Search

INTRODUCTION Maternal smoking during pregnancy disturbs fetal lung development, and induces in their offspring childhood respiratory diseases. Whether it has a continued impact on offspring adult lung health and exerts a casual effect of chronic respiratory diseases (CRDs), remains uncertain. We seek to determine the causal relationships between maternal smoking around birth and offspring adult CRDs, using summary data from previously described cohorts. METHODS Mendelian randomization (MR) study was used to analyze the genome-wide associations of maternal smoking around birth and offspring adult CRDs, including respiratory insufficiency, chronic obstructive pulmonary disease (COPD), related respiratory insufficiency, emphysema, COPD, COPD hospital admissions, early onset of COPD, later onset of COPD, asthma, idiopathic pulmonary fibrosis (IPF), lung cancer (LC), small cell lung carcinoma (SCLC), and lung squamous cell carcinoma (LUSC). RESULTS After removing single-nucleotide polymorphisms (SNPs) associated with smoking by the offspring, maternal smoking around birth was associated with increased risk of offspring adult respiratory diseases (OR=1.14; 95% CI: 1.013-1.284; p=0.030), respiratory insufficiency (OR=2.413; 95% CI: 1.039-5.603; p=0.040), COPD (OR=1.14; 95% CI: 1.013-1.284; p=0.003), and asthma (OR=1.336; 95% CI: 1.161-1.538; p<0.001). Besides, maternal smoking during pregnancy was associated with a greater risk of LUSC (OR=1.229; 95% CI: 0.992-1.523; p=0.059) than the risk of IPF (0R=1.001; 95% CI: 0.999-1.003; p=0.224), LC (0R=1.203; 95% CI: 0.964-1.501; p=0.103), or SCLC (OR=1.11; 95% CI: 0.77-1.601; p=0.577). CONCLUSIONS In this MR analysis, maternal smoking around birth caused a strong risk factor for the offspring to develop lung problems and CRDs in adulthood. The policy related to smoking cessation for mothers during pregnancy should be encouraged. [ABSTRACT FROM AUTHOR]

Summary: Obesity may track across generations, due to genetics and shared family environmental factors, or possibly intrauterine programming. However, many studies only assess associations between maternal body mass index (BMI) and offspring BMI in childhood. To determine whether maternal and paternal associations with offspring BMI differ and whether associations persist into adulthood, a systematic review and meta‐analysis was done. PubMed, Embase, Web of Science, and Google Scholar (to October 2022) were searched. Observational studies reporting associations between maternal or paternal BMI and adult offspring BMI were included. Offspring BMIs were reported as continuous or categorical measures. Forty‐six studies were included in the systematic review. Meta‐analyses were conducted using random‐effects models. Parental BMI was positively associated with offspring BMI in adulthood. The pooled mother–offspring standardized mean difference (SMD) was 0.23 (95% confidence interval [CI]: 0.20, 0.26), and father–offspring SMD was similar: 0.22 (95% CI: 0.19, 0.25) in adjusted models. Offspring of mothers with overweight or obesity had the same risk of higher BMI as offspring of fathers with overweight or obesity. If these associations are causal, they support interventions targeting all family members, rather than focusing solely on mothers, to obtain a healthy weight development among offspring. [ABSTRACT FROM AUTHOR]

Background: Based on evidence there are accepted links among early nutrition, epigenetic processes, and cognitive performance. Almond as a nutritious food could exert neuroprotective effects and improve anxiety, learning, and memory. Methods: In the current study, female rats were fed with a diet containing 5% (w/w) almonds during the mating period (two days) and gestation period (21 consecutive days). Then, the effect of the almond diet on short-term memory (Y maze), anxiety (elevated plus maze), and stress adaptation (forced swimming test) were investigated in the adult male offspring. The hippocampus (HIP), prefrontal cortex (PFC), and amygdala (AMY) of offspring were collected, and the level of cyclic AMP response element-binding proteins (CREB), brain-derived neurotrophic factor (BDNF) was assessed by western blotting. Also, Monoamine oxidases (MAO)-A and B activity were evaluated via enzymatic assays. Results: Our results indicated that prenatal almond consumption improved memory, made a modest reduction in anxiety-like behavior, and increased stress adaptation in adult male offspring. Also, molecular assessments showed an increased level of CREB phosphorylation and BDNF in the HIP and PFC of the almond group, while the activity of MAO-A and MAO-B was inhibited by almond consumption in mentioned areas. Discussion: These findings introduce almonds as a beneficial diet during pregnancy, for improving short-term memory, stress adaptation, and cognitive performance in adult offspring. [ABSTRACT FROM AUTHOR]

