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In this study, Felodipine-loaded nanoparticles were prepared using the nanoprecipitation method, with quince seed mucilage serving as the polymer matrix and Tween 80 utilized as a stabilizing agent. The nanoparticles were thoroughly characterized using a range of analytical techniques, including dynamic light scattering (DLS), zeta potential measurement, Fourier-transform infrared spectroscopy (FTIR), thermal analysis, X-ray diffraction (XRD), and scanning electron microscopy (SEM). The Felodipine nanoparticles displayed an amorphous structure, with formulation FEL 4 achieving the highest entrapment efficiency of 67.68%. This formulation also had an average particle size of 675 ± 2.04 nm and a zeta potential of − 31.7 ± 1.34 mV. Saturation solubility tests revealed a significant enhancement in water solubility for the nanoparticles compared to pure Felodipine. Additionally, in vitro drug release studies demonstrated a sustained release profile over 24 h in phosphate buffer. Acute oral toxicity evaluations confirmed that the Felodipine nanoparticles did not exhibit any signs of toxicity. Overall, this study showed the successful fabrication of quince seed mucilage-based Felodipine-loaded nanoparticles as a promising approach to enhance solubility and achieve sustained drug release, with no evident toxicity. [ABSTRACT FROM AUTHOR]

Introduction and Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) formerly known as Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease. Identifying MASLD risk factors could help early intervention and reduce the burden of the disease. Previous studies investigated the association between sarcopenia and NAFLD. Several trials were published after the last meta-analysis with indecisive results. This is an updated meta-analysis which aims to assess the association between sarcopenia, MASLD, and MASLD-related fibrosis. Materials and Methods: Relevant trials published on PubMed, Web of Science, Scopus, and Cochrane Library databases until October 2022 were included. We included studies in which skeletal mass index (SMI) or sarcopenia was compared between patients with and without NAFLD now MASLD. Also, studies comparing fibrosis between MASLD patients with and without sarcopenia were included. Data were pooled as odds ratios (ORs) and 95 % confidence intervals (CIs) using Review Manager Software. Results: A total of 25 studies were included. The incidence of sarcopenia was significantly higher in MASLD than controls (OR, 1.25; 95 % CI, 1.08-1.44; P = 0.003). SMI odds showed no significant difference between MASLD patients and controls (OR, 1.02; 95 % CI, 0.91-1.15; P = 0.7). MASLD patients with sarcopenia had higher odds of fibrosis than MASLD patients without sarcopenia (OR, 1.49; 95 % CI, 1.03-2.14; P = 0.03). Conclusions: Sarcopenia increased MASLD's probability and was associated with a higher probability of liver fibrosis in MASLD patients. However, SMI had no predictive value of MASLD occurrence. [ABSTRACT FROM AUTHOR]

Background: Plant growth and development can be greatly impacted by drought stress. Suitable plant growth promoting rhizobacteria (PGPR) or biochar (BC) application has been shown to alleviate drought stress for plants. However, their co-application has not been extensively explored in this regard. Methods: We isolated bacterial strains from rhizospheric soils of plants from arid soils and characterized them for plant growth promoting characteristics like IAA production and phosphate solubilization as well as for drought tolerance. Three bacterial strains or so called PGPRs, identified as Bacillus thuringiensis, Bacillus tropicus, and Bacillus paramycoides based on their 16S rRNA, were screened for further experiments. Wheat was grown on normal, where soil moisture was maintained at 75% of water holding capacity (WHC), and induced-drought (25% WHC) stressed soil in pots. PGPRs were applied alone or in combination with a biochar derived from pyrolysis of tree wood. Results: Drought stress substantially inhibited wheat growth. However, biochar addition under stressed conditions significantly improved the wheat growth and productivity. Briefly, it increased straw yield by 25%, 100-grain weight by 15% and grain yield by 10% compared to the control. Moreover, co-application of biochar with PGPRs B. thuringiensis, B. tropicus and B. paramycoides further enhanced straw yield by 37–41%, 100-grain weight by 30–36%, and grain yield by 22–22.57%, respectively. The co-application also enhanced soil quality by increasing plant-available phosphorus by 4–31%, microbial biomass by 33–45%, and soil K+/Na+ ratio by 41–44%. Conclusion: Co-application of PGPRs and biochar alleviated plant drought stress by improving nutrient availability and absorption. Acting as a nutrient reservoir, biochar worked alongside PGPRs, who solubilized nutrients from the former and promoted wheat growth. We recommend that the co-application of suitable PGPRs and biochar is a better technology to produce wheat under drought conditions than using these enhancers separately. [ABSTRACT FROM AUTHOR]

Life-threatening events including terminal illness intensify the search for meaning and incite individuals to get closer to religion. Terminal patients can often find religious practices as helpful as medical therapy for bettering both physical and mental health. The present research aims to explain the interaction between religion, spirituality, and social support in coping with terminal illness among Muslim hepatitis C patients in Pakistan. A semi-structured open-ended interview guide was utilized to collect the data. Participants expressed that the deployment of religious and spiritual beliefs along with socio-emotional support during illness fostered medical therapy. Participants also revealed that belief in God provided them the strength to be steadfast during the terminal stage of the disease. Religious beliefs enabled terminal participants to accept death as an eventual reality and a normal part of their lives. Furthermore, participants put forward their longing for those kinds of religious practices that terminal diseases usually restrained them from receiving. The emotional support stemming from social relationships also improved resilience to cope with the terminal stage of illness. The study concludes that the interplay of religion, spirituality, and social support normalizes the fear of death, lessens pain, and improves resilience among Muslim hepatitis C patients in Pakistan. [ABSTRACT FROM AUTHOR]

Human islet amyloid polypeptide (amylin or hIAPP) is a 37 residue hormone co‐secreted with insulin from β cells of the pancreas. In patients suffering from type‐2 diabetes, amylin self‐assembles into amyloid fibrils, ultimately leading to the death of the pancreatic cells. However, a research gap exists in preventing and treating such amyloidosis. Plumbagin, a natural compound, has previously been demonstrated to have inhibitory potential against insulin amyloidosis. Our investigation unveils collapsible regions within hIAPP that, upon collapse, facilitates hydrophobic and pi‐pi interactions, ultimately leading to aggregation. Intriguingly plumbagin exhibits the ability to bind these specific collapsible regions, thereby impeding the aforementioned interactions that would otherwise drive hIAPP aggregation. We have used atomistic molecular dynamics approach to determine secondary structural changes. MSM shows metastable states forming native like hIAPP structure in presence of PGN. Our in silico results concur with in vitro results. The ThT assay revealed a striking 50% decrease in fluorescence intensity at a 1:1 ratio of hIAPP to Plumbagin. This finding suggests a significant inhibition of amyloid fibril formation by plumbagin, as ThT fluorescence directly correlates with the presence of these fibrils. Further TEM images revealed disappearance of hIAPP fibrils in plumbagin pre‐treated hIAPP samples. Also, we have shown that plumbagin disrupts the intermolecular hydrogen bonding in hIAPP fibrils leading to an increase in the average beta strand spacing, thereby causing disaggregation of pre‐formed fibrils demonstrating overall disruption of the aggregation machinery of hIAPP. Our work is the first to report a detailed atomistic simulation of 22 μs for hIAPP. Overall, our studies put plumbagin as a potential candidate for both preventive and therapeutic candidate for hIAPP amyloidosis. [ABSTRACT FROM AUTHOR]

