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The interforaminal region is considered more favorable for implant placement than the posterior mandible in edentulous patients, mainly because the inferior alveolar nerve can interfere with implant placement in the severely resorbed posterior mandible. However, complications in the interforaminal region may occur due to the presence of the mandibular incisive nerve. This scoping review aims to describe the mandibular incisive nerve anatomy related to the potential interference in implant therapy. A comprehensive literature search was conducted in the following databases: MEDLINE (via PubMed), Web of Science, and Scopus. This scoping review was structured according to the Joanna Briggs Institute method. Thirteen studies were included in the review. All of the studies were observational cohort anatomical studies, carried out mainly by CBCT and on cadavers. A total of 1,471 patients/cadavers were studied. The mandibular incisive nerve was present in 87% to 100% of cases, with an average length of 9.97 mm and an average diameter of 1.97 mm. The mandibular incisive nerve may be damaged during drilling and implant placement, especially when using implant lengths > 12 mm. Damage to the mandibular incisive nerve due to implant placement could be present, but it is necessary to conduct more studies focusing on assessing mandibular incisive nerve damage to understand the clinical relevance of this nerve and its associated morbidities, such as neurosensorial alterations. Due to the different anatomical characteristics of this nerve, CBCT analysis is recommended for implant therapy in the anterior mandible to prevent the described complications. [ABSTRACT FROM AUTHOR]

Traditionally, metal-ceramics, metal-reinforced acrylics, and--more recently--full-contour or layered zirconia have been the materials of choice for definitive fixed implant-supported rehabilitations. Polymethyl methacrylate (PMMA) is commonly used in implant dentistry for the fabrication of implant-supported interim prostheses and as milled or 3D-printed prototypes. This article describes a novel protocol to prosthetically restore a completely edentulous patient following a digital workflow, with fixed, screw-retained, implant-supported prostheses fabricated from CAD/CAM milled PMMA, with no metal substructure. After a 2-year follow-up in terms of esthetics, phonetics, function, and biologic tissue response, the outcome remains functional and free of mechanical, biomechanical, or biologic complications. The aim of this article is to illustrate the feasibility of using milled PMMA as a viable definitive prosthetic material for the fixed implant rehabilitation of edentulous patients. [ABSTRACT FROM AUTHOR]

Aquatic communities are increasingly exposed to complex mixtures of contaminants, mainly pesticides due to the impact of agricultural activity. The aim of this study was to evaluate the toxicity of an eight-pesticide cocktail on larvae of the South American common toad, Rinella arenarum. The cocktail represents a realistic mixture of insecticides (cypermethrin, chlorpyrifos and lambda-cyhalothrin), herbicides (glyphosate, glufosinate ammonium, prometryn and metolachlor), and a fungicide (pyraclostrobin) previously found in aquatic organisms (Prochilodus lineatus) from the Salado River Basin, an area with strong agricultural pressure. Computational simulations through the Density Functional Tight-Binding method indicated a strong spontaneous trend toward the formation of the cocktail, suggesting that it may act as a novel xenobiotic entity in the environment. The cocktail effects were evaluated in early-developing and premetamorphic larvae, at feasible concentrations found in real scenarios. The mixture led to high mortality and teratogenicity in early-developing larvae. Premetamorphic larvae showed endocrine disruption, oxidative stress, and impairments in detoxification and hepatic functioning. Neurotoxicity, genotoxicity, cardiotoxicity and high mortality under stress conditions were also observed in exposed larvae. This novel evaluation highlights the ecotoxicological risk for aquatic organisms exposed to complex mixtures and underscores the need to consider cocktail effects in studies regarding ecosystems health. [ABSTRACT FROM AUTHOR]

We analyze the causal effects of taking parental leave on the post-birth hourly wage distribution of parental-leave-eligible mothers in Luxembourg. To deal with selection into parental leave, we match participants with non participants' rich pre-intervention characteristics obtained from Social Security records for 2005–2010. In addition, we deal with selection into employment by using principal stratification and non parametric bounds. While the key identifying assumptions employed are not refutable (e.g., unconfoundedness and monotonicity), we present suggestive evidence about their plausibility in our context. Inference is for a subpopulation of parental-leave-eligible mothers who are always employed regardless of parental leave participation—about 80% of all eligible mothers. Our estimated bounds on quantile treatment effects of parental leave suggest substantial negative and significant impacts in most quantiles above the median of the wage distribution. These wage penalties, which are bounded between 10 and 26%, appeared present for high-earner mothers 2–5 years after parental leave. [ABSTRACT FROM AUTHOR]

B cells exclusively expressing IgD on the cell surface (IgD+IgM− B cells) have been identified in mammals, where they seem to play a still not well-defined role in peripheral tolerance. These cells have also been reported in catfish (Ictalurus punctatus) peripheral blood and in several mucosal tissues of rainbow trout (Oncorhynchus mykiss), including gut, gills and skin. As in mammals, the precise function of these cells remains obscure, yet, in rainbow trout mucosal surfaces, these cells have been shown to be differentiated to plasma-like cells. Interestingly, in the gills, these IgD+IgM− B cells expressed high levels of the CC chemokine receptor 7 (CCR7), receptor that in mammals controls the migration of B and T cells to secondary lymphoid organs. In this work, we have established that this is also true for the trout skin, where CCR7 defines a specific subset of IgD+IgM− B cells that are further differentiated to a plasma-like profile than those not expressing CCR7. These findings increase the current understanding of this enigmatic B cell population and point to CCR7 as a key differentiation marker for these cells. [ABSTRACT FROM AUTHOR]

Background: This study explores changes in treatment adherence and alliance during a novel parent- and child-psychotherapy for pediatric irritability. Associations between in-session therapeutic processes and symptom change were examined. Methods: Forty participants (Mean age = 11.23, SD = 1.85; 37.5% female, 77.5% white) with severe irritability, and their parents, received 12 sessions of exposure-based cognitive behavioral therapy (CBT) with parent management training (PMT). Measures included clinician-rated adherence to the manual, alliance scales (Alliance Scale for Children-revised; TASC-r, and Working Alliance Inventory; WAI, respectively), and clinician-, parent- and child-reported irritability scales (Affective Reactivity Index; ARI). Linear mixed models examined session-by-session changes and associations between adherence/alliance and subsequent irritability, and vice versa. Results: First, adherence to standard treatment elements decreased over time (Bs ≥ − 0.03, ps ≤ 0.010), while the focus on specific treatment components increased (i.e., exposure: B = 0.15, p = 0.001; PMT: B = 0.07, p = 0.002). Second, adherence to standard treatment elements were associated with decreased clinician-reported irritability (Bs ≥ − 2.23, p ≤ 0.042). For the alliance measures, parent-reported alliance increased over time (Bs ≥ 0.10, p ≤ 0.01); child-reported alliance did not change. Bidirectional associations were found between alliance and symptoms; specifically, child-reported alliance predicted clinician-rated irritability at next session (Bs ≥ − 0.66, p ≤ 0.053), and decreases in clinician- (Bs ≥ − 0.02, ps ≤ 0.043) and parent- (B = − 0.15, p = 0.024) reported irritability predicted increased alliance at next session. Conclusions: Findings underscore the predictive role of treatment adherence and therapeutic alliance on outcomes, in exposure-based CBT for pediatric irritability. Trial registration : ClinicalTrials.gov identifier: NCT02531893; date of registration: 25/08/2015. [ABSTRACT FROM AUTHOR]

