological conditions, with the southeast and west regions showing much lower ecological vulnerability values. The spatial autocorrelation analysis suggested that the high-high clustering region of EVI is located in the east, west, and Renhe districts, primarily due to the mining industries of variations scales. We also found that the clustering of low ecological vulnerable regions, mostly surrounds the vanadium titanomagnetite excavation industry, thanks to the local restoration projects. [ABSTRACT FROM AUTHOR]