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Purpose: To investigate the odds and associations of pregnancy outcomes with exposure to biopsy-confirmed celiac disease (CD) in Northeast Iran. Methods: In this regional retrospective cohort study, pregnancy records of all women with celiac disease who visited Celiac Disease Clinic of Imam-Reza Hospital from 2017 to 2023 (exposed group) and a sample of women without CD (unexposed group) were extracted using the Electronic Health Record of Mashhad University of Medical Sciences called "Sina". The unexposed group was randomly selected of the database and matched to exposed group on age, location of residence, socioeconomic factors. Our exclusion criteria included age ≥ 45, presence of concomitant disorders, history of non-obstetric uterine surgery, induction of pregnancy through assisted reproductive technology, and any concurrently ongoing pregnancy at the time of study. Pregnancy outcomes evaluated in this study included normal delivery, miscarriage, preterm labor, preeclampsia, and stillbirth. Adjusted odds ratios were calculated using logistic regression adjusted for confounders. Results: Ninety pregnancy records of women with CD and 270 pregnancies of women without CD were included in this study. Low neonatal birthweight (i.e. under 2500 g) had no significant association with CD (aOR = 0.99, 95% CI = 0.92–1.06), as well as postpartum hemorrhage (aOR = 1.12, 95%CI = 0.91–1.38), fetal anomaly (aOR = 0.89, 95%CI = 0.69–1.15), miscarriage (aOR = 1.00, 95%CI = 0.91–1.10), ectopic pregnancy (aOR = 0.94, 95%CI = 0.73–1.20), preterm labor (aOR = 1.00, 95%CI = 0.92–1.10), gestational diabetes mellitus (aOR = 1.07, 95%CI = 0.98–1.16), gestational hypertension (aOR = 0.99, 95%CI = 0.89–1.11), and gestation hypothyroidism (aOR = 0.95, 95%CI = 0.82–1.11). However, we found significantly lower odds of preeclampsia in pregnancies affected by CD (aOR = 0.83, 95%CI = 0.69–0.99). Conclusion: Celiac disease was not associated with increased odds of low neonatal birthweight, postpartum hemorrhage, fetal anomaly, miscarriage, ectopic pregnancy, preterm labor, gestational diabetes mellitus, gestational hypertension and gestational hypothyroidism. Preeclampsia had significantly lower odds in pregnancies affected with CD. [ABSTRACT FROM AUTHOR]

The current research aims to identify new combined genetic algorithm methods to solve complex problems. The researcher has analyzed the results and findings of the previous researchers using a systematic reviewing approach and has identified the effective factors by implementing the 7 steps of Sandelowski and Barroso’s method. Among 4320 articles, 54 articles were selected based on the CASP method. In this manner, in order to evaluate reliability and quality control, the Kappa index was used, and its value was deemed to be in high compatibility regarding the identified factors. The results of the analysis of the collected data in ATLAS TI software led to the identification of 9 categories and 33 primary codes of new combined genetic algorithm methods to solve complex problems. Based on the coding, 9 categories, and 33 initial codes were identified. The identified categories are layout design, supply network, programming, Anticipation, inventory control, information security, imaging, medical imaging and wireless network. [ABSTRACT FROM AUTHOR]

Background: Tissue staining is pivotal in histology and histopathology, shouldering a noteworthy role in identifying and classifying tissues and diseases. Due to their non-production of toxic effluents, the utilization of plant-based dyes aligns harmoniously with environmental sustainability and the well-being of laboratory personnel and the general public. Furthermore, this approach is highly cost-effective, further enhancing its appeal. Objectives: This research study explored the feasibility of staining various tissues in mice, such as the liver, kidney, intestine, and cartilage, utilizing a dye extracted from black carrots. Methods: An ethanol extract of 200 g of fresh black carrots (Daucus carota L.) was prepared using 95% ethanol saturated with two different solvents in 200 mL of distilled water. Subsequently, the prepared sections of mice tissue were immersed in the extracted dye solution for 20 minutes, followed by assessment using a light microscope. Hematoxylin-eosin staining was used as a control. Results: The dye extracted from the black carrot using alum and acetic acid successfully stained the cartilage, kidney, intestine, and liver tissues, giving them a bluish-gray coloration. Phytochemical screening further confirmed the presence of anthocyanins in the black carrot extract. Conclusion: The dye derived from black carrots exhibits natural tissue staining capabilities, making it an alternative to hematoxylin-eosin in histology and histopathology laboratories. [ABSTRACT FROM AUTHOR]