Background: Sepsis mortality can be significantly reduced with early diagnosis and appropriate treatment. It is crucial to have tools that enable the early identification of patients at high risk of sepsis mortality from the triage stage. The National Early Warning Score (NEWS) and recently the International Early Warning Score (IEWS), are widely used for this purpose. However, its oxygenation parameters are primarily validated in populations at sea level. Given that patient oxygenation varies with altitude, there is a need to investigate the applicability of this scores at different altitudes. The purpose of this study is to compare the discriminatory capacity of sepsis mortality in emergency departments between the standard NEWS and IEWS scale and a NEWS and IEWS scale adjusted for barometric pressure in Bogotá, a city located 2600 m above sea level. A prospective recruitment was conducted in the triage area of the emergency department, including all patients with suspected sepsis. The scales under evaluation were calculated. Subsequently, the sensitivity, specificity, predictive values, and areas under the curve (AUC) of each scale were assessed for mortality prediction. Results: A total of 304 patients were recruited. The overall mortality rate was 19.4% and the septic shock mortality rate was 59.3%. The AUC for the standard NEWS was 0.78 (95% CI: 0.72–0.83), and for the standard IEWS was 0.81(95% CI: 0.75–0.87), altitude-adjusted NEWS, it was 0.79(95% CI: 0.73–0.84), and for the altitude-adjusted IEWS was 0.82(95% CI: 0.76–0.88). Conclusions: Adjustment of oxygen saturation for altitude above sea level in NEWS (NEWSa) does not improve its predictive capacity for mortality in patients with sepsis in the emergency department, however, this same adjustment in the IEWS value significantly improves the predictive capacity compared to NEWS and NEWSa. [ABSTRACT FROM AUTHOR]

Background: Overcrowding is a common issue in emergency departments worldwide. One condition associated with overcrowding is the Emergency Department Length of Stay(EDLOS). Prolonged EDLOS is linked to increased hospitalization costs, worsening clinical outcomes, and deterioration in patient-reported outcomes. Consequently, there is a need to reduce EDLOS, and the scientific literature reports multiple strategies aimed at this goal. Therefore, the objective of this study was to determine strategies statistically significant in reducing the EDLOS. Method: A systematic search was conducted in PubMed, Scopus, the Latin American and Caribbean Health Sciences Literature (LILACS) database, and Google Scholar from January 2000 to January 2024. Studies that included patient care strategies in emergency departments to reduce EDLOS, in adults or pediatric populations, and observational or experimental studies were included. The quality of the studies was assessed using the Cochrane Collaboration's Risk of Bias tool for Interventional Studies, and the certainty of the evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation criteria. A mean difference analysis in minutes was performed using a random-effects model. Results: A total of 3410 studies were identified using the search strategy with a total of 245,404 patients were analyzed. Three types of strategies were identified with results in reducing EDLOS. Interventions performed by physicians in the triage area (liaison, supervision, and advanced triage) showed a significant reduction of -21.87 min (95% CI -28.35; -15.38). The second intervention was the use of Point-of-Care Testing, which showed a reduction of -41.98 min (95% CI -98.13; 14.15). The third intervention was the creation of fast-track strategies, which documented a reduction of -21.81 min (95% CI -41.79; -1.83). Most of the studies were of the before-and-after type. The certainty of the evidence for the first intervention was moderate, while for the other two groups, it was considered low. Conclusion: The presence of a physician in the triage team demonstrated a reduction in patient EDLOS, although with high heterogeneity among the analyzed studies. Similarly, the use of fast-track strategies is also significantly useful in reducing EDLOS, while POCT reduces EDLOS but not significantly. [ABSTRACT FROM AUTHOR]

Background: Germline TP53 gene variants are intricately linked to Li-Fraumeni syndrome, a rare and aggressive hereditary cancer syndrome. This study investigated the frequency and spectrum of TP53 pathogenic variants associated with Li-Fraumeni syndrome in a large cohort of mainly breast cancer patients from Russia. Methods: The study analyzed 3,455 genomic DNA samples from cancer patients using next-generation sequencing panels and whole-genome sequencing. Clinically significant TP53 variants were identified and validated using Sanger sequencing. The clinical and family history characteristics of patients with TP53 variants were analyzed. Results: The analysis identified 13 (0.4%) individuals with clinically significant germline TP53 variants, all of whom were females with either unilateral breast cancer or breast cancer as part of multiple primary malignant neoplasms. The average age of breast cancer manifestation was 39.9 years, with a median of 36 years. Only 38.5% of the TP53 mutation carriers met the modified Chompret criteria for TP53 testing. Conclusions: The findings underscore the necessity of thorough phenotype and family history analysis in genetic counseling to effectively diagnose LFS, and emphasize the importance of identifying TP53 variant carriers for developing treatment strategies, prognosis, and monitoring, as well as for identifying high-risk family members. The study also highlights that the current guidelines fail to identify over half of the TP53 mutation carriers, suggesting the need for a more comprehensive approach to genetic testing in suspected hereditary cancer cases. [ABSTRACT FROM AUTHOR]