Introduction: Preeclampsia (PE) enhances the vulnerability of adult offspring to serious illnesses. The current study investigated whether preeclamptic fetal programming impacts hemodynamic and renal vasodilatory disturbances in endotoxic adult offspring and whether these interactions are influenced by antenatal therapy with pioglitazone and/or losartan. Methods: PE was induced by oral administration of L-NAME (50 mg/kg/day) for the last 7 days of pregnancy. Adult offspring was treated with lipopolysaccharides (LPS, 5 mg/kg) followed 4-h later by hemodynamic and renovascular studies. Results: Tail-cuff measurements showed that LPS decreased systolic blood pressure (SBP) in male, but not female, offspring of PE dams. Moreover, PE or LPS reduced vasodilations elicited by acetylcholine (ACh, 0.01-7.29 nmol) or N-ethylcarboxamidoadenosine (NECA, 1.6-100 nmol) in perfused kidneys of male rats only. The latter effects disappeared in LPS/PE preparations, suggesting a postconditioning action for LPS against renal manifestation of PE. Likewise, elevations caused by LPS in serum creatinine and inflammatory cytokines (TNFα and IL-1β) as well as in renal protein expression of monocyte chemoattractant protein-1 (MCP-1) and AT1 receptors were attenuated by the dual PE/LPS challenge. Gestational pioglitazone or losartan reversed the attenuated ACh/NECA vasodilations in male rats but failed to modify LPS hypotension or inflammation. The combined gestational pioglitazone/losartan therapy improved ACh/NECA vasodilations and eliminated the rises in serum IL-1β and renal MCP-1 and AT1 receptor expressions. Conclusion: Preeclamptic fetal programming of endotoxic hemodynamic and renal manifestations in adult offspring depends on animal sex and specific biological activity and are reprogrammed by antenatal pioglitazone/losartan therapy. [ABSTRACT FROM AUTHOR]

The onset of complex diseases at a later stage of life has been linked with maternal folic acid (FA) ingestion. However, little is known regarding the underlying molecular fingerprints of the offspring. We integrated proteomics–metabolomics profiles and analyzed the influence of maternal FA supplementation on the metabolism of adult offspring rats. Twenty pregnant female rats were randomly assigned to a FA supplementation (FolS group, 10 mg/kg FA) or control group (2 mg/kg FA respectively). Such an omics approach revealed that the dopaminergic synapse pathway, tricarboxylic acid cycle and neural development‐related metabolites such as glutamic acid and γ‐aminobutyric acid were significantly up‐regulated in the FolS group, whereas pyruvic acid, oxalic acid and adipic acid were reduced. Maternal FA supplementation can cause alterations of metabolites and protein in the offspring rats. [ABSTRACT FROM AUTHOR]

Purpose: The objective of this paper is to synthesize a systematic review and showcase the findings of how interparental conflict affects the adult offspring’s relationship satisfaction. Approach: The paper follows a systematic review approach adhering to PRISMA Guidelines. Findings: Three major themes were identified by the researcher that explained the consequences of interparental conflict on adult offspring. The themes are - Offspring Factors, Offspring factors feature the significant components and factors of offspring that highlight the differences in impact of interparental conflict on one’s own romantic relationship; Consequences of Interparental Conflict on Offspring, which highlights the various corollaries on offspring of divorce; and Parent Factors help understand the different parental elements that affect relationship satisfaction of adult offspring. Limitations: 4 full text articles could not be accessed by the author, and hence were not accounted for in the study. Practical Implications: The study helps practitioners comprehend the extensive effects of interparental conflict for usage in therapeutic setups. It also highlights research gaps in existing literature such as lack of studies focusing on men, LGBTQ+ population, children from polygamous families and multicultural cohorts. Value/Originality: Despite the numerous studies published on the topic interparental conflict and its effects on adult offspring, no review has been done to the author’s knowledge, thereby limiting the accessibility of precise information. The research aims to bridge this gap, and make comprehensive findings easily accessible. [ABSTRACT FROM AUTHOR]

