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Pressure from population growth and climate change stress the limited water resources in the Mediterranean region and threaten food security and social stability. Enhancing food production requires the transformation of irrigation systems and enhancement of local capacity for sustainable water and soil management in irrigated agriculture. The aim of this work is the conversion of traditional irrigation practices, by introducing the practice of optimal irrigation scheduling based on local ET estimation and soil moisture monitoring, and the use of continuous feeding by fertigation to enhance both water and nutrient use efficiency. For this, two trials were established between August and November 2023 in two different pedoclimatic zones (Serein and Sultan Yacoub) of the inner Bekaa Plain of Lebanon, characterized by semi-arid and dry subhumid conditions and different soil types. Greenhouse cucumber was tested to compare the prevailing traditional farmers' practices with the advanced, technology-based, methods of water management. Results showed a significantly higher amount of water applied by the farmers to the protected cucumber, with a potential for average saving of 105 mm of water applied in each season by improved practices. Water input in the traditional practices revealed potential stress to plants. With more than 20% increase in cucumber yield by the transformed practices, a general trend was observed in the fertilization approach and amounts, resulting in lower nutrient recovery in the farmer's plots. The science-based practices of water and nutrient management showed higher application and agronomic water use efficiency of full fertigation, exceeding 60%, associated with double and triple higher nitrogen use efficiency, compared to those results obtained by the traditional water and fertilizer application methods. The monitored factors can contribute to severe economic and environmental consequences from nutrient buildup or leaching in the soil–groundwater system in the Mediterranean region. [ABSTRACT FROM AUTHOR]

Objectives: We previously demonstrated the potential of radiomics for the prediction of severe histological placenta accreta spectrum (PAS) subtypes using T2-weighted MRI. We aim to validate our model using an additional dataset. Secondly, we explore whether the performance is improved using a new approach to develop a new multivariate radiomics model. Methods: Multi-centre retrospective analysis was conducted between 2018 and 2023. Inclusion criteria: MRI performed for suspicion of PAS from ultrasound, clinical findings of PAS at laparotomy and/or histopathological confirmation. Radiomic features were extracted from T2-weighted MRI. The previous multivariate model was validated. Secondly, a 5-radiomic feature random forest classifier was selected from a randomized feature selection scheme to predict invasive placenta increta PAS cases. Prediction performance was assessed based on several metrics including area under the curve (AUC) of the receiver operating characteristic curve (ROC), sensitivity, and specificity. Results: We present 100 women [mean age 34.6 (±3.9) with PAS], 64 of whom had placenta increta. Firstly, we validated the previous multivariate model and found that a support vector machine classifier had a sensitivity of 0.620 (95% CI: 0.068; 1.0), specificity of 0.619 (95% CI: 0.059; 1.0), an AUC of 0.671 (95% CI: 0.440; 0.922), and accuracy of 0.602 (95% CI: 0.353; 0.817) for predicting placenta increta. From the new multivariate model, the best 5-feature subset was selected via the random subset feature selection scheme comprised of 4 radiomic features and 1 clinical variable (number of previous caesareans). This clinical-radiomic model achieved an AUC of 0.713 (95% CI: 0.551; 0.854), accuracy of 0.695 (95% CI 0.563; 0.793), sensitivity of 0.843 (95% CI 0.682; 0.990), and specificity of 0.447 (95% CI 0.167; 0.667). Conclusion: We validated our previous model and present a new multivariate radiomic model for the prediction of severe placenta increta from a well-defined, cohort of PAS cases. Advances in knowledge: Radiomic features demonstrate good predictive potential for identifying placenta increta. This suggests radiomics may be a useful adjunct to clinicians caring for women with this high-risk pregnancy condition. [ABSTRACT FROM AUTHOR]

Objectives: We previously demonstrated the potential of radiomics for the prediction of severe histological placenta accreta spectrum (PAS) subtypes using T2-weighted MRI. We aim to validate our model using an additional dataset. Secondly, we explore whether the performance is improved using a new approach to develop a new multivariate radiomics model. Methods: Multi-centre retrospective analysis was conducted between 2018 and 2023. Inclusion criteria: MRI performed for suspicion of PAS from ultrasound, clinical findings of PAS at laparotomy and/or histopathological confirmation. Radiomic features were extracted from T2-weighted MRI. The previous multivariate model was validated. Secondly, a 5-radiomic feature random forest classifier was selected from a randomized feature selection scheme to predict invasive placenta increta PAS cases. Prediction performance was assessed based on several metrics including area under the curve (AUC) of the receiver operating characteristic curve (ROC), sensitivity, and specificity. Results: We present 100 women [mean age 34.6 (±3.9) with PAS], 64 of whom had placenta increta. Firstly, we validated the previous multivariate model and found that a support vector machine classifier had a sensitivity of 0.620 (95% CI: 0.068; 1.0), specificity of 0.619 (95% CI: 0.059; 1.0), an AUC of 0.671 (95% CI: 0.440; 0.922), and accuracy of 0.602 (95% CI: 0.353; 0.817) for predicting placenta increta. From the new multivariate model, the best 5-feature subset was selected via the random subset feature selection scheme comprised of 4 radiomic features and 1 clinical variable (number of previous caesareans). This clinical-radiomic model achieved an AUC of 0.713 (95% CI: 0.551; 0.854), accuracy of 0.695 (95% CI 0.563; 0.793), sensitivity of 0.843 (95% CI 0.682; 0.990), and specificity of 0.447 (95% CI 0.167; 0.667). Conclusion: We validated our previous model and present a new multivariate radiomic model for the prediction of severe placenta increta from a well-defined, cohort of PAS cases. Advances in knowledge: Radiomic features demonstrate good predictive potential for identifying placenta increta. This suggests radiomics may be a useful adjunct to clinicians caring for women with this high-risk pregnancy condition. [ABSTRACT FROM AUTHOR]

In the current study, the agricultural waste materials Date Seed Ash (DSA) is investigated. Various concentrations of DSA (5%, 10%, 15%, and 20%) were applied, and the impact of DSA on the surface morphology and chemical composition of the tested soil (soft clay) was examined using scanning electron microscopy and energy dispersive X-ray. The results indicated that soft clay soil treated with DSA exhibited increased overall strength. By adding 15% DSA, the unconfined compression strength improves to more than double that of the sample without any treatment. Moreover, examining the morphology of soil samples treated with 10% and 15% DSA uncovered the formation of hydrated particles and cement-like compounds resulting from the interaction between the soil and DSA. In addition, as the DSA % grows, the compressibility and volume change factors decrease. The California Bearing Ratio and unconfined compression strength tests confirmed that DSA was an effective stabilizer of soft clay soil. In this study, the most effective amount of Date Seeds Ash (DSA) was 15% by adding weight to enhance the fundamental properties, and strength of soft clay soil. [ABSTRACT FROM AUTHOR]

In plant production, evaluation of salt stress protectants concerning their potential to improve growth and productivity under saline stress is critical. Bacillus subtilis (Bs) and cobalt (Co) have been proposed to optimize salt stress tolerance in coriander (Coriandrum sativum L. cv. Balady) plants by influencing some physiological activities. The main aim of this work is to investigate the response of (Bs) and (Co) as eco-safe salt stress protectants to resist the effect of salinity, on growth, seed, and essential oil yield, and the most important biochemical constituents of coriander produced under salt stress condition. Therefore, in a split-plot factorial experiment design in the RCBD (randomized complete block design), four levels of salinity of NaCl irrigation water (SA) were assigned to the main plots; (0.5, 1.5, 4, and 6 dS m−1); and six salt stress protectants (SP) were randomly assigned to the subplots: distilled water; 15 ppm (Co1); 30 ppm (Co2); (Bs); (Co1 + Bs); (Co2 + Bs). The study concluded that increasing SA significantly reduced coriander growth and yield by 42.6%, which could be attributed to ion toxicity, oxidative stress, or decreased vital element content. From the results, we recommend that applying Bs with Co (30 ppm) was critical for significantly improving overall growth parameters. This was determined by the significant reduction in the activity of reactive oxygen species scavenging enzymes: superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) and non-enzyme: proline by 5, 11.3, 14.7, and 13.8% respectively, while increasing ascorbic acid by 8% and preserving vital nutrient levels and enhancing plant osmotic potential to buffer salt stress, seed yield per plant, and essential oil yield increased by 12.6 and 18.8% respectively. The quality of essential oil was indicated by highly significant quantities of vital biological phytochemicals such as linalool, camphor, and protein which increased by 10.3, 3.6, and 9.39% respectively. Additional research is suggested to determine the precise mechanism of action of Bs and Co's dual impact on medicinal and aromatic plant salt stress tolerance. [ABSTRACT FROM AUTHOR]

