One important technique of producing ultra‐clean fuel or value‐added chemicals is through Fischer‐Tropsch synthesis. The solubility of synthesis gases (H2 and CO) in the liquid phase is a significant aspect, which paves the way for evaluation of the product's distribution during the process. In this work, a complete equation has been developed that can predict the solubility of syngas in line with experimental data. The majority of average absolute deviation (AAD) of results was lower than 2.5 %. In addition, the effect of thermodynamic parameters, i.e., pressure and temperature, and the H2/CO ratio is considered in this equation by four different factors. The impact of pressure on syngas is divided into two adjustment components, denoted as n1 for CO and n2 for H2. The subsequent factor is n3, which illustrates how temperature affects the solubility of syngas. Further, the n represents the H2‐to‐CO feed ratio impacts on syngas solubility. Considering these factors and their mutual interactions allows for evaluating syngas solubility and chain growth accurately. [ABSTRACT FROM AUTHOR]