This study aimed to examine the caregiver burden among offspring of Holocaust survivors (OHS) caring for their parents during the COVID-19 pandemic, hypothesizing that caregivers whose parents suffer from posttraumatic stress disorder (PTSD) would report an increased burden. The sample consisted of 109 caregivers with older adult care recipient parents (average caregivers' age = 57.67, SD = 8.49). Caregivers were divided into three groups: 20 OHS who reported that at least one care recipient had PTSD, 60 OHS who reported that their care recipients did not have PTSD, and 29 comparison caregivers (whose care recipients did not undergo the Holocaust). Caregivers completed questionnaires about SARS-CoV-2 exposure, COVID-19 concerns, helping their care recipients, their experiences of caregiver burden, and perceived changes to their caregiver burden during the pandemic. The caregivers also reported PTSD symptoms-in themselves as well as in their care recipients. Relative to comparisons, OHS with parental PTSD reported higher caregiver burden in four aspects: time-dependent burden, developmental burden, physical burden, and social burden. Furthermore, OHS reported a greater perceived increase in caregiver burden during the pandemic than the comparisons. The study findings illuminate the difficulties OHS caregivers, especially those whose care recipients have PTSD, face during the COVID-19 pandemic. This group of caregivers is at risk of experiencing more distress and may need help and support. Further research is needed to determine whether people taking care of their posttraumatic parents following other massive traumatic events also feel a heavier caregiver burden-both in general and specifically during the current pandemic. [ABSTRACT FROM AUTHOR]

Evidence is building for an association between the level of anxiety experienced by a mother during pregnancy and offspring cognition and structural and functional brain correlates. The current study uses fMRI to examine the association between prenatal exposure to maternal anxiety and brain activity associated with endogenous versus exogenous cognitive control in 20-year-old males. Endogenous cognitive control refers to the ability to generate control over decisions, strategies, conflicting information and so on, from within oneself without external signals, while exogenous control is triggered by external signals. In line with previous results of this long-term follow-up study we found that 20-year-olds of mothers reporting high levels of anxiety during weeks 12-22 of pregnancy exhibited a different pattern of decision making in a Gambling paradigm requiring endogenous cognitive control, compared to adults of mothers reporting low to average levels of anxiety. Moreover, the blood oxygenation level dependent (BOLD) response in a number of prefrontal cortical areas was modulated by the level of antenatal maternal anxiety. In particular, a number of right lateralized clusters including inferior frontal junction, that were modulated in the adults of mothers reporting low to average levels of anxiety during pregnancy by a task manipulation of cognitive control, were not modulated by this manipulation in the adults of mothers reporting high levels of anxiety during pregnancy. These differences in brain functional correlates provide a neurobiological underpinning for the hypothesis of an association between exposure to maternal anxiety in the prenatal life period and a deficit in endogenous cognitive control in early adulthood. [ABSTRACT FROM AUTHOR]

Resveratrol (RSV) can protect against non-communicable diseases by improving cholesterol metabolism. However, it is unclear that effects of maternal RSV intake on health of adult offspring. In this study, we examined effects of maternal RSV intake during lactation on cholesterol metabolism in adult male rat offspring. Female Wistar rats were fed a control diet (CON) supplemented with or without RSV (20 mg/kg body weight/day) during their lactation period. Male offspring were weaned onto a standard diet and maintained on this diet for 36 weeks. As a result, plasma cholesterol level significantly decreased in RSV offspring compared to CON offspring. Furthermore, a decrease in hepatic 3-hydroxy-3-methylglutaryl-CoA reductase level and an increase in hepatic LDL-receptor level were observed in the RSV offspring. These results indicate that maternal RSV intake causes long-term decrease in plasma cholesterol level in the offspring through suppression of hepatic cholesterol biosynthesis and promotion of hepatic cholesterol uptake. [ABSTRACT FROM AUTHOR]

Background: Maternal lipid intake in the early postnatal period has a long-term effect on the possibility of fatty liver formation in children; besides, the importance of lipid consumption during lactation for children's health has been suggested. Green tea extract (GTE) contains abundant catechins, and it has been reported to improve lipid metabolism and prevent fatty liver. Objective: The aim of this study was to examine the effects of maternal GTE intake during lactation on hepatic lipid accumulation in adult male rats exposed to a continuous high-fat (HF) diet from the foetal period. Methods: Pregnant Wistar rats received diets containing 13% (control-fat, CON) or 45% (high-fat, HF) fat. CON-fed mothers received the same diet during lactation, whereas HF-fed mothers received either HF diet alone or HF diet supplemented with 0.24% GTE. At weaning, male offspring were divided into three groups, i.e. CON/CON/CON, HF/HF/HF (HF-offspring) or HF/HF+GTE/HF (GTE-offspring), and were fed until 51 weeks. Results: A significant hepatic triglyceride (Tg) accumulation was observed in the HF-offspring when com- pared with the other offspring. This is presumed to be caused by the promotion of Tg synthesis derived from exogenous fatty acid due to a significant increase in diacylglycerol O-acyltransferase 1 and a decrease in Tg expenditure caused by decreasing microsomal triglyceride transfer protein (MTTP) and long-chain acyl-CoA dehydrogenase. On the other hand, attenuated hepatic Tg accumulation was observed in the GTE-offspring. The levels of the hepatic lipid metabolism-related enzymes were improved to the same level as the CON- offspring, and particularly, MTTP was significantly increased as compared with the HF-offspring. Conclusion: This study indicates the potential protective effects of maternal GTE intake during lactation on HF diet-induced hepatic lipid accumulation in adult male rat offspring and the possible underlying mechanisms. [ABSTRACT FROM AUTHOR]