The adsorption of Cs(I), Sr(II) and Y(III) from aqueous solutions using silica polystyrene (SPS) impregnated with Aliquat-336 (A-336) and Theonyl triflouroacetone (HTTA) was investigated. The synthesized materials; SPS, A-336@SPS and HTTA@SPS were characterized using FTIR, XRD and SEM. The order of adsorption capacity is Cs(I)>Sr(II)>Y(III). The adsorption capacity (qe) for Cs(I), Sr(II) and Y(III) was found to be 2.3, 0.75 and 0.55 mg/g, respectively. The maximum separation factor of SF(Cs/Sr), SF(Cs/Y) and SF(Sr/Y) was 16.01, 29.32, and 1.83, respectively. The selective adsorption of Cs(I) by A-336@SPS is attributed to the formation of strong complex between nitrogen atom of A-336@SPS and Cs(I). [ABSTRACT FROM AUTHOR]

Internationally, respirable crystalline silica (RCS) occupational exposure limits (OELs) are being reassessed and, in some jurisdictions, lowered, putting pressure on the capabilities of the analytical techniques used to achieve robust analyses and reliable detection limits. In preparation of a lower OEL, options for lowering the limit of detection (LoD) for RCS analysis have been assessed. Using a Direct-on-Filter X-Ray Diffraction (XRD) analysis under reduced scan speeds in combination with low-noise RCS sampling filters, an LoD of 0.25 µg/filter and a limit of quantification (LoQ) of 0.82 µg/filter can be achieved. Both limits would translate in an LoD of 0.24 µg/m3 and LoQ of 0.78 µg/m3 when sampling respirable dust for 8 h at 2.2 L/min, providing a technical solution to monitor exposures at the proposed OEL of 0.025 mg/m3 (25 µg /m3) and below, with general sampling conditions as typically applied in Australia. This is the first report showing that the OEL of 0.025 mg/m3 (25 µg /m3) is measurable by one of the standardized, direct-on-filter XRD methods. [ABSTRACT FROM AUTHOR]

In plant production, evaluation of salt stress protectants concerning their potential to improve growth and productivity under saline stress is critical. Bacillus subtilis (Bs) and cobalt (Co) have been proposed to optimize salt stress tolerance in coriander (Coriandrum sativum L. cv. Balady) plants by influencing some physiological activities. The main aim of this work is to investigate the response of (Bs) and (Co) as eco-safe salt stress protectants to resist the effect of salinity, on growth, seed, and essential oil yield, and the most important biochemical constituents of coriander produced under salt stress condition. Therefore, in a split-plot factorial experiment design in the RCBD (randomized complete block design), four levels of salinity of NaCl irrigation water (SA) were assigned to the main plots; (0.5, 1.5, 4, and 6 dS m−1); and six salt stress protectants (SP) were randomly assigned to the subplots: distilled water; 15 ppm (Co1); 30 ppm (Co2); (Bs); (Co1 + Bs); (Co2 + Bs). The study concluded that increasing SA significantly reduced coriander growth and yield by 42.6%, which could be attributed to ion toxicity, oxidative stress, or decreased vital element content. From the results, we recommend that applying Bs with Co (30 ppm) was critical for significantly improving overall growth parameters. This was determined by the significant reduction in the activity of reactive oxygen species scavenging enzymes: superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) and non-enzyme: proline by 5, 11.3, 14.7, and 13.8% respectively, while increasing ascorbic acid by 8% and preserving vital nutrient levels and enhancing plant osmotic potential to buffer salt stress, seed yield per plant, and essential oil yield increased by 12.6 and 18.8% respectively. The quality of essential oil was indicated by highly significant quantities of vital biological phytochemicals such as linalool, camphor, and protein which increased by 10.3, 3.6, and 9.39% respectively. Additional research is suggested to determine the precise mechanism of action of Bs and Co's dual impact on medicinal and aromatic plant salt stress tolerance. [ABSTRACT FROM AUTHOR]

Background: Chronic Kidney Disease (CKD) patients encounter many obstacles that affect their physical and psychological well-being. The primary objective of the present study was to investigate potential correlates of optimism/pessimism in a sample of patients with CKD, including socio-demographics, body appreciation and disordered eating symptoms. As a secondary objective, we proposed to examine the psychometric properties of an Arabic translation of the Optimism–Pessimism Short Scale–2 (SOP2) before its use in our sample. Methods: A cross-sectional study was carried out between April and May 2023, enrolling 108 participants from three hospitals in Lebanon providing insights into their sociodemographic characteristics, physical activity levels, body appreciation, optimism, pessimism, and eating attitudes. Results: Results indicated that the Arabic-language adaptation of the SOP2 has good reliability coefficients. The two facets of the scale displayed a strong correlation to each other, and highly similar correlations with external study variables (i.e., household crowding index, physical activity, body appreciation, disordered eating), suggesting that the SOP2 can be interpreted as a unidimensional measure for the psychological dispositional optimism as proposed by the developers. Furthermore, findings revealed a strong positive correlation between body appreciation and optimism, suggesting that CKD patients who appreciate their bodies tend to exhibit a more optimistic outlook on life. Conversely, higher body appreciation is associated with lower pessimism, indicating that a positive body image may mitigate feelings of hopelessness and despair in CKD patients. Conclusion: This study contributes to the literature in two ways. First, it offers the Arabic SOP2 as an brief tool to administer, and psychometrically sound instrument that can be useful for clinical and research purposes. Second, it unveils a clear correlation between higher body appreciation and a more optimistic, less pessimistic mindset in patients with CKD. [ABSTRACT FROM AUTHOR]

Background: Human activities have significantly contributed to a persistent climate change trend, posing substantial threats to human health. Nurses regularly interact with patients experiencing the consequences of climate change, making their engagement in addressing this issue crucial. Nonetheless, our understanding of nurses' viewpoints regarding climate change remains limited. Aim: This scoping review aims to identify practicing nurses' and nursing students' perceptions of climate change. Design: To fulfil this objective, a documentary search strategy was developed using an iterative process. Methods: The search strategy was tested in four bibliographic databases, as well as in the grey literature. A 2‐stage selection process was conducted, and relevant data were extracted from selected articles for analysis. Results: Twenty‐two scientific articles and 11 documents from nursing associations were selected. The findings suggest that while many nurses and nursing students are concerned about climate change and its effects on their patients' health, their role in addressing the climate crisis is not well understood. Many barriers such as having a heavy workload and the lack of support hindered their ability to adjust their practice in response to the changing climate. Furthermore, many expressed a need for trainings on climate change issues. Conclusions: These results raise a great and urgent demand for these professionals to receive appropriate training to cope with climatic threats to health. Future research should focus on the development of nursing climate leadership, and healthcare organizations should support nursing initiatives and help raise nurses' awareness regarding climate change. [ABSTRACT FROM AUTHOR]