There has been a rapid expansion in centers performing balloon pulmonary angioplasty (BPA) and pulmonary thromboendarterectomy (PTE) for chronic thromboembolic pulmonary hypertension (CTEPH). The purpose of this scoping review was to identify cardiothoracic imaging predictors of outcomes and to identify gaps to address in future work. A scoping review was conducted using the framework outlined by Arksey and O'Malley and Levac et al. in MEDLINE and EMBASE. The study protocol was preregistered in OSF Registries and performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews (PRISMA-ScR) guidelines. There were 1117 identified studies, including 48 involving pulmonary thromboendarterectomy (n = 25) and balloon pulmonary angioplasty (n = 23). CT was the most common preoperative imaging modality used (n = 21) and CT level of disease was the most reported imaging predictor of outcomes for pulmonary thromboendarterectomy. Although must studies evaluated hemodynamic improvements, imaging was of additional use in predicting clinically significant procedural complications after balloon pulmonary angioplasty, as well as mortality and long-term outcome after pulmonary endarterectomy. Predictors reported in MRI and digital subtraction angiography were less commonly reported and warrant multicenter validation. Cardiothoracic imaging may predict clinically significant outcomes after balloon pulmonary angioplasty and pulmonary thromboendarterectomy. Radiologists involved in the assessment of CTEPH patients should be aware of key predictors and future investigations could focus on multicenter validation and new technologies. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this study is to empirically examine how the seven human resource management (HRM) practises, namely, leadership development, professional investment, egalitarian practises, developmental appraisals, family-friendly practises, engagement practises and generous benefits, are associated with perceived organisational support (POS) and destructive deviance in the context of Indian organisational culture. Design/methodology/approach: In total, 265 middle-level IT personnel provided the study's data. To test the suggested study hypotheses, confirmatory factor analysis and PROCESS Macros were used. Findings: Results show that putting in place leadership development, professional investment, egalitarian practises, developmental appraisal, family-friendly practises, engagement practises and generous benefits generates POS that, in turn, significantly contributes to reducing destructive deviance. Additionally, POS was found to partially mediate the relationship between perceived HRM practises and destructive deviance. Research limitations/implications: The results would help firms reduce detrimental employee deviation. To do this, managers must develop and put into effect the seven HRM practises, which demonstrate to workers that the organisation appreciates their contributions and cares about their well-being, thereby lowering disruptive deviance. In essence, IT businesses should carefully plan and implement the HRM practises they expressly want to use rather than mindlessly copying those of rival organisations. Furthermore, to adapt to the workforce's evolving needs, these HRM practises must be properly matched with both individual and organisational goals. Originality/value: By including destructive deviance as a result of POS, this study adds to the body of research on organisational support theory. The literature on POS and negative behaviours will take a new turn with such a focus on destructive deviance. Additionally, this study encourages academics to investigate an underlying mechanism that accounts for how HRM practises affect employees' conduct. This study also adds to the sparse body of knowledge on POS for non-Western workers. The study's findings confirm that POS is a crucial concept for both Asian and Western workers. [ABSTRACT FROM AUTHOR]

The current agri-food systems are unable to fulfill global demand and account for 33% of all greenhouse gas emissions. Conventional agriculture cannot produce more food because of the scarcity of arable land, the depletion of freshwater resources, and the increase in greenhouse gas emissions. Thus, it is important to investigate alternate farming methods. Algae farming is a feasible alternative that produces food, feed, and feedstock using wastelands and unconventional agricultural settings such as coastal regions, salt-affected soils, and urban/peri-urban environments. This review focuses on three emerging scenarios. First is seawater, which makes up 97.5% of the water on Earth. However, it is nevertheless used less often than freshwater. Second is a growing trend of people moving from rural to urban regions for improved employment prospects, living standards, and business chances. However, most rural migrants are essentially skilled in agriculture, which limits their applicability in metropolitan environments. The third scenario focuses on excellent crop yields and soil fertility; it is essential to maintain appropriate levels of organic matter and soil structure. In this case, algae have remarkable potential for osmoregulation-based salt tolerance and may provide valuable metabolites when cultivated in brackish or saltwater. Using brackish water, treated wastewater, and saltwater, algal culture systems may be established in arid/semi-arid, urban/peri-urban, and coastal areas to fulfill the increasing need for food, feed, and industrial feedstocks. It may also provide migrants from rural areas with work possibilities, which would allay environmental footprints. [ABSTRACT FROM AUTHOR]

Background. Nurse emigration, often termed "brain drain," poses significant challenges to Ghana's healthcare sector. Aim. This study explores nurse managers' perspectives on determinants and strategies for mitigating nurse emigration in Northern Ghana. Methods. Sixteen nurse managers were interviewed using semistructured interviews between October and December 2023. Purposive sampling was used to select the participants. QDA Miner Lite version 6 was used for systematic coding and thematic data analysis, following the conventional content analysis approach. Results. Following data encoding and classification, the study identified three primary categories: determinants of brain drain, impact of brain drain on the healthcare system, and mitigating factors of brain drain. Conclusion. The study reveals that various factors, including inadequate pay, limited opportunities for career growth, and lack of access to technology, drive the brain drain among Ghanaian nurses. These lead to negative impacts on the healthcare system, such as increased workload, reduced patient satisfaction, and a shortage of skilled nurses. To tackle this issue, solutions including offering career advancement opportunities and improving salaries and working conditions among others have been highlighted to mitigate the brain drain among Ghanaian nurses. [ABSTRACT FROM AUTHOR]

Using the MTT 3-(4, 5-dimethylthiazol-2yl-2, 5-diphenyltetrazolium bromide) assay induced by hydrogen peroxide (H2O2) and the ability to increase the cytotoxicity of doxorubicin in HepG2 and MDA-MB-231 cells, the protective effects of ethanolic extract of tamarillo were assessed in the current study. The cells were pre-treated with tamarillo ethanolic extract at 10 g/mL for 4 h before being exposed to 0.6 mM H2O2 for 3 h showed the greatest protection, with a significant increase (P 0.05) in cell viability of 79% compared to the control (57%). The results support a role that cyto-protective effect of tamarillo and doxorubicin which low in toxicity opens a new possible approach for possible future use in conventional chemotherapeutic drugs and radiation therapy. [ABSTRACT FROM AUTHOR]

Recently, learning through multi-classifiers is of huge interest in economic as well as industrial domains. In addition, the neural network becomes an emerging technique for learning. Nevertheless, the accuracy of the neural network is imperfect due to its loss function. Hence, a new cross entropy-based function is devised. The aim is to develop a model to classify IoT services and build a semantic graph network using a fractional cross entropy-based loss function (FCEBLF). Originally, the service recipe of IFTTT (if-this-then-that) is considered to extract the title and description. Here, the edge and nodes are used for constructing a semantic graph, where semantic features are obtained. Meanwhile, term frequency and inverse document frequency (TF-IDF) are accomplished using IFTTT recipes. Moreover, the natural language processing (NLP) features are extracted to further increase the efficiency. In addition, the obtained features are fused. Thus, the fusion of features is executed by using deep neural network (DNN) based on Hellinger distance. Lastly, the classification of IoT service is attained based on deep residual network (DRN) in which loss function is enhanced using FCEBLF. The proposed FCEBLF + DRN outperformed with high micro-F1 of 91.2%, precision of 91%, and recall of 91.4%. [ABSTRACT FROM AUTHOR]

Background and Objectives: Achalasia has several treatment modalities. We aim to compare the efficacy and safety of laparoscopic Heller myotomy (LHM) with those of pneumatic dilatation (PD) in adult patients suffering from achalasia. Methods: We searched Cochrane CENTRAL, PubMed, Web of Science, SCOPUS and Embase for related clinical trials about patients suffering from achalasia. The quality appraisal and assessment of risk of bias were conducted with GRADE and Cochrane's risk of bias tool, respectively. Homogeneous and heterogeneous data was analyzed under fixed and random-effects models, respectively. Results: The pooled analysis of 10 studies showed that PD was associated with a higher rate of remission at three months, one year, three years and five years (RR = 1.25 [1.09, 1.42] (p = 0.001); RR = 1.13 [1.05, 1.20] (p = 0.0004); RR = 1.48 [1.19, 1.82] (p = 0.0003); RR = 1.49 [1.18, 1.89] (p = 0.001)), respectively. LHM was associated with lower number of cases suffering from adverse events, dysphagia and relapses (RR = 0.50 [0.25, 0.98] (p = 0.04); RR = 0.33 [0.16, 0.71] (p = 0.004); RR = 0.38 [0.15, 0.97] (p = 0.04)), respectively. There is no significant difference between both groups regarding the lower esophageal pressure, perforations, remission rate at two years, Eckardt score after one year and reflux. Conclusion: PD had higher remission rates than LHM at three months, one year and three years, but not at two years or five years. More research is needed to determine whether PD has a significant advantage over LHM in terms of long-term remission rates. [ABSTRACT FROM AUTHOR]