The U.S. National Longitudinal Lesbian Family Study has followed offspring with sexual minority parents from conception into adulthood. It was initiated in 1986, and it has a 92% retention rate to date. In the current investigation, the 25-year-old offspring answered questions about sexual attraction, sexual identity, and sexual experiences; their responses were compared with those of same-age adults from a population-based survey. The analytic samples consisted of 76 offspring of lesbian parents and 76 demographically matched participants from the National Survey of Family Growth. All 152 respondents were 25 years old, 48.7% were female, 90.8% identified as White, 9.2% were people of color, and all had attended at least some college. Although most respondents in each sample identified as "heterosexual or straight," compared to their matched counterparts in the population-based survey, the female and male offspring of lesbian parents were significantly more to likely to report same-sex attraction, sexual minority identity, and same-sex experience. These findings suggest that adult offspring from planned lesbian families may be more likely than their peers to demonstrate diversity in sexual attraction, identity, and expression. [ABSTRACT FROM AUTHOR]

Background: Hoarding disorder is associated with significant impairment for the individual such as lower rates of employment and social isolation. However, less is known about the impact of this condition on the children of people with hoarding disorder (HD). No qualitative research to date has focussed exclusively on the experiences of adult offspring of parents with hoarding difficulties. The present qualitative study set out to investigate the experiences of adult offspring of parents with hoarding difficulties, exploring the present, and longer‐term impacts of parental hoarding. Method: Seven females between the ages of 35 and 62 years were interviewed using a semi‐structured format; all reported parental hoarding within the clinically significant range. Interpretative phenomenological analysis was utilised to analyse interview transcripts. Results: Four superordinate themes were extracted from the data: psychological and emotional outcomes, coping strategies, perceptions of parental hoarding, and impact on relationships. Conclusions: The research demonstrated the significant impacts of parental hoarding on their offspring, both individually and on a relational level. The outcomes of this research provide clinical implications for working with this population, as well as suggestions for future research. [ABSTRACT FROM AUTHOR]

Background and aims: Pregnancy is an important period in women life regarding different aspects including physical activity which may be effective on various health indices of offspring. One of the common and expanding women diseases is breast cancer and two of its related indices are BRCA1 and P53. Thus, the aim of present study was estimating the effect of aerobic training during pregnancy in pregnant rats on the expression of BRCA1 and P53 genes of their offspring’s breast tissue. Methods: 20 female Sprague Dawley rats were randomly divided into two groups of exercise during pregnancy (T) (221±9.9) and control (C) (223.8±12.8). The aerobic exercise training was performed immediately after observation of the vaginal plaque of approving pregnancy for 21 days and 5 sessions per week with moderate intensity. About 2 to 3 days before delivery, their training program was terminated. Tissue sampling of Pairs 4, 5, and 6 of breast tissues in 8 weeks offspring rats was performed to evaluate the expression of BRCA1 and P53 gene. Data was analyzed using SPSS software and statistical tests of Shapiro-Wilk to control the distribution of data, and independent t-test for comparisons of between groups. Results: Aerobic training with moderate intensity during pregnancy increased significantly mRNA of the BRCA1 gene (P=0.001), but there was no significant change in mRNA of the P53 (P=0.69). Conclusion: Considering the effect of exercise during pregnancy on increasing BRCA1 gene expression in their offspring's and association of the gene with breast, it seems that moderate exercise during pregnancy can reduce the risk of breast cancer in children. [ABSTRACT FROM AUTHOR]