The accurate classification of human activities in crime scenes during forensics (criminalistics) is of utmost importance in classifying suspicious and unlawful activities, easing their acceptability and interpretability by judges during legal procedures in courts or by other non-experts in the field of forensics. This paper implements machine learning (ML) algorithms: support vector machine (SVM) and decision tree (DT), to demonstrate with a high accuracy, how data emanating from smartphones' sensors reveal and isolate relevant information about static and dynamic human activities in criminalistics. Smartphones' data from five different sensors (accelerometer, gravity, orientation, Gyroscope and light), related to ten recurrent crime scenes activities, grouped into three classes of events (normal, felony and none-felony events) are classified by the proposed algorithms, with novelty being the classification decisions based on the entire period of the events and not instantaneous decision makings. Three independent data-subsets were made, with permutations done between them and at each time, two sets used for training and the third set used for testing. Time- and frequency-domain features were initially used separately and then combined for the model training and testing. The best average training accuracies of 100% and 97.8% were obtained for the DT and SVM, respectively, and the testing accuracies of 89.1% were obtained for both algorithms. We therefore believe that these results will serve as a solid persuasive and convincing argument to judges and non-experts of the field of forensics to accept and easily interpret computer-aided classification of suspicious activities emanating from criminalistic studies. [ABSTRACT FROM AUTHOR]

Reducing carbon dioxide (CO2) emissions urgently requires the large-scale deployment of carbon-capture technologies. These technologies must separate CO2 from various sources and deliver it to different sinks1,2. The quest for optimal solutions for specific source–sink pairs is a complex, multi-objective challenge involving multiple stakeholders and depends on social, economic and regional contexts. Currently, research follows a sequential approach: chemists focus on materials design3 and engineers on optimizing processes4,5, which are then operated at a scale that impacts the economy and the environment. Assessing these impacts, such as the greenhouse gas emissions over the plant’s lifetime, is typically one of the final steps6. Here we introduce the PrISMa (Process-Informed design of tailor-made Sorbent Materials) platform, which integrates materials, process design, techno-economics and life-cycle assessment. We compare more than 60 case studies capturing CO2 from various sources in 5 global regions using different technologies. The platform simultaneously informs various stakeholders about the cost-effectiveness of technologies, process configurations and locations, reveals the molecular characteristics of the top-performing sorbents, and provides insights on environmental impacts, co-benefits and trade-offs. By uniting stakeholders at an early research stage, PrISMa accelerates carbon-capture technology development during this critical period as we aim for a net-zero world.A framework that integrates materials, process design, techno-economics and life-cycle assessment can be used to accelerate the development of carbon-capture technology as we aim for a net-zero world. [ABSTRACT FROM AUTHOR]

Chick performance and hatchability are adversely affected by microbial contamination of hatching eggs. Egg disinfection is therefore crucial to limiting bacterial numbers and optimizing production. The present study was applied to detect the effect of hatching eggs spraying (nest and floor) with two commercial disinfectants: A (H2O2, peracetic and acetic acid) and B (glutraldehyde and Benzalkonium chloride) on hatching parameters and eggshell microbial counts. Hatching eggs were collected from broiler breeder flocks at different ages (37, 47 and 57 weeks). The obtained results indicated that both disinfectants reduced the levels of bacteria in similar ways, but there were no significant differences between them. Concerning the hatching parameters; hatchability percentages (total and true) were lower than standard in both nest and floor eggs, and higher hatchability percentages were found in eggs sanitized with disinfectant A. However, the lowest values were reported in eggs of 57 weeks old breeders with both disinfectants. Conclusively, disinfectants A and B reduced the microbial load of hatching eggs of different ages, and some hatchability parameters were affected with flock age and the used disinfectants. [ABSTRACT FROM AUTHOR]

Kidney anion exchanger 1 (kAE1) is an isoform of the AE1 protein encoded by the SLC4A1 gene. It is a basolateral membrane protein expressed by α-intercalated cells in the connecting tubules and collecting duct of the kidney. Its main function is to exchange bicarbonate and chloride ions between the blood and urine to maintain blood pH at physiological threshold. The kAE1 protein undergoes multiple post-translational modifications such as phosphorylation and ubiquitination and interacts with many different proteins such as claudin-4 and carbonic anhydrase II. Mutations in the gene may lead to the development of distal renal tubular acidosis, characterized by the failure to acidify the urine, which may result in nephrocalcinosis and in more severe cases, renal failure. In this review, we discuss the structure and function of kAE1, its post-translational modifications, and protein–protein interactions. Finally, we discuss insights gained from the study of kAE1 mutations in humans and in mice. [ABSTRACT FROM AUTHOR]

Purpose: The aims of this research are to investigate the reasons for adopting big data (BD) and big data analytics (BDA), determine their extent of usage, and identify potential obstacles to their adoption in a developing country, Egypt. Motivation: Prior literature criticized the audit profession for the slow adoption of BDA, and little is known about the adoption of BD and BDA in developing countries. The reluctance to incorporate BD and BDA into auditing can be attributed to their potential obstacles. In addition, prior studies focused on the Big-4 audit firms in developed countries with little known about adopting BD and BDA in local audit firms and developing countries. Design/methodology/approach:To achieve the objectives of this study, 16 audit practitioners with various positions, specializations, and experience levels were interviewed. The 16 participants belong to audit firms of different sizes: international audit firms, local audit firms, and a governmental auditing agency. Thematic analysis was employed through using the MAXQDA software package to analyze the data. Main findings: The findings revealed that the reasons for using BD and BDA go beyond improving audit efficiency and effectiveness and satisfying clients. All audit firms collect and analyze large volumes of traditional accounting data. However, the Big-4 firms manage and analyze non-financial data and new data items as complementary audit evidence. Also, it was found that the type of audit firm affects the use of these technologies, with international firms being superior to other firms. The Accountability State Authority lags behind other audit firms in adopting BD and BDA. Furthermore, it was found that some obstacles to adopting BD and BDA arise due to the specific characteristics of the Egyptian context, while others are universal. Practical implications/Managerial impact: Determining the reasons for and obstacles to adopting BD BDA is useful for audit firms and regulators to remove these obstacles and encourage using such new audit technologies. The findings might help developers of BDA software packages to enhance their packages to meet auditor requirements. Moreover, academic scholars can benefit from the findings of this study by gaining an understanding of the main differences between developed and developing countries in relation to adopting BD and BDA. Novelty/Contribution: This study was conducted in Egypt, a developing country with a an underdeveloped audit environment. Therefore, this study enriches the relevant literature by providing information about BD and BDA in an unexplored developing environment. Besides, it delves deeper into the reasons and obstacles to using BD and BDA in external financial auditing in a developing country. Also, it adds to the literature by identifying the most common BDA software packages and techniques that auditors use in a developing country. Moreover, it considers audit practitioners' viewpoints on audit firms of various sizes. [ABSTRACT FROM AUTHOR]

Considerable attention has been given to the advancement of ferrocement concrete beams. In 12 ferrocement beams, conventional bar reinforcing and two types of mesh were employed in place of stirrups, and the beams were tested with simple support under a centrally concentrated load. It is discussed how various reinforcing methods affect failure loads and the structural response. The utilization of mild steel bars in combination with welded metal mesh in two or three layers results in higher moment than using only welded metal mesh without upper steel bars, regardless of the specific type of welded metal mesh used. Also Flexural strength was much improved when reinforcing ferrocement beams using fiberglass steel mesh and mild steel bars instead of just mild steel stirrups. Finally we can say that mild steel reinforced with welded metal mesh exhibited the most favorable structural performanceFerrocement beams exhibited superior crack control and avoided spalling in contrast to traditional beams. Among the specimens reinforced with fiberglass mesh, those had the lowest occurrence of spalling compared to beams reinforced with welded metal mesh. One practical alternative to traditional reinforced concrete beams is thin ferrocement forms, which have several advantages and are expected to have positive effects on the environment and the economy in both developed and developing nations. [ABSTRACT FROM AUTHOR]

