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Presents information on a study which examined cerebral blood flow and cerebral vascular resistance in lambs during sleep-wake cycles before and after infusion of N-nitro-L-arginine (L-NNA), an inhibitor of nitric oxide synthase. Surgery and experimental procedures; Acute effects of L-NNA infusion; Sleep characteristics in the control period.

Abstract: The paper describes the design of a readout element, proposed as a radiation monitor, which implements an embedded sensor based on a floating-gate transistor. The paper shows the design of a microelectronic circuit composed of a sensor, an oscillator, a modulator, a transmitter and an integrated antenna. A prototype chip has recently been fabricated and tested exploiting a commercial 180nm, four metal CMOS technology. Simulation results of the entire behavior of the circuit before submission are presented along with some measurements of the actual chip response. In addition, preliminary tests of the performance of the Ultra-Wide Band transmission via the integrated antenna are summarized. As the complete chip prototype area is less than 1mm2, the chip fits a large variety of applications, from spot radiation monitoring systems in medicine to punctual measurements of radiation level in High-Energy Physics experiments. A sensitivity of 1mV/rad was estimated within an absorbed dose range up to 10krad and a total power consumption of about 165 μW. [Copyright &y& Elsevier]