An immunologic system attacking the body's own tissues is a hallmark of autoimmune disorders, which encompass a wide range of unique conditions. Numerous essential biologic functions, including the regulation of the immune system, inflammation, cell division, and tissue repair, are carried out by cytokines. Natural compounds are an effective treatment for autoimmune illnesses by modulation of inflammatory cytokines and infiltration of leukocytes into the inflamed tissue. Here, anti-arthritic study was carried out using oral administration of Azelaic acid (AzA) for 28 days with doses (20, 40, and 80 mg/kg) in Complete Freund's Adjuvant (CFA) induced arthritis model. AzA ameliorated the adjuvant-induced arthritis by decreasing arthritic score, paw volume, improved body-weight alterations and serum levels of PGE2, 5-LOX and anti-ccp. AzA showed significant down regulation of NF-κB, COX-II, TNF-α, IL-17, IL-1β, IL-6, and up regulation of IL4 and IL10. Hemoglobin and RBCs count remarkably increased and ESR, CRP, platelets, WBCs levels markedly reduced in post treatment. In addition, the weakened SOD (superoxide dismutase), Catalase (CAT), Glutathione (GSH) activity and the increased levels of malondialdehyde (MDA) were all reversed by AzA treatment. And showed improved radiographical and histologic alterations in the structure of the joints. Molecular docking studies targeting COX-II, iNOS, TNF-α, 5-LOX, IL4, IL10, IL-6, and IL-17 establish a correlation between theoretical and experimental results. Results showed that AzA inhibit pro-inflammatory cytokines (COX-II, TNF-α, 5-LOX, IL-17, NF-κB, IL-1β, and IL-6) and increase anti-inflammatory cytokines, which supported the anti-arthritic and immunomodulatory potential of AzA. [ABSTRACT FROM AUTHOR]

Emulgels have emerged as a promising drug delivery system for enhancing the topical delivery of hydrophobic drugs. The present study was designed to formulate and characterize the emulgels prepared by using pectin for topical delivery of econazole nitrate. For this purpose, pectin, a natural gelling agent, was extracted from Abelmoschus esculentus (okra pods). The extracted pectin was thoroughly characterized for its physicochemical and micromeritic properties. The response surface methodology from Design-Expert was used to optimize the emulgel preparation. The optimized formulations (F1, F2 and F3) were thoroughly characterized through particle size (PS) and zeta potential (ZP) measurements, as well as compatibility assessment of various ingredients and drug release profiles. The zeta potential measurements revealed values of − 16.9 ± 0.467 mV, − 17.9 ± 0.200 mV and − 13.7 ± 0.109 mV for F1, F2 and F3, respectively, indicating good formulation stability. Furthermore, the polydispersity index (PDI) values (0.230 ± 0.005, 0.226 ± 0.002 and 0.075 ± 0.059 for F1, F2 and F3, respectively) indicated uniform and stable formulations with minimal particle size variation. Among the formulations, F3 exhibited superior spreadability (14.954 gm.cm/s), crucial for optimal topical application, while F1 displayed the highest viscosity (1360.151 Pa), ensuring better retention on the skin and prolonged drug release. Regarding drug content (%), F3 achieved the highest value (79.091%), highlighting its potential for delivering a higher dosage of econazole nitrate. Overall, this scientifically stringent study demonstrates the suitability of pectin extracted from okra pods for formulating emulgels with favorable characteristics, providing a solid foundation for further exploration and development of topical drug delivery systems. [ABSTRACT FROM AUTHOR]

The volume of data transferred across communication infrastructures has recently increased due to technological advancements in cloud computing, the Internet of Things (IoT), and automobile networks. The network systems transmit diverse and heterogeneous data in dispersed environments as communication technology develops. The communications using these networks and daily interactions depend on network security systems to provide secure and reliable information. On the other hand, attackers have increased their efforts to render systems on networks susceptible. An efficient intrusion detection system is essential since technological advancements embark on new kinds of attacks and security limitations. This paper implements a hybrid model for Intrusion Detection (ID) with Machine Learning (ML) and Deep Learning (DL) techniques to tackle these limitations. The proposed model makes use of Extreme Gradient Boosting (XGBoost) and convolutional neural networks (CNN) for feature extraction and then combines each of these with long short-term memory networks (LSTM) for classification. Four benchmark datasets CIC IDS 2017, UNSW NB15, NSL KDD, and WSN DS were used to train the model for binary and multi-class classification. With the increase in feature dimensions, current intrusion detection systems have trouble identifying new threats due to low test accuracy scores. To narrow down each dataset's feature space, XGBoost, and CNN feature selection algorithms are used in this work for each separate model. The experimental findings demonstrate a high detection rate and good accuracy with a relatively low False Acceptance Rate (FAR) to prove the usefulness of the proposed hybrid model. [ABSTRACT FROM AUTHOR]

Cancer and related disorders are the most common cause of cancer-related mortality with the incidence of 1 in 9 among the pre-menopausal Pakistani females. among the most common ailments worldwide, indicating the importance of developing particular techniques that could help attenuate the effects of breast cancer and related outcomes. The primary aim of the current study was to review the role of inflammatory and stress markers in the development and progression of breast cancer. Four hundred ninety-eight (n = 498) patients with breast cancer and four hundred and ninety-eight (n = 498) age- and sex-matched controls were selected for this case‒control study. Serum samples were obtained, and the levels of stress and inflammatory markers, including Matrix metalloproteases (MMPs), Interleukins (ILs), Heat shock proteins (HSPs), Malondialdehyde (MDA), Nitric Oxide (NO), inducible Nitric Oxide Synthase (iNOS) and Tumour necrosis factor-alpha (TNF-α), were determined. Most (62%) patients had metastatic breast cancer (stage III or IV) with an adverse grade (65% with Grade III and 35% with Grade II). The present study showed that the levels of oxidants such as MDA, ILs, MMPs and HSPs were significantly greater, while the levels of antioxidants such as Superoxide Dismutase (SOD), Glutathione (GSH), Catalase (CAT), vitamin A, C and D were significantly lower in breast cancer patients than in controls, suggesting their diagnostic importance and role in the pathophysiology of breast cancer. Oxidants, including IL-1, HSP27 and MMP9, which are highly specific and sensitive, may be used to develop the pathophysiological pathways of metastatic breast cancer in these patients. These pathways include cell invasion, cell migration and epithelial–mesenchymal transition. Therefore, we concluded that an increase in growth factors, e.g., Vascular Endothelial Growth Factor (VEGF), Tumour Growth Factor-beta (TGF-β) and B-cell lymphoma (Bcl2), under the influence of these variables plays a crucial role in the metastasis of breast cancer. [ABSTRACT FROM AUTHOR]

Introduction and Objectives: Hepatorenal syndrome (HRS) is a serious complication of cirrhosis treated with various medications. We aim to evaluate terlipressin and albumin’s effectiveness and safety compared to albumin and noradrenaline in adult hepatorenal disease patients. Materials and Methods: Clinical trials from four databases were included. Cochrane’s approach for calculating bias risk was utilized. We rated the quality evaluation by Grading of Recommendations Assessment, Development, and Evaluation (GRADE). We included the following outcomes: serum creatinine (mg/dl), urine output (ml/24 h), mean arterial pressure (mmHg), reversal rate of HRS, mortality rate, blood plasma renin activity (ng/ml/h), plasma aldosterone concentration (pg/ml), urine sodium (mEq/l), and creatinine clearance (ml/ min). Results: Our analysis of nine clinical studies revealed that the noradrenaline group was associated with higher creatinine clearance (MD = 4.22 [0.40, 8.05]), (P = 0.03). There were no significant differences in serum creatinine levels (MD = 0.03 [-0.07, 0.13]), urinary sodium (MD = -1.02 [-5.15, 3.11]), urine output (MD = 32.75 [-93.94, 159.44]), mean arterial pressure (MD = 1.40 [-1.17, 3.96]), plasma renin activity (MD = 1.35 [-0.17, 2.87]), plasma aldosterone concentration (MD = 55.35 [-24.59, 135.29]), reversal rate of HRS (RR = 1.15 [0.96, 1.37]), or mortality rate (RR = 0.87 [0.74, 1.01]) between the two groups (p-values > 0.05). Conclusions: Noradrenaline is a safe alternative medical therapy for HRS. [ABSTRACT FROM AUTHOR]

