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Some problems of modern analysis of the genome of domestic animals and the possibility of applying the results of the research in the selection have considered. Molecular genome analysis has progressed rapidly. Today, using modern DNA analysis, the domestic animals breeding value can be safely foreseen. Based on the scientist's intuition of early-20th century, after half a century, genetic markers had discovered. Thus, the traditional selection method has integrated with molecular techniques of selection by applying marker-assisted selection (MAS). Microsatellites have attracted great attention from scientists because they are widespread in the genome and have a high level of polymorphism. Thousands of SNPs have discovered with their exact position in the genome. This very reliable method occurred for analyzing the genome which shows the change of only one nucleotide base into the DNA molecule. All modern achievements of molecular genetics have opened the way for practical application in the selection of all kinds of domestic animals. Today, a combination of molecular or genomic selection combined with a traditional is very reliable method for a faster, more accurate assessment of the breeding value of animals. [ABSTRACT FROM AUTHOR]