This paper introduces a groundbreaking approach to demand response management, aiming to empower consumers through innovative strategies. The key contribution is the concept of "acquiring flexibility rights", wherein consumers engage with power aggregators to curtail energy usage during peak-load periods, receiving incentives in return. A flexibility right coefficient is introduced, allowing consumers to tailor their participation in demand response programs, ensuring their well-being. Additionally, a lighting intensity control system is developed to enhance residential lighting network efficiency. The study demonstrates that high-energy consumers, adopting a satisfaction factor of 10, can achieve over 61% in electricity cost savings by combining the lighting control system and active participation in demand response programs. This not only reduces expenses but also generates income through the sale of flexibility rights. Conversely, low-energy consumers can fully offset their expenses and accumulate over USD 33 in earnings through the installation of solar panels. This paper formulates an optimization problem considering flexibility rights, lighting control, and time-of-use tariff rates. An algorithm is proposed for a distributed solution, and a sensitivity analysis is conducted for evaluation. The proposed method showcases significant benefits, including cost savings and income generation for consumers, while contributing to grid stability and reduced blackout occurrences. Real data from a residential district in Tehran validates the method's effectiveness. This study concludes that this approach holds promise for demand response management in smart grids, emphasizing the importance of consumer empowerment and sustainable energy practices. [ABSTRACT FROM AUTHOR]

Purification is an important step in the production of viral vaccines that strongly affects product recovery and subsequent immune responses. The present study was carried out with the aim of improving the purification of infectious bursal disease virus (IBDV) by the tangential flow filtration (TFF) method. Then, the effect of the purified virus on the induction of immune responses against IBDV in specific pathogen free (SPF) chickens was investigated. The IBD07IR strain was propagated in embryonated SPF eggs. The virus was purified using a 100 kDa cassette. The quality of the recovered viruses was evaluated by titration. A total number of 60 SPF chickens were randomly divided into three groups (n = 20) and received the concentrated viral antigen, commercial live IBDV vaccine and phosphate-buffered saline at the age of 3 weeks by eye drop method. The bursa of Fabricius was examined histopathologically for possible changes. Sera were collected at 1-week intervals from day 0 until the end of 6 weeks after vaccination. The IBDV-specific antibody levels, induction of cell-mediated immunity and mRNA expression levels of cytokines were evaluated. The results showed that despite a relative raise in virus titer from 7.66 to 8.17 embryo infectious dose (EID)50 mL-1 following purification, both the purified IBDV and commercial vaccine are able to induce strong immune responses against the virus. Within a context of egg-based IBDV vaccine production, a single-step TFF can be applied for the relatively purification. This platform requires a further study in the selection of multiple membranes to optimize the operating conditions and final product. [ABSTRACT FROM AUTHOR]

Nitraria schoberi L. is a medicinal plant with antioxidant, antifungal, anti-inflammatory and, anti-viral properties. This plant is also tolerant to salinity and drought. The main aim of this study was to perform elicitation in cell suspension culture of N. schoberi to detect the production of total phenolic and flavonoid contents. In order to accomplish this study, hypocotyls and cotyledonary leaves of N. schoberi were cultured in different callus induction treatments. At the next step, the calli from the best callus induction treatment were transferred to cell suspension cultures containing sodium chloride (NaCl) and salicylic acid (SA) alone or in combination. Total phenolic and flavonoid contents in treatments were measured using a spectrophotometer (absorbance at 765 nm and 430 nm, respectively). According to the results, although callus induction was observed in all treatments, the maximum fresh weight (FW) (7.6 g) and dry weight (DW) (3.7 g) were obtained by culturing hypocotyl explants in MS medium supplemented with 2, 4-dichrolophenoxyacetic acid (2, 4-D) at 0.5 mg/L. The highest total phenolic content (62.2 mg/g) and total flavonoid content (48.24 mg/g) were detected in suspension culture containing 100 millimolar (mM) NaCl and 50 micromolar (µM) SA. Elicitation in suspension culture of N. schoberi can be an effective method for increasing the production of secondary metabolites (phenolic and flavonoid compounds). [ABSTRACT FROM AUTHOR]

