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Objective: To describe the gene alteration status in high-grade neuroendocrine cervical carcinoma (NECC) specimens and to explore the potential association of unique gene alterations with survival. Methods: Results from tumor-based molecular testing on specimens from women with high- grade NECC in the Neuroendocrine Cervical Tumor Registry were reviewed and analyzed. Tumor specimens could be from primary or metastatic sites and obtained at initial diagnosis, during treatment, or at recurrence. Results: Molecular testing results were available for 109 women with high-grade NECC. The genes most frequently mutated were PIK3CA (mutated in 18.5% of patients), TP53 (17.4%), and MYC (14.5%). Other targetable alterations identified were alterations in KIT (7.3%), KRAS (7.3%), and PTEN (7.3%). Women with tumors having an RB1 alteration (6.4%) had a median overall survival (OS) of 13 months, compared to 26 months for women with tumors that did not have an RB1 alteration (p=0.003). None of the other genes evaluated were shown to be associated with OS. Conclusion: Although no individual alteration was found in a majority of tumor specimens from patients with high-grade NECC, a large proportion of women with this disease will have at least one targetable alteration. Treatments based on these gene alterations may offer additional targeted therapies for women with recurrent disease, who currently have very limited therapeutic options. Patients with tumors that harbor RB1 alterations have decreased OS. [ABSTRACT FROM AUTHOR]

To address disparities in COVID-19 outcomes among Latinos with limited English proficiency in Maryland, our team developed a culturally congruent intervention that coupled a statewide social marketing campaign with community-based COVID-19 services. In the first year, we reached 305 122 people through social media advertisements and had 9607 visitors to the Web site. Social marketing campaigns represent an opportunity to promote COVID-19 testing and vaccine uptake among Latino populations, especially when they are paired with community services that simultaneously address structural barriers to care. (Am J Public Health. 2023;113(3):263–266. https://doi.org/10.2105/10.2105/AJPH.2022.307191) [ABSTRACT FROM AUTHOR]

Copyright of Revista Alergia de Mexico is the property of Coleg. Mexicano de Inmunologia Clinica y Alergia A.C.; Soc. Lat. de Alergia, Asma e Inmunologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In Oaxaca, in 2019, 90.1% of the certified mezcal produced domestically was produced, in addition to an unknown amount of non-certified mezcal, which in its production generates waste, bagasse the most important. Although it is currently underutilized in Oaxaca, there are various investigations into its potential, which have been aimed at obtaining various products and metabolites for industrial use. The exact data on the amount generated in the palenques and their characteristics is unknown; however, it is important information since it is the basis for establishing management strategies. In this work, carried out in the Central Valleys region of Oaxaca during 2017, the basic characterization of the solid residues of the mezcal agribusiness by species used is presented, and coefficients that can be applied for general estimation of rapid production are estimated of these residues, and serve as a basis for management strategies. It is concluded that there are differences in the characteristics of the residues and the amount of bagasse generated between the different evaluated species. [ABSTRACT FROM AUTHOR]

Copyright of CULCyT: Cultura Científica y Tecnológica is the property of Cultura Cientifica y Tecnologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This article discusses the history of the legends and myths of the Patagonian giants in the region of the Strait of Magellan as a result of explorations and ocean voyages in the Pacific Ocean at the start of the 16th century. The author comments on the representation of these myths in historical documents and artistic works created at the time. The stories related by Italian explorer Antonio Pigafetta, who was commissioned by Spanish monarch Charles I, regarding the legendary giants is also explored.