Simple Summary: Dietary supplementation with polyherbal phytogenic additives has shown positive effects on growth performance and health status in dairy and finishing ruminants. However, there is little information on the effects of polyherbal phytogenic additive supplementation in dairy calves. This study aimed to evaluate the effects of a polyherbal phytogenic additive on the growth performance, health parameters, and blood metabolites of dairy calves. Dietary supplementation with low doses (2 g/d) of the evaluated polyherbal phytogenic additive improved the daily weight gain, final body weight, starter intake, and milk + milk replacer intake without affecting the disease incidence. This study aimed to evaluate the effects of dietary supplementation with increasing levels of a polyherbal phytogenic additive (PPA) on growth performance, health parameters, and blood metabolites of dairy calves. Forty female Holstein calves (43.35 ± 2.41 kg body weight and 25.1 ± 2.2 d of age) were housed in individual pens and randomly assigned to four treatments (n = 10) with increasing levels of PPA: 0 (CON), 2 (PPA2), 3 (PPA3), and 4 (PPA4) g PPA/d for 67 d. Compared to the CON treatment, supplementation with the PPA2 treatment increased (quadratic effect p = 0.02) the average daily gain and final body weight of the dairy calves. Also, a higher starter intake (SI), and intake of milk + milk replacer was observed (linear and quadratic effect p = 0.0001) in response to supplementation with the PPA2, PPA3, and PPA4 treatments. The evaluated treatments did not affect (p > 0.05) the feed conversion ratio, or the number of cases of diarrhea, pneumonia, and otitis. The evaluated treatments did not affect (p > 0.05) most of the hematological and biochemical blood parameters. However, compared to the CON treatment, supplementation with the PPA2 treatment increased (quadratic effect p < 0.05) the blood concentration of the segmented neutrophils and plasma protein. Likewise, the serum glucose concentration decreased (linear effect p < 0.05) with supplementation of the PPA2, PPA3, and PPA4 treatments. Compared with the CON treatment, the PPA4 supplementation decreased the serum urea concentration (linear effect p = 0.04). In conclusion, supplementation with 2 g/d of PPA can be used as a natural alternative to improve the growth rate and stimulate starter and milk + milk replacer intake in dairy calves without adverse effects on health parameters or blood metabolites. [ABSTRACT FROM AUTHOR]

Background: Canine chronic enteropathies (CE) are a group of disorders defined by persistent or recurrent clinical signs of gastrointestinal disease without a primary neoplastic, metabolic, parasitic, or other infectious cause. In this prospective, multicentre, uncontrolled, open-label study, a commercial dry diet with a protein source of extensively hydrolysed poultry feather was assessed in the management of dogs with CE that had not responded to previous dietary and antibacterial therapies. Dogs with moderate or marked protein-losing enteropathy were excluded. After screening, dogs entered stage 1 and started the test diet. Gastrointestinal endoscopy was performed, and only dogs with histopathological evidence of small intestinal inflammation confirming CE could continue to stage 2 of the trial. The test diet was fed for 10 weeks throughout stages 1 and 2, and the primary outcome measure was clinical success defined as a reduction in canine inflammatory bowel disease activity index (CIBDAI) of ≥ 75%. Secondary outcomes included body condition score (BCS, scale 1–9) and faecal consistency score (scale 1–5). Results (median [range]) for dogs with confirmed CE that participated in both study stages are reported. Results: A total of 15 dogs commenced stage 1, and 13 of these progressed to stage 2 (age 4.2 [1.1–7.1] years; BCS 3 (2–4); previous diet therapies 2 [1–3]) of which two were withdrawn at week 5 for protocol deviations. CIBDAI scores decreased from 9 (7–16; n = 13) at baseline to 2 (1–11; n = 13) at week 2 (P < 0.001), 2 (0–6; n = 13) at week 5 (P < 0.001), and 1 (0–3; n = 11) at week 10 (P < 0.001). Treatment success was achieved by 8/13 dogs at week 5 and 10/11 dogs at week 10. Faecal score (n = 11) and BCS (n = 11) improved between baseline (1 [1–3] and 3 [3–4], respectively; P < 0.001) and week 10 (4 [3–5] and 4 [3–5], respectively; P < 0.001). Conclusions: Dogs with CE that had failed to respond to previous dietary and antibacterial therapy showed clinical improvement within 10 weeks when fed a dry extruded diet with a single protein source hydrolysed to amino acids and oligopeptides, without concurrent immunosuppressant treatment. [ABSTRACT FROM AUTHOR]

Neurodegenerative diseases comprise a group of chronic, usually age-related, disorders characterized by progressive neuronal loss, deformation of neuronal structure, or loss of neuronal function, leading to a substantially reduced quality of life. They remain a significant focus of scientific and clinical interest due to their increasing medical and social importance. Most neurodegenerative diseases present intracellular protein aggregation or their extracellular deposition (plaques), such as α-synuclein in Parkinson's disease and amyloid beta (Aβ)/tau aggregates in Alzheimer's. Conventional treatments for neurodegenerative conditions incur high costs and are related to the development of several adverse effects. In addition, many patients are irresponsive to them. For these reasons, there is a growing tendency to find new therapeutic approaches to help patients. This review intends to investigate some phytocompounds' effects on neurodegenerative diseases. These conditions are generally related to increased oxidative stress and inflammation, so phytocompounds can help prevent or treat neurodegenerative diseases. To achieve our aim to provide a critical assessment of the current literature about phytochemicals targeting neurodegeneration, we reviewed reputable databases, including PubMed, EMBASE, and COCHRANE, seeking clinical trials that utilized phytochemicals against neurodegenerative conditions. A few clinical trials investigated the effects of phytocompounds in humans, and after screening, 13 clinical trials were ultimately included following PRISMA guidelines. These compounds include polyphenols (flavonoids such as luteolin and quercetin, phenolic acids such as rosmarinic acid, ferulic acid, and caffeic acid, and other polyphenols like resveratrol), alkaloids (such as berberine, huperzine A, and caffeine), and terpenoids (such as ginkgolides and limonene). The gathered evidence underscores that quercetin, caffeine, ginkgolides, and other phytochemicals are primarily anti-inflammatory, antioxidant, and neuroprotective, counteracting neuroinflammation, neuronal oxidation, and synaptic dysfunctions, which are crucial aspects of neurodegenerative disease intervention in various included conditions, such as Alzheimer's and other dementias, depression, and neuropsychiatric disorders. In summary, they show that the use of these compounds is related to significant improvements in cognition, memory, disinhibition, irritability/lability, aberrant behavior, hallucinations, and mood disorders. [ABSTRACT FROM AUTHOR]