Newcastle disease (ND) is a highly contagious viral infection affecting poultry production in many countries. Strict biosecurity and the administration of live attenuated vaccines against the ND virus (NDV) are the main implements of controlling programs. This study evaluated the efficacy and potency of the Razi Clone12IR Newcastle vaccine in specific pathogen-free (SPF) chickens. Chickens were vaccinated with either the Razi Clone12IR vaccine (group A1, n=20) or an imported Clone vaccine (B1, n=20) in the first week of life and boosted in the second week via eye drop, while negative control chickens received PBS (C1, n=20). Half of the birds in each group were challenged with the virulent NDV strain in the third post-vaccination week (A2, B2, and C2 groups). Specific antibody responses were determined in the collected sera by the hemagglutination inhibition (HI) assay for up to eight weeks. Cell-mediated immunity (CMI) was determined by the lymphocyte proliferation assay three and six weeks after the second vaccination. Sections of the tissues and organs, including the trachea, lungs, cecal tonsils, spleen, the bursa of Fabricius, liver, and small intestine, were subjected to histopathology. The immunized groups A1 and B1 showed significantly higher HI antibody titers before the challenge than the control group. In addition, lymphocyte proliferation responses significantly increased in the peripheral blood of the vaccinated groups. After the challenge, the A2 and B2 groups conferred good protection and drastically reduced virus shedding. No main lesions were noted in the tissues or organs of the vaccinated group in histopathology. In a few cases, mild microscopic lesions were observed, including the infiltration of inflammatory cells, which was related to the effect of the vaccine virus. These results indicate that the Razi Clone12IR vaccine is safe and can be an efficient tool for NDV infections by inducing protective humoral and CMI responses. [ABSTRACT FROM AUTHOR]

Many urban planners have used Lefebvre's concept of the right to the city as a dominant approach in urban studies. In this research, we try to draw a framework for the urban development of Bandar Abbas through the application of urban development components based on the right-to-the-city approach. Interpretive structural modeling is used in drawing urban development based on the right-to-the-city approach. The centrality of citizens in decision-making, self-management of space, the right to planning and designing the space, the right to transparency, and access to information at the first class are considered the key variables of Bandar Abbas urban development. The right to manage and organize the space, the right to accountability, democratic (institutional) capacity building, and social priorities in the decision-making process are the subcomponents of Bandar Abbas urban development. The presented model is the realization of people in space, where people take over the space and enjoy the benefits of urban life, if needed, they can freely express their opinions and limitations in the space and organize the city according to their needs. [ABSTRACT FROM AUTHOR]

In recent years, information and communication technology in the field of e-commerce has reduced many of the challenges of business development. E-commerce can be used to develop the agricultural sector and to market agricultural products. This research is a survey aimed at evaluating the adoption of greenhouse owners to Affecting the use information and communication technology in managing greenhouse units in Isfahan Township. The type of research is descriptive-analytic. The statistical community is about 460 and 197 number of sample units are accidentally chosen using Cochran formula with possible precision. The research method was library and field based. After determining the indices and variables of the research, a researcher-made questionnaire was used to collect the required statistical data in the study area. The main tool of the research is questionnaire and its processing is done in the software Spss21. The reliability of questionnaire has been gained through using cronbach alpha also the validity of the research was also calculated using the KMO coefficient higher than 0.7. Results of this research showed that 10 percent greenhouse owners have started accepting the use information and communication technology in managing greenhouse units. The results of the research show that the there was a correlation between the level of education, job satisfaction and income level with the components of adopting, decision, persuasion, and knowledge of meaningful and positive. The results of regression analysis also show that variables such as age, job, experience and communication channels, psychological factors and decision describe 46 percent of the dependent variable of accepting the use of the internet. [ABSTRACT FROM AUTHOR]