The study investigated the impact of high‐involvement work systems (HIWS) on knowledge‐sharing intention (KSI) through the mediation of organizational commitment (OC) and the moderation of workplace allocentrism, particularly in the manufacturing units of small and medium enterprises operating in Pakistan. Data collection involved 328 workers, utilizing self‐administered structured questionnaires translated into Urdu to ensure understanding and inclusivity. SmartPLS software was used to analyze data using the structural equation modeling technique for the examination of complex relationships between multiple variables simultaneously. The findings suggest that the association between HIWS and KSI strengthens among the individuals high in workplace allocentrism and that cultural factors play a significant role in shaping how employees respond to HIWS and engage in knowledge‐sharing behaviors. The study highlights the importance of considering cultural factors in organizational practices and strategies, thus providing novel insights for entrepreneurs to enhance the performance, innovation, and competitiveness of their enterprises through a knowledge‐sharing culture. Overall, study offers valuable contributions to both academia and practice by shedding light on the intricate relationships between HIWS, KSI, OC, and workplace allocentrism. [ABSTRACT FROM AUTHOR]

Background: Portal hypertension (PH) is a clinically significant entity that could present with life-threatening gastrointestinal bleeding. Cirrhosis is the most common cause of PH, with well-documented histopathology and etiology. However, in idiopathic portal hypertension (IPH), no single histopathologic finding is associated with PH. Our systematic review aims to identify and summarize the prevalence of the common histological findings of IPH. Methods: We systematically searched PubMed, Cochrane CENTRAL, Web of Science, and Scopus till 1ST March 2022 for studies describing the histopathological features of IPH. Data were extracted from eligible studies and pooled as events rate and 95% confidence interval (CI) using binary random-effects model by open meta-analyst software. Results: We included 23 retrospective studies with a total sample size of 813 patients. The overall incidence of nodular regenerative hyperplasia was 38.6%, 59.8% for portal fibrosis, 51.3% for periportal fibrosis, 39.3% for perisinusoidal fibrosis, 89.8% for portal vein sclerosis, 42.2% for portal inflammation, 53.3% for mega-sinusoids, 39.5% for thickening of portal vein branches, 93.8% for narrowing of portal veins, 53.3% for hepatic veins/venous outflow obstruction, 51.4% for aberrant portal/periportal vessels, 42.4% for shunt vessel, 50.9% for ductular proliferation, and 16.3% for steatosis. Conclusion: Due to the relatively non-pathognomonic and non-specific nature of IPH, a combination of different histological features such as the portal and periportal fibrosis, portal vein sclerosis, mega-sinusoids, narrowing of portal veins, hepatic venous outflow obstruction, aberrant portal or periportal vessels, and ductular proliferation may be of value in diagnosing IPH as the incidence rate of these features was at approximately 50%. [ABSTRACT FROM AUTHOR]

Four eight‐coordinated luminescent samarium complexes of type [Sm(hfpd)3L2] and [Sm(hfpd)3L′] [where hfpd = 1,1,1,5,5,5‐Hexafluoro‐2,4‐pentanedione L = tri‐octyl‐phosphine oxide (TOPO) and L′ = 1,10‐phenanthroline (phen), neocuproine (neoc) and bathocuproine (bathoc) were synthesized via a stoichiometrically controlled approach. This allows for precise control over the stoichiometry of the complexes, leading to reproducible properties. This investigation focuses on understanding the impact of secondary ligands on the luminescent properties of these complexes. Infrared (IR) spectra provided information about the molecular structures, whereas 1H and 13C nuclear magnetic resonance (NMR) spectra confirmed these structural details along with the coordination of ligands to trivalent Sm ion. The UV–vis spectra revealed the molar absorption coefficient and absorption bands associated with the hfpd ligand and photoluminescence (PL) spectroscopy demonstrated intense orange‐red emission (648 nm relative to 4G5/2 → 6H9/2) from the complexes. The Commission Internationale de l'Éclairage (CIE) triangles indicated that the complexes emitted warm orange red light with color coordinates (x, y) ranging from (0.62, 0.36) to (0.40, 0.27). The investigation of the band gap as well as color parameters confirms the utility of these complexes in displays and LEDs. [ABSTRACT FROM AUTHOR]

Over a century ago, there are anecdotal stories of the use of therapeutic anthelminthic plants, such as papaya (Carica papaya) against cestode infections. Various studies have explored the efficacy of traditional plants in the inactivation of protoscolices and have reported the scolicidal effect of plants. Further, these plants have relatively lower side effects compared to chemotherapeutic agents and are suggested to be used for treatment of this disease in humans as well. Thus, in the present study the in vitro scolicidal effect of C. papaya and J. regia on Echinococcus granulosus protoscolices was explored from sheep, goat and human cysts in Jammu region of North Western Himalayas.The ethanolic extracts of J. regia and C. papaya showed significant scolicidal activity against E. granulosus, under in vitro conditions with reference to the known standard drug “praziquantel”. Against J. regia, highest mortality was observed at 30 mg/ml concentration at different exposure time as 10 min. (88.58%), 20 min. (91.24%), 30 min. (93.16%) and 40 min. (96.64%). Against C. papaya, highest mortality was observed at 30 mg/ml concentration at different exposure time as 10 min. (82.95%), 20 min. (85.83%), 30 min. (90.23%) and 40 min. (92.95%). [ABSTRACT FROM AUTHOR]

Asian economies had faced high economic instability as compared to advanced economies due to unstable exchange rates, financial dependence on advanced economies, and macroeconomic imbalances. To overcome uncertainty, earlier studies considered output volatility in the research models, while in this study, business cycle fluctuations are estimated through GDP de-trended through the Hodrick-Prescott filter, where the cyclical component of GDP is used as representative of business cycle fluctuations. This study has attempted to investigate the determinants of business cycle fluctuations among 20 Asian economies in the short run and long run through the panel ARDL model during 1990–2015. ARDL method is used as it is more suitable for cyclical component data series as compared to the standard co-integration method. Data was taken from world development indicators published by World Bank. The unit root tests showed that all the series were stationary with a mix of level and first difference, confirming the suitability of the panel ARDL technique. Panel regression analysis showed the positive and significant impact of external debt, foreign direct investment, imports, and real effective exchange rate while the negative and significant influence of exports and net domestic credit on business cycle fluctuations. Short-run analysis depicted a significant ECM value which confirmed short-run convergence toward the equilibrium. [ABSTRACT FROM AUTHOR]

Background: The objective of the study was to examine whether physicians working in tertiary care hospitals adopt diseasepreventing and health-promoting behaviors. Methodology: A descriptive cross-sectional study was conducted in twin cities at 10 randomly chosen tertiary healthcare facilities. Medical professionals were given the Health-Promoting Lifestyle Profile II (HPLP II) questionnaire, which included sociodemographic data, diet intake, spiritual growth, health responsibility, interpersonal interactions, physical exercise, and stress management. Participants responded on a four-point Likert scale from "never" to "routinely." Responses were categorized as "poor," "moderate," "good," or "excellent." Data were analyzed using SPSS 23. Results: The average age of participants was 31.6 years, with a standard deviation of 10.1 years. The sample had a moderate health promotion lifestyle profile, with an HPLP-II mean score of 126.68 and a standard deviation of 19.69. Among health promotion aspects, 'Spiritual Growth' had the highest mean score (25.30±4.731), and 'Physical Activity' had the lowest (17.48±4.392). Physicians affiliated with Rawal Institute of Medical Sciences had the highest aggregate scores in promoting a healthy lifestyle, while those affiliated with Pakistan Institute had lower scores. Female doctors exhibited better health responsibility practices than male physicians, while male physicians had better nutritional habits. Conclusion: Healthcare staff in the twin cities generally followed healthy behaviors. These results emphasize the need to focus on doctors' well-being and to develop and implement policies to enhance their efforts in promoting healthy lifestyles. [ABSTRACT FROM AUTHOR]