Simple Summary: This research focuses on advanced transformer models application for super-enhancers prediction in human cell lines purely from DNA sequence data. By applying the GENA-LM transformer model, effective differentiation between super-enhancers and enhancers across multiple cell lines was achieved compared to previously used techniques. The approach suggests sequences processing without any additional information about epigenetic landscape within fine-tuned model application for the enhancer/super-enhancer classification task. The study discloses the application of transformer-based deep learning models for the task of super-enhancers prediction in human tumor cell lines with a specific focus on sequence-only features within studied entities of super-enhancer and enhancer elements in the human genome. The proposed SE-prediction method included the GENA-LM application at handling long DNA sequences with the classification task, distinguishing super-enhancers from enhancers using H3K36me, H3K4me1, H3K4me3 and H3K27ac landscape datasets from HeLa, HEK293, H2171, Jurkat, K562, MM1S and U87 cell lines. The model was fine-tuned on relevant sequence data, allowing for the analysis of extended genomic sequences without the need for epigenetic markers as proposed in early approaches. The study achieved balanced accuracy metrics, surpassing previous models like SENet, particularly in HEK293 and K562 cell lines. Also, it was shown that super-enhancers frequently co-localize with epigenetic marks such as H3K4me3 and H3K27ac. Therefore, the attention mechanism of the model provided insights into the sequence features contributing to SE classification, indicating a correlation between sequence-only features and mentioned epigenetic landscapes. These findings support the potential transformer models use in further genomic sequence analysis for bioinformatics applications in enhancer/super-enhancer characterization and gene regulation studies. [ABSTRACT FROM AUTHOR]

Perovskite solar cells are part of the third generation of solar cells, a technology that holds the potential to reduce the use of fossil fuels in energy production. Some factors, such as stability and toxicity, jeopardize the scaling process towards commercialization and access to worldwide markets. This work comprises a review over the last decade on PSC advances and progress in the most highly cited databases. A marked trend was found in replacing Pb for Sn from the absorbing perovskite materials, as well as finding the transport layers that will help in the stability and the efficiency of the solar cell. WO3 is presented as a viable element for the formation of the electron transport layer. Spiro-OMeTAD is the most used compound for the hole transport layer, but other viable substitutes were also found. Lastly, the Cs2SnI6 double perovskite was identified as one of the most stable perovskites that emerged in these 10 years. The efficiency and stability of Sn-based solar cells is still very low when compared to their Pb-based counterparts, driving the current research in material science to enhance their performance. [ABSTRACT FROM AUTHOR]

This research explores the design of a system for monitoring driver drowsiness and supervising seat belt usage in interprovincial buses. In Peru, road accidents involving long-distance bus transportation amounted to 5449 in 2022, and the human factor plays a significant role. It is essential to understand how the use of non-invasive sensors for monitoring and supervising passengers and drivers can enhance safety in interprovincial transportation. The objective of this research is to develop a system using a Raspberry Pi 4 and Arduino Nano that allows for the storage of monitoring data. To achieve this, a conventional camera and MediaPipe were used for driver drowsiness detection, while passenger supervision was carried out using a combination of commercially available sensors as well as custom-built sensors. RS485 communication was utilized to store data related to both the driver and passengers. The simulations conducted demonstrate a high level of reliability in detecting driver drowsiness under specific conditions and the correct operation of the sensors for passenger supervision. Therefore, the proposed system is feasible and can be implemented for real-world testing. The implications of this research suggest that the system's cost is not a barrier to its implementation, thus contributing to improved safety in interprovincial transportation. [ABSTRACT FROM AUTHOR]

Objectives Primary nodal marginal B-cell lymphoma (NMZL) is rare and histologically very variable. Its large-cell presentation is difficult to distinguish from nodal diffuse large B-cell lymphoma (nDLBCL) due to the absence of specific markers for nodal marginal zone lymphomas in general. Methods Using a comprehensive cohort of NMZLs and a control cohort of nDLBCLs, we conducted a methylome analysis on subgroups of both. Results The methylomes were strikingly different between the cohorts but unexpectedly homogeneous within the NMZL cohort. This allowed us to describe the morphologic spectrum of NMZL in all its value ranges. The considerable overlap in growth pattern and cytology of NMZL with nDLBCL was explored morphometrically, leading to an operational tool for separating both by a simple measurement of cell size and nuclear size. This was integrated in a hierarchical approach, including a scoring system for the parameter growth pattern, follicular colonization, follicular dendritic network, IgD expression, and Ki-67 rate, and led to a proposal for a classifier that we present here. Conclusions This methylome-based study extends the morphological spectrum of NMZL towards large cell morphology and offers a conventional way to distinguish it from nDLBCL. [ABSTRACT FROM AUTHOR]

The increasing role of algorithms shaping our use of communication technology—particularly on social media—comes with a growth of empirical research attempting to assess how literate users are regarding these algorithms. This rapidly emerging field is marked by great diversity in terms of how it theorizes and measures our understanding of algorithms, due, in part, to the opaque "black box" nature of the algorithms themselves. In this review article, we summarize the state of knowledge on algorithmic literacy, including its definitions, development, measurement, and current theorizing on human–algorithm interaction. Drawing on this existing work, we propose an agenda including four different directions that future research could focus on: (1) balancing users' expectations of algorithmic literacy with developers' responsibility for algorithmic transparency, (2) methods for engaging users in increasing their literacy, (3) further developing the affective and behavioral facets of literacy, and (4) addressing the new algorithmic divide. [ABSTRACT FROM AUTHOR]

Mycobacteriophages are viruses that specifically infect bacteria of the Mycobacterium genus. A substantial collection of mycobacteriophages has been isolated and characterized, offering valuable insights into their diversity and evolution. This collection also holds significant potential for therapeutic applications, particularly as an alternative to antibiotics in combating drug-resistant bacterial strains. In this study, we report the isolation and characterization of a new mycobacteriophage, Vic9, using Mycobacterium smegmatis mc (2)155 as the host strain. Vic9 has been classified within the B2 subcluster of the B cluster. Morphological analysis revealed that Vic9 has a structure typical of siphophages from this subcluster and forms characteristic plaques. The phage adsorbs onto host strain cells within 30 min, and according to one-step growth experiments, its latent period lasts about 90 min, followed by a growth period of 150 min, with an average yield of approximately 68 phage particles per infected cell. In host range experiments, Vic9 efficiently lysed the host strain and also exhibited the ability to lyse M. tuberculosis H37Rv, albeit with a low efficiency of plating (EOP ≈ 2 × 10−5), a typical feature of B2 phages. No lysis was observed in other tested mycobacterial species. The genome of Vic9 comprises 67,543 bp of double-stranded DNA and encodes 89 open reading frames. Our analysis revealed unique features in Vic9, despite its close relationship to other B2 subcluster phages, highlighting its distinct characteristics even among closely related phages. Particularly noteworthy was the discovery of a distinct 435 bp sequence within the gene cluster responsible for queuosine biosynthesis, as well as a recombination event within the structural cassette region (Vic_0033-Vic_0035) among members of the B1, B2, and B3 subclusters. These genetic features are of interest for further research, as they may reveal new mechanisms of phage-bacteria interactions and their potential for developing novel phage therapy methods. [ABSTRACT FROM AUTHOR]