Since the beginning of life on earth, mankind has always used animals and plants for its nutrition and has continuously trained and developed them for their benefits and social, cultural, and economic needs. In the past, livestock and crop breeding were done by traditional farmers and ranchers. It improves the performance of livestock and crops, they performed the selection, which is one of the principles of plant breeding and livestock breeding. They made this choice with the help of information that was passed down to them from successive generations. It is a participatory plant breeding and production of crops with the help of researchers alongside farmers. Farmers work with researchers, scientists, and other stakeholders -even consumers-to improve crops and develop resilient plant varieties. Farmers are aware of their needs and have a conscious understanding of their agricultural land in terms of soil type, seed type, weather conditions, surface water, underground water conditions, etc. Therefore, they can play an important role in making decisions about the implementation of plant breeding and the type of planting pattern in the cultivated microclimates. In other words, farmers determine their cultivation goals based on their environments, conditions, tastes, and local cultures. The seed that is obtained in this way by the breed researchers with the help of the leading farmers, actually contributes significantly to the food governance of the people of that region and that country. [ABSTRACT FROM AUTHOR]

Background: In severe COVID-19 cases, a hypercoagulable state may occur. Antiphospholipid syndrome-related auto-antibodies (APSRAs) contribute to coagulopathy, but their role in COVID-19 remains unclear. We aimed to investigate the prevalence of positive APSRAs and their effect on clinical outcomes in confirmed COVID-19 patients. Materials and Methods: In this cross-sectional study, severe hospitalized COVID-19 cases were enrolled. Demographic and clinical data were obtained from the day of admission. APSRAs including IgG and/or IgM anticardiolipin (aCL) and anti-ß2-glycoprotein1 (anti-ß2GP1) as well as lupus anticoagulant (LAC) were measured. Results: In this study, 54 severe COVID-19 cases with positive RT-PCR and chest CT scans were recruited. Positive APSRAs were found in 7 (12.9%) patients. Positive LAC was a more prevalent marker as compared to other tests (11.1%). The prevalence of positive aCL (IgM or IgG) and anti-ß2 GPI (IgM or IgG) w as 1.8% (in an elderly woman). Lower oxygen saturation was found in the positive APSRAs group as opposed to the negative APSRAs group (70.3±9 vs. 84.8±9.7%). The mortality rate in the positive APSRAs group was significantly higher relative to the negative APSRAs group (83.3% vs. 27.1%; Pvalue: 0.01). Likewise, the mechanical ventilation requirement in the positive group was also higher (50% vs. 27.1%, P-value: 0.28). Conclusion: This study indicated that LAC might be associated with critical cases and high mortality of COVID-19. Nonetheless, the mortality was not related to macrothrombotic incidence. [ABSTRACT FROM AUTHOR]

The hydrangea (Hydrangea macrophylla (Thunb). Ser.), an ornamental plant, has good marketing potential and is known for its capacity to change the colour of its inflorescence depending on the pH of the cultivation media. The molecular mechanisms causing these changes are still uncertain. In the present study, transcriptome and targeted metabolic profiling were used to identify molecular changes in the RNAome of hydrangea plants cultured at two different pH levels. De novo assembly yielded 186,477 unigenes. Transcriptomic datasets provided a comprehensive and systemic overview of the dynamic networks of the gene expression underlying flower colour formation in hydrangeas. Weighted analyses of gene co-expression network identified candidate genes and hub genes from the modules linked closely to the hyper accumulation of Al3+ during different stages of flower development. F3′5′H, ANS, FLS, CHS, UA3GT, CHI, DFR, and F3H were enhanced significantly in the modules. In addition, MYB, bHLH, PAL6, PAL9, and WD40 were identified as hub genes. Thus, a hypothesis elucidating the colour change in the flowers of Al3+-treated plants was established. This study identified many potential key regulators of flower pigmentation, providing novel insights into the molecular networks in hydrangea flowers. [ABSTRACT FROM AUTHOR]