The monoterpene oxide, Eucalyptol (1,8-Cineole), a primary component of eucalyptus oil, has been evaluated pharmacologically for anti-inflammatory and analgesic activity. Current research aimed to evaluate Eucalyptol's anti-arthritic potential in a Complete Freund's adjuvant induced arthritis that resembles human rheumatoid arthritis. Polyarthritis developed after 0.1 mL CFA injection into the left hind footpad in rats. Oral administration of Eucalyptol at various doses (100, 200 and 400 mg/kg) significantly reduced paw edema, body weight loss, 5-LOX, PGE2 and Anti-CCP levels. Real‐time PCR investigation showed significant downregulation of COX-2, TNF-α, NF-κB, IL-17, IL-6, IL-1β and upregulation of IL-4 and IL-10 in Eucalyptol treated groups. Hemoglobin and RBCs counts significantly increased post-treatment with Eucalyptol while ESR, CRP, WBCs and platelets count significantly decreased. Eucalyptol significantly increased Superoxide Dismutase, Catalase and Glutathione levels compared to CFA-induced arthritic control however, MDA significantly decreased post-treatment. Further, radiographic and histopathological examination of the ankle joints of rodents administered Eucalyptol revealed an improvement in the structure of the joints. Piroxicam was taken as standard. Furthermore, molecular docking findings supported the anti-arthritic efficacy of Eucalyptol exhibited high binding interaction against IL-17, TNF-α, IL-4, IL-10, iNOS NF-κB, 5-LOX, and COX-2. Eucalyptol has reduced the severity of CFA induced arthritis by promoting anti-inflammatory cytokines for example IL-4, IL-10 and by inhibiting pro-inflammatory cytokines such as 5-LOX, COX-2, IL-17, NF-κB, TNF-α, IL-6 and IL-1β. Therefore, Eucalyptol might be as a potential therapeutic agent because of its pronounced anti-oxidant and anti-arthritic activity. [ABSTRACT FROM AUTHOR]

Throughout the globe morphological, biochemical and genetic variability exists in chilli and is harnessed to achieve specific breeding objectives. In this study, chilli germplasm was characterized based on horticultural traits, biochemical quantification and simple sequence repeat (SSR) polymorphism for diversity estimation. A total of 36 SSR primers were utilised to study the genetic divergence among 48 genotypes of chilli collected from nine states of India. Among the 36 primers, sixteen amplified null alleles. A total of 41 alleles were detected with average 2.05 alleles per locus. The largest number of alleles (5) were obtained with marker CAMS-234. The polymorphic information content ranged from 0.06 to 0.72 with an average of 0.50. On the basis of SSR analysis, the UPGMA cluster classified 48 genotypes into three groups. There was significant variability in germplasm for all morpho-biochemical traits. Kashi Anmol (100.50 q/ha) expressed the highest yield. Highest vitamin C content at green stage was recorded in IC-561635 (187 mg/100 g) and the greatest capsaicin content (9547.90 µg/g) equivalent to pungency of 171,862.2 Scoville heat units (SHU) was recorded in Bhut Jolokia. Principal component analysis indicates that the first five principal components explain 74.63% per cent of the total variation. Additionally, analysis of molecular variance (AMOVA) showed that 1% of the total genetic variation occurred among the population and 99% genetic variation within the populations, whereas the pairwise Fst specified the moderate genetic variation ranging from 0.002 to 0.020. The present investigation has strengthened the knowledge of genetic worth of this germplasm for application in various genetic improvement programmes. [ABSTRACT FROM AUTHOR]

With increased worldwide energy demand and carbon dioxide emissions from the use of fossil fuels, severe problems are being experienced in modern times. Energy is one of the most important resources for humankind, and its needs have been drastically increasing due to energy consumption, the rapid depletion of fossil fuels, and environmental crises. Therefore, it is important to identify and search for an alternative to fossil fuels that provides energy in a reliable, constant, and sustainable way that could use available energy sources efficiently for alternative renewable sources of fuel that are clean, non-toxic, and eco-friendly. In this way, there is a dire need to develop technologies for biofuel production with a focus on economic feasibility, sustainability, and renewability. Several technologies, such as biological and thermochemical approaches, are derived from abundant renewable biological sources, such as biomass and agricultural waste, using advanced conversion technologies for biofuel production. Biofuels are non-toxic, biodegradable, and recognized as an important sustainable greener energy source to conventional fossil fuels with lower carbon emissions, combat air pollution, empower rural communities, and increase economic growth and energy supply. The purpose of this review is to explain the basic aspects of biofuels and their sustainability criteria, with a particular focus on conversion technologies for biofuel production, challenges, and future perspectives. [ABSTRACT FROM AUTHOR]

Realizing an oxide thin film with proper stoichiometry is one of the most challenging objects in materials science. Owing to the growth dynamics as well as kinetics, the physical properties of thin films often differ from their bulk counterparts. Here, we report pulsed laser-deposited thin films of LaBO3 (B = Mn, Fe, Co) grown on a SrTiO3 (001) substrate under various thermodynamic conditions. Structural, magnetic, and optical studies have been carried out. The x-ray diffraction study confirms that an appropriate choice of growth thermodynamics may help one to realize epitaxially grown films on the SrTiO3 substrate with out-of-plane lattice parameters 3.976, 3.984, and 3.825 Å for LaMnO3 (LMO), LaFeO3 (LFO), and LaCoO3 (LCO), respectively. A mixed valence state of Mn2+, 3+, 4+ for LMO, a Fe3+ state for LFO, and a mixed state of Co2+, 3+ for LCO have been confirmed by x-ray photoelectron spectroscopy, which is in good agreement with the Ellingham diagram. The optical study showed a bandgap of 1.2, 2.5, and 1.5 eV for LMO, LFO, and LCO, respectively. Ultraviolet photoelectron spectroscopy (UPS) shows a glimpse of the valence band maximum and Fermi level position. UV, UPS, and photoconductive study simultaneously results in a type II band bending, i.e., staggered type bending is observed at these interfaces. Room temperature weak ferromagnetism along with the insulating nature and a sign of photovoltaic application of these thin films fascinate to carry forward rigorous study from fundamental as well as technological points of view. [ABSTRACT FROM AUTHOR]

The optoelectronic properties of two layered copper oxyselenide compounds, with nominal composition Sr2ZnO2Cu2Se2 and Ba2ZnO2Cu2Se2, have been investigated to determine their suitability as p-type conductors. The structure, band gaps and electrical conductivity of pristine and alkali-metal-doped samples have been determined. We find that the strontium-containing compound, Sr2ZnO2Cu2Se2, adopts the expected tetragonal Sr2Mn3SbO2 structure with I4/mmm symmetry, and has a band gap of 2.16 eV, and a room temperature conductivity of 4.8 × 10−1 S cm−1. The conductivity of the compound could be increased to 4.2 S cm−1 when sodium doped to a nominal composition of Na0.1Sr1.9ZnO2Cu2Se2. In contrast, the barium containing material was found to have a small zinc oxide deficiency, with a sample dependent compositional range of Ba2Zn1−xO2−xCu2Se2 where 0.01 < x < 0.06, as determined by single crystal X-ray diffraction and powder neutron diffraction. The barium-containing structure could also be modelled using the tetragonal I4/mmm structure, but significant elongation of the oxygen displacement ellipsoid along the Zn–O bonds in the average structure was observed. This indicated that the oxide ion position was better modelled as a disordered split site with a displacement to change the local zinc coordination from square planar to linear. Electron diffraction data confirmed that the oxide site in Ba2Zn1−xO2−xCu2Se2 does not adopt a long range ordered arrangement, but also that the idealised I4/mmm structure with an unsplit oxide site was not consistent with the extra reflections observed in the electron diffractograms. The band gap and conductivity of Ba2Zn1−xO2−xCu2Se2 were determined to be 2.22 eV and 2.0 × 10−3 S cm−1 respectively. The conductivity could be increased to 1.5 × 10−1 S cm−1 with potassium doping in K0.1Ba1.9Zn1−xO2−xCu2Se2. Hall measurements confirmed that both materials were p-type conductors with holes as the dominant charge carriers. [ABSTRACT FROM AUTHOR]