Epidemiological evidence from the past 20 years indicates that environmental chemicals brought into the air by the vaporization of volatile organic compounds and other anthropogenic pollutants might be involved, at least in part, in the development or progression of psychiatric disorders. This evidence comes primarily from occupational work studies in humans, with indoor occupations being the most important sources of airborne pollutants affecting neural circuits implicated in mood disorders (e.g., major depressive disorder and bipolar disorder). The current mini review brings together recent findings of indoor airborne pollution from different fields of research, including genetics, neuropathology, and neuroimaging, for gauging underlying physiological mechanisms leading to emotional disturbances that impact nearly all aspects of human behavior. A better understanding of how indoor airborne pollutants affect brain neurons to augment clinical symptoms associated with psychiatric disorders will undoubtedly be useful in the subsequent treatment of patients with major depressive and/or bipolar disorders. This article is part of the themed issue, "Understanding the Link Between Environmental Pollutants, Brain & Behavior." [ABSTRACT FROM AUTHOR]

Background: Gastric cancer remains a major global health challenge, ranking fourth in cancer-related deaths. Total gastrectomy with lymphadenectomy is the standard treatment, with advancements in surgery shifting towards minimally invasive techniques to reduce surgical trauma and metabolic response. Esophagojejunal anastomotic leak is a frequent complication of gastrectomy, significantly increasing morbidity and mortality rates by up to 64%. Materials and methods: A retrospective cohort study reviewed adults undergoing total gastrectomy for gastric cancer who developed esophagojejunal anastomotic leaks. The study described patient characteristics, diagnostic methods, and management at Clinica Universitaria Colombia from 2013 to 2023. Results: Among 500 patients who had total gastrectomy, 54 developed esophagojejunal leaks. The cohort was 64.8% male, average age 55.2 years (± 14.87), and average BMI 24.5 kg/m². Notably, 18.5% smoked, 11.1% had lung disease, and 9.3% had heart disease or diabetes. Chest tomography was used in 60% of cases, followed by endoscopy in 35.2%. Endoscopic management with fully covered stents was the main strategy, used in 84% of cases. Average hospitalization was 18 days, with 33% needing intensive care, and overall hospital stay was 23.31 ± 16.33 days. Patients undergoing neoadjuvant and elective laparoscopic surgeries had a significant 30-day mortality risk. Conclusions: Despite advances in surgical techniques and perioperative management, esophagojejunal anastomotic leaks continue to represent a serious complication, increasing morbidity and mortality. Therefore, early postoperative detection, based on the patient's clinical signs that allow confirmatory studies to be performed, is crucial. This facilitates the implementation of timely treatments, whether conservative, through the use of endoscopic or percutaneous strategies, or surgical procedures. The next step for the scientific community will be to conduct studies with long-term follow-ups to ensure consistency of the high-quality results reported so far. [ABSTRACT FROM AUTHOR]

This paper presents a methodology for detecting the pest Aleurothrixus floccosus in citrus crops in Pedregal de Arequipa, Peru. The study employs simple random sampling during image collection to minimize bias, alternating and extracting leaves from different citrus trees. Image processing techniques, including noise reduction, edge smoothing, and segmentation, are applied for pest detection. Machine learning algorithms are used to classify the images, culminating in a robust detection methodology. A dataset of 1200 images was analyzed during the study. [ABSTRACT FROM AUTHOR]

Background/Objectives: Decompensated cirrhosis is characterized by systemic inflammation and innate and adaptive immune dysfunction. Hepatic encephalopathy (HE) is a prevalent and debilitating condition characterized by cognitive disturbances in which ammonia and inflammation play a synergistic pathogenic role. Extraskeletal functions of vitamin D include immunomodulation, and its deficiency has been implicated in immune dysfunction and different forms of cognitive impairment. The aim was to assess changes in cognitive function and inflammation in decompensated patients with cirrhosis receiving vitamin D supplementation. Methods: Patients with cirrhosis discharged from decompensation in two tertiary hospitals in Spain (from September 2017 to January 2020) were assessed before, at 6 and 12 months after vitamin D supplementation. A comprehensive neuropsychological battery and neuroinflammatory markers were examined. In a subgroup of patients, peripheral immune blood cells were analyzed. Results: Thirty-nine patients were recruited. Of those, 27 completed the 6 months evaluation and were analyzed [age 62.4 ± 11.3 years; 22 men; Model for End-Stage Liver Disease (MELD) 11.7 ± 4.0; prior overt HE 33%; median 25-hydroxyvitamin D (25OHD) plasma level 12.7 µgr/L] and 22 achieved 12 months assessment. At baseline, learning and memory (R = 0.382; p = 0.049) and working memory (R = 0.503; p = 0.047) subtests correlated with plasma 25OHD levels. In addition, processing speed (R = −0.42; p = 0.04), attention (R = −0.48; p = 0.04), Tinnetti balance (R = −0.656; p < 0.001) and Tinnetti score (R = −0.659; p < 0.001) were linked to neuroinflammation marker IL-1β. Patients with lower 25OHD had a greater proportion of TH1cells at baseline and a larger amelioration of IL-1β and IL-6 following supplementation. An improvement in working memory was found after 25OHD replacement (46.7 ± 13 to 50 ± 11; p = 0.047). Conclusions: This study supports that vitamin D supplementation modulates low-grade inflammation in decompensated cirrhosis providing cognitive benefits, particularly in working memory. [ABSTRACT FROM AUTHOR]

The integration of phase-change materials (PCMs) into thermal energy storage systems offers significant potential for reducing energy consumption and improving thermal comfort, crucial issues for achieving sustainable building stocks. Nevertheless, the performance of PCM-based systems is strongly influenced by the container geometry. Among the various forms of incorporating PCMs into building applications, macroencapsulation is the most versatile and is, therefore, widely used. Herewith, this paper analyzes the impact of macrocapsule geometry on PCM thermal performance. Thermal properties of the material were first tested using Differential Scanning Calorimetry at five heating/cooling rates to evaluate its influence on phase-change temperatures and enthalpy. Then, an experimental setup evaluated four macrocapsule geometries on the enclosed PCM behavior during charging and discharging processes. The PCM characterization revealed that the slowest-tested rate minimized the supercooling effect. Analysis across different macrocapsule geometries showed that sectioning the contact surface improved heat transfer efficiency by fully mobilizing the PCM and reducing phase-change times. Conversely, double-layered geometry designs hindered heat transfer, presenting challenges in completing PCM charging and discharging. These findings suggest that optimizing its performance is a necessary direction for further research, which may include adjusting the PCM operating temperature range across layers or redesigning the geometry to misalign contact surfaces. [ABSTRACT FROM AUTHOR]

