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Interferon-I (IFN-I) signaling pathway plays a vital role in the differentiation of germinal center B cells and the pathogenesis of systemic lupus erythematosus (SLE). Therefore, targeting the IFN-I signaling pathway could serve as an effective treatment strategy in SLE. Arctigenin is an active ingredient present in the seeds of Arctium lappa L. It has been reported to act as a negative regulator of inflammatory responses. However, the role of arctigenin remains unknown in the regulation process of the IFN-I-mediated differentiation of germinal center B cells and the pathogenesis of SLE. In the present study, we demonstrated that arctigenin alleviated the progression of spontaneous lupus in MRL/ lpr mice and imiquimod-mediated lupus mice. Especially, arctigenin significantly reduced the proportions of germinal center B cells (7.1%, vs. 5.12%, p < 0.01), follicular helper T cells (11.49%, vs. 5.53%, p < 0.05), and plasma cells (2.44%, vs. 1.39%, p < 0.01) in the lupus-prone mice. In vitro studies have shown that arctigenin significantly inhibited the IFN-α-induced CD69 and interferon-stimulated gene (ISG) expressions along with the phosphorylation of JAK1 and STAT1 by nearly half in murine B cells via activating PP2A. Overall, these data highlighted the role of arctigenin in regulating the IFN-I-mediated differentiation of germinal center B cells and the pathogenesis of SLE. Thus, arctigenin may be used as a potentially effective therapeutic target for the treatment of SLE. • Arctigenin treatment ameliorated the disease progression in the lupue-prone mice. • Arctigenin inhibited the germinal center reactions in the lupue-prone mice. • Arctigenin inhibited the IFN-I-mediated activation of B cells in vitro and in vivo. • Arctigenin inhibited the activation of the IFN-I pathway via PP2A in B cells. [ABSTRACT FROM AUTHOR]

In this work, the morphological and conformational evolution of bio-based polyethylene glycol (PEG)-acrylic rosin polymer in water was studied by scanning electron microscopy (SEM), polarized optical microscopy (POM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), Rayleigh light scattering (RLS) and dynamic light scattering (DLS) techniques during a heating and cooling cycle. When the concentration was higher than the critical micelle concentration (CMC), a reversible transformation process, i.e. from micelle to irregular lamella aggregations, was detected. As the concentration was equal to or below the CMC, individual unimers aggregated into needle-shaped crystals composed of acrylic rosin crystalline core in the heating run. The crystallization of acrylic rosin blocks acted as seeds and thus, in the subsequent cooling process, the PEG corona crystallized into the cube-shaped crystals. The cytotoxicity assay showed the biocompatibility of bio-based polyethylene glycol-acrylic rosin polymer. This has great potential in the application of drug delivery and release triggered by temperature. [ABSTRACT FROM AUTHOR]

Sediment waves are common on the seafloor, but large-scale ones developed in submarine canyons are rarely reported. In this study, we document for the first time the Quaternary deep-water canyon-confined large-scale sediment waves developed on the northern South China Sea margin based on the analysis of a high-quality 3-D seismic reflection volume combined with a 2-D multichannel seismic reflection profile and three wells. Results show that the onset of these canyon-confined large-scale sediment waves can be dated back to the Penultimate Glacial Maximum (PGM)(ca.140 ka). This was the last period for the Pearl River Delta to prograde over the shelf edge. And these sediment waves have continued to develop and migrate upslope until present. The large-scale sediment waves pertaining to the PGM have a dominant down-slope asymmetrical 2-D morphology with wavelengths of 1.059–6.090 km and wave heights of 3.3–32.5 m. The present large-scale sediment waves show an up-slope asymmetrical 2-D morphology with dimensions of 0.667–5.628 km wavelength and 2.7–14.0 m wave height, which are smaller relative to those at the PGM. Grain sizes of the sediment waves at the PGM and present are interpreted to be coarse, inferred from seismic reflection data by high amplitude reflections (HARs). After a comprehensive analysis of the types of sediment-laden flows, the sediment provenances, the seafloor topography and the features of the sediment waves, these large-scale sediment waves might be interpreted as cyclic steps generated by the down-slope flowing supercritical turbidity currents and associated internal hydraulic jumps along high gradient (approximately greater than 1.28°) canyon thalwegs characterized by numerous slope breaks. The evolution of the large-scale sediment waves from partially depositional at the PGM to erosion-dominated at the present is controlled by variations of the sediment supply and the submarine slope accommodation along the canyon thalweg, which is manifested in the co-evolution of the sediment waves with the canyon. The findings of this study tell us that in addition to axial channels and mass-transport complexes, large-scale sediment waves can also develop on the canyon floor, which helps to improve our understanding of the complex canyon processes. The 'large-scale sediment waves' described here may be a new potential deepwater-reservoir element for the deep-water hydrocarbon exploration associated with submarine canyons. • Large-scale sediment waves are identified on the canyon floor using 3-D seismic reflection data. • These sediment waves formed during the Penultimate Glacial Maximum (~140 ka) and have continued to develop to the present. • These canyon-confined large-scale sediment waves might be interpreted as cyclic steps. • The development of large-scale sediment waves and canyons is a synergistic evolutionary process. • Deep-water sandstones related to canyon-confined large-scale sediment waves may have potential for hydrocarbon exploration. [ABSTRACT FROM AUTHOR]