Introduction. The disability Rating Scale (dRS) is a short, efficient, rapid instrument for monitoring general functional recovery from moderate to severe traumatic brain injury (TBi). The 8-item dRS is a published and validated assessment instrument but has not yet been adapted to native Arabic-speaking caregivers of patients with TBi. This study aimed to translate, crossculturally adapt, and test the reliability of the Arabic version of the dRS. Methods. Cross-cultural adaptation and translation were performed according to the recommended guidelines: translation, back-translation, expert review, and pretesting. Reliability was assessed via a test-retest procedure at 2-week intervals using the Kappa coefficient among 42 caregivers of patients with TBi. Results. The agreement among the raters was excellent, varying from 0.88 to 1. Translating the dRS into Arabic was easy based on the translators' information. The test-retest reliability was excellent (interclass correlation coefficient = 0.99 with a 95% Ci 0.998 to 0.999 [F(41) = 1100.7, p < 0.001]. The Cronbach's alpha for the internal consistency of the dRS was 0.917. There was good agreement (convergent validity) between the dRS scores with the Short Form 36 Health Survey Questionnaire [rs(42) = 0.895, p = 0.001]. Conclusions. The Arabic version of the dRS can be used among Arabic-speaking caregivers of patients with TBi. The Arabic translated version of the dRS can be used among caregivers of patients with TBi telephonically by expert professional. The translated questionnaire was easy to comprehend among caregivers of patients with TBi, with excellent test re-test reliability and good convergent validity. [ABSTRACT FROM AUTHOR]

The impacts of climate change on heritage collections in Mediterranean museums are serious and lead to accelerated material degradation, loss of value, increasing conservation costs and climatisation. Climate change scenarios and simulation models have been developed to predict the extreme and average future environmental conditions and to assess the future long-term risks caused by global warming for museum buildings and their collections in Mediterranean countries, with Egypt being particularly at risk. This paper presents the results of the risk analysis of the indoor and outdoor environments in Alexandria Museum of Fine Arts (AMFA) in Egypt to provide an overview of the current situation of conservation and museum management and to provide evidence-based data to support decision-making regarding preventive conservation given the museum's limited funding, capacity and resources. Unfortunately, the air quality in the museum cannot be considered satisfactory and specific measures need to be taken to improve the level of air quality and museum and building management. The results enabled an assessment of indoor air quality and provided information on potential risks to the museum building and collections, including variations in temperature (T) and relative humidity (RH), concentrations of NO2, SO2, O3, CO2, acetic and formic acid and lighting conditions, as well as the location and management of the museum. The results necessitate the development of a preventive conservation plan to address the challenges associated with high T/RH fluctuations and pollution pressure. This requires more regular use of the HVAC system within certain T/RH set points as well as minimising light exposure and the use of UV-filtering glazing. Care should be taken to ensure that housekeeping and emergency preparedness reduce the damping and salt florescence in the museum building. However, dealing with the impact of climate change on indoor and outdoor environments and museum collections in Mediterranean museums requires a holistic and adaptive approach that includes joint collaboration, research, training and strategic planning to ensure the long-term preservation of valuable cultural heritage collections in different climates with customised adaptations based on local environmental conditions, resources and needs. Resilience planning should be region-specific and take into account the potential impacts of extreme weather events, sea level rise and other climate-related challenges. [ABSTRACT FROM AUTHOR]

Ports are vital in the global trading system but are also vulnerable to climate-related threats. This problem has not been widely studied, especially in Egypt. However, there is an urgent need to address climate-related threats to Egyptian ports, which could have significant economic and trade-related consequences. Therefore, exploring the Egyptian port administrations' and stakeholders' perceptions regarding climatic hazards is an urgent and essential matter for sustainable and resilient ports, considering their strategic economic importance. Consequently, this article is the first to examine how the port authorities perceive and respond to climate hazards in one of the most important and largest commercial Egyptian ports; it also explores their adaptation strategies and plans, considering the national agenda to develop the coastal ports respecting the sustainable development pillars, and fills the gaps in regional and national studies on seaports and climatic hazards. The paper focuses on the Great Alexandria Port, which includes the Alexandria and El-Dekheila ports. A questionnaire is designed and distributed in different port sectors for gathering relevant data and conducting interviews, discussions, and workshops. The findings declare obvious concern about developing the Egyptian ports under the national projects umbrella. Also, the port authorities are aware of the risks of climate change and believe some adaptation measures are necessary and could be essential soon. They are taking steps to adapt their ports, considering a specific strategy that includes rehabilitating infrastructure (breakwater and berths), functional facilities, and services, improving drainage systems to enhance their port's resilience, and achieving the 2030 Agenda for Sustainable Development. Our research findings suggest that there are opportunities for scientists to engage with the port stakeholders to proactively develop plans to alleviate climate change's effects on their ports. [ABSTRACT FROM AUTHOR]

As urbanization increases, streetlights have become significant consumers of electrical power, making it imperative to develop effective control methods for sustainability. This paper offers a comprehensive review on control methods of smart streetlight systems, setting itself apart by introducing a novel light scheme framework that provides a structured classification of various light control patterns, thus filling an existing gap in the literature. Unlike previous studies, this work dives into the technical specifics of individual research papers and methodologies, ranging from basic to advanced control methods like computer vision and deep learning, while also assessing the energy consumption associated with each approach. Additionally, the paper expands the discussion to explore alternative functionalities for streetlights, such as serving as communication networks, environmental monitors, and electric vehicle charging stations. This multidisciplinary research aims to be a pivotal resource for both academics and industry professionals, laying the groundwork for future innovation and sustainable solutions in urban lighting. [ABSTRACT FROM AUTHOR]

Background: Considerable improvements in the prognosis of pediatric cancer patients have been achieved over recent decades due to advances in treatment. Nevertheless, as the most common and distressing health issue for pediatrics with cancer, cancer-related pain is still a significant hurdle that impedes patients' journey to recovery, compromises their quality of life, and delays the positive outcome and effectiveness of their treatments. Purpose: Taking into consideration that acceptability studies are imperative for the design, evaluation, and implementation of healthcare interventions, this study aims to explore pediatric oncology patients' readiness to use a mobile health application that emphasizes social assistance and peer support in addition to conventional pain management methods. Design and methods: This study followed the Qualitative description approach. Twelve participants were chosen based on purposive sampling and maximum variation sampling. Interviews were analyzed using the conventional content analysis. Results: Analysis of the interviews revealed four major categories: (A) The need for connectedness; (B) An innovative way to connect yet fearful; (C) A 3D approach; (D) Fears of the unfamiliar. Conclusions: This study is the first in Lebanon and the region to undertake an initiative towards introducing technology for pain assessment and management of children with cancer through a dedicated digital platform. The study results attested to the acceptability and potential utilization of this platform by children with cancer. Practice implications: Nurses need to be trained to play an essential role in teaching children with cancer about the significance of social support and assisting them to establish their social support network. Children with cancer are encouraged to voice out their need for help. Our proposed application can create an enabling environment to harness the power of social support and provide children with cancer the opportunity to connect on a deeper level in a supportive and pity-free space. [ABSTRACT FROM AUTHOR]

In Lebanon, olive oil is an integral part of its history and culinary traditions. However, the quality of this product, originating from different growing regions of the country, is rarely addressed. The objectives of this study were to compare the fatty acids and phenolic profiles of virgin olive oils produced from two local and eight European varieties, and to use these profiles as a tool for their characterization. Seventy-six samples were collected from two olive-growing regions of Lebanon and at two harvesting times. Fatty acid composition was determined by gas chromatography with a flame ionization detector, total phenols was determined by spectrophotometry and individual phenols by high performance liquid chromatography with diode array detector. All samples were also analyzed using near infrared spectroscopy. The experimental data were collected in numerical matrices and treated by chemometric methods. The results showed the significant effect of the geographical origin, the olive variety and the harvesting time on the ripening and industrial yield of the olives and on the major fatty acids and phenols of olive oil. Moreover, the used chemometric methods allowed the discrimination of European olive varieties based on their high contents of oleic acid, oleacein and oleocanthal. [ABSTRACT FROM AUTHOR]