Background: Ankylosing spondylitis (AS) is an inflammatory autoimmune disease that mostly affects different joints of the body. Macrophages are the predominant cells that mediate disease progression by secreting several pro-inflammatory mediators. Different receptors are involved in macrophages' function including the adenosine receptors (AR). Our main objective in this study was to assess the effect of applying A2A adenosine receptor agonist (CGS-21,680) on the gene expression of inflammatory mediators including bone morphogenetic proteins (BMP)-2, 4 and matrix metalloproteinases (MMP)-3, 8, 9, and 13 on the macrophages from AS patients compared to healthy macrophages.Methods: Monocytes were isolated from the whole blood of 28 individuals (AS patients and healthy controls in a 1:1 ratio). Macrophages were differentiated using macrophage colony-stimulating factor (M-CSF), and flow cytometry was performed to confirm surface markers. CGS-21,680 was used to treat cells that had been differentiated. Using SYBR green real-time PCR, relative gene expression was determined.Results: Activating A2AAR diminished MMP8 expression in healthy macrophages while it cannot reduce MMP8 expression in patients' macrophages. The effect of A2AAR activation on the expression of BMP2 and MMP9 reached statistical significance neither in healthy macrophages nor in the patients' group. We also discovered a significant positive connection between MMP8 expression and patient scores on the Bath ankylosing spondylitis functional index (BASFI).Conclusion: Due to the disability of A2AAR activation in the reduction of MMP8 expression in patients' macrophages and the correlation of MMP8 expression with BASFI index in patients, these results represent defects and dysregulations in the related signaling pathway in patients' macrophages. [ABSTRACT FROM AUTHOR]

Background: Osteoporosis is one of the most prevalent bone diseases which is preventable. Implementing educational programs is an important step in prevention of chronic diseases in the community setting. One of the theories used for predicting behavior and performing educational intervention is theory of planned behavior (TPB) which predicts the intention of an individual toward doing a specific behavior. This study was conducted to assess the effect of educational intervention based on TPB on behavioral responses of premenopausal women in prevention from osteoporosis in Fasa city, Iran.Methods: This study is a quasi-experimental study performed on 200 women aging from 35 and 55 years who referred to health centers in Fasa city; iran in 2019. Simple random sampling was applied to assign participants to control and intervention groups (100 participant for each group). Data were gathered by a "valid" and "reliable" questionnaire arranged based on the constructs of TPB, nutrition performance and physical activity. An educational program on osteoporosis prevention was conducted. educational intervention was performed in six sessions through group discussions and educational films and booklet for experimental group and then the changes in the scores of the two groups were evaluated and compared. Obtained data were analyzed by SPSS-22 software through Chi-square, independent t-test, paired t-test and ANOVA tests.Results: The mean ages of studied participants in experimental and control groups were respectively 43.39 [Formula: see text] 5.20 and 42.94 [Formula: see text] 5.52. In experimental group, the average scores of knowledge [2 weeks (31.12 [Formula: see text] 4.20) and 2 months (39.04 [Formula: see text] 4.10) after educational intervention (p < 0.001)], constructs of theory of planned behavior [attitude construct: 2 weeks (89.32 [Formula: see text] 9.22) and 2 months (98.57 [Formula: see text] 9.13) after educational intervention (p < 0.001), Subjective norms construct: 2 weeks(88.39 [Formula: see text] 8.84) and 2 months (122.57 [Formula: see text] 8.58) after educational intervention (p < 0.001), Perceived behavioral control construct: 2 weeks (88.56 [Formula: see text] 8.38) and 2 months (120.15 [Formula: see text] 8.33) after educational intervention (p < 0.001), Behavioral intention construct: 2 weeks (54.44 ± 4.72) and 2 months (60.26 [Formula: see text] 4.12) after educational intervention (p < 0.001)], nutrition performance [2 weeks (19.88 ± 2.56) and 2 months (24.14 [Formula: see text] 2.36) after educational intervention (p < 0.001)] and physical activity [2 weeks (16.75 [Formula: see text] 1.42) and 2 months (18.94 [Formula: see text] 1.68) after educational intervention (p < 0.001)] had more significant enhancement than control group 2 weeks and 2 months after educational intervention.Discussion: TPB was effected in nutrition performance and physical activity in osteoporosis prevention of subjects. This theory can be used as a framework for designing and performing educational intervention for preventing osteoporosis and promoting women's health. [ABSTRACT FROM AUTHOR]