The authors categorized communication strategies employed to exchange social support (type and person centeredness) in three online forums about parents with harmful drinking. Data included discussion postreplies over 2 months; N = 1,644 units of analysis. Support type categories were identification, emotional, informational, network, and esteem. For person centeredness, most messages were moderate (expressed sympathy, provided distraction), followed by high (helped with feelings), and then low (minimized feelings). Adult offspring of parents with harmful drinking predominantly communicate self-interested forms of support in online forums. Based on principles of supportive communication, esteem support and high person centeredness may enhance social support in these settings. [ABSTRACT FROM AUTHOR]

High parental age at childbirth has repeatedly been linked to childhood malignancies, while few studies have focused on the offspring's risk of adult cancer. In this population-based case-control study, we identified 32,000 patients with lymphoid neoplasms, diagnosed at ages 0-79 years during the period 1987-2011, and 160,000 matched controls in Sweden. Using prospectively registered data on their first-degree relatives, we evaluated the impact of parental age on the risk of lymphoid neoplasms by subtype. Overall, each 5-year increment in maternal age was associated with a 3% increase in incidence of offspring lymphoid neoplasms (hazard ratio = 1.03, 95% confidence interval: 1.02, 1.04). The association was similar for paternal age and present even among individuals older than 70 years of age at diagnosis. Stratified analyses further revealed that the association was limited to certain subtypes, mostly of indolent nature. Risks of chronic lymphocytic leukemia, follicular lymphoma, and mantle cell lymphoma were 5%-10% higher per 5-year increment in maternal age, but no associations were observed for acute lymphoblastic leukemia, plasma cell neoplasms, or diffuse large B-cell lymphoma. These findings indicated that prenatal genetic or epigenetic changes influence risk of adult lymphoid neoplasms and suggest a difference in this association between aggressive and indolent lymphoma subtypes. [ABSTRACT FROM AUTHOR]

Among the numerous consequences of prenatal alcohol exposure (PAE) is an increase in anxiety-like behavior that can prove debilitating to daily functioning. A significant body of literature has linked gestational day 12 (G12) heavy ethanol exposure with social anxiety, evident in adolescent males and females. However, the association between non-social anxiety-like behavior and moderate alcohol exposure, a more common pattern of drinking in pregnant women, is yet unidentified. To model moderate PAE (mPAE), we exposed pregnant Sprague-Dawley rats to either room air or vaporized ethanol for 6 h on G12. Adolescent offspring were then tested on postnatal days (P) 41-47 in one of the following four anxiety assays: novelty-induced hypophagia (NIH), elevated plus maze (EPM), light-dark box (LDB) and open-field (OF). Our findings revealed significant increases in measures of anxiety-like behavior in male PAE offspring in the NIH, LDB and OF, with no differences observed in females on any test. Additionally, male offspring who demonstrated heightened anxiety-like behavior as adolescents demonstrated decreased anxiety-like behavior in adulthood, as measured by a marble-burying test (MBT), while females continued to be unaffected in adulthood. These results suggest that mPAE leads to dynamic changes in anxiety-like behavior exclusively in male offspring. [ABSTRACT FROM AUTHOR]

Background and objective Existing evidence that supports maternal smoking to be a potential risk factor for chronic obstructive pulmonary disease (COPD) for adult offspring has barely been mentioned in major guideline documents, suggesting a need for more robust and consistent data. We aimed to examine whether such early life exposure can predispose to COPD in middle age, possibly through its interaction with personal smoking. Methods The fifth-decade follow-up of the Tasmanian Longitudinal Health Study cohort, which was first studied in 1968 ( n = 8583), included a 2004 postal survey ( n = 5729 responses) and subsequent laboratory attendance ( n = 1389) for comprehensive lung function testing between 2006 and 2008. Multivariable linear and logistic regression models included sampling weights. Results Post-bronchodilator airflow obstruction (less than fifth percentile) was detected for 9.3% ( n = 123) of middle-aged offspring. Its association with heavy maternal smoking (>20 cigarettes/day) during childhood was 2.7-fold higher than for those without exposure (95% confidence interval [1.3, 5.7] P = 0.009). Maternal smoking per se approximately doubled the adverse effect of personal smoking on gas transfer factor ( z-score −0.46 [−0.6 to −0.3] vs −0.25 [−0.4 to −0.1], P[interaction] = 0.048) and was paradoxically associated with reduced residual volumes for non-smokers. Conclusions Heavy maternal smoking during childhood appears to predispose to spirometrically defined COPD. The interplay between maternal and personal smoking on gas transfer factor suggests that early life exposure increases an individual's susceptibility to adult smoking exposure. These findings provide further evidence to suggest that maternal smoking might be a risk factor for COPD and reinforce the public health message advocating smoking abstinence. [ABSTRACT FROM AUTHOR]