Introduction and hypothesis: Pelvic organ prolapse (POP) is a benign condition that can adversely affect women's quality of life. Minimally invasive mesh sacrocolpopexy is an effective surgical treatment for POP. This study aims to assess the perioperative, postoperative, and long term (10 years) outcome of a single institution cohort undergoing minimally invasive sacrocolpopexy. Methods: This retrospective study included all cases of laparoscopic sacrocolpopexy performed between 2003 and 2016. Patients were contacted by phone in 2022 for long term follow-up. Data on operative time, length of hospital stay, conversion rate, perioperative injuries, early and late postoperative complications and subjective success rates were collected. Results: Ninety-five patients were included aged 60±12 years. Most patients (72%) presented grade 3 POP. Grade of prolapse (3±0.4 vs 3±0.5, p<0.01) and hospital stay (3±1.1 vs 3.1±1.7; p<0.01) were significantly higher in patients who developed early postoperative complications (1st year). At long term follow-up (12±3 years), 48 patients responded. Nine subjects (19%) presented a subjective recurrence with bulge symptoms. Surgery satisfaction was of 79%. The most frequent de novo reported symptom was urge urinary incontinence followed by stress urinary incontinence. Three cases (3%) of mesh erosion were described, all occurred after the 5th postoperative year. Conclusions: Laparoscopic mesh sacrocolpopexy is a safe surgical technique that shows satisfying and consistent long-term results despite the occasional onset of new urinary symptoms. [ABSTRACT FROM AUTHOR]

In this study, the most modern Fiber-Reinforced Polymer (FRP) composites, Basalt Fiber-Reinforced Polymer (BFRP) bars, have been used to reinforce concrete columns as main longitudinal reinforcement bars, under the effect of both concentric and eccentric loading setup, 50 mm from Reinforced Concrete (R.C.) column center. Eight full-scale R.C. columns with longitudinal steel bars or BFRP bars have been tested. The spacing between the mild steel stirrups has been 200 mm. Some of the R.C. columns have been enhanced externally with BFRP wrapping sheets as strips with a width of 100 mm and at a spacing of 200 mm measured from the BFRP wrapping sheet's center and arranged between mild steel stirrups in order to minimize the free length of confinement to study the effect of BFRP wrapping sheets in enhancing of concrete column capacity. The test results have confirmed the significant enhancement in concrete confinement efficiency in BFRP R.C. columns, especially in the concentric case. An analytical study has been carried out to compare the design equations in different codes with each other. In addition, the obtained results yield a proposed design equation for the R.C. column with BFRP bars and strengthened externally with BFRP sheets. [ABSTRACT FROM AUTHOR]

Simple Summary: The availability of multiple gene panel testing allows us to identify germline pathogenic variants of validated cancer genes. We evaluated the prevalence and clinical/prognostic impact of deleterious germline mutations in OC patients. Germline panel testing should be performed for all patients with ovarian cancer. Better prognosis was found for germline mutated ovarian cancer patients. Endometrioid and clear cell histology subtypes show more deleterious mutations in other genes. Data on deleterious variants in genes other than BRCA1/2 remain limited. A retrospective cohort study was performed, including primary OC cases with TruRisk® germline gene panel testing between 2011 and 2020. Patients with testing after relapse were excluded. The cohort was divided into three groups: (A) no mutations, (B) deleterious BRCA1/2 mutations, and (C) deleterious mutations in other genes. A total of 702 patients met the inclusion criteria. Of these 17.4% (n = 122) showed BRCA1/2 mutations and a further 6.0% (n = 42) in other genes. Three-year overall survival (OS) of the entire cohort was significantly longer in patients with germline mutations (85%/82.8% for cohort B/C vs. 70.2% for cohort A, p < 0.001) and 3-year progression-free survival (PFS) only for cohort B (58.1% vs. 36.9%/41.6% in cohort A/C, p = 0.002). In multivariate analysis for the subgroup of advanced-stages of high-grade serous OC, both cohorts B/C were found to be independent factors for significantly better outcome, cohort C for OS (HR 0.46; 95% CI 0.25–0.84), and cohort B for both OS and PFS (HR 0.40; 95% CI 0.27–0.61 and HR 0.49; 95% CI 0.37–0.66, respectively). Germline mutations were detected in a quarter of OC patients, and a quarter of those in genes other than BRCA1/2. Germline mutations demonstrate in our cohort a prognostic factor and predict better prognosis for OC patients. [ABSTRACT FROM AUTHOR]

Tundra environments are experiencing elevated levels of wildfire, and the frequency is expected to keep increasing due to rapid climate change in the Arctic. Tundra wildfires can release globally significant amounts of greenhouse gasses that influence the Earth's radiative balance. Here we develop a novel method for estimating carbon loss and the resulting radiative forcings of gaseous and aerosol emissions from the 2015 tundra wildfires in the Yukon–Kuskokwim Delta (YKD), Alaska. We paired burn depth measurements using two vegetative reference points that survived the fire event – Sphagnum fuscum and Dicranum spp. – with measurements of local organic matter and soil carbon properties to estimate total ecosystem organic matter and carbon loss. We used remotely sensed data on fire severity from Landsat 8 to scale our measured losses to the entire fire-affected area, with an estimated total loss of 2.04 Tg of organic matter and 0.91 Tg of carbon and an average loss of 3.76 kg m -2 of organic matter and 1.68 kg m -2 of carbon in the 2015 YKD wildfires. To demonstrate the impact of these fires on the Earth's radiation budget, we developed a simple but comprehensive framework to estimate the radiative forcing from Arctic wildfires. We synthesized existing research on the lifetime and radiative forcings of gaseous and aerosol emissions of CO 2 , N 2 O, CH 4 , O 3 and its precursors, and fire aerosols. The model shows a net positive cumulative mean radiative forcing of 3.67 W m -2 using representative concentration pathway (RCP) 4.5 and 3.37 W m -2 using RCP 8.5 at 80 years post-fire, which was dominated by CO 2 emissions. Our results highlight the climate impact of tundra wildfires, which positively reinforce climate warming and increased fire frequency through the radiative forcings of their gaseous emissions. [ABSTRACT FROM AUTHOR]

Plant-derived nanovesicles (PDNVs) have become attractive alternatives to mammalian cell-derived extracellular vesicles (EVs) both as therapeutic approaches and drug-delivery vehicles. In this study, we isolated tomato fruit-derived NVs and separated them by the iodixanol density gradient ultracentrifugation (DGUC) into twelve fractions. Three visible bands were observed at densities 1.064 ± 0.007 g/mL, 1.103 ± 0.006 g/mL and 1.122 ± 0.012 g/mL. Crude tomato PDNVs and DGUC fractions were characterized by particle size-distribution, concentration, lipid and protein contents as well as protein composition using mass spectrometry-based proteomics. Cytotoxicity and anti-inflammatory activity of the DGUC fractions associated to these bands were assessed in the lipopolysaccharide (LPS)-stimulated human monocytic THP-1 cell culture. The middle and the low-density visible DGUC fractions of tomato PDNVs showed a significant reduction in LPS-induced inflammatory IL-1β cytokine mRNA production. Functional analysis of proteins identified in these fractions reveals the presence of 14-3-3 proteins, endoplasmic reticulum luminal binding proteins and GTP binding proteins associated to gene ontology (GO) term GO:0050794 and the regulation of several cellular processes including inflammation. The most abundant middle-density DGUC fraction was loaded with curcumin using direct loading, sonication and extrusion methods and anti-inflammatory activity was compared. The highest entrapment efficiency and drug loading capacity was obtained by direct loading. Curcumin loaded by sonication increased the basal anti-inflammatory activity of tomato PDNVs. [ABSTRACT FROM AUTHOR]