The Oligocene Nasrand intrusive rocks (NIRs), located in the central part of the Urumieh–Dokhtar magmatic arc, are mainly composed of granite and subordinate diorite and gabbro. These rocks are characterized by the enrichment of light rare earth elements (LREEs), Nb‐Ta negative anomalies, and high LILE/HFSE, suggesting a subduction‐related origin. The felsic rocks with granite compositions have high SiO2 content (69.77–77.88 wt.%), low Mg# (0.02–0.43), low Nb/Ta, and Zr/Hf (Avg: 12.53, and 33.08, respectively). The initial 87Sr/86Sr ratio and εNd(t) values in felsic rocks range from 0.70577 to 0.70576 and 0.4 to −0.3, respectively. These data suggest that these felsic rocks originated from juvenile crust by heat rising from basaltic magmas in an orogenic setting. The mafic‐intermediate rocks and dikes are gabbro, gabbroic diorite, and monzodiorite, with low SiO2 content (48.08–56.11 wt.%) and high Mg# (0.37–0.68), with average ratios of Nb/Ta and Zr/Hf are 27.88 and 39.84, respectively. The initial 87Sr/86Sr ratio and εNd(t) values for mafic‐intermediate rocks and dikes are 0.70583 to 0.70476 and −0.1 to +2.6, respectively. These characteristics indicate magma from a mantle source that had undergone minor mixing with juvenile crust. It seems mantle‐derived juvenile magma underplating played an important role in the crustal growth in the Urumieh–Dokhtar magmatic belt during the Ediacaran to Early Cambrian, relative to other time frames. [ABSTRACT FROM AUTHOR]

Background and Objectives: Probiotics are added into the food or feed systems and provide beneficial effects to the human or animal health. This study aimed to isolate the gastrointestinal native Lactobacillus strains with high probiotic, cholesterol-assimilation and aflatoxin-degradation capabilities from native chickens. Materials and Methods: About 70 Lactobacillus isolates were isolated from ileum of the Fars province native chickens and were investigated for their probiotic properties. Results: Of 70 Lactobacillus isolates, 10 showed high probiotic capabilities, including survival at acidic conditions (pH up to 2.5), tolerance of 0.5% bile and 6-10% NaCl salts, growth in a wide range of temperature from 15 to 45°C, antagonistic effects against different important bacterial pathogens (Pseudomonas aeruginosa, Escherichia coli, Streptococcus mutans, Clostridium defficile, Enterococcus hirae, Salmonella enterica and Staphylococcus aureus) and sensitivity to some important antibiotics. The selected strains had an aggregation time less than 120 min. The 16S-rDNA sequencing showed that the selected strains were highly related to Lactobacillus reuteri and L. casei. Finally, the selected strains in this study along with 10 other probiotic strains isolated and characterized in our pervious study were used to evaluate their cholesterol assimilation and aflatoxin B1 degradation capabilities. The potentials of cholesterol assimilation of the selected strains were significantly different (P<0.05) and ranged from 2.3% to 99%. The highest content of cholesterol assimilation was obtained in isolates M20 and M4 with more than 98% absorption. Moreover, four strains 43, OR7, M21 and OR9 were able to absorb AFB1 with 58.6%, 52.33%, 47% and 31.6% efficiency respectively. Conclusion: It could be concluded that the strains 43, M21 and OR7 showed high probiotic potentials for application in the poultry industry. [ABSTRACT FROM AUTHOR]

Utilizing subunit vaccines is one of the strategies to address influenza infection. Recent innovations have focused on high doses of vaccine antigens and immune enhancers or adjuvant to induce more robust and long-lasting immune responses. Here, an effect of the B cell-activating factor receptor (BAFF-R) to increase the magnitude and durability of immune responses of the recombinant HA1 (rHA1) protein against the H1N1 influenza virus was studied. The HA1 protein and the effector domain of BAFF-R were expressed in the pET-28a (+) vector. Eight-week-old BALB/c mice were equally grouped into five groups (n=20). The 15 and 25 μg/μL of rHA1 were mixed with 2 μg/μL of rBAFF-R and injected three times for vaccinated groups. Three control groups were received normal saline and two concentrations of rHA1. The ability of rBAFF-R in eliciting HA-specific antibody response and stimulating T lymphocyte proliferation to induce the cell-mediated immunity was assayed. Induction of protection was evaluated following the challenge with PR8 strain. Analysis of immune responses showed that the co-administration of rBAFF-R with rHA1 boosted HI responses to the antigen in mice, whilst it was not able to promote the T cell proliferation responses against influenza. Compared to rHA1alone, the rBAFF-R/rHA1 generated efficient protection for the animals. There were no significant differences in eliciting the immune responses in mice immunized with the lower dose of rHA1 than that with the higher dose. The data indicate the rBAFF-R can enhance the primary and memory immune responses to protect against influenza infection. [ABSTRACT FROM AUTHOR]