This study investigates the synthesis of zinc-based metal–organic frameworks (MOFs) using tetrahydrofuran (THF) as a solvent, focusing on forming distinct phases as models for potential battery applications. Contrary to expectations, the synthesis produced three unique phases: alpha, beta, and Zn-MOF-74a, instead of the anticipated Zn-MOF-74 structure. Comprehensive structural analysis using X-ray diffraction, infrared spectroscopy, and thermogravimetric analysis (TGA) revealed distinct crystallographic features for each phase, particularly the novel Zn-MOF-74a phase, which exhibits a heart-shaped pore structure and differs from the classic hexagonal MOF-74. The study also includes the first structural determination of the dry H4DOBDC precursor, providing crucial insights for future research. The results demonstrate the significant impact of solvent choice, temperature, and pH on MOF phase formation and offer potential applications in energy storage and catalysis, especially for larger molecules. Further investigation is required to fully understand the electrochemical properties and phase stability of the newly identified Zn-MOF-74a and beta phases. [ABSTRACT FROM AUTHOR]

This study highlighted the nutritional importance of Catostylus perezi (an edible jellyfish) in Pakistan; a society where a large proportion of the population suffers from malnutrition, while C. perezi, a blessing of the sea, is wasted or exported. In the present study, the amino acid and fatty acid profiles of the oral arms and umbrella of C. perezi were determined by HPLC. The total amino acid concentration (ΣAA) in the oral arms was 151.19 mg/100g, while in the umbrella it was 100.17 mg/100g. The ratio of total essential amino acids to total non-essential amino acids (TEAA/TNEAA) was 0.72 in the oral arms, while it was 0.70 in the umbrella. Higher amount of ω-3 with lower ratio of ω-6/ω-3 in oral arms (0.52), rather umbrella (ω-6/ω-3 ratio; 0.62). The antimicrobial activity, MIC, MBC, and MFC of the whole body of the edible jellyfish were determined. On the basis of polarity, different solvents were used, e.g. water, methanol, dichloromethane, chloroform, and n-hexane. Among all the extracts, the water extract gave the highest ZOI against C. xerosis (29 mm), while the n-hexane extract gave the lowest ZOI against S. aureus (MRSA) ATCC 33591 (8.20 mm). The water extract of C. perezi had high potential against C. xerosis with the highest AMI and PAI (1.53 and 153, respectively), while the same extract had the highest TAI against E. coli (81.43 mL/g). For fungi/yeast, the methanolic extract had the highest ZOI (29.70 mm) against S. cerevisiae and the lowest MIC/MFC (2.40 µg/mL) against the same pathogen. The n-Hexane extract gave the lowest ZOI (11.10 mm) against P. variotii and the highest MIC/MFC (31.60 µg/mL) against Penicillium sp. Atomic force microscopy (AFM) was used to analyse the disintegrating effect of the extracts (with the highest antimicrobial effect) on the cells of selected Gram-positive, Gram-negative and yeast species. The amino acid and fatty acid profiles and antimicrobial assessment showed that C. perezi has great nutritional importance, so the use of C. perezi as food is highly recommended for the Pakistani community. [ABSTRACT FROM AUTHOR]

This study presents a novel hybrid‐sandwich composite structure, customized for nose radomes applications, incorporating a foam core and distinct opposite face sheets composed of Kevlar and S‐Glass materials. Addressing in‐phase electromagnetic properties, UV protection and low velocity impact responses in our previously published work, this paper empirically and numerically investigates the damage tolerance response of the proposed structures through compression after impact (CAI) testing. The low velocity impacts (LVIs) on S‐Glass face sheets exhibited unique energy dispersion and absorption mechanisms, resulting in variations in indent damage depths and widths across all impact energy levels as compared with LVIs on Kevlar face sheets. After experimentally assessing the CAI behavior, a FE model is developed to predict CAI behavior, which closely aligned with experimental findings. This study, unprecedented in existing literature, proposes hybrid sandwich structures for nose radome aerospace applications, with superior specific impact and residual strength compared to various composite sandwich structures documented in the published literature expanding its utility beyond radomes. Highlights: Innovative composites with superior low velocity impact response, tested for compression after impact performance.Designed for nose radomes found suitable for other impact prone applications.Experimental and numerical modeling showed comparable results.Major differences observed in damage mechanics, resistance, and tolerances. [ABSTRACT FROM AUTHOR]

Summary: Location‐based underwater communication applications such as strategic surveillance, disaster prevention, marine research, and mine detection have given the field of underwater wireless sensor networks (UWSN) a head start. Node localization is a prerequisite for accurate data collection, target monitoring, and network management in UWSNs. However, the unique characteristics of the underwater environment, such as signal attenuation, multipath propagation, and variable acoustic properties, pose a major challenge to effective node localization. Accurate sensor node location data is essential for successful underwater data collection, but difficult to achieve as the GPS system cannot be used in an underwater environment. In this paper, existing node localization techniques such as ALS, SLUM, MASL, SLMP, UDB, USP, etc., and recent advances such as the fusion of range‐based and range‐free techniques, the fusion of RSSI and AoA to improve localization accuracy by using directional information in addition to signal strength, and the use of optimization techniques such as PSO, COA, and WOA algorithms to improve the accuracy of the applied node localization algorithm, e.g., TP‐TSFLA, and challenges related to UWSN are discussed. Also, different localization algorithms that affect the accuracy of UWSN localization techniques have been evaluated and compared with NS2 in terms of localization error, localization coverage, energy consumption, and average communication cost metrics. In addition, this paper also provides an up‐to‐date investigation of localization techniques. Finally, the tools available for simulation are presented, followed by open research questions that need to be addressed in the localization of nodes. [ABSTRACT FROM AUTHOR]

Jordan is currently facing an energy crisis characterized by a heavy dependence on imported fossil fuels, prompting the nation to target a 50% share of renewable energy by 2030. This study introduces a novel approach by simulating hybrid solar-geothermal heat pump systems tailored to various Jordanian locations, assessing both their energy efficiency and economic feasibility. Unlike previous studies that focused solely on geothermal or solar technologies, this research uniquely combines these two renewable sources, offering a comprehensive evaluation across multiple climates. Key findings include the superior performance factors of vertical (4.0) and horizontal geothermal heat pumps (4.2) in Amman, compared to the air-to-water heat pump (3.5). Additionally, Aqaba station demonstrated an exceptional solar contribution, meeting 99.34% of heating demand, while Amman achieved 77.93%. Notably, Maan station provided the highest solar contribution for space heating at 6,902 kWh/year, and Amman airport station led in CO2 emission avoidance at 2,120.29 kg/year. The economic analysis revealed that while vertical heat pump systems were economically unviable with a negative NPV of -4,987.51 JD, horizontal and air-to-water systems showed promising NPVs of 5,734.27 JD and 8,428.46 JD, respectively, with payback periods of 9.44 and 6.5 years. Additionally, this study is the first to employ both the fuzzy Best–Worst Method (BWM) and Analytic Hierarchy Process (AHP) techniques to rank station suitability, identifying Maan station as the most optimal and Ghor El-Safi as the least. The results underscore the potential of hybrid solar-geothermal systems to significantly reduce energy consumption and CO2 emissions, despite initial financial barriers, and highlight the importance of further investment in geothermal technologies to enhance Jordan's energy security and reduce fossil fuel dependency. [ABSTRACT FROM AUTHOR]