To maximize the economic benefits of Hyacinthus orientalis L., the micropropagation and morphogenesis induction of five Hyacinthus cultivars were investigated under four different concentrations of indole acetic acid (IAA) with two cytokinins, benzyl adenine (BA), or kinetin (Kin). Days for morphogenesis initiation and shoot formation in the red cultivars were fewer than in the blue and white cultivars. Blue cultivars showed an increase in fresh weight and chlorophyll content under either BA or Kin, but they showed an increase in shoot height in the BA treatments only. IAA at 1.5 mg/L caused a time reduction in days for morphogenesis induction and shoot formation and enhanced shoot height and fresh weight. Kin had a lesser impact than BA on all parameters at all concentrations. The number of shoots differed significantly among the cultivars. The Murashige and Skoog (MS) medium supplemented with 3.0 mg/L indole-3-butyric acid (IBA) produced the highest percentage of root formation (93.3%), number of roots/plantlet (5.26), and root length (1.10 cm). The Jan Bos cultivar at 3.0 mg/L IBA had the highest mean rooting percentage (100%) and number of roots per plantlet (6.66), while Pink Pearl had the highest root length (1.39 cm). [ABSTRACT FROM AUTHOR]

Simple Summary: Testing for a homologous recombination deficiency (HRD) in primary high-grade ovarian cancer is crucial for recommending the appropriate therapy. Patients with a BRCA germline mutation are defined as harboring an HRD deficiency. However, there is a group of approximately 20% of patients without a BRCA mutation which harbor an HRD deficiency based on tumor genomic analyses. In the current research, we wanted to share the experience of a high-volume tertiary cancer center with implementing central HRD testing—in another institution—to reduce doubts about logistic issues and to the highlight critical aspects that hinder HRD testing. We showed that the results of HRD testing became available in a timely manner for the therapy decision. However, it was important to obtain as much tumor tissue as possible during the first diagnosis—before any other intervention—as the tumor quantity and quality were critical for HRD testing. Additional BRCA germline testing further reduced the failures of HRD testing and should additionally be routinely conducted. The chemotherapy backbone for patients with high-grade advanced epithelial ovarian cancer (HG-AOC) is carboplatin and paclitaxel followed by a maintenance therapy either with bevacizumab, with a PARP inhibitor, or with a combination of both, which is defined by the presence of a homologous recombination deficiency (HRD) and by the BRCA1/2 status. This study included patients with a primary diagnosis of HG-AOC treated between December 2019 and December 2021. The HRD status was measured using the Myriad myChoice® test on all the patients with an indication for tumor HRD testing. Germline testing was conducted on all the patients using the TruRisk® panel as recommended by the national guidelines. HRD testing was requested for 190 patients, and, for 163 patients (85.8%), an HRD test result was available. An HRD test result could not be reported in 27 patients due to an insufficient tumor yield. The median time that it took to receive the HRD test results was 37 days (range of 8–97). In total, an HRD was present in 44.7% (73/163) of the patients based on a GIS ≥ 42 in 42.9% of the patients and based on a tumor BRCA1/2 mutation in 3 cases (all with a GIS < 42). The germline testing results were available for 148 patients, and, in 18 patients (12.2%), a deleterious germline mutation was detected. Of the 27 patients without sufficient HRD testing, BRCA1/2 germline testing results were available for 19 patients (70.4%), and a deleterious germline mutation was detected in 2 patients (7.4%). The implementation of HRD testing is feasible, and the results become available for treatment decisions in a timely manner for most patients. The prerequisite for HRD testing with the Myriad myChoice® test is a sufficient amount of tumor tissue. The cotesting of HRD and BRCA1/2 germline testing should be aimed for in order to enable optimal and timely treatment decisions on maintenance therapy as well as to test patients on whom the HRD test will not be evaluable. [ABSTRACT FROM AUTHOR]

Background: To date, the vast majority of research on disordered eating symptomatology and body image disturbances from the Arab world have been performed exclusively among women; and mainly used thinness-oriented measures that are not sensitive to detect muscularity-oriented symptoms, which are more evident in males. Therefore, the objective of our study was to validate the Arabic version of the Muscle Dysmorphic Disorder Inventory (Ar-MDDI), in order to make it accessible for Arabic-speaking populations. Methods: Using a snowball sampling technique, men university students (n = 396) from multiple universities in Lebanon filled the survey in this cross-sectional designed study (January–May 2022). A soft copy of the questionnaire was created using google forms software, and sent to participants through the different social media platforms such as Facebook, Instagram, and WhatsApp. We used the Muscle Dysmorphic Disorder Inventory to assess Muscle Dysmorphia, along with the Big Three Perfectionism Scale to assess perfectionism and Eating Attitude Test (EAT) to evaluate the inappropriate eating attitudes. To explore the factor structure of Ar-MDDI, we computed a principal-axis Exploratory Factor Analysis (EFA) with the first split-half subsample using the FACTOR software. We used data from the second split-half to conduct a Confirmatory Factor Analysis (CFA) using the SPSS AMOS v.29 software. Pearson correlation test was used to test the convergent and divergent validity of the Ar-MDDI scale with the other scores included in the study. Results: The results of the EFA revealed three factors, which explained 57.68% of the common variance: Factor 1 = Appearance intolerance, Factor 2 = Drive for size, and Factor 3 = Functional impairment. The CFA fit indices of the three-factor model of the Ar-MDDI scale showed good results. Moreover, 254 (64.1%) of the participants had inappropriate eating attitudes (EAT scores ≥ 20). Indices suggested that configural, metric, and scalar invariance was supported according to eating attitudes. No significant difference between participants with appropriate versus inappropriate eating attitudes in terms of functional impairment, drive for size and appearance intolerance. Perfectionism scores correlated positively with the Ar-MDDI, which suggests divergent validity. Conclusion: Our findings revealed that the validation of the Arabic scale yielded excellent properties, preliminarily supporting its use for the assessment of muscle dysmorphia among Arabic-speaking university men. This would hopefully allow for its timely detection and management in Arab clinical settings and encourage cross-cultural research on this topic. Plain English Summary: Muscle dysmorphic disorder (MDD) refers to an important muscularity-oriented dimension related to eating disorder (ED) symptoms and body image disturbances. One widely used self-report measure to assess the MDD construct is the Muscle Dysmorphic Disorder Inventory (MDDI). Despite its high clinical relevance, MDD has not been previously investigated in the Lebanese context and among the Arabic-speaking communities in general. Indeed, the multiple scales assessing ED symptomatology that have previously been translated to the Arabic language and adapted to the Lebanese population have been mainly focused on thinness-oriented ED; and no Arabic validation of muscularity-oriented body image and disordered eating symptoms measures, including the MDDI, exists so far to the best of our knowledge. To overcome this gap, the present study aimed to validate the Arabic version of the MDDI (Ar-MDDI) in a sample of Lebanese men university students. The findings showed that the AR-MDDI is robust in terms of reliability, factor structure, convergent and divergent validity. We, therefore, preliminarily recommend its use in clinical practice, preventive interventions and future research in Arab settings. [ABSTRACT FROM AUTHOR]

Background: The literature highly concentrates on disorders related to body image among women but only minimally when it comes to the male population; hence, in order to provide general practitioners, and primary care physicians in general, and psychiatrists in particular, with additional information concerning muscle dysmorphia among male university students in Lebanon, this study seemed essential, and was therefore conducted to (1) identify the prevalence of MDD, and (2) evaluate the indirect effect of eating attitudes in general and orthorexia nervosa in particular, in the association between perfectionism and muscle dysmorphic disorder (MDD) among a sample of male university students. Methods: In this cross-sectional study conducted between September 2021 and May 2022, 396 male university students from multiple universities in Lebanon filled the online Arabic questionnaire. Results: The results showed that 26 (6.6%) of the participants had MDD. Orthorexia nervosa and eating attitudes mediated the association between perfectionism and MDD; higher perfectionism was significantly associated with higher ON and more inappropriate eating; higher ON and more inappropriate eating were significantly associated with higher MDD, whereas perfectionism had a significant total direct effect on MDD. The high prevalence of MDD among male university students in Lebanon implies further investigation on the national level in the country. Conclusion: Awareness campaigns among the university students could be adopted at the national level to increase the level of knowledge on the concepts of obsessive self-destructive perfectionism, orthorexia nervosa and muscle dysmorphia. [ABSTRACT FROM AUTHOR]