Background: Transjugular intrahepatic portosystemic shunt (TIPSS) is highly effective for treatment of variceal bleeding; however, factors contributing to rebleeding complications remain unclear. Aims: In this study, we aim to determine risk factors for recurrent portal hypertensive gastrointestinal bleeding following TIPSS. Methods: Utilising the Advancing Liver Therapeutic Approaches multicentre database, we retrospectively identified adult patients who underwent TIPSS for secondary prophylaxis of variceal bleeding and had a gastrointestinal rebleeding event within 1 year. We developed multivariable logistic regression models to identify clinical/procedural characteristics associated with rebleeding. Results: We identified 476 patients, predominately middle‐aged (mean age 57), male (62%) and White (65%), with mean MELD‐Na 16. 16% (n = 77) had a rebleeding event; these patients were more likely to be male (p = 0.016), with higher serum creatinine (p = 0.005), MELD‐Na (p = 0.0002), portal hypertensive gastropathy on pre‐TIPSS upper endoscopy (p = 0.000) and with higher incidence of TIPSS revision (p = 0.000). There were no significant differences in type of TIPSS endoprosthesis, concurrent embolotherapy, and post‐TIPSS pressure gradients between those who experienced rebleeding and those who did not. After adjusting for TIPSS revision, multivariable analysis revealed MELD‐Na and presence of portal hypertensive gastropathy on pre‐TIPSS endoscopy were independently associated with rebleeding. Conclusions: In this retrospective analysis of a multicentre, nationally representative database, we found that apart from TIPSS‐related factors, high MELD‐Na and portal hypertensive gastropathy on pre‐TIPSS endoscopy were independent predictors of rebleeding within 1 year following TIPSS. These variables may be used to identify high‐risk patients who may require additional monitoring following TIPSS. [ABSTRACT FROM AUTHOR]

Brain aging is a chronic process linked to inflammation, microglial activation, and oxidative damage, which can ultimately lead to neuronal loss. Sialic acid-binding immunoglobulin-like lectin-11 (SIGLEC-11) is a human lineage-specific microglial cell surface receptor that recognizes α -2-8-linked oligo−/polysialylated glycomolecules with inhibitory effects on the microglial inflammatory pathways. Recently, the SIGLEC11 gene locus was prioritized as a top tier microglial gene with potential causality to Alzheimer's disease, although its role in inflammation and neurodegeneration remains poorly understood. In this study, aged Siglec-11 transgenic (tg) mice, which expressed the human SIGLEC-11 receptor on microglia and tissue macrophages, were investigated. The brains of the Siglec-11 tg mice were analyzed in 6-month-old mature mice and 24-month-old aged mice using immunohistochemistry and transcriptomics. Results showed decreased density and fewer clusters of ionized calcium binding adaptor molecule 1 (Iba1)-positive microglial cells in the hippocampus and substantia nigra, as well as less lipid-laden microglia in the Siglec-11 tg in comparison to wildtype (WT) controls. Additionally, Siglec-11 tg mice exhibited less age-related neuronal loss in the substantia nigra pars compacta in comparison to WT mice. Transcriptome analysis revealed suppression of oxidative phosphorylation and inflammatory pathways in Siglec-11 tg brains at 6 months, with further suppression of complement and coagulation cascades at 24 months of age in comparison to WT mice. Gene transcript levels of the pro-inflammatory cytokines tumor necrosis factor alpha (Tnf) and interleukin 1 beta (Il-1β) as well as the oxidative stress markers cytochrome b-245 alpha and beta (Cyba and Cybb) and the nitric oxide synthase 2 (Nos2), were reduced in the brains of 24-month-old Siglec-11 tg mice relative to WT controls. Brains of 24-month-old Siglec-11 tg mice also exhibited lower gene transcription of complement components 3, 4, and integrin alpha M (C3, C4, and Itgam), along with the complement C1q subcomponents a-c (C1qa, C1qb , and C1qc). In summary, aged Siglec-11 tg mice displayed reduced brain inflammation and oxidative stress, as well as protection against age-related neuronal loss in the substantia nigra. [ABSTRACT FROM AUTHOR]

Introduction: Bovine mastitis is a major infectious disease affecting dairy cattle, impacting public health and milk industry profitability. Staphylococcus aureus is a contagious pathogen responsible for causing bovine subclinical mastitis. Its pathogenesis and antimicrobial resistance highlight the need for alternative treatments, being the nanoencapsulation of essential oils (EO) very promising. Methods: Nanostructured lipid carriers (NLCs) containing 5% of Melaleuca armillaris EO were synthesized and characterized. Their physicochemical characteristics, antimicrobial activity against methicillin-resistant and sensitive S. aureus (MRSA and MSSA, respectively), and protective activity against polymorphonuclear cells were evaluated. Results: NLC-EO nanoparticles were morphologically spherical and the mean size was around 190 nm, Polydispersity index (PdI) was 0.21 (±0.01), Z potential was −18.4 (±0.4) and EO encapsulation efficiency was 71.5%. Of this parameters Z potential was the only which changed after 6 months of storage at four°C, turning into a more negative value of −31.6 (±1.9). NLC-EO showed a biphasic behavior with a fast initial release during the first 6 h, followed by a slow phase for at least 72 h. Free and nanoencapsulated EO had a minimum inhibitory concentration (MIC90) of 6.25 μL/mL; however, free EO had a minimum inhibitory concentrations of biofilm formation (MICB90) of 3.12 μL/mL and for EO nanoencapsulated was 6.25 μL/mL. Minimum inhibitory concentrations of biofilm formation and eradication (MECB90) were 12.5 μL/mL and 6.25 μL/mL for the nanoencapsulated EO and free EO, respectively. Empty NLC inhibited biofilm formation, but not planktonic growth or eradicated preformed biofilms. Discussion: The EO was efficiently encapsulated and released from NLC, and its antimicrobial activity against MRSA and MSSA was high. Neutrophil viability was higher when EO was encapsulated, being an important result for future experiments evaluating intracellular EO activity, where Staphylococcus aureus survives and evades poorly penetrating antibiotics activity. [ABSTRACT FROM AUTHOR]

