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Multi-modal services, typically integrated by visual, audio, and haptic signals, have been considered as promising killer services in 5G and beyond 5G era. However, due to essential difference among these signals, how to guarantee quality of multi-modal services is a significant technical challenge. Existing transmission schemes, which deliver and process each modality signal separately, cannot meet such requirements as low latency, high reliability, and high throughput. To get over the dilemma, this paper proposes a general cross-modal transmission strategy by taking advantage of the potential correlation among modalities, which consists of a delivery mechanism at the sender and a signal restoration procedure at the receiver. On the one hand, a visual-aided haptic content compression method is designed for the delivery mechanism. By utilizing the category correlation among modalities, haptic signals with similar visual content can be effectively compressed, reducing transmission burden. On the other hand, a fine-grained haptic to image synthesis (FHIS) approach is proposed for realizing signal restoration. Through exploring strong matching properties among modalities, the FHIS can restore the impaired, missing, delayed visual images from the received haptic signals. Experiments on a standard visual-haptic database and a practical platform evaluate the performance of the constructed cross-modal transmission strategy. [ABSTRACT FROM AUTHOR]

The various types of error coupling transmission mechanisms and the dimensional tolerance optimization design of multi-faceted shafting assembly are analyzed by taking the multi-faceted shafting assembly as the research object. Monte Carlo method is used to simulate the measured size of assemly ring,and the mean value of radial run-out tolerance and its distribution law are obtained. A prediction method for the radial circle run-out of variable boundary circle is proposed,and the integrated cumulative error including the coaxiality and the matching tolerance of shaft hole is established. This method is extended to the assembly error modeling of complex assembly to realize the prediction of the radial run-out tolerance in the design. With the goal of accumulating the radial runout at the end of the assembly,the average assembly accuracy,assembly reliability,and processing cost are set as constraints,and the optimization of system structure and its component tolerances is performed. Taking the design of a certain type of torque converter as an example,the feasibility and practicability of this method for predicting the cumulative radial run-out tolerance of the shaft system are verified. [ABSTRACT FROM AUTHOR]

Schematic illustration of the chitosan polymeric micelles delivery mechanism. COSA micelles are selectively taken up by circulating monocytes (Ly-6Chi monocytes) in blood. The subsequent travel of these cells results in a considerable proportion of COSA accumulation in the tumor. • Chitosan polymer (COSA) was synthesized and the characterizations of COSA micelles were investigated. • COSA micelles exhibited good self-assembly ability, good dispersion stability and low toxicity. • COSA micelles were selectively taken up by circulating monocytes in a receptor-mediated way. • COSA micelles in macrophages can be exocytosed and subsequently taken up by cancer cells. • COSA micelles are promising candidates for diseases in which monocytes are directly implicated. Micelles are one of the most investigated nanocarriers for drug delivery. In this study, polymeric micelles based on chitosan were prepared to explore the delivery mechanism which was critical for enhancing tumor targeting but still remain elusive. The chitosan polymer COSA was synthesized and the polymeric micelles showed good self-assembly ability, good dispersion stability and low toxicity. After being intravenously administered, the micelles were selectively taken up by circulating monocytes in a receptor-mediated way (almost 94% uptake in Ly-6Chi monocytes, below 7% in all other circulating cells) and reach the tumor with the subsequent travel of these cells. In addition, the micelles in macrophages (differentiated from circulating monocytes) can be exocytosed and subsequently taken up by cancer cells. The delivery mechanism of COSA micelles is directional for the novel strategies to enhance tumor targeting and the micelles are promising candidates for diseases in which monocytes are directly implicated. [ABSTRACT FROM AUTHOR]