The CaTiO3 has been extensively investigated as a highly promising optical material mostly for its optoelectronic properties and its function as a host for transition metals doped in the CaTiO3. Electronic and optical properties of CaTi1−xCuxO3 (2‐D and 3‐D) have been thoroughly analyzed using first‐principles calculations based on Density Functional Theory (DFT). The calculations of these properties in both 2‐D and 3‐D configurations have performed by the use of generalized gradient approximation plus Hubbard (GGA + U). The electronic characteristics including the electronic band structure, partial density of states, and total density of states have been meticulously computed for CaTi1−xCuxO3 in both 2‐D and 3‐D. Upon analyzing the obtained results, we investigated that conduction and valence bands overlapped for both 2‐D and 3‐D structures revealing the metallic nature. We observed transitions mainly attributed to Cu‐d, Ti‐d, Ti‐p, and O‐p orbitals in both 2‐D and 3‐D configurations. Discussion delves into the significance of electronic band structure calculations in understanding optical properties. Peaks in the energy loss function are observed at 13 eV in both cases referred to the plasmon energy. Static values of the dielectric functions, extinction coefficient, reflectivity, and refraction are also computed. Our obtained results showed that the CaTi1−xCuxO3 compound in 3‐D form is more apt for optoelectronic devices and UV‐LED applications. [ABSTRACT FROM AUTHOR]

The sustainable and effective nanomaterials for photocatalyst are greatly enviable to protect water bodies from organic waste. In this regard, nanocomposite of NiO-PdO-Pd was prepared via sol gel route using organic pattern and scrutinized catalytic agent for remediation of methyl orange (MO) in water. Verification of phase formation in obtained product was done utilizing X-ray diffraction, energy-dispersive spectroscopic analysis, along with Raman spectroscopy while the nano-structures were explored using FE-scanning electron microscopy. Existence of organic functional groups (OFGs) in the obtained product was revealed using Fourier-transform-infrared spectroscopy along with gas-chromatography-mass spectrometry. Functionalized nanocomposite (FN) was studied for degradation of MO both under solar light and under dark environment. Organic compound incorporated NiO-PdO-Pd has demonstrated outstanding catalytic behavior with 96% and 76% degradation of MO under light as well as under dark, within 15 min. Additionally, catalyst has proved to be having excellent stability with pseudo-first-order kinetics under light (R2 = 0.86) and under dark conditions (R2 = 0.94). [ABSTRACT FROM AUTHOR]

A spherically symmetric black hole solution in the conformal Weyl gravity was found by Mannheim and Kazanas in 1988. While the quasinormal modes (QNMs) of these black holes have been considered in a few works, here we complement these studies by considering in detail the regime of vanishing cosmological constant and negative values of the Weyl parameter for which we find quasinormal frequencies for scalar, Dirac and electromagnetic perturbations with the time-domain integration and WKB methods. In particular, we derive the compact and remarkably accurate analytic formula for the frequencies in the form of expansion in terms of the inverse multipole number. Comparison with the time-domain integration shows that the 6th order WKB method with the Padé approximants is quite accurate, unless the black hole is in the near extreme state. [ABSTRACT FROM AUTHOR]

Background: The use of ChatGPT among university students has gained a recent popularity. The current study aimed to assess the factors driving the attitude and usage of ChatGPT as an example of generative artificial intelligence (genAI) among university students in the United Arab Emirates (UAE). Methods: This cross-sectional study was based on a previously validated Technology Acceptance Model (TAM)-based survey instrument termed TAME-ChatGPT. The self-administered e-survey was distributed by emails for students enrolled in UAE universities during September-December 2023 using a convenience-based approach. Assessment of the demographic and academic variables, and the TAME-ChatGPT constructs' roles in ChatGPT attitude and usage was conducted using univariate followed by multivariate analyses. Results: The final study sample comprised 608 participants, 91.0% of whom heard of ChatGPT while 85.4% used ChatGPT before the study. Univariate analysis indicated that a positive attitude to ChatGPT was associated with the three TAME-ChatGPT attitude constructs namely, lower perceived risks, lower anxiety, and higher scores on the attitude to technology/social influence. For the ChatGPT usage, univariate analysis indicated that positive attitude to ChatGPT use was associated with being male, Arab in nationality, and lower point grade average (GPA) as well as the four ChatGPT usage constructs namely, higher perceived usefulness, lower perceived risks of use, higher scores on the behavior/cognitive construct and higher scores on the ease-of-use construct. In multivariate analysis, only TAME-ChatGPT constructs explained the variance in attitude towards ChatGPT (80.8%) and its usage (76.9%). Conclusion: The findings indicated that ChatGPT usage is commonplace among university students in the UAE. The determinants of use included the perceived usefulness, lower perceived risks, cognitive and behavioral factors, perceived ease of use, while the attitude was determined by lower perceived risks, lower anxiety, and higher scores for attitude to technology/social influence. These factors should be considered for understanding the motivators for successful adoption of genAI including ChatGPT in higher education. [ABSTRACT FROM AUTHOR]

The paper presents output feedback control of a class of two-time-scale nonlinear systems. State feedback control for two-time-scale system is converted into output feedback via two high-gain observers. The high-gain observers are designed for reduced-order, quasi-steady-state, and boundary layer models of the two-time-scale system. Analyses reveal three-time-scale structure of the closed-loop system. Convergence of the closed-loop system is guaranteed under sufficient conditions. Simulation results of control of inverted pendulum on a cart illustrate the application of the proposed methodology. [ABSTRACT FROM AUTHOR]

Charcoal rot disease, caused by Macrophomina phaseolina, poses a major threat to tomatoes. Encapsulating biocontrol bacteria in alginate offers a novel and effective solution with advantages in viability, shelf life, and controlled release. The current research was conducted to develop alginate beads of biocontrol bacteria and to evaluate their inhibitory capacity against M. phaseolina in combination with essential metal iron (Fe) using in vitro and in planta tests. In vitro, Pseudomonas chlororaphis subsp. chlororaphis (PCC-01) exhibited 71% antifungal activity. It also had plant growth-promoting traits of indole-3-acetic acid, hydrogen cyanide, phosphate, and mineral solubilization. FTIR and UV–vis spectra specified good affinity of PCC-01 and alginate, as revealed by changes in the intensity of peaks, particularly at the protein regions (1600–1200 cm−1). The bacterial-loaded alginate beads had excellent properties of encapsulation efficiency (96.20%), swelling ratio (66.47%), moisture content (92.50%), size [1.31 mm (wet) and 0.70 mm (dry)], and ensured slow release of entrapped bacteria up to 120 days. PCA-based biplot, hierarchical clustering, and heat map analysis for in vitro bioassays verified that the antifungal activity of PCC-01-alginate beads improved in nutrient medium supplemented with Fe (91–98%), followed by Mn (74–86%) and Zn (60–76%) via dual culture and modified dual culture methods. In planta, multivariate statistical analyses based on 18 traits related to growth parameters, yield, and biochemical indices of the tomato plants confirmed the greater disease-managing potential of Fe-amended alginate beads of PCC-01 through maximal economic benefits. Therefore, different formulations of PCC-01 and Fe could be prepared and commercialized as a single application product for sustainable and profitable tomato crop production. [ABSTRACT FROM AUTHOR]

Background: Environmental soil contamination is a serious problem for humans worldwide, as it causes many diseases. Methods: The present study focuses on utilizing biosurfactants produced by Pseudomonas stutzeri (P. stutzeri) NA3 and Bacillus cereus (B. cereus) EN6, as an electrolyte for removing chromium (Cr) from contaminated soil using the electrokinetic (EK) process. Results: As a result, biosurfactants produced by P. stutzeri NA3 and B. cereus EN6, being lipopeptides, increase heavy metal mobility in the EK process. The Cr removal efficiency of a novel electrolyte (biosurfactants) in the EK process was compared with that of NA3 and EN6 biosurfactants. The EK results revealed a maximum Cr removal of 75 and 70% by NA3 and EN6, respectively, at the end of 7 days. Discussion: The biosurfactant aids in the breaking down of the heavy metals that are present deeper into the soil matrix. From the metagenomics analysis, it was identified that biosurfactant changes the microbial community with an enhanced ability to remove heavy metals. The phytotoxicity assay confirms that NA3 biosurfactant solution showed 95% seed germination and can lower hazardous pollutants in the soil. Conclusion: The application of biosurfactants as a potent electrolyte for the remediation of hazardous pollutants is an integrated process. Overall, the results of this study suggest that biosurfactants can serve as an economic and efficient electrolyte in the EK process to remove Cr from polluted soil. [ABSTRACT FROM AUTHOR]