Despite decades of literature on the benefits of physical activity (PA) on cardiovascular disease (CVD) and other health outcomes, rates of physical inactivity and sedentary time remain alarmingly high and are likely contributing to the global increase in CVD. Roughly one-third of the world's population does not meet the World Health Organization (WHO) guideline recommended levels of aerobic PA, defined as ≥ 150 min of moderate-intensity PA or ≥75 min of vigorous-intensity PA, or an equivalent combination of both. This is in addition to recommending individuals perform at least 2 days of muscle-strengthening activities per week involving all major muscle groups, which provide additional CVD benefits beyond aerobic PA. Disparities by sex and between high- and low-income countries persist, with modeling studies suggesting a direct global economic cost of $5 billion dollars. To combat the global health crisis of physical inactivity, the WHO implemented a global action plan on PA in 2013, which set a target of a 15% relative reduction in physical inactivity by 2030. Barriers to attaining adequate PA levels are abundant, however, step counting represents a relatively novel metric of PA with a growing body of literature supporting their utility given mounting evidence of CVD benefits, with trends that mirror intensity-centric metrics of PA that are used in WHO guidelines. This manuscript provides an up-to-date review of the evidence on the benefits of PA, steps, and cardiovascular outcomes. [ABSTRACT FROM AUTHOR]

The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, the Netherlands, and co-rapporteur Member State, France, for the pesticide active substance spinosad and the assessment of applications for maximum residue levels (MRLs) are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012. The conclusions were reached on the basis of the evaluation of the representative uses of spinosad as insecticide on bulb/dry onions, maize (fodder and grain), sweet corn, grapes (table and wine), lettuce, potato, aubergine, pepper and tomato. MRLs were assessed in field leek and field and greenhouse strawberries, cane fruits, lettuce & plants salad (others), spinach and similar leaves (others), herbs and edible flowers (others), cardoons, rhubarb and animal commodities. The conclusions from 2018 were updated in 2024 following the request from the European Commission with regard to the endocrine-disrupting properties. The reliable end points, appropriate for use in regulatory risk assessment and the proposed MRLs, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are reported where identified. [ABSTRACT FROM AUTHOR]

The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State Austria for the pesticide active substance lysate of Willaertia magna C2c Maky and the considerations as regards the inclusion of the substance in Annex IV of Regulation (EC) No 396/2005 are reported. The context of the peer review was that required by Regulation (EC) No 1107/2009 of the European Parliament and of the Council. The conclusions were reached on the basis of the evaluation of the representative use of lysate of Willaertia magna C2c Maky as a fungicide against downy mildew (Plasmopara viticola) on grapevines and table grapes. The reliable endpoints, appropriate for use in regulatory risk assessment, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns were not identified. [ABSTRACT FROM AUTHOR]

The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State Spain and co-rapporteur Member State Germany for the pesticide active substance phosphine are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012. The conclusions were reached on the basis of the evaluation of the representative uses of phosphine as a post-harvest indoor insecticide to control insects infesting stored grains (barley, oat, rye, wheat), cacao and coffee beans, tree nuts and oilseeds and dried fruit via gassing application (gas-tight rooms/container). The reliable end points, appropriate for use in regulatory risk assessment are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified. [ABSTRACT FROM AUTHOR]

The genus Capsella serves as a model for understanding speciation, hybridization, and genome evolution in plants. Here, we present a chromosome-scale genome assembly of Capsella orientalis , the maternal progenitor of a cosmopolitan allotetraploid C. bursa-pastoris. Using nanopore sequencing and data on chromatin contacts (Hi-C), we assembled the genome into eight pseudo-chromosomes with high contiguity, evidenced by a benchmarking universal single-copy orthologs (BUSCO) completeness score of 99.3%. Comparative analysis with C. rubella and C. bursa-pastoris revealed overall synteny, except for 2 Mb inversion on chromosome 4 of C. rubella. Comparative genome analysis highlighted the conservation of gene content and structural integrity in the C. orientalis -derived subgenome of C. bursa-pastoris , with the exception of a 1.8 Mb region absent in O subgenome but present in C. orientalis. The genome annotation includes 27,675 protein-coding genes, with most exhibiting one-to-one orthology with Arabidopsis thaliana. Notably, 2,155 genes showed no similarity to A. thaliana ones. These results establish a robust genomic resource for C. orientalis , facilitating future studies on polyploid evolution, gene regulation, and species divergence within Capsella. [ABSTRACT FROM AUTHOR]

The random motion (the diffusion) of guest molecules in nanoporous host materials is key to their manifold technological applications and, simultaneously, a ubiquitous phenomenon in nature quite in general. Based on a specification of the different conditions under which molecular diffusion in nanoporous materials may occur and of the thus resulting relevant parameters, a survey of the various ways of the measurement of the determining parameters is given. Starting with a condensed introduction to the respective measuring principles, the survey notably includes a summary of the various parameters accessible by each individual technique, jointly with an overview of their strengths and weaknesses as well as of the respective ranges of observation. The presentation is complemented by basic relations of diffusion theory and molecular modeling in nanoporous materials, illustrating their significance for enhancing the informative value of each measuring technique and the added value attainable by their combination. By providing guidelines for the measurement and reporting of diffusion properties of chemical compounds in nanopores, the document aims to contribute to the clarification and standardization of the presentation, nomenclature, and methodology associated with the documentation of diffusion phenomena in nanoporous materials serving for catalytic, mass separation, and other relevant purposes. [ABSTRACT FROM AUTHOR]

Copyright of Momento: Revista de Física is the property of Universidad Nacional de Colombia, Departamento de Fisica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This study examines paternal and maternal sensitivity as predictors of toddlers' attachment security in two naturalistic contexts. Seventy‐three mostly White middle‐class families participated between 2015 and 2019 when children (49.3% girls) were approximately 29.48 months old. Each child–parent dyad completed a home and playground visit. Findings revealed paternal and maternal sensitivity were significantly associated at home and marginally at the playground. Paternal sensitivity was only predictive of security to the father at the playground, showing a medium effect, while small effects of maternal sensitivity on security to the mother were found in both contexts. Cross‐parent contributions to security were small and limited to the playground. The need to consider the greater ecology of child–parent relationships and suggestions for larger‐scale research are discussed. [ABSTRACT FROM AUTHOR]