Background: Climate change is a major threat to human health. Nurses are in contact with patients suffering from the effects of climate change in their daily work. Therefore, they need to be involved in combating it at both the individual and collective levels. However, there is still very little known about nurses' perception of climate change and their role toward it. A few recent studies have embarked on the process of examining the perceptions of these health professionals relative to climate change, but no exploratory review of the literature has been conducted on nurses' perception of this phenomenon. Objective: The purpose of this protocol is to develop a research strategy for an exploratory review of the literature focused on identifying nurses' perceptions of climate change. Methods: Firstly, with the help of a specialized librarian, we defined keywords and their combinations, using an iterative process, to develop a documentary search strategy. This strategy was tested in the following four bibliographic databases: MEDLINE (PubMed), CINAHL, Embase, and Web of Science. A search of the grey literature will also be conducted to supplement the results of the bibliographic database search. The next step will be for 2 members of the research team to carry out a 2-stage selection process using the web-based systematic review software Covidence. They will carry out this selection process independently, with the aim of identifying relevant studies that meet the inclusion criteria for our exploratory review. Finally, data on year of publication, authors, geographic area, article type, study objectives, methodology, and key findings will be extracted from selected articles for analysis. The data will be analyzed by the research team based on an in-depth examination of the findings and will be directed toward answering the research question and fulfilling the study's objective. Results: The results will help in defining nurses' perceptions of climate change more clearly as well as the role they can play and what they need to be able to bring forward solutions to this phenomenon. The findings should also serve to guide the health sector and nursing faculty's interventions aimed at preparing health professionals to act on the potential threats associated with climate change. Conclusions: The preliminary search suggests a possible gap between the importance of the nursing role in addressing the health impacts of climate change and the nurses' lack of knowledge and awareness on this matter. The results will allow for raising nurses' awareness of their role in the fight against climate change and the ways to address its health effects. This study will also open up new research perspectives on how to equip nurses to better integrate response to climate change issues into their professional practice. [ABSTRACT FROM AUTHOR]

Copyright of Cinq Continents is the property of University of Bucharest, Faculty of Geography and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: Multiple groups have reported on the usefulness of ablating in atrial regions exhibiting abnormal electrograms during atrial fibrillation (AF). Still, previous studies have suggested that ablation outcomes are highly operator‐ and center‐dependent. This study sought to evaluate a novel machine learning software algorithm named VX1 (Volta Medical), trained to adjudicate multipolar electrogram dispersion. Methods: This study was a prospective, multicentric, nonrandomized study conducted to assess the feasibility of generating VX1 dispersion maps. In 85 patients, 8 centers, and 17 operators, we compared the acute and long‐term outcomes after ablation in regions exhibiting dispersion between primary and satellite centers. We also compared outcomes to a control group in which dispersion‐guided ablation was performed visually by trained operators. Results: The study population included 29% of long‐standing persistent AF. AF termination occurred in 92% and 83% of the patients in primary and satellite centers, respectively, p = 0.31. The average rate of freedom from documented AF, with or without antiarrhythmic drugs (AADs), was 86% after a single procedure, and 89% after an average of 1.3 procedures per patient (p = 0.4). The rate of freedom from any documented atrial arrhythmia, with or without AADs, was 54% and 73% after a single or an average of 1.3 procedures per patient, respectively (p < 0.001). No statistically significant differences between outcomes of the primary versus satellite centers were observed for one (p = 0.8) or multiple procedures (p = 0.4), or between outcomes of the entire study population versus the control group (p > 0.2). Interestingly, intraprocedural AF termination and type of recurrent arrhythmia (i.e., AF vs. AT) appear to be predictors of the subsequent clinical course. Conclusion: VX1, an expertise‐based artificial intelligence software solution, allowed for robust center‐to‐center standardization of acute and long‐term ablation outcomes after electrogram‐based ablation. [ABSTRACT FROM AUTHOR]

This article highlights the effects of Digital Transformation as a General Purpose Technology and bank stability on banking inclusion and thus on financial inclusion in Sub‐Saharan African countries. We use simultaneous panel model estimates covering 36 Sub‐Saharan African countries from 2004 to 2017. The results show positive and significant effects of digital transformation as general purpose technology and bank stability on financial inclusion. The results show also that the effect of digital transformation on financial inclusion is more substantial when the banking sector is stable. [ABSTRACT FROM AUTHOR]

This study describes the duration and reasons for hospitalisation for three cohorts of younger adults with neurological conditions who either used residential aged care (RAC) or lived in the community. Hospitalisations as a clinical event indicate conditions for which younger people in RAC may need support as they move into community‐based housing. Data describing 3 years of hospitalisations in Victorian public hospitals and emergency departments were used. The neurological conditions occurring among the three cohorts include (1) Cerebral Vascular Accident (CVA), (2) Traumatic Brain Injury (TBI) and (3) Multiple Sclerosis (MS). Frequency of hospitalisation, length of stay and leading causes of potentially preventable hospitalisations were examined. Two hundred and fifty‐two (2.7%) of 9333 patients hospitalised for these neurological conditions subsequently used RAC. Hospitalisations were more frequent for those using RAC compared to those living in the community for cohorts with CVA and TBI (6.26 vs. 2.65 events per person‐year for CVA and 4.34 vs. 1.88 for TBI) while hospitalisations were more frequent among those in the community compared to those using RAC for the cohort living with MS (3.62 vs. 5.35 per person‐year). However, for all the cohorts, the average length of acute hospital stays was longer among RAC users than among those in the community (19.6 vs. 6.2 days for CVA, 15.5 vs. 4.5 for TBI and 12.2 vs. 7.0 for MS). Leading causes for hospitalisation were complex comorbidities and changes in health status (such as seizures, ulcers, dehydration and cellulitis). Efforts should be made to design supports and proactively manage health needs leading to these hospitalisations. [ABSTRACT FROM AUTHOR]

Aim: Amphibian populations are threatened globally by anthropogenic change and Batrachochytrium dendrobatidis (Bd), a fungal pathogen causing chytridiomycosis disease to varying degrees of severity. A closely related new fungal pathogen, Batrachochytrium salamandrivorans (Bsal), has recently left its supposed native range in Asia and decimated some salamander populations in Europe. Despite being noticed initially for causing chytridiomycosis‐related population declines in salamanders, Bsal can also infect anurans and cause non‐lethal chytridiomycosis or asymptomatic infections in salamanders. Bsal has not yet been detected in the United States, but given the United States has the highest salamander biodiversity on Earth, predictive assessments of salamander risk to Bsal infection will enable proactive allocation of research and conservation efforts into disease prevention and mitigation. Location: The United States, Europe and Asia. Methods: We first predicted the environmental suitability for the Bsal pathogen in the United States through an ecological niche model based on the pathogen's known native range in Asia, validated on the observed invasive range in Europe using bioclimatic, land cover, elevation, soil characteristics and human modification variables. Second, we predicted the susceptibility of salamander species to Bsal infection using a machine‐learning model that correlated life history traits with published data on confirmed species infections. Finally, we mapped the geographic ranges of the subset of species that were predicted to be susceptible to Bsal infection. Results: In the United States, the overlap of environmental suitability and susceptible salamander species was greatest in the Pacific Northwest, near the Gulf of Mexico, and along the Atlantic coast, and in inland states east of the Plains region. Main Conclusions: The overlap of these metrics identify salamander populations that may be at risk of developing Bsal infection and suggests priorities for pre‐emptive research and conservation measures to protect at‐risk salamander species from an additional pathogenic threat. [ABSTRACT FROM AUTHOR]