Background: The aim of this study was to determine the effect of preconception endurance exercise training with voluntary exercise activity during pregnancy in mother mice on lipid profile in adult offsprings. Materials and Methods: Twenty four C57BL/6 female mice were randomly divided into four subgroups: trained in preconception period and exercised during pregnancy (TE)(20.3±1.02g); trained in preconception periods but unexercised during pregnancy (TC)(21.58±0.4g); untrained in preconception periods but exercised during pregnancy (CE)(21.02±0.23g); untrained and unexercised (CC)(19.23±0.45g). Trained mice were subjected to a protocol of moderate endurance exercise training over a period of 4 weeks for 5 days before pregnancy. The fasting blood samples were collected from adult mice(8 weeks old) and serum levels of glucose and lipid profile were measured. Data were analyzed using two way ANOVA and Tukey's post hoc test. Results: The Glucose test results in offspring showed that there was a significant interaction between group and sex and group main effect (p<0.001) Glucose levels of male offspring were significantly lower in TC and TE groups. Results on LDL also showed that the sex main effect was significant (p<0.001), and LDL levels of male born to TE and TC dams lower than in female offspring. Conclusion: Improving the mother's physical fitness by providing regular endurance training in the preconception period and maintaining it by exercise activty throughout pregnancy may have potential for eliciting positive changes in lipid profile of offspring, specially males. [ABSTRACT FROM AUTHOR]

Background: Intergenerational effects of child abuse have been documented, but it is unknown whether maternal childhood abuse influences offspring mental health in adolescence or adulthood.Methods: To examine whether maternal experience of childhood abuse is associated with depressive symptoms in adolescent and young adult offspring, we linked data from two large longitudinal cohorts of women (N = 8,882) and their offspring (N = 11,402), and we examined three possible pathways by which maternal experience of abuse might be associated with offspring depressive symptoms: maternal mental health, family characteristics, and offspring's own experience of abuse.Results: Offspring of women who experienced severe versus no childhood abuse had greater likelihood of high depressive symptoms (RR = 1.78, 95% CI = 1.47, 2.16) and persistent high depressive symptoms (RR = 2.47, 95% CI = 1.37, 4.44). Maternal mental health accounted for 20.9% and offspring's exposure to abuse accounted for 30.3% of the elevated risk of high depressive symptoms. Disparities in offspring depressive symptoms by maternal abuse exposure were evident at age 12 years and persisted through age 31 years.Conclusions: Findings provide evidence that childhood abuse adversely affects the mental health of the victim's offspring well into adulthood. As offspring exposure to abuse and maternal mental health accounted for more than 50% of the elevated risk of high depressive symptoms among offspring of women who experienced abuse, improving maternal mental health and parenting practices may reduce offspring risk for depressive symptoms in these families. [ABSTRACT FROM AUTHOR]

Background Prenatal maternal depressive, anxious, and stress symptoms have been found to be associated with child and adolescent behavior problems. In this paper, we investigate their impact on behavior problems and depressive symptoms in adulthood. Methods Participants included 3,099 mother-offspring pairs from the Mater University Study of Pregnancy (MUSP), an Australian based, prebirth cohort study. We used latent class growth analysis (LCGA) with parallel processes to identify trajectories of maternal depressive, anxious, and stress symptoms over four time periods between the mothers' first clinic visit and 5 years postpregnancy. We fitted the estimates from the maternal trajectories in multivariate logistic regression models to predict internalizing and externalizing behavior at age 21. We adjusted for a wide range of prenatal and postnatal factors, including maternal life events, relationship quality, contact with the new born, as well as concurrent maternal depressive and anxious symptoms and father's history of mental health problem. Results LCGA found seven groups of mothers; one group of mothers exhibited high levels of depressive, anxious, and stress symptoms during pregnancy but not at later time points. Their offspring experienced increased levels of behavior problems and depressive symptoms. Conclusions This paper provides the first evidence that high levels of maternal subjective depressive, anxious, and stress symptoms experienced in early pregnancy may predict internalizing and externalizing behavior problems and depressive symptoms in young adults. [ABSTRACT FROM AUTHOR]