This article proposes a controller for dc–dc converters to achieve fast load-transient responses. The controller is developed for both continuous conduction mode (CCM) and discontinuous conduction mode (DCM) of operation. The main idea is developed for buck converters, but it is shown that the proposed controller can be applied to other topologies, such as the noninverting buck–boost converter. The controller derivation, analysis, and experimental verifications are provided in both CCM and DCM, and its performance is compared with other methods. The main advantage of the proposed controller is that it minimizes the recovery times associated with load-transient responses in dc–dc converters while maintaining component sizes and other system parameters within the acceptable range. The proposed controller can be used to minimize load transients in electronic portable devices and electric vehicle charging. [ABSTRACT FROM AUTHOR]

While steer-by-wire (SBW) systems benefit from improved performance and comfort, they require a large number of sensors impacting whole system reliability. In order to address this challenge fault tolerance property against sensor faults has to be improved. Application of redundancy for the sensors is the best solution proposed so far. This paper proposes a novel solution of analytical redundancy based on various position estimation methods for both electrical motor and steering wheel position sensors. Three different estimation techniques including extended programmable cascaded low-pass filter (EPCLPF), stator flux linkage estimator using stator currents, as well as stator flux linkage estimator using stator voltages are proposed for this purpose. The faulty sensors are recognized using a voting technique in which a comparison between the sensors' outputs with the estimated values is made. In this way, the SBW system reliability is highly improved with no additional cost and space. Simulation and experimental results are presented to confirm the presented fault tolerant SBW system capabilities. [ABSTRACT FROM AUTHOR]

Aim: This study aimed to investigate the effect of circadian rhythm stability and amplitude on musculoskeletal disorder prevalence and work–family conflict among nurses. Design: This cross‐sectional study was conducted on 386 nurses working in three hospitals, in Shahroud, Iran. Method: The data were collected using the Circadian Rhythm Inventory, Nordic Musculoskeletal Disorders, and Carlson Work‐Family Conflict questionnaires. Results: The highest prevalence of musculoskeletal disorders was reported in the lower back (68.4%), upper back (65.5%) and shoulders (53.6%), respectively. No significant relation was found between circadian rhythm stability and amplitude, and musculoskeletal disorders prevalence. The nurses who could not overcome drowsiness reported more Work Interference with Family (WIF), Family Interference with Work (FIW) (time‐based) and FIW (strain‐based) compared to the nurses who overcame drowsiness. In addition, the appropriate nurses for shift work experienced less WIF, FIW (behavioural‐based) and WIF (strain‐based) compared to the nurses who could not work overtime or at night. [ABSTRACT FROM AUTHOR]

Groundwater level observations due to the lack of synoptic water-level measurements are often available with irregular time intervals. The results lead to an inaccurate understanding of the parameters affecting groundwater level changes and their time delays. This paper presents a simple and low-cost approach to interpolate the irregular, periodic intervals of recorded groundwater level data for the Najafabad aquifer located in central Iran. Forty-six monitoring wells with an average of 20 years of data were used for this study. Piecewise cubic Hermite interpolating polynomial (PCHIP), cubic spline, linear, and nearest neighbor are the selected interpolation methods. Cross-validation with leave-one-out technique was also applied to evaluate the accuracy of the methods under three conditions, including low, average, and high groundwater level decline. The analysis proved that (1) PCHIP interpolation showed a high performance in all of the groundwater level decline conditions (0.22 < RMSE < 0.59 and 0.72 < R2 < 0.98). (2) Under slight and without abrupt fluctuations of groundwater level conditions, cubic spline showed a better performance than the linear interpolation (R2 = 0.98, RMSE = 0.49 for cubic spline and R2 = 0.98, RMSE = 0.51 for linear). The selected approach reduces the uncertainty in the study of issues such as changes in groundwater recharge and storage, groundwater flow directions, surface–groundwater interaction, and groundwater modeling. [ABSTRACT FROM AUTHOR]