Pseudomonas syringae pv. coronafaciens (Ps-c) is a pathogenic bacterium species that can be found in agricultural environments and causes diseases in plants. During a survey in 2019–2020 of different areas, bacterial halo blight (BHB) caused by Ps-c in oat (Avena sativa L.) was observed in many oat fields in Huan county, Gansu Province of China. Average leaf disease incidence was approximately 1 to 14%. The symptoms of BHB were mainly observed on leaves of oat and appeared as white to yellow streaks. After 20–30 d, the streaks became yellow necrotic lesions and spread over whole leaves, eventually causing leaves to wilt and senesce. Symptomatic leaves of affected oats were collected to investigate the etiology of BHB disease. A group of 32 bacterial isolates (HK7) phenotypically similar were isolated from the necrotic lesion margins. Pathogenicity tests of this group of isolates by wounding and injection demonstrated that the symptoms induced by them on oat were similar to those observed in the field. HK7 isolates were identified as Ps-c based on Biolog Gen III MicroStation, morphological, physiological and biochemical characterization, 16S rRNA and gyrB gene sequence analysis, which compared with a reference strain (Ps-c ATCC 19608). Furthermore, Ps-c was host specific. After inoculation of Ps-c on A. sativa (B7) and A. nuda (B2) in greenhouse by Completely Randomized Design (CRD), number of tillers, plant height, flag-leaf length, flag-leaf width, fresh weight, dry weight, panicle length, grains per spike, reproductive branche number and thousand grains weight of infected oat decreased by 19.44%, 11.49%, 11.34%, 9.23%, 11.61%, 7.57%, 6.11%, 9.73%, 9.31% and 4.15% compared with that of healthy oat, respectively. BHB (Ps-c) is a new bacterial disease on oat in China and has a negative effect on plant growth, forage and grain yield of oat, and these negative effects increased with the increase of disease severity. [ABSTRACT FROM AUTHOR]

Purpose: To report on the recovery of strength and functional capacity symmetry following multiligament knee surgical reconstruction (MLKR), as well as the capacity of athletes to return to sport. Methods: This prospective cohort study recruited 47 patients undergoing MLKR between February 2018 and July 2021. Forty patients had full outcome assessment postoperatively at 6, 12 and 24 months and were included in the analysis, 75% were knee dislocation one injuries and 60% were injured playing sport. Patient‐reported outcome measures (PROMs) assessed included the International Knee Documentation Committee score, the Knee Outcome Survey, the Lysholm Knee Score and the Tegner Activity Scale (TAS). Patient satisfaction was also assessed. Objective assessment included assessment of active knee flexion and extension range of motion (ROM), the single (single horizontal hop for distance [SHD]) and triple (triple horizontal hop for distance [THD]) hop tests for distance and peak isokinetic knee flexor/extensor torque. Results: All PROMs significantly improved (p < 0.001) from presurgery to 24 months postsurgery. At 24 months, 70% of patients were satisfied with their sports participation. Active knee flexion (p < 0.0001) and extension (p < 0.0001) ROM significantly improved over time, as did the limb symmetry indices (LSIs) for the SHD (p < 0.0001), THD (p < 0.0001), peak knee extensor (p < 0.0001) and flexor (p = 0.012) torque. While LSIs for the SHD, THD and knee flexor strength tended to plateau by 12 months, knee extensor strength continued to improve from 12 to 24 months. Conclusions: The majority of patients undergoing modern MLKR surgical techniques and rehabilitation can achieve excellent knee function, with low complication rates. Level of Evidence: Level IV. [ABSTRACT FROM AUTHOR]

Building on previous studies on third-party observations (TPOs) of mistreatments, in this study, we investigate the effects of TPO of workplace deviance (TPO-WD). Drawing on conservation of resource theory, we explore the intermediary process through which TPO-WD, influences employees' workplace thriving. Using multi-wave data from 346 employees, our results suggest that those who observe, or hear about, incidents of workplace deviance experience a heightened level of emotional exhaustion, which has a detrimental impact on workplace thriving. Furthermore, we also test how these relationships are impacted by the extent of employees' organizational identification and a cooperative psychological climate. These findings not only provide a resource-based view on how TPO-WD affects workplace thriving but also highlight the critical importance of cooperative psychological climate as a resource passageway to prevent damaging employees' workplace thriving. JEL Classification: L2 Firm Objectives, Organization, and Behaviour [ABSTRACT FROM AUTHOR]

Purpose: Hexavalent chromium has been a benchmark corrosion inhibitor before it was phased out because of its carcinogenic properties. However, because it was phased out, many alternative corrosion inhibitors have been introduced but failed to meet the performance of this benchmark inhibitor. Consequently, benzotriazole (BTA) was reported to exhibit chromate-like inhibition performance. Subsequently, Intelli-ion was reported by researchers to exhibit chromate-like performance also with claims of being a unique alternative. This paper aims to review the inhibition performance of these two alternatives. Above all, promotes the unique inhibition performance of Intelli-ion that makes it suitable for application in many sectors. Design/methodology/approach: In this paper, the corrosion inhibition performances of BTA and Intelli-ion were compared systematically by reviewing some related literatures based on the opinion of the authors. Findings: Different methodologies for measuring the inhibition performance of BTA showed that it's an inhibitor of choice. However, the cut edge corrosion performance of Intelli-ion and BTA corrosion inhibitors on galvanized steel of 55% Wt.% Al, 44% Wt.% Zn and 1% Wt.% Si in 5 Wt.% NaCl solution was compared when subjected to scanning vibrating electrode technique (SVET) for 24 h. The results showed faint blue-colored region depicting negative cathodic current density for the Intelli-ion while there was a high-intensity of red-colored region depicting a positive anodic current density for BTA. In other words, the Intelli-ion inhibitor had a better overall cut-edge corrosion inhibition performance than the BTA inhibitor. Originality/value: This paper compares and further, summarizes the corrosion inhibition performance of Intelli-ion and BTA by evaluating SVET results from the literature. In addition, it serves as an overview and reference for the unique inhibition performance of Intelli-ion when applied in field applications. [ABSTRACT FROM AUTHOR]

Objectives: To elucidate the burden and clinico-epidemiological attributes of congenital and hereditary anomalies (CA) in the extended Peshawar Valley of Pakistan. Method: This is a multicenter cross sectional study carried out in Buner, Charsadda, Mardan, Nowshera, Peshawar and Swabi districts, during 2017-2021. The pediatric and adult patients with CA were recruited from hospitals, public places and through door-to-door surveys. The anomalies were classified with the help of specialized clinicians. Descriptive statistics was employed. Results: In this study, 1065 independent subjects with certain types of CA from independent households were included. The index males were 71%; the majority of subjects originated from rural areas (72%), and spoke Pashto (96%). The CA were categorized into 10 major and at least 104 minor categories. There was highest representation of neurological disorders, n=375 (proportion.: 0.352; 95% CI: 0.323-0.381), followed by limb defects (n=281; prop.: 0.264), sensorineural defects (n=128; prop.: 0.120), musculoskeletal defects (n=84; prop.: 0.079), visual impairments (n=67; prop.: 0.063), hemoglobinopathies (n=40; prop.: 0.038), ectodermal disorders (n=34; prop.: 0.032), cardiovascular anomalies (n=19; prop.: 0.018), and orofacial anomalies (n=19; prop). Among the neurological disorder, intellectual disabilities and cerebral palsy were highly prevalent. The majority of the cases had a sporadic presentation (68%), and isolated occurrence (72%), whereas parental consanguinity was witnessed in 58% of cases. Conclusion: A wide range of CA were witnessed in this cohort with a preponderance of neurological disorders. The majority of the anomalies are of severe nature rendering a high morbidity burden in the population and requiring early detection, intervention and management. [ABSTRACT FROM AUTHOR]