1. Feasibility of CD19 CAR T-cell therapy in patients with cardiac lymphoma.
- Author
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Kuipers, Maria T., Spanjaart, Anne M., Bonifazi, Francesca, diBlasi, Roberta, Zinzani, Pier L., Thieblemont, Catherine, Baudet, Mathilde, Biemond, Bart J., Kok, Wouter E. M., and Kersten, Marie J.
- Subjects
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CARDIAC patients , *ARRHYTHMIA , *T cells , *CD19 antigen , *LYMPHOMAS , *DIFFUSE large B-cell lymphomas , *CARDIAC magnetic resonance imaging - Abstract
This document discusses the feasibility of using CD19 CAR T-cell therapy in patients with cardiac lymphoma. The article highlights that cardiac non-Hodgkin lymphoma is not well-represented in medical literature, and the exact incidence is unknown. The authors present three cases of patients with cardiac lymphoma who received CAR T-cell therapy. The first two patients had successful outcomes with no significant cardiac events, while the third patient experienced severe cardiotoxicity after CAR T infusion. The authors suggest that a multidisciplinary approach and preventive measures for severe cytokine release syndrome are important in optimizing the safety and efficacy of CAR T-cell therapy in patients with cardiac lymphoma. [Extracted from the article]
- Published
- 2024
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