Action potential (AP) shape is a critical electrophysiological parameter, in particular because it strongly modulates neurotransmitter release. As it greatly varies between neuronal types, AP shape is also used to distinguish neuronal populations. For instance, AP duration ranges from hundreds of microseconds in cerebellar granule cells to 2-3 ms in SNc dopaminergic (DA) neurons. While most of this variation across cell types seems to arise from differences in the voltage- and calcium-gated ion channels expressed, a few studies suggested that dendritic morphology also affects AP shape. AP duration also displays significant variability in a same neuronal type, although the determinants of these variations are poorly known. Using electrophysiological recordings, morphological reconstructions, and realistic Hodgkin--Huxley modeling, we investigated the relationships between dendritic morphology and AP shape in rat SNc DA neurons from both sexes. In this neuronal type where the axon arises from an axon-bearing dendrite (ABD), the duration of the somatic AP could be predicted from a linear combination of the ABD and non-ABDs' complexities. Dendrotomy experiments and simulation showed that these correlations arise from the causal influence of dendritic topology on AP duration, due in particular to a high density of sodium channels in the somatodendritic compartment. Surprisingly, computational modeling suggested that this effect arises from the influence of sodium currents on the decaying phase of the AP. Consistent with previous findings, these results demonstrate that dendritic morphology plays a major role in defining the electrophysiological properties of SNc DA neurons and their cell- to-cell variations. [ABSTRACT FROM AUTHOR]

Copyright of RumeliDE Journal of Language & Literature Research / RumeliDE Dil ve Edebiyat Araştırmaları Dergisi is the property of RumeliDE Uluslararasi Hakemli Dil & Edebiyat Arastirmalari Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Vincristine is an essential component of rhabdomyosarcoma treatment. However, it can cause motor neurotoxicity, necessitating dose reductions. We retrospectively reviewed the rates and patterns of vincristine-induced motor neuropathy in children treated for rhabdomyosarcoma, and investigated effects on outcome. Fifteen of 43 patients (35%) developed motor neuropathies necessitating dose reductions, which ranged from 1.7% to 58% of planned cumulative dose. Older age was the only significant clinical risk factor. Almost half (47%) recovered during treatment with subsequent dose escalation. Most patients had complete resolution of symptoms upon follow-up. There was no discernible effect of treatment reduction on survival or relapse rates. [ABSTRACT FROM AUTHOR]

Simple Summary: Gastric cancer is mainly linked to Helicobacter pylori infection. It is therefore important to decipher the mechanisms involved in H. pylori-induced gastric carcinogenesis, and especially the early events. We have previously demonstrated that the infection leads to an epithelial-to-mesenchymal transition (EMT) favoring gastric carcinogenesis. H. pylori infection is also associated with high levels of oxidative stress. In this work, we aimed at investigating the modulation of Nrf2, a major regulator of cellular antioxidant response to oxidative stress, upon infection with H. pylori and to decipher its implication in EMT. We demonstrated that H. pylori-induced Nrf2 downregulation may participate in gastric cells' EMT, one crucial tumorigenic event in gastric cancer. These results could pave the way for new therapeutic strategies using Nrf2 modulators to reduce gastric carcinogenesis associated with H. pylori infection. Background: Gastric cancer, the fifth most common cancer worldwide, is mainly linked to Helicobacter pylori infection. H. pylori induces chronic inflammation of the gastric mucosa associated with high oxidative stress. Our study aimed at assessing the implication of Nrf2, a major regulator of cellular redox homeostasis, in H. pylori-induced gastric carcinogenesis. Methods: Using three different gastric epithelial cell lines, a non-cancerous (HFE-145) and two different subtypes of gastric cancer (AGS and MKN74), we analyzed the modulation of Nrf2 expression over time. After invalidation of Nrf2 by CRISPR-cas9, we assessed its role in H. pylori-induced epithelial-to-mesenchymal transition (EMT). Finally, we evaluated the expression of Nrf2 and ZEB1, a central EMT transcription factor, in human gastric tissues. Results: We first demonstrated that the Nrf2 signaling pathway is differentially regulated depending on the infection stage. Rapidly and transiently activated, Nrf2 was downregulated 24 h post-infection in a VacA-dependent manner. We then demonstrated that Nrf2 invalidation leads to increased EMT, which is even exacerbated after H. pylori infection. Finally, Nrf2 expression tended to decrease in human patients' gastric mucosa infected with H. pylori. Conclusions: Our work supports the hypothesis that Nrf2 downregulation upon H. pylori infection participates in EMT, one of the most important events in gastric carcinogenesis. [ABSTRACT FROM AUTHOR]

Tundra environments are experiencing elevated levels of wildfire, and the frequency is expected to keep increasing due to accelerating climate change in the Arctic. Tundra wildfires can release globally significant amounts of greenhouse gasses that influence the Earth's radiative balance. Here we develop a novel method for estimating carbon loss and the resulting radiative forcings of gaseous and aerosol emissions from 2015 tundra wildfires in the Yukon-Kuskokwim Delta (YKD), AK. We paired burn depth measurements using two vegetative reference points that survived the fire event--Sphagnum fuscum and Dicranum spp.--with measurements of local organic matter and soil carbon properties to estimate total ecosystem organic matter and carbon loss. We used remotely-sensed data of fire severity from Landsat 8 to scale our measured losses to the entire fire-affected area, with an estimated total loss of 2.04 Tg of organic matter and 0.91 Tg of carbon, and an average loss of 3.76 kg m-2 of organic matter and 1.68 kg m-2 of carbon in the 2015 YKD wildfires. To demonstrate the impact of these fires on Earth's radiation budget, we developed a simple but comprehensive framework to estimate the radiative forcing from Arctic wildfires. We synthesized existing research on the lifetime and radiative forcings of gaseous and aerosol emissions of CO2, N2O, CH4, O3 and its precursors, and fire aerosols. The model shows a net positive cumulative mean radiative forcing of 3.67 W m-2 using RCP 4.5 and 3.37 W m-2 using RCP 8.5 at 80 years post-fire, which was dominated by CO2 emissions. Our results highlight the climate impact of tundra wildfires, which positively reinforce climate warming and increased fire frequency through the radiative forcings of their gaseous emissions. [ABSTRACT FROM AUTHOR]

Lightweight reinforced concrete (LWC) is widely used in various reinforced concrete (RC) applications, such as its use in diverse types of reinforced concrete slabs. The aim of this study is to analyze the behavior of reinforced foam concrete slabs (flat slab type) that are exposed to fire conditions under the influence of eccentric loads as well as concentric loads. This analysis has been done using the finite element method by a (ANSYS) software program. The validity of the adopted models was verified through comparison with a previous experimental study. The studied specimens were eleven reinforced concrete flat slabs with a thickness of 150 mm. The lightweight polystyrene foam concrete was used in these specimens with a density of 1820 kg/m3. The results showed that the fire effect lead to a decrease in the maximum carrying load of foam concrete slabs by 25%. Also, by comparing the finite element results with the selected experimental study, the results showed a great agreement with the analytical study used in this research. [ABSTRACT FROM AUTHOR]

The need to reduce carbon emissions has recently become prevalent in light of concerns related to climate change. Since the cement industry causes approximately 8% of global CO2 emissions, it might be an urgent necessity to include cement replacement materials within the concrete industry. An important question arises about if such replacement negatively affects the cyclic or seismic behavior of reinforced concrete (RC) elements. This research presents an experimental investigation of the effect of using different percentages of metakaolin replacement on the monotonic and cyclic behavior of RC beams. The investigated parameters include the flexural strength, ductility and energy dissipation capacity of the tested beams. The current paper also aims to study the effect of using the CFRP-strengthening technique with 15% metakaolin replacement on the behavior of RC beams under the same loading protocols. The experimental results reveal that metakaolin can be used as a partial substitute for cement up to 20% without negative effect on the concrete behavior under both loading protocols. For cyclic loading, the percentage of replacement did not negatively affect the ductility; rather, it provided some improvement. [ABSTRACT FROM AUTHOR]