The species richness of organisms associated with altitudinal gradients tends to decline with increasing altitude, however, this pattern is not observed in mygalomorph. The present study tests the hypothesis that the richness and abundance of ground-dwelling mygalomorph spiders will be positively correlated with the increase in altitude, as well as will be influenced by variation of potential prey along an altitudinal gradient in the Brazilian semi-arid domain. Sampling took place during August 2020 to August 2021, through pitfall traps, totaling 50 traps/area/month. A total of 125 adult individuals belonging to 10 morphospecies were collected along the altitudinal gradient. Theraphosidae was the richest family in morphospecies, the most abundant mygalomorph was Neodiplotele caucaia Gonzalez-Filho, Lucas & Brescovit, 2015, Guyruita sp., and Diplura sanguínea (F.O. Pickard-Cambridge, 1896). Our results shows that mygalomorph abundance and species richness were affected by potential prey availability and not by altitude perse. Therefore, our results shows that the biotic (e.g., availability of potential preys) and no abiotic (e.g., elevation) may have a key factor to the mygalomorph spider assemblage modulation along an altitudinal gradient. The study opens precedents for further investigations on the distribution patterns of mygalomorph spiders in the Brazilian semiarid region. [ABSTRACT FROM AUTHOR]

This study uses Texas's 2017 integration of the state disability and mental health agencies as a case study, combining interviews with Texas agency and advocacy organization leaders to examine perceptions of agency integration and augmented synthetic control analyses of 2014–2020 Medical Expenditure Panel Survey to examine impacts on mental health service use among individuals with co-occurring cognitive disabilities (including intellectual and developmental disabilities) and mental health conditions. Interviewees described the intensive process of agency integration and identified primarily positive (e.g., decreased administrative burden) impacts of integration. Quantitative analyses indicated no effects of integration on receipt of mental health-related services among people with co-occurring conditions. While leaders identified some potentially beneficial impacts of state agency integration, the limited impact of integration beyond the agency suggests that interventions at multiple levels of the service system, including those targeting providers, are needed to better meet the mental health service needs for this population. [ABSTRACT FROM AUTHOR]

We report a 40‐year‐old African American female with a novel variant in exon 8 of DNA methyltransferase 3 alpha (DNMT3A), (NM_022552.4: c.905G>C, p.G302A) who presented with a history of recurrent carotid paragangliomas, mediastinal mass, intellectual disability, dysarthria, cholelithiasis, diabetes mellitus, hypertension, and dysmorphic features. We interpret this novel variant as likely pathogenic and causative for the patient's syndromic features of Heyn–Sproul–Jackson syndrome. Heyn–Sproul–Jackson syndrome is a condition caused by gain‐of‐function genetic changes in DNMT3A. Paragangliomas have also been observed in non‐syndromic patients with genetic alterations in DNMT3A. We describe a patient with clinical features of Heyn–Sproul–Jackson syndrome such as intellectual disability, dysarthria, brachydactyly, and lack of brain MRI findings to add evidence to associate paragangliomas with DNMT3A and draw particular attention to the potential involvement of the proline‐tryptophan‐tryptophan‐proline domain of DNMT3A. [ABSTRACT FROM AUTHOR]

Many current embedded systems comprise heterogeneous computing components including quite powerful GPUs, which enables their application across diverse sectors. This study demonstrates the efficient execution of a medium-sized self-supervised audio spectrogram transformer (SSAST) model on a low-power system-on-chip (SoC). Through comprehensive evaluation, including real time inference scenarios, we show that GPUs outperform multi-core CPUs in inference processes. Optimization techniques such as adjusting batch size, model compilation with TensorRT, and reducing data precision significantly enhance inference time, energy consumption, and memory usage. In particular, negligible accuracy degradation is observed, with post-training quantization to 8-bit integers showing less than 1% loss. This research underscores the feasibility of deploying transformer neural networks on low-power embedded devices, ensuring efficiency in time, energy, and memory, while maintaining the accuracy of the results. [ABSTRACT FROM AUTHOR]

To achieve optimal controllability in a dual steering tractor (a four-wheel, iso-diametric tractor equipped with a dual-hydraulic steering system), this study proposes a coordinated approach that combines experimental testing (using a special agricultural tractor) with numerical analysis of the entire vehicle, developed in Bond Graph-3D. For certain crops, a dual steering vehicle is used to meet the needs of professionals who require easy maneuverability in narrow spaces and/or reduced steering time. This study aims to explore the reasons behind the need for dual steering tractors, highlighting the advantages and disadvantages of these two different configurations and ultimately focusing on the combined benefits of both. Based on an extensive review of the literature and drawing from previous studies, this paper analyzes aspects such as the variation in noise levels (or comfort level) experienced at the steering wheel when switching from Ackermann steering to a dual steering system. After outlining the theoretical methodology used to describe the model, both experimental and numerical analyses of a vineyard tractor in operation are presented. The goal of this work is to provide guidance on design methods and, through the Bond Graph-3D model, suggest the best control algorithms to minimize steering noise and enhance driving comfort. This research aims to pave the way for future control strategies in electrohydraulic steering systems. [ABSTRACT FROM AUTHOR]

Copyright of Acta Ortopédica Mexicana is the property of Sociedad Mexicana de Ortopedia, AC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Herein, a simple and cost-effective chemical bath deposition methodology was employed to synthesize Co-doped SnS thin films, focusing on the improvement of the optical and electrical properties of the films by modulating the Co2+ ion concentrations in the reaction solution. X-ray diffraction analysis revealed a phase transformation from amorphous to a Herzenbergite orthorhombic phase with increasing Co2+ concentration. Chemical structure analysis via X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy confirmed the incorporation of Co2+ ions, along with the presence of SnS, Sn2S3, and minor CoO phases. Optical studies demonstrated a significant bandgap widening from ~ 1.0 eV (undoped) to ~ 1.7 eV (Co-doped), making the films suitable for photovoltaic applications. Electrical characterization showed a marked decrease in resistivity from ~ 3 × 109 to 22 × 106 Ω cm. These results highlight the potential of Co-doped SnS thin films for next-generation photovoltaic devices, emphasizing the importance of doping optimization to balance performance and structural integrity. [ABSTRACT FROM AUTHOR]

Structural brain preservation (SBP) and classical cryonics are techniques aimed at preserving the human brain for potential future applications. Reluctant public discourse around these techniques may be explained with intuitive aversions identified by moral psychology. In the first part of the paper, we conjecture the existence of a self-sustaining cycle of moral condemnation of SBP and classical cryonics due to quick, affect-laden moral intuitions. In the second part, we propose an alternative framing of SBP and classical cryonics through a thought experiment featuring a time machine metaphor called "Schrödinger’s chrono-cat", which might avoid triggering aversive moral intuitions and foster public discourse. We discuss the limitations of this framing and its consequences. [ABSTRACT FROM AUTHOR]