People linked through social ties are known to have interdependent health. Our aim was to investigate such collateral health effects in the context of offspring mortality after a parent's death in children aged 10-59 years. The data (N = 3,753,368) were from a linked-registers database that contains the total Swedish population. In minor children, we found elevations in mortality risks associated with a parent's death. Adult offspring experienced a reduced mortality risk recently after a parent's death, which over time approached, and in some instances even exceeded, that of the general population. Mother's death tended to have a stronger influence than father's death, unnatural parental deaths had a stronger effect than natural ones, and male offspring were more vulnerable than female offspring. [ABSTRACT FROM AUTHOR]

This study examined whether having a depressed parent intensifies the secondary deficits that often co-occur with offspring’s depression symptoms. The sample was adult offspring of parents who had been diagnosed with depression 23 years earlier ( N = 143) and demographically matched nondepressed parents ( N = 197). Respondents completed mailed questionnaires. After controlling for demographic factors, offspring who were more depressed experienced more impairment: physical dysfunction, pain, and disability; anxiety, smoking, and drinking-related problems; poorer social resources; negative events and severe stressors; and reliance on emotional discharge coping. Parental status (depressed or not depressed) was not directly related to offspring impairment once offspring depression symptoms were controlled. However, parental status moderated associations between offspring’s depression severity and their impairment: relationships between depression and impairments were generally stronger for offspring of depressed parents than for offspring of nondepressed parents. Depressed individuals who are offspring of depressed parents may be at particular risk for the secondary deficits of depression. [ABSTRACT FROM AUTHOR]

Emotions towards a relationship partner provide relevant and specific information about relationship quality. Based on this assumption the present study was performed to identify different types of emotional relationship quality of middle-aged adult children with their ageing parents. This was done by cluster analytic procedures in a sample of 1,208 middle-aged adult children (482 men, 726 women). Using ratings of positive and negative emotions towards their mother and father as grouping variables, the same four-cluster solution emerged for both the child–mother relationship and the child–father relationship. Clusters were labelled as amicable, disharmonious, detached and ambivalent relationships. Results showed that especially amicable relationships clearly prevailed followed by ambivalent, detached and disharmonious relationships. Clusters differed significantly with respect to gender of adult child, willingness to support, expected parental support and overt conflicts. In a cross-classification of cluster membership regarding the child–mother relationship (four clusters) and the child–father relationship (four clusters), all possible 16 combinations were observed, with a considerable degree of divergence regarding the type of relationship quality within the same family. Results are discussed with respect to types of emotional relationship quality, within family differences and the intrafamilial regulation of relationship quality. [ABSTRACT FROM AUTHOR]

This study examined the influence of maternal psychological distress symptoms during offspring’s preschool, middle childhood, and adolescent years on the distress symptoms of offspring in adulthood. Data were derived from the British Cohort Study, a longitudinal study of children born in a one-week period in 1970. Results indicated that greater symptoms of maternal distress that persisted over multiple stages of offspring development were generally associated with greater symptoms of distress in adult offspring. The effect of greater maternal distress symptoms that persisted across preschool, middle childhood, and adolescence on adult offspring, however, was not significantly different from the long term effects of a single, but early, exposure to maternal distress once offspring’s psychosocial adjustment during adolescence was considered. The relationship between mother and offspring distress symptoms did not vary for male and female offspring. The results provide general support for a cumulative effect perspective in that continuous exposure to maternal distress symptoms had negative consequences in adulthood, and that the adult effect of exposure in early or middle childhood was explained by adolescent adjustment. [ABSTRACT FROM AUTHOR]

A growing number of jurisdictions have introduced legislation to give children the right to information about, and identity of, ‘their’ gamete donor. This has been accompanied by a reduction in the social stigma associated with infertility and building families with the assistance of donated gametes. This changing culture has meant that an increasing number of parents are seeking assistance regarding how to share their family history, including the donor insemination conception story. The literature suggests that the sharing of information is best undertaken when the children are young. There is virtually no literature available for parents who wish to share their family history with adult offspring, or for those professionals whose guidance they may seek. This paper addresses this emerging area of practice. It is suggested that there are three main areas that will be of assistance with any attempt to understand the individual and family dynamics involved: identity and self-image, stigma and power. Strategies and suggestions emerging from each of these areas of knowledge are outlined. This paper aims to generate discussion and to encourage others to share their clinical experiences in this area. [ABSTRACT FROM AUTHOR]

The aim of this study was to examine the association between changes in mother’s education level during early childrearing years with offspring’s tobacco and alcohol (TA) use in adulthood. It was hypothesised that use of TA is lower among offspring whose mothers improve their level of education compared with offspring for whom mother’s education level does not increase. Information on TA use among 1,015 adults (from a national survey in 1998; response rate 72.7%) was linked with information on their mother’s education levels recorded in the National Education Register from 28 to 8 years earlier (mother’s education in 1970 and change in level of education from 1970 to 1990). Multiple logistic regression revealed an inverse association between increase in maternal education level and risk of high alcohol use among female offspring. Higher level of mother’s education measured in 1970 was associated with lower risk of daily smoking and lower risk of moderate and high levels of alcohol use among male and female offspring. Low level of tobacco and alcohol consumption among adult offspring is influenced by mother’s level of education. Research on social inequalities in health behaviour should include more attention to the possible effects of mother’s social mobility during childrearing years. [ABSTRACT FROM AUTHOR]

Based on equity theory, the present study analyzes to what extent justice evaluations mediate the effects of perceived parental differential treatment (PDT) on relationship quality with siblings and parents as experienced in middle adulthood. Middle-aged adult offspring (N = 709) rated how often they and a sibling received parental recognition, nurturance, and demands for assuming filial responsibility. In addition, they indicated their justice evaluations of PDT and completed measures of relationship quality to sibling and parents. Justice evaluations emerged as either partial or complete mediators between PDT and relationship quality. Moreover, justice evaluations turned out to be more powerful predictors of relationship quality to parents than PDT per se. Implications are discussed concerning factors contributing to justice evaluations and the role of PDT within the context of other justice issues in families. [ABSTRACT FROM AUTHOR]

Abbott R, Dunn VJ, Robling SA, Paykel ES. Long-term outcome of offspring after maternal severe puerperal disorder.Acta Psychiatr Scand 2004: 110: 365–373.© Blackwell Munksgaard 2004.To study adult mental health in offspring of mothers who experienced severe puerperal disorder.Mothers, followed up a mean of 23 years after puerperal disorder requiring hospitalization, were interviewed regarding adult psychiatric illness, childhood neurotic symptoms and conduct problems of 48 offspring of the index episode and 62 additional siblings.In these predominantly young adults the lifetime rate of ICD-10 adult psychiatric illness was 26%, and was higher in offspring of puerperal episodes (35% vs. 15%,P = 0.07). There were also high rates of childhood symptoms and problems.There are high lifetime rates of adult psychiatric illness in young adult offspring of mothers with puerperal disorder, which are likely to increase further with time, and warrant special attention. [ABSTRACT FROM AUTHOR]

This article reports on an investigation into the relation between young adults' retrospective reports of their mothers' and fathers' division of household labor (egalitarian or traditional) and parenting styles (authoritative, permissive, authoritarian, or disengaged). Participants' own gender attitudes were also tested in relation to parents' division of labor and parenting. The sample included 294 women and men (M =19-years old) who were raised in 2-parent households and came from a range of ethnic backgrounds. When mothers' parenting was evaluated, permissive parenting was more likely among those from egalitarian households whereas authoritarian parenting was more likely among those from traditional households. When fathers' parenting was evaluated, authoritative parenting was more likely among participants from egalitarian households and disengaged parenting was more likely among those from traditional households. The association between fathers' parenting style and division of labor was specific to the division of childcare (rather than housework). Participants' gender attitudes were not related to parents' division of labor or parenting style. [ABSTRACT FROM AUTHOR]

Creatine plays a crucial role in developing the brain, so much that its genetic deficiency results in mental dysfunction and cognitive impairments. Moreover, creatine supplementation is currently under investigation as a preventive measure to protect the fetus against oxidative stress during difficult pregnancies. Although creatine use is considered safe, posing minimal risk to clinical health, we found an alteration in morpho-functional maturation of neurons when male rats were exposed to creatine loads during brain development. In particular, increased excitability and enhanced long-term potentiation (LTP) were observed in the hippocampal pyramidal neurons of weaning pups. Since these effects were observed a long time after creatine treatment had been terminated, long-lasting modifications persisting into adulthood were hypothesized. Such modifications were investigated in the present study using morphological, electrophysiological, and calcium imaging techniques applied to hippocampal Cornu Ammonis 1 (CA1) neurons of adult rats born from dams supplemented with creatine. When compared to age-matched controls, the treated adult offspring were found to retain enhanced neuron excitability and an improved LTP, the best-documented neuronal substrate for memory formation. While translating data from rats to humans does have limitations, our findings suggest that prenatal creatine supplementation could have positive effects on adult cognitive abilities. [ABSTRACT